Lightnews — Scholar-powered news

Reposted by Yoann Santin

Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 1d

Happy to share our new review in Royal Society Open Biology 🎉
tRNA-modifying enzymes in bacterial stress adaptation:
How tRNA mods rewire translation under oxidative + antibiotic stress (MoTTs, moonlighting, therapy angles).
Read: doi.org/10.1098/rsob...
#RNAsky #microsky #AMR #RNAmodifications

tRNA-modifying enzymes in bacterial stress adaptation | Open Biology

Transfer RNAs (tRNAs) and their modifications are central to bacterial translation and physiology, yet their roles in stress adaptation remain underexplored. While extensively studied in eukaryotes, a...

doi.org

16 24

Reposted by Yoann Santin

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 1h

The Legionella effector RidL promotes mitochondrial fragmentation through phosphorylation activation of the large GTPase Drp1 https://www.biorxiv.org/content/10.1101/2025.10.07.680855v1

1 1

Reposted by Yoann Santin

Cascales Lab @cascaleslab.bsky.social · 2h

Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here:
emploi.cnrs.fr/Offres/Docto...

Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)

emploi.cnrs.fr

12 12

Reposted by Yoann Santin

Constantin Anoyatis @canopele.bsky.social · 1d

Proud of our new study out in @cp-cellreports.bsky.social!
Using E. coli lacking all 8 endopeptidases, we provide direct evidence that peptidoglycan expansion during elongation requires ED-mediated insertion of one glycan strand at a time. This can be performed by MepS, MepM, MepH and PBP7 #microsky

Role of endopeptidases in lateral cell wall expansion in Escherichia coli

Peptidoglycan, the major constituent of bacterial cell walls, is a giant macromolecule made of glycan strands cross-linked by short peptides, which pr…

www.sciencedirect.com

1 7 5

Reposted by Yoann Santin

Patricia Bernal @pbernalt6ss.bsky.social · 2d

Our paper, describing how the T6SSs of P. putida shape the tomato rhizosphere, is now in its final format in @isme-microbes.bsky.social ISME Communications. If you'd like to learn more, here is a thread (1/11) or read the Article doi.org/10.1093/isme....

2 18 51

Reposted by Yoann Santin

Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 17h

🧐Checkout our preprint revealing the stepwise firing💥 mechanism of a Contractile Injection System @xujwet.bsky.social [email protected] trapped the complex by structure-guided engineering🧪 in multiple intermediate states and imaged them by multimodal #cryoEM❄️🔬
www.biorxiv.org/content/10.1...

1 27 51

Reposted by Yoann Santin

Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 2d

Université Grenoble Alpes opens a full professorship in microbiology in 2026. The selected candidate will develop their research program on quantitative approaches in microbiology in the Laboratoire Interdisciplinaire de Physique. More info: liphy.univ-grenoble-alpes.fr/en/join-us/r...

Professorship (tenure) in 'Quantitative approaches in microbiology' (CNU Sections 64/65) | LIPhy - Université Grenoble Alpes

liphy.univ-grenoble-alpes.fr

8 5

Reposted by Yoann Santin

Basile Beaud Benyahia @babebe.bsky.social · 4d

Wonderful pair of papers by Augustinas Silale and Ben Berks on the diversity of BAM complexes.

Most diderm bacteria lack all BAM accessory previously identified in E. coli.

These two papers show a whole new set of accessory proteins in Bacteroidota.

How many more BAMs is there out there?
👁️👃🏼👁️

Augustinas Silale @augustsilale.bsky.social · 7d

Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social

We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.

doi.org/10.1038/s415...

Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology

Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.

doi.org

4 10

Reposted by Yoann Santin

Tracy Palmer @proftracypalmer.bsky.social · 4d

Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 4d

The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model https://www.biorxiv.org/content/10.1101/2025.10.04.680436v1

19 32

Reposted by Yoann Santin

Vivek Mutalik @vivekmutalik.bsky.social · 4d

#microsky

Jelena Godrijan 🫧❾🌊🦋 @godi.bsky.social · 4d

⚠️New paper ➡️ isolating >600 freshwater microbes using dilution-to-extinction and low-nutrient, lake-mimicking media.

🤯Expands cultured diversity to ~70 % of detected genera and enables physiological studies of streamlined oligotrophs.

🔗 www.nature.com/articles/s41...
#protistsonsky

Bringing the uncultivated microbial majority of freshwater ecosystems into culture - Nature Communications

A large fraction of aquatic bacteria remains uncultured. Here, the authors cultivated 627 strains of abundant freshwater bacteria from 14 European lakes, thus generating a collection that includes many previously uncultured, oligotrophic bacteria that may serve as model organisms.

www.nature.com

1 9

Reposted by Yoann Santin

Phill Stansfeld @pstansfeld.bsky.social · 5d

Just in time for Becca’s thesis submission, their paper on MreB membrane interactions is published in @biophysj.bsky.social: www.cell.com/biophysj/ful... 🎉

3 10

Yoann Santin @ysantin.bsky.social · 5d

Great meeting !!

3

Reposted by Yoann Santin

Jan-Willem Veening @veeninglab.com · 5d

Finally out, such an awesome piece of work, very proud of this one: www.cell.com/cell-systems... #MicroSky

2 27 61

Yoann Santin @ysantin.bsky.social · 5d

Many thanks to the organization : @cascaleslab.bsky.social @romévoulhoux @maellepllt.bsky.social @thicoz.bsky.social @juliengiraud.bsky.social

3

Yoann Santin @ysantin.bsky.social · 5d

Very happy to have participated in the second edition of Secretion Day in Marseille. Great discussions with former colleagues! The Secretion community is awesome!

1 11

Yoann Santin @ysantin.bsky.social · 5d

Whaou 🤓

cryoEM papers @cryoempapers.bsky.social · 20d

Correlative MS Imaging for cellular identification and analysis of in situ cryo-ET www.biorxiv.org/content/10.1101/2025.09.16.676641v1 #cryoem

Reposted by Yoann Santin

Anthony Vecchiarelli @cellforganized.bsky.social · 15d

New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧵

Collaboration with the Giessen and Pi labs

Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!

www.biorxiv.org/content/10.1...

Engineering Spatial Control of Bacterial Organelles

Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacte...

www.biorxiv.org

2 23 40

Reposted by Yoann Santin

Roni Odai @rodai.bsky.social · 7d

Viral AlphaFold Database (VAD) is live in Science Advances

~27,000 predicted viral protein monomers & homodimers

Conserved folds across bacteria, archaea & eukaryotic viruses

New toxin–antitoxin system KreTA uncovered

Vast “functional darkness” remains uncharted

www.science.org/doi/10.1126/...

The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes

VAD is a Viral AlphaFold Database of protein monomers and homodimers from viruses infecting hosts across the tree of life.

www.science.org

1 34 79

Reposted by Yoann Santin

Tung Le @tunglejic.bsky.social · 5d

Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!

John Innes Centre @johninnescentre.bsky.social · 5d

Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.

Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.

Find out more: www.jic.ac.uk/training-car...

Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre

The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…

www.jic.ac.uk

84 46

Reposted by Yoann Santin

Jelena Godrijan 🫧❾🌊🦋 @godi.bsky.social · 6d

🌊🔬 Looking for a postdoc to join our team!
Cocco-Channel project ➡️ studying coccolithophore phycospheres and their role in ocean carbon cycling.
✔️ Plus if you bring experience in microbial ecology, molecular/microscopy tools & fieldwork
👉 More info: euraxess.ec.europa.eu/jobs/375178
#protistsonsky

1 19 21

Reposted by Yoann Santin

Malcolm White @mfwhite2.bsky.social · 7d

My pleasure @erinedoherty.bsky.social and @benmorehouse.bsky.social - for me this was the stand-out discovery of the last year in the field

Erin Doherty @erinedoherty.bsky.social · 7d

And thanks to @mfwhite2.bsky.social for this great perspective on both works! www.nature.com/articles/d41...

Bacteria use a decoy defence molecule to set a trap for viruses

Some bacterial-infecting viruses use ‘sponges’ to mop up defence molecules, but bacteria can fight back by responding when a sponge captures decoy molecules.

www.nature.com

7 22

Yoann Santin @ysantin.bsky.social · 7d

@archaellum.bsky.social opens the first day of Secretion Day in Marseille ! The Archea World at a glance 🤩

2 6

Reposted by Yoann Santin

Benjamin Ezraty @ben-ezraty.bsky.social · 7d

@lcbofficiel.bsky.social @cnrsbiologie.bsky.social @univ-amu.fr

PLOS Biology @plosbiology.org · 8d

During chlorite-induced #OxidativeStress MsrPQ repairs periplasmic proteins oxidized at Met residues. @ben-ezraty.bsky.social &co show that in these conditions the #Ecoli chaperone Spy is overproduced & oxidized; its reduction by MsrPQ helps maintain functionality @plosbiology.org 🧪 plos.io/3VHTAI9

Maintaining Spy in its reduced state (left) by MsrP during chlorite stress is critical for its chaperone activity. Image credit: Benjamin Ezraty.

1 2 2

Reposted by Yoann Santin

Joe Parham @joeparham19.bsky.social · May 29

We are excited to share our preprint describing how Sulfolobus cells coordinate DNA segregation with cell division! In eukaryotes this type of regulation involves checkpoints and CDK-cyclins. But how does this work in archaea? This is the question we ask in our paper: www.biorxiv.org/content/10.1...

Temporal and spatial coordination of DNA segregation and cell division in an archaeon.

Cells must coordinate DNA segregation with cytokinesis to ensure that each daughter cell inherits a complete genome. Here, we explore how DNA segregation and division are mechanistically coupled in ar...

www.biorxiv.org

4 26 48

Reposted by Yoann Santin

Augustinas Silale @augustsilale.bsky.social · 7d

Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social

We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria.

doi.org/10.1038/s415...

Structure of a distinct β-barrel assembly machinery complex in the Bacteroidota - Nature Microbiology

Structural and functional characterization of the β-barrel assembly machinery complex in Bacteroidota reveals a distinct, seven-component complex with a large extracellular domain that may enable β-barrel–surface lipoprotein complex assembly.

doi.org

4 21 50