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brangwynnelab.bsky.social @brangwynnelab.bsky.social · 18d

A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize

Bioengineer Clifford Brangwynne wins Keio Medical Science Prize

Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell bi...

www.princeton.edu

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HHMI @hhmi.org · 19d

🎉 Congratulations to HHMI Investigators Clifford Brangwynne and Akiko Iwasaki, the two winners of the 30th annual Keio Medical Science Prize. This international prize, awarded by Keio University in Tokyo, honors scientists who have made major contributions to the fields of medical or life sciences.

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Anita Donlic @anitadonlic.bsky.social · Aug 20

I’m thrilled to share our preprint that uses deep learning to interrogate structure-function relationships in condensates! biorxiv.org/content/10.1... In here, we ask: can AI read condensate biology from pictures alone? Turns out yes... see what we discover below! 🤖🧬🖼️ (1/10)

Deep Learning of Functional Perturbations from Condensate Morphology

Biomolecular condensates compartmentalize the interior of living cells to spatiotemporally organize complex functions, yet linking molecular interactions within condensates to their mesoscale organiza...

biorxiv.org

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Anita Donlic @anitadonlic.bsky.social · Aug 20

Cells organize key processes in biomolecular condensates, such as the multiphase nucleolus where ribosomes are made 🏭. Due to its dynamic and compartmentalized nature, small molecule perturbations of this process💊 lead to fast and distinct morphology rearrangements🌀. (2/10)

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yoonji kim @yoonjikim.bsky.social · Aug 19

☁️ bonus squid game themed fun graphical abstract #오징어게임

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yoonji kim @yoonjikim.bsky.social · Aug 19

Our squid primary cell isolation protocol is now out in
@cp-starprotocols.bsky.social⭐️🦑🧫This protocol enables molecular studies of cephalopod biology, aging, and basic cell physiology. Thanks to @brangwynnelab.bsky.social Hailey Tanner and Josh Rosenthal! Check it out here tinyurl.com/3knvkhyh 🤩

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Nature @nature.com · Aug 6

Nature research paper: Lithium deficiency and the onset of Alzheimer’s disease

go.nature.com/4ftdsb2

Lithium deficiency and the onset of Alzheimer’s disease - Nature

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.

go.nature.com

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A. Sánchez Alvarado @planaria1.bsky.social · Aug 6

Evolution’s eye game is wild, but mollusks take it to another level

CRISPR in apple snails gives us a new model to dissect how nature rebuilds complex organs like the camera-type eyes we humans possess

It turns out Evolution doesn’t just innovate, it rewinds, remixes, & regenerates

rdcu.be/ezw0t

A genetically tractable non-vertebrate system to study complete camera-type eye regeneration

Nature Communications - Accorsi et al. show that the apple snail Pomacea canaliculata has eyes similar to humans and can fully regenerate them. They then developed genetic tools to establish these...

url.us.m.mimecastprotect.com

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Fletcher Lab @fletcherlabucb.bsky.social · Aug 7

Check out our most recent published paper in @natcomms.nature.com about the effects of cell surface crowding in cell-cell fusion: rdcu.be/ezCOF

Cell surface crowding is a tunable energetic barrier to cell-cell fusion

Nature Communications - Cell-cell fusion is fundamental to physiological processes such as muscle formation and viral infection. Here, the authors show that the proteins embedded on the plasma...

rdcu.be

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brangwynnelab.bsky.social @brangwynnelab.bsky.social · Jul 12

Congrats to Jing @jesszhiyuezhao.bsky.social‬
& @dnamystrom.bsky.social‬ on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR

Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior

Nature Communications - Chromatin heterogeneity in the cell nucleus modulates the size, mobility, and formation of biomolecular condensates; decreasing chromatin heterogeneity correlates with...

rdcu.be

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yoonji kim @yoonjikim.bsky.social · Jul 8

Super excited for @dnamystrom.bsky.social ✨huge congrats and can’t wait for all the cool science and discoveries to come 🔎🥳💚💜

Amy Strom @dnamystrom.bsky.social · Jul 7

I'm thrilled to announce my next career step-- I’m joining Genentech as a Principal Scientist & Lab Head in Discovery Oncology!
I’ll be hunting new ways to target cancers using my background in disordered nuclear proteins.

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yoonji kim @yoonjikim.bsky.social · Jul 8

🥳💚💜💚💜🥳

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Amy Strom @dnamystrom.bsky.social · Jun 16

If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...

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brangwynnelab.bsky.social @brangwynnelab.bsky.social · Jun 16

Awesome paper alert! Learn about spectrum of chromatin condensate morphologies due to elastocapillary effects (no, liquids do not need to be spherical!), from amazing duo @dnamystrom.bsky.social & Hongbo Zhao, w/ important contributions from co-authors Jorine Eeftens, Mikko Haataja, Andrej Kosmrlj.

Amy Strom @dnamystrom.bsky.social · Jun 16

If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...

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brangwynnelab.bsky.social @brangwynnelab.bsky.social · Jun 11

Princeton's new Omenn-Darling Bioengineering Institute is hiring! New building opening this Fall, & Princeton is an awesome place to live & do amazing research at intersection of engineering & life sciences. **Please spread the word*** bioengineering.princeton.edu/join/open.

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brangwynnelab.bsky.social @brangwynnelab.bsky.social · Jun 9

Start of 2025 @mblscience.bsky.social Physiology course! This is the second year of Amy @gladfelterlab.bsky.social and I co-Directing this absolutely amazing and life-changing course: www.mbl.edu/education/ad...

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Nadav Shai @nadavshai.bsky.social · Jun 3

🦟 Join us at the #VosshallLab @RockefellerUniv
and @HHMI as a postdoctoral scientist! We're seeking a creative individual who is enthusiastic about our research in mosquito neurogenetics.
Apply: hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Some of our 2025 cool science>

hhmi.wd1.myworkdayjobs.com

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Leslie B Vosshall PhD @leslievosshall.bsky.social · Jun 3

Join the #VosshallLab as a postdoctoral scientist. Fully funded, right here in New York City @rockefelleruniv.bsky.social
hhmi.wd1.myworkdayjobs.com/en-US/Extern...

Postdoctoral Scientist - Vosshall Lab

Primary Work Address: 1230 York Avenue, New York, NY, 10065 Current HHMI Employees, click here to apply via your Workday account. We have an outstanding opportunity for a Postdoctoral Scientist to joi...

hhmi.wd1.myworkdayjobs.com

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brangwynnelab.bsky.social @brangwynnelab.bsky.social · May 28

Nucleoli as biomolecular bubble tea! Congrats to former Princeton ugrad Holly Cheng (now GS @MIT) ->Holly's senior thesis work, a close collab w Roggeveen Wang & @zs-biophys.bsky.social‬ &Stone. Come for the cool movies & stay for the viscoelasticity! www.pnas.org/doi/10.1073/pnas.2407423122

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Qiwei Yu @qiweiyu.bsky.social · May 9

Our work on lipid domain pattern formation is now published in Soft Matter as part of the themed collection "Pioneering Investigators": pubs.rsc.org/en/content/a...

Grateful for my advisor Andrej Košmrlj for his mentorship, and for our collaborators for teaching us a lot about membranes!

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brangwynnelab.bsky.social @brangwynnelab.bsky.social · Apr 21

What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity, revealing impact of encoded protein function. Fantastic work from @lindsayabecker.bsky.social @sofiquinodoz.bsky.social @davidaknowles.bsky.social www.biorxiv.org/content/10.1...

Genome-wide mapping of mesoscale neuronal RNA organization and condensation

Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...

www.biorxiv.org

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Leah Houri-Zeevi @leahhouri.bsky.social · Apr 20

✨🦟✨HOW DO MOSQUITOES HAVE SEX? ✨🦟✨

Join us for a wild journey into hidden female control, rapidly evolving stimulation devices, fierce species competition, and DEADLY MOSQUITOES!

www.biorxiv.org/content/10.1...

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Oded Rechavi @odedrechavi.bsky.social · Apr 17

WOW!! A new pre-print rethinking how mosquitoes, the world's deadliest animal, mates. Amazing work from Leah @leahhouri.bsky.social (former PhD student in my lab) conducted in @leslievosshall.bsky.social's lab. Huge implications (see below) www.biorxiv.org/content/10.1...

www.biorxiv.org

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jared toettcher @toettch.bsky.social · Mar 25

I'm so happy to report that our preprint on light-induced collective cell migration has now been published in Cell Systems! This project was a lot of fun and will be the basis for a lot of our ongoing & future work.

Large-scale control over collective cell migration using light-activated epidermal growth factor receptors

Programmable control over tissue movement is a fundamental challenge for tissue engineering and wound healing. Suh, Thornton, et al. discovered that a light-controlled EGF receptor controls long-range...

www.cell.com

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brangwynnelab.bsky.social @brangwynnelab.bsky.social · Mar 20

Princeton's Omenn-Darling Bioengineering Institute is looking for a Cell Engineering facility Director. A tremendous opportunity to join our growing community, in brand-new building & brand new Institute! Please spread the word!!! bioengineering.princeton.edu. puwebp.princeton.edu/AcadHire/app...

Omenn-Darling Bioengineering Institute

bioengineering.princeton.edu

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