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Dan Bose @danbose.bsky.social · 2d

Great review of the super #NeuroBioUK2025 meeting in September. Well done to everyone who organised it @exdrososcientia.bsky.social @alexfellows1.bsky.social and @dozenoaks.bsky.social for putting together such a great meeting for the community! 👏🧠🔬 tinyurl.com/4jn7yrmt roll on next year!

NeuroBio UK 2025: Insights, Innovation, and Inspiration in Neuroscience - FocalPlane

NeuroBio UK 2025: Insights, Innovation, and Inspiration in Neuroscience -

tinyurl.com

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Reposted by Dan Bose

Ule Lab @ulelab.bsky.social · 14d

Collective challenges need collective solutions. Happy to share the insights we've gained from the way our cells handle this: www.nature.com/articles/s41... and its summary www.crick.ac.uk/news/2025-09....

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Reposted by Dan Bose

Connor Rogerson @doctorconnor.bsky.social · 13d

We have space for two postdoctoral fellows in the Taipale Lab at the @sangerinstitute.bsky.social. This is a core-funded open position! Come with your ideas and interests and we can develop a project together.

sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Postdoctoral Fellow - Gene Regulation and Functional Genomics

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...

sanger.wd103.myworkdayjobs.com

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Reposted by Dan Bose

Marco Trizzino @marcotrizzino.bsky.social · 16d

Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org!
Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social
www.embopress.org/doi/full/10....

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Dan Bose @danbose.bsky.social · 15d

Come and hear about our latest story! It's a really nice series as well- sign up for the mailing list for updates #condensates #UKcondensates

Janet Kumita @jrkumita.bsky.social · 15d

Come join us for the next monthly on-line seminar (3rd October, 1 pm BST) aimed to connect the UK Biomolecular Condensate community (All are welcome to come and listen). @danbose.bsky.social @physicsoflifeuk.bsky.social

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Dan Bose @danbose.bsky.social · 16d

Will do- thanks!!

Dan Bose @danbose.bsky.social · 16d

This looks super useful!

John Ngo @johntngo.bsky.social · 16d

🚀 Our new paper is out @natmethods.nature.com!

Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.

🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/

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Dan Bose @danbose.bsky.social · 19d

Such a cool story- great to see it finally out in the wild #enhancers #geneRegulation

mathiaseder.bsky.social @mathiaseder.bsky.social · 19d

✨Exciting news: the main story of my PhD is out in Science!

Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.

📖 Read the full story here: www.science.org/doi/10.1126/...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

www.science.org

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Reposted by Dan Bose

mathiaseder.bsky.social @mathiaseder.bsky.social · 19d

✨Exciting news: the main story of my PhD is out in Science!

Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.

📖 Read the full story here: www.science.org/doi/10.1126/...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

www.science.org

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Reposted by Dan Bose

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 21d

New review on computational design of intrinsically disordered proteins 🖥️🍝 by @giuliotesei.bsky.social @fpesce.bsky.social & 👴

doi.org/10.48550/arX...

Figure 3 from the paper with the caption: "Role of machine learning in de novo design of IDRs. (A) Machine-learning models can be trained on diverse data sources, from molecular dynamics simulations to annotations of cellular localization and protein structures from the Protein Data Bank. (B) Often implemented as neural networks using sequence-encoded features as input, these models can initially be trained on a limited region of sequence space as surrogate models. Through active learning, additional simulations are performed during the design campaign to generate new data, and the surrogate model is retrained on the expanded dataset to progressively improve its accuracy. (C) Machine-learning models have been developed to predict biophysical observables, biological annotations, and protein structures. When combined, machine-learning models can be used to identify a set of sequences that strike a trade-off between multiple design objectives, defining a Pareto front."

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Reposted by Dan Bose

Janet Kumita @jrkumita.bsky.social · Jul 28

We (and many!) have been thinking a lot about how to quantifiably measure the material properties of biomolecular condensates inside cells. Chris (my final year PhD student) wrote this great review article about microscopy-based techniques link.springer.com/article/10.1... @phar.cam.ac.uk

Microscopy-based techniques for studying the material properties of biomolecular condensates in the cellular environment - Biophysical Reviews

The material properties of biomolecular condensates, such as interfacial tension, viscoelasticity, stiffness, and molecular dynamics, are crucial for their biological functions in processes like signa...

link.springer.com

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Dan Bose @danbose.bsky.social · 21d

Looking forward to catching up with everyone at the @biochemsoc.bsky.social #transcription and #chromatin UK #TCUK meeting today in sunny Manchester! #BiochemEvent 🧬🔬☔️ www.eventsforce.net/biochemsoc/f...

www.eventsforce.net

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Reposted by Dan Bose

Nature Reviews Genetics @natrevgenet.nature.com · 22d

New online! Is enhancer-driven gene regulation all wrapped up?

Is enhancer-driven gene regulation all wrapped up?

Nature Reviews Genetics, Published online: 16 September 2025; doi:10.1038/s41576-025-00880-9In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.

www.nature.com

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Dan Bose @danbose.bsky.social · 27d

Nice use of #smFRET to study #idr #dynamics

bioRxiv Biophysics @biorxiv-biophys.bsky.social · 27d

The role of intrinsically disordered domains in regulating G protein coupled receptor signaling https://www.biorxiv.org/content/10.1101/2025.09.10.675278v1

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Reposted by Dan Bose

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 27d

👀

Multiple human enhancer RNAs contain long translated open reading frames

genesdev.cshlp.org/content/earl...

Multiple human enhancer RNAs contain long translated open reading frames

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

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Reposted by Dan Bose

Jackson Hoffman @jxhoffman.bsky.social · Sep 8

Really excited to get our seminars back up and running. @gracebower.bsky.social is going 1st and if you haven't read her range extender story, you're in for a treat!
+
@creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!

FragileNucleosome @fnucleosome.bsky.social · Sep 5

Let’s kickstart new series of #FragileNucleosome seminars! We are delighted to have @gracebower.bsky.social from Kvon lab and @creminslab.bsky.social to present their work!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

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Reposted by Dan Bose

Kurianlab @kurianlab.bsky.social · Sep 9

www.nature.com/articles/s41...?

ALFA nanobody-guided endogenous labeling - Nature Chemical Biology

Small peptide tags (like ALFA) cause minimal disruption of proteins, but they typically lack fluorescence, which would enable knockin screening. Now, antigen-stabilizing fluorescent protein-fused nano...

www.nature.com

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Reposted by Dan Bose

Pradeepa Madapura @pradeepmadapura.bsky.social · Sep 8

Great news, no more grant deadlines 😀 MRC applicant-led funding – UKRI share.google/lP742F01GmuK...

Simplifying access to MRC applicant-led funding

We’re introducing a new flexible research grant and removing closing dates from our board funding opportunities.

share.google

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Reposted by Dan Bose

Carmelo Ferrai @carmeloferrai.bsky.social · Sep 7

The emerging roles of long non-coding RNAs in the nervous system

www.nature.com/articles/s41...

The emerging roles of long non-coding RNAs in the nervous system - Nature Reviews Neuroscience

Long non-coding RNAs are abundant in the brain, where they are proposed to regulate numerous processes. In this Review, Mattick and colleagues describe our current understanding of their mechanisms of...

www.nature.com

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Dan Bose @danbose.bsky.social · Sep 3

Cracking lineup of @fnucleosome.bsky.social seminars over the next few months!

Jeff Vierstra @jeffvierstra.bsky.social · Sep 1

Looks like a great couple of months of seminars! Come check out my talk on November 5th if you want to learn about our progress in mapping the nucleotide-resolved structure and function of cis-regulatory DNA elements across thousands of cell types and states.

FragileNucleosome @fnucleosome.bsky.social · Sep 1

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...

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Dan Bose @danbose.bsky.social · Sep 3

Last day to register for the awesome #NeuroBioUK25! Everything #molecular #neurobiology to kick off you autumn!

Ali Twelvetrees @dozenoaks.bsky.social · Aug 28

The programme is up for #NeuroBioUK25 - take a look! And don’t forget to register by the 3rd of September…. neurobiouk.sites.sheffield.ac.uk/programme

NeuroBioUK - Programme

9 AM Arrival, registration & coffee Session 1: Organelle and synaptic signalling Session Chair: 9:45 AM Introduction 9:50 AM Sally Horton, The Francis Crick Institute, "CDKL5 in synaptic formation,...

neurobiouk.sites.sheffield.ac.uk

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Dan Bose @danbose.bsky.social · Aug 28

Just dropped: Super exciting lineup this year for NeuroBio UK! There's still time to register if you haven't done so yet!

Ali Twelvetrees @dozenoaks.bsky.social · Aug 28

The programme is up for #NeuroBioUK25 - take a look! And don’t forget to register by the 3rd of September…. neurobiouk.sites.sheffield.ac.uk/programme

NeuroBioUK - Programme

9 AM Arrival, registration & coffee Session 1: Organelle and synaptic signalling Session Chair: 9:45 AM Introduction 9:50 AM Sally Horton, The Francis Crick Institute, "CDKL5 in synaptic formation,...

neurobiouk.sites.sheffield.ac.uk

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Reposted by Dan Bose

Helen Czerski @helenczerski.bsky.social · Aug 23

Ooh, look. When we covered the climate impacts of machine learning (“AI”) on Rare Earth in June we found it really frustrating that none of the tech companies would tell anyone the water and energy costs. Now Google has made at least some of it public. More of this! (and preferably raw data too).

In a first, Google has released data on how much energy an AI prompt uses

It’s the most transparent estimate yet from one of the big AI companies, and a long-awaited peek behind the curtain for researchers.

www.technologyreview.com

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Reposted by Dan Bose

Exciting Instruments @ei-science.bsky.social · Jul 22

Are you a @biophysicalsoc.bsky.social member? Vote in the 2025 election by 01/08! @timcraggs.bsky.social is nominated as Industry Rep. We encourage everyone to vote for this important cause, regardless of who you're voting for 🙂 www.biophysics.org/elections/bp... #biophysics #lifescience

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Dan Bose @danbose.bsky.social · Jul 22

Had a super day at the inaugural Nucleic Acids Institute 🧬🧬🧬summer symposium at The University of Sheffield. Loads of fantastic talks and posters and discussion from across all of our faculties and research themes, and two inspiring keynotes

Congratulations also to all our prize winners!🥇🎖️🥈

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