When GRASP55 is gone, lysosomal enzymes don’t reach their destination.
Dr. Yanzhuang Wang (Shenzhen Bay Laboratory) reveals how GRASP55 controls sorting of β-Hexosaminidase A by regulating M6P tagging and trafficking.
www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
Dr. Yanzhuang Wang (Shenzhen Bay Laboratory) reveals how GRASP55 controls sorting of β-Hexosaminidase A by regulating M6P tagging and trafficking.
www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
August 29, 2025 at 1:16 PM
When GRASP55 is gone, lysosomal enzymes don’t reach their destination.
Dr. Yanzhuang Wang (Shenzhen Bay Laboratory) reveals how GRASP55 controls sorting of β-Hexosaminidase A by regulating M6P tagging and trafficking.
www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
Dr. Yanzhuang Wang (Shenzhen Bay Laboratory) reveals how GRASP55 controls sorting of β-Hexosaminidase A by regulating M6P tagging and trafficking.
www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
At the University of Michigan, researchers found that SARS-CoV-2 hijacks the host cell’s Golgi apparatus by lowering GRASP55 and raising TGN46, fragmenting the Golgi to boost viral assembly and secretion—highlighting a potential antiviral target.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion
Author summary SARS-CoV-2, the etiologic agent of COVID-19, is an enveloped RNA virus. Despite extensive research, the molecular mechanisms governing SARS-CoV-2 assembly and secretion remain poorly un...
journals.plos.org
June 21, 2025 at 12:35 AM
At the University of Michigan, researchers found that SARS-CoV-2 hijacks the host cell’s Golgi apparatus by lowering GRASP55 and raising TGN46, fragmenting the Golgi to boost viral assembly and secretion—highlighting a potential antiviral target.
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
#GRASP55 isn't just structural—it helps lysosomal enzymes get where they’re going. New research shows that knocking out GRASP55 leads to immature β-hexosaminidase A (HEXA) being misrouted and secreted instead of reaching the lysosome. www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology #Lysosomes
June 6, 2025 at 6:47 PM
#GRASP55 isn't just structural—it helps lysosomal enzymes get where they’re going. New research shows that knocking out GRASP55 leads to immature β-hexosaminidase A (HEXA) being misrouted and secreted instead of reaching the lysosome. www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology #Lysosomes
Oh wait did I already know you did your thesis with Adam?!?
So cool. He was ahead of me (in sooooo many ways) but we shared undergrad mentors. And we're interested in the yeast GRASP55 homolog, though no actual experiments yet. Soon, I hope??
So cool. He was ahead of me (in sooooo many ways) but we shared undergrad mentors. And we're interested in the yeast GRASP55 homolog, though no actual experiments yet. Soon, I hope??
May 14, 2025 at 10:32 PM
Oh wait did I already know you did your thesis with Adam?!?
So cool. He was ahead of me (in sooooo many ways) but we shared undergrad mentors. And we're interested in the yeast GRASP55 homolog, though no actual experiments yet. Soon, I hope??
So cool. He was ahead of me (in sooooo many ways) but we shared undergrad mentors. And we're interested in the yeast GRASP55 homolog, though no actual experiments yet. Soon, I hope??
From MBoC
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A, by Yanzhuang Wang, Hou Lab at Shenzhen Bay Laboratory, et al.
www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A, by Yanzhuang Wang, Hou Lab at Shenzhen Bay Laboratory, et al.
www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
May 7, 2025 at 3:21 PM
From MBoC
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A, by Yanzhuang Wang, Hou Lab at Shenzhen Bay Laboratory, et al.
www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A, by Yanzhuang Wang, Hou Lab at Shenzhen Bay Laboratory, et al.
www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
ATCC's resource, RRID:CVCL_0493, was just reported to be used in "Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules". We appreciate the author's support of reproducibility. #OpenScience #RRID
doi.org
March 12, 2025 at 7:01 AM
ATCC's resource, RRID:CVCL_0493, was just reported to be used in "Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules". We appreciate the author's support of reproducibility. #OpenScience #RRID
Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules: @Cell Reports @cellpress.bsky.social . ParaFrap team involved in this study: Nicolas Blanchard (Infinity Lab, Toulouse) #toxoplasma www.cell.com/cell-reports...
Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules
Cebrian et al. demonstrate that the Golgi membrane-associated protein GRASP55 is recruited
to late phagosomes in BMDCs. This interaction is essential for trafficking peptide-loaded
MHC-I and MHC-II mo...
www.cell.com
February 25, 2025 at 3:52 PM
Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules: @Cell Reports @cellpress.bsky.social . ParaFrap team involved in this study: Nicolas Blanchard (Infinity Lab, Toulouse) #toxoplasma www.cell.com/cell-reports...
Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules
Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules
Cebrian et al. demonstrate that the Golgi membrane-associated protein GRASP55 is recruited to late phagosomes in BMDCs. This interaction is essential for trafficking peptide-loaded MHC-I and MHC-II molecules to the cell surface and for achieving efficient…
dlvr.it
February 17, 2025 at 8:50 PM
Dendritic cell phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules
DC phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
February 16, 2025 at 4:31 PM
DC phagosomes recruit GRASP55 for export of antigen-loaded MHC molecules @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
GRASP55 Safeguards Proper Lysosome Function by Controlling Sorting of Lysosomal Enzymes at the Golgi www.biorxiv.org/content/10.1...
GRASP55 Safeguards Proper Lysosome Function by Controlling Sorting of Lysosomal Enzymes at the Golgi
Lysosomes are multifunctional organelles that play important roles in cellular recycling, signaling, and homeostasis, relying on precise trafficking and activation of lysosomal enzymes. While the Golg...
www.biorxiv.org
December 13, 2024 at 2:41 PM
GRASP55 Safeguards Proper Lysosome Function by Controlling Sorting of Lysosomal Enzymes at the Golgi www.biorxiv.org/content/10.1...
Nice preprint @jnuechel.bsky.social! Following his paper on the mTORC1-GRASP55 metabolic sensory hub.
Lysosomes: degradative hubs, signalling platforms, and guardians against Alzheimer's. GRASP55 links Golgi sorting to lysosomal function, preventing enzyme misrouting.
www.biorxiv.org/content/10.1...
Lysosomes: degradative hubs, signalling platforms, and guardians against Alzheimer's. GRASP55 links Golgi sorting to lysosomal function, preventing enzyme misrouting.
www.biorxiv.org/content/10.1...
December 13, 2024 at 9:21 AM
Nice preprint @jnuechel.bsky.social! Following his paper on the mTORC1-GRASP55 metabolic sensory hub.
Lysosomes: degradative hubs, signalling platforms, and guardians against Alzheimer's. GRASP55 links Golgi sorting to lysosomal function, preventing enzyme misrouting.
www.biorxiv.org/content/10.1...
Lysosomes: degradative hubs, signalling platforms, and guardians against Alzheimer's. GRASP55 links Golgi sorting to lysosomal function, preventing enzyme misrouting.
www.biorxiv.org/content/10.1...
GRASP55 Safeguards Proper Lysosome Function by Controlling Sorting of Lysosomal Enzymes at the Golgi https://www.biorxiv.org/content/10.1101/2024.12.10.627846v1
December 12, 2024 at 3:30 PM
GRASP55 Safeguards Proper Lysosome Function by Controlling Sorting of Lysosomal Enzymes at the Golgi https://www.biorxiv.org/content/10.1101/2024.12.10.627846v1
GRASP55 Safeguards Proper Lysosome Function by Controlling Sorting of Lysosomal Enzymes at the Golgi https://www.biorxiv.org/content/10.1101/2024.12.10.627846v1
December 12, 2024 at 3:30 PM
GRASP55 Safeguards Proper Lysosome Function by Controlling Sorting of Lysosomal Enzymes at the Golgi https://www.biorxiv.org/content/10.1101/2024.12.10.627846v1
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A https://www.biorxiv.org/content/10.1101/2024.10.16.618769v1
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A https://www.biorxiv.org/content/10.1101/2024.10.16.618769v1
The Golgi apparatus plays a crucial role in the delivery of lysosomal enzymes. Golgi Reassembly Stac
www.biorxiv.org
October 17, 2024 at 9:30 AM
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A https://www.biorxiv.org/content/10.1101/2024.10.16.618769v1
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A https://www.biorxiv.org/content/10.1101/2024.10.16.618769v1
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A https://www.biorxiv.org/content/10.1101/2024.10.16.618769v1
The Golgi apparatus plays a crucial role in the delivery of lysosomal enzymes. Golgi Reassembly Stac
www.biorxiv.org
October 17, 2024 at 9:30 AM
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A https://www.biorxiv.org/content/10.1101/2024.10.16.618769v1