Lightnews — Scholar-powered news

Reposted by Bede Portz

David W. Sanders! @davidwsanders.bsky.social · 7h

Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...

UT Southwestern researcher receives NIH Director’s New Innovator Award

David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...

www.utsouthwestern.edu

3 4 29

Bede Portz @ysptsps.bsky.social · 1d

This is so obvious in hindsight yet I hadn’t considered the evolutionary pressure against lysines in this context. Do you know if WNK ( with no lysine) family kinases are involved in regulating quality control?

Reposted by Bede Portz

Sylvain Gigan @sylvaingigan.bsky.social · 1d

A strong quality for a good researcher is the ability to sometimes ignore small details, and sometimes delves into them with the greatest care, and more importantly to being able to switch wisely between the two modes.

1 7 36

Bede Portz @ysptsps.bsky.social · 2d

Harrison Bader battling through injury he got facing Nitro in the joust. #GoPhils #Phillies #americangladiator

Bede Portz @ysptsps.bsky.social · 2d

www.sciencedirect.com/science/arti...

Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription

Extrachromosomal, circular DNA (ecDNA) is a prevalent oncogenic alteration in cancer genomes, often associated with aggressive tumor behavior and poor…

www.sciencedirect.com

1 8

Reposted by Bede Portz

Craig Kaplan @triggerloop.bsky.social · 3d

Happy to participate in Pittsburgh SCADaddle 5K for SCAD research. SCAD is the kind of heart attack that mostly affects healthy women >40 without traditional risk factors. Can be associated with peri or postpartum and commonly SCAD patients also suffer migraines @scadalliance.bsky.social

Cute young at heart couple earring race medals from a 5K charity run/walk on a sunny day in Pittsburgh

3 18

Bede Portz @ysptsps.bsky.social · 4d

Turned this game on against my better judgement only to see PSU mismanage (charitable) the clock and bungle the play calling, Allar to take the most Allar sack, and for us to give ball to UCLA to score. All while announcers excoriate us.

1 1

Bede Portz @ysptsps.bsky.social · 4d

Wow please tell me that was also a deliberate reference to Taylor Swift's new album too

1 1

Reposted by Bede Portz

David Kuster @rnadavid.bsky.social · 4d

Translation landscape of stress granules | Science Advances

www.science.org/doi/10.1126/...

Translation landscape of stress granules

Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

www.science.org

11 26

Bede Portz @ysptsps.bsky.social · 4d

wait you can actually make outlook worse?

1 5

Bede Portz @ysptsps.bsky.social · 4d

My rock climbing gym has paper copies of Cell and Neuron, and I ran into a buddy there working on a drug discovery paper while his kid climbed. #Boston #NorthShore

3 1 31

Reposted by Bede Portz

Camille Moore @camille-moore.bsky.social · 6d

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes

Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

www.science.org

4 34 84

Reposted by Bede Portz

Alex Holehouse @alexholehouse.bsky.social · 6d

Also needs to be said that (as some folks know) our software packages are named after birds, so while I was away, the lab filled my office with birds... ...but honestly... *very* tastefully.

Will stay for the foreseeable future!

BIRDS! EVERYWHERE! GEESE! PEACOCKS! HUMMINGBIRDS!

2 30

Bede Portz @ysptsps.bsky.social · 15d

If we take just a lil bit of Tylenol or maybe make a slightly less potent analog would that be like a vaccine that prevents autism?

1 1

Bede Portz @ysptsps.bsky.social · 15d

Area man who looks like he is in pixies has never heard pixies more at 11

2

Bede Portz @ysptsps.bsky.social · 15d

Will read. Relationship to development of serous ovarian cancers?

1 1

Reposted by Bede Portz

Angie Rasmussen @angierasmussen.bsky.social · 15d

Still trying to figure out what MAHA hates more: women or vaccines.

Brian Wasik @brianrwasik.bsky.social · 15d

I still can't get over the suggestion for pregnant women to 'tough it out' spoken by the softest man that has ever lived.

14 60 250

Reposted by Bede Portz

J. Elvis Weinstein @jelvisweinstein.bsky.social · 16d

I know antifa isn't a real organization because I don't get 40 texts a week from them asking for donations.

390 6.3K 32K

Bede Portz @ysptsps.bsky.social · 17d

Go birds 🦅 unbelievable

3

Bede Portz @ysptsps.bsky.social · 26d

Mine as well.

1 1

Bede Portz @ysptsps.bsky.social · 27d

Major Medical Prizes Given to Cell Biology and Cystic Fibrosis Pioneers www.nytimes.com/2025/09/11/h...

Major Medical Prizes Given to Cell Biology and Cystic Fibrosis Pioneers

www.nytimes.com

1 3 13

Reposted by Bede Portz

Stirling Churchman @stirlingchurchman.bsky.social · 29d

Our new pre-print from the Greenberg and Churchman labs shows that activity-dependent modulation of RNA stability is a major, and underappreciated, mechanism of gene regulation in neurons. Tutorial below! www.biorxiv.org/content/10.1... (1/11)

HuD controls widespread RNA stability to drive neuronal activity-dependent responses

Neuronal activity shapes brain development and refines synaptic connectivity in part through dynamic changes in gene expression. While activity-regulated transcriptional programs have been extensively...

www.biorxiv.org

1 22 66

Bede Portz @ysptsps.bsky.social · Sep 5

Bargaining such a hard word to spell

1 1

Bede Portz @ysptsps.bsky.social · Sep 5

I hate everything. I knew it was too good to be true as a Philly sports fan to win two super bowls in 5 years. Furious with Carter. Miss Darius Slay.

2 1

Bede Portz @ysptsps.bsky.social · Sep 4

Go birds!!! 🦅

1 2