#Megakaryocytes
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searchengine.activitypub.awakari.com.ap.brid.gy
Intravenous infusion of engineered megakaryocytes to produce oncolytic platelets in vivo for enhanced cancer immunotherapy Proceedings of the National Academy of Sciences, Volume 123, Issue 7, Febr...

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awakari.com
February 12, 2026 at 7:33 AM
drinfosec.bsky.social
🚨🧵by Dr. @harryspoelstra.bsky.social on XTwitter (Feb 8, 2026):

"Megakaryocytes and afucosylated IgG in post-acute COVID-19: Bridging immune dysregulation and vascular pathology — A narrative review

🔥Long COVID isn't lingering, it could be a vicious..."

🧵
threadreaderapp.com/thread/20204...
Megakaryocytes and afucosylated IgG in post-acute COVID-19: Bridging immune dysregulation and vascular pathology — A narrative review 🔥Long COVID isn't lingering, it could be a vicious, self-sustaining loop of rogue megakaryocytes and weaponized afucosylated antibodies trapping patients….. maybe for some, lifelong! #Leonardi_effect ➡️This interesting review synthesizes emerging evidence that IMMUNE DYSREGULATION and HEMOSTATIC IMBALANCE are central drivers of post-acute sequelae of SARS-CoV-2 (PASC / long COVID), with persistent thrombo-inflammatory processes underlying many prolonged symptoms. ➡️Let’s break this down:
February 9, 2026 at 3:04 AM
killianhurley.bsky.social
Agree - Megakaryocytes are involved in fibrosis in the marrow but how do they get involved in fibrosis in the lung? @ild-ipfdoc.bsky.social @ipfdoc.bsky.social
February 8, 2026 at 4:06 PM
castltrastondrs.bsky.social
Their persistence in #PASC remains uncertain but may contribute to chronic immune activation .
- Megakaryocyte Dysfunction As immune-responsive cells, megakaryocytes may sustain thrombo-inflammatory processes following #SARSCoV2 infection through prolonged inflammatory signaling .
February 8, 2026 at 6:28 AM
castltrastondrs.bsky.social
#Medsky🧪 #IDsky #immunosky #publichealth This review examines the potential connections between #megakaryocytes (platelet-producing cells) & afucosylated IgG antibodies in #postacuteCOVID sequelae (PASC) #Longcovid .
- PASC involves persistent symptoms lasting ≥3 months,
Megakaryocytes and afucosylated IgG in post-acute COVID-19: Bridging immune dysregulation and vascular pathology — A narrative review
Post-acute sequelae of SARS-CoV-2 infection (PASC), also referred to as long COVID, encompasses a constellation of persistent symptoms lasting for at …
www.sciencedirect.com
February 8, 2026 at 6:28 AM
drpujamehta1.bsky.social
Megakaryocytes def have a role in haematological myeloproliferative disorders in bone marrow fibrosis, producing TGFb, FGF…

(Can we resurrect #CurePF4all ?? 🍀)
February 8, 2026 at 1:29 AM
kaminskimed.bsky.social
Rephrasing question to revive #CurePF4All convo here: Do megakaryocytes contribute to Pulmonary Fibrosis?
What think you @ipfdoc.bsky.social @drpujamehta1.bsky.social @knipelab.bsky.social @elizabethredente.bsky.social @ild-ipfdoc.bsky.social @kerrijohannson.bsky.social
@drdayjee.bsky.social ?
Do megakaryocytes contribute to organ fibrosis?
Abstract. Megakaryocytes, the platelet precursors, have been known to populate tissues other than the bone marrow, most prominently the lung, but also the
academic.oup.com
February 7, 2026 at 7:40 PM
biorxiv-cellbio.bsky.social
ATP11A and ATP11C are plasma membrane phosphatidylserine flippases in in vitro human megakaryocytes. https://www.biorxiv.org/content/10.64898/2026.01.30.702765v1
February 2, 2026 at 9:30 PM
biorxivpreprint.bsky.social
ATP11A and ATP11C are plasma membrane phosphatidylserine flippases in in vitro human megakaryocytes. https://www.biorxiv.org/content/10.64898/2026.01.30.702765v1
February 2, 2026 at 9:30 PM
virussucks.com
Regarding @buonsenso.bsky.social 's post on plasmapheresis, researchers found that SARSCoV2 virus reservoirs in megakaryocytes and blood plasma, which activates platelets that stick to vessel walls.

See Nicolas Huot's presentation on SARS-CoV-2 persistence: youtube.com/watch?v=dGbb...
January 25, 2026 at 2:32 PM
virussucks.com
SARSCoV2 reservoirs found in megakaryocytes & produce pre-activated platelets in #LongCOVID patients that are primed to stick to vessel walls.

Ticagrelor is a direct-acting anti-platelet drug that improves blood flow. It increases adenosine-mediated vessel health and may reduce neuroinflammation.
January 16, 2026 at 9:23 PM
virussucks.com
See the PolyBio presentation that shows the presence of the SARS-CoV-2 virus in megakaryocytes and platelets of Long COVID patients by Morgane Bomsel from the Institut Cochin.

Timestamp:(youtu.be/dGbb7UDcoHw?...)
Megakaryocytes are the bone marrow cells responsible for producing platelets.
PolyBio Fall 2025 Symposium
YouTube video by PolyBio Research Foundation
youtu.be
January 11, 2026 at 9:18 PM
virussucks.com
#SARSCoV2 in megakaryocytes produce pre-activated platelets in #LongCOVID patients that are "primed" to stick to vessel walls.

​Ticagrelor is a direct-acting anti-platelet drug that improves blood flow that increases adenosine-mediated vessel health and may reduce neuroinflammation.
#neuroCOVID
January 11, 2026 at 9:05 PM
itsmeder.bsky.social
June 25, 2020: Rapkiewicz et al., Lancet (case series) showed that in people who died from COVID, their organs were full of tiny blood clots made of platelets and megakaryocytes - which usually stay in the bone marrow - showing up in places like the lungs and heart, where they don’t usually belong
December 21, 2025 at 5:33 AM
france-bioimaging.bsky.social
[WEBINAR] Join the next France volumeEM WebCafe ☕

This edition will focus on 3D imaging of bone marrow megakaryocytes, featuring Dr. Anita Michel (Head of the EM plateform MicroEleCS - UMRS 1255).

📅 When? December, 18th - 13:00
🔗 How to join? bit.ly/3KxXxgy
December 8, 2025 at 3:45 PM
simoncleary.bsky.social
Love these 3D renderings of the extracellular matrix cages surrounding megakaryocytes!

bsky.app/profile/wcla...
wclairemasson.bsky.social Claire Masson @wclairemasson.bsky.social · Oct 9
3/ 🔬
Using high-resolution 3D imaging, we mapped ECM proteins around MKs.
Surprisingly, laminin and collagen IV form a 3D cage that completely surrounds MKs and connects to the sinusoidal basement membrane.
👉 This “ECM cage” stabilizes MKs in their vascular niche.
December 8, 2025 at 11:39 AM
cp-trendscellbio.bsky.social
Homeostasis of megakaryocytes: balancing tissue residency and consumptive platelet production
Homeostasis of megakaryocytes: balancing tissue residency and consumptive platelet production
Megakaryocytes (MKs) release platelets through a terminal event that results in the complete consumption of their cytoplasm. Once viewed as end-stage conductors of platelet biogenesis, MKs are now recognized as multifunctional regulators of the bone-marrow (BM) niche, supporting hematopoietic stem cell (HSC) maintenance, immune regulation, and extracellular matrix (ECM) remodeling. This multiple identity raises a fundamental question: how is MK homeostasis orchestrated to preserve a functional BM MK pool despite consumptive platelet production? Herein we review recent mechanistic insights into the biology of diverse MK functions, MK lineage development, and homeostatic regulation of megakaryopoiesis. Beyond classical systemic regulation, which maintains platelet counts within a physiological range by sensing the circulating platelet pool, we highlight BM tissue-level homeostatic circuits that treat the MK itself as the primary regulated variable.
dlvr.it
December 2, 2025 at 1:02 PM
imm.ox.ac.uk
#WIMMinFocus
These #megakaryocytes show six strange shapes as they respond to Galectin one. Their actin cytoskeleton is stained to reveal this variety.
Six of a Kind by Natalie Jooss
Honourable Mention, 2025 WIMM Image Competition.
#SciComm @rdm.ox.ac.uk @medsci.ox.ac.uk
November 26, 2025 at 1:25 PM
bvmurciasalud.bsky.social
#PubSaludMurcia Monolobated megakaryocytes and ring sideroblasts: A morphological prelude to multihit TP53 and complex karyotype @Area6VegaMedia
Monolobated megakaryocytes and ring sideroblasts: A morphological prelude to multihit TP53 and complex karyotype
Click on the article title to read more.
doi.org
November 25, 2025 at 8:02 AM
teiflab.bsky.social
Maansson et al., 2025. Liquid biopsy epigenetics: establishing a molecular profile based on cell-free DNA [review] febs.onlinelibrary.wiley.com/doi/full/10....
Various analytes of liquid biopsies. Cancer cells shed various analytes into the bloodstream, all of which can be analyzed in liquid biopsies. (A) Extracellular vesicles contain various molecules, including DNA, RNA, and proteins representing the biology of the tumor. (B) Several types of cell-free RNA (cfRNA) molecules can be found in plasma, including noncoding micro-RNA (miRNA), long noncoding RNA (lncRNA), messenger RNA (mRNA), and tumor-derived RNA fusions. (C) Circulating tumor cells (CTCs) from primary tumors or metastatic sites directly represent cancer biology at the site of origin. CTCs can group together with healthy cells, creating CTC clusters. (D) Many features of cell-free DNA (cfDNA) provide great insights into tumor biology. These features include fragmentomics focusing on cfDNA fragment lengths and fragment end motifs (FEMs), 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) patterns and post-translational modifications (PTMs) of circulating histones. In addition, somatic variants, such as single-nucleotide variants (SNVs), insertions and deletions (indels), and copy number alterations (CNAs) are detectable in liquid biopsies. Origin of cell-free DNA (cfDNA) in healthy individuals and various diseases. (A) In a healthy population, the tissue of origin of cfDNA can be traced to hematopoietic (90%) and nonhematopoietic cells (10%). Of circulating peripheral blood mononuclear cells (PBMCs), monocytes (yellow) and granulocytes (green) are the main contributors to the cfDNA pool. Erythroblasts (pink) and megakaryocytes (blue) are the main contributors from the bone marrow. Nonhematopoietic cfDNA primarily originates from endothelial and liver cells (red). (B, C) Pathological conditions can alter the origin of cfDNA; however, most of the cfDNA still originates from healthy tissues shown in (A) (gray). Patients with acute myocardial infarction (AMI) have increased cfDNA from cardiac (purple) cells (B). Similarly, cancer patients have an increased fraction of cfDNA from the organ of the primary tumor and the metastatic site (C). This is illustrated with an increased fraction of colon (orange) and neuron (brown) cfDNA in a colorectal cancer (CRC) patient with a brain metastasis. Different cell-free DNA (cfDNA) methylation detection methods. (A) Normal and tumor cells have different methylation profiles, which are detectable in the bloodstream. Several strategies for cfDNA methylation quantification exist, each with their own strengths (+) and limitations (−). (B) Bisulfite conversion is the gold standard of methylation profiling; however, it is limited by high DNA degradation requiring a high input content. (C) As an alternative to bisulfite, enzymatic methyl sequencing (EM-seq) preserves the DNA integrity while providing single base-pair (bp) resolution of 5-methylcytosine (5mC) with higher coverage and less GC bias than bisulfite conversion. (D) Two separate 5mC cfDNA enrichment strategies exist, cell-free methylated DNA immunoprecipitation and high-throughput sequencing (cfMeDIP–seq) and T7-MBD-seq. cfMeDIP utilizes anti-5mC-DNA antibodies to isolate methylated cfDNA fragments, whereas T7-MBD-seq uses methyl-binding domain 2 protein (MBD2) to enrich for 5mC. Precipitated cfDNA is sequenced, generating a coverage profile representing the genomic region's methylation status. (E) 6-letter sequencing with Duet is one of the more recently developed methods and enables quantification of 5mC and 5-hydroxymethylcytosine (5hmC) at single-bp resolution. (F) Native cfDNA is sequenced with long reads using nanopore technology, generating both an epigenetic and genetic profile at single-bp resolution. Fragmentomics of active and inactive genes. (A) Stable regions in the genome result in cell-free DNA (cfDNA) coverage peaks and valleys corresponding to the underlying chromatin structure. Regions with more dynamic chromatin result in a flatter cfDNA coverage profile. (B) Inactive genes are enriched for 5-methylcytosine (5mC) and do not have a structured cfDNA coverage profile around the transcript start site (TSS). cfDNA fragments from inactive genes have a peak at approximately 165 bp corresponding to caspase-activated DNase (CAD) cleavage in internucleosomal regions, leading to distinct fragment end motifs (FEMs). (C) Active genes are depleted of nucleosomes around the TSS, leading to distinct cfDNA coverage profiles. cfDNA fragments from active genes are shorter, with approximately 10-bp oscillations. Gene activity is also characterized by hypomethylation, causing the DNA to be more loosely bound to the nucleosome, allowing for internucleosomal CAD cleavage and altered FEM frequencies.
November 24, 2025 at 11:24 AM
protpapers.bsky.social

Major histocompatibility complex class II-expressing bone marrow megakaryocytes activate CD4+ T cells and induce regulatory T cell fate

https://www.biorxiv.org/content/10.1101/2025.11.21.689743v1
November 23, 2025 at 5:38 AM
biorxiv-immuno.bsky.social
Major histocompatibility complex class II-expressing bone marrow megakaryocytes activate CD4+ T cells and induce regulatory T cell fate https://www.biorxiv.org/content/10.1101/2025.11.21.689743v1
November 22, 2025 at 9:16 PM
biorxivpreprint.bsky.social
Major histocompatibility complex class II-expressing bone marrow megakaryocytes activate CD4+ T cells and induce regulatory T cell fate https://www.biorxiv.org/content/10.1101/2025.11.21.689743v1
November 22, 2025 at 9:16 PM
megaman55.bsky.social
Join us to pursue cutting-edge research at the interface of megakaryocyte biology and translational medicine. We have NIH-funded postdoc positions available to investigate platelet production and the broader functions of megakaryocytes. I’ll be attending ASH and would be happy to connect.
November 20, 2025 at 7:12 PM
drseanmullen.bsky.social
Masking makes sense. SARS-CoV-2 can persist, and new evidence from France shows infected megakaryocytes + platelets — meaning real blood involvement. This virus isn’t just respiratory, and protecting your air protects your blood.

Don’t know anything about viral persistence? Know that it’s the norm👇
mcollinsmorton.bsky.social Michael Collins Morton @mcollinsmorton.bsky.social · Nov 16
"No man is an island, entire of itself."
John Donne

For me, choosing to wear a respirator mask in all public spaces signifies an awareness of my connection to the human community, whose collective well-being is grievously threatened by the ongoing pandemic of Covid-19.

#COVID19 #respirator
A black-and-white photograph of Michael Collins Morton standing near a suburban street, wearing a flat cap, a respirator mask, and a trench coat.
November 16, 2025 at 8:19 PM