Drosophila Abi maintains blood cell homeostasis by promoting clathrin-mediated endocytosis of Notch
#Drosophila
#Drosophila
Drosophila Abi maintains blood cell homeostasis by promoting clathrin-mediated endocytosis of Notch
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
January 1, 2026 at 12:23 AM
Drosophila Abi maintains blood cell homeostasis by promoting clathrin-mediated endocytosis of Notch
#Drosophila
#Drosophila
Ad5-nCoV booster vaccination confers enhanced protection against symptomatic BA.5 infection through cross-reactive NAbs with expanded epitope breadth and NK cell-mediated innate immunity enhancement
link.springer.com/article/10.1...
link.springer.com/article/10.1...
December 31, 2025 at 3:49 PM
Ad5-nCoV booster vaccination confers enhanced protection against symptomatic BA.5 infection through cross-reactive NAbs with expanded epitope breadth and NK cell-mediated innate immunity enhancement
link.springer.com/article/10.1...
link.springer.com/article/10.1...
CysLT2R functions as a checkpoint receptor that restrains CysLT1R-mediated mast cell activation, a protective pathway in asthma highlighting the therapeutic promise of LTD4-based CysLT2 receptor-biased agonists @cp-cellreports.bsky.social
@harvardmed.bsky.social
www.cell.com/cell-reports...
@harvardmed.bsky.social
www.cell.com/cell-reports...
December 31, 2025 at 3:01 PM
CysLT2R functions as a checkpoint receptor that restrains CysLT1R-mediated mast cell activation, a protective pathway in asthma highlighting the therapeutic promise of LTD4-based CysLT2 receptor-biased agonists @cp-cellreports.bsky.social
@harvardmed.bsky.social
www.cell.com/cell-reports...
@harvardmed.bsky.social
www.cell.com/cell-reports...
p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
December 31, 2025 at 2:51 PM
p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma @cp-cellreports.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Mycobacterial protein MPT53 prompts lung epithelial cells release of lncRNA TRCR1-enriched exosomes that enhance monocyte antimicrobial activity via CLOCK-mediated epigenetic reprogramming @cp-cellhostmicrobe.bsky.social
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
December 31, 2025 at 2:45 PM
Mycobacterial protein MPT53 prompts lung epithelial cells release of lncRNA TRCR1-enriched exosomes that enhance monocyte antimicrobial activity via CLOCK-mediated epigenetic reprogramming @cp-cellhostmicrobe.bsky.social
www.cell.com/cell-host-mi...
www.cell.com/cell-host-mi...
WO2025257220 describes a bispecific CD40–MUC1 agonist that confines CD40 signalling to MUC1-overexpressing tumours. Tumour-dependent engagement induces local dendritic cell and T-cell activation while limiting systemic CD40 activation and cytokine-mediated toxicity.
[Credit: Merck Group]
[Credit: Merck Group]
December 31, 2025 at 2:18 PM
WO2025257220 describes a bispecific CD40–MUC1 agonist that confines CD40 signalling to MUC1-overexpressing tumours. Tumour-dependent engagement induces local dendritic cell and T-cell activation while limiting systemic CD40 activation and cytokine-mediated toxicity.
[Credit: Merck Group]
[Credit: Merck Group]
Genetic screening of lncRNAs in human embryonic stem cells reveals novel regulators of pluripotency and provides insights into lcRNA-mediated regulation of hESC growth and differentiation. #OCT4 #VRTN https://ow.ly/H0t150XMxxO
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
December 31, 2025 at 1:35 PM
Genetic screening of lncRNAs in human embryonic stem cells reveals novel regulators of pluripotency and provides insights into lcRNA-mediated regulation of hESC growth and differentiation. #OCT4 #VRTN https://ow.ly/H0t150XMxxO
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death
Science Advances
www.science.org/doi/10.1126/...
Science Advances
www.science.org/doi/10.1126/...
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death
CRISPRa reveals separable regulatory axes and molecular drivers of the two-cell like state.
www.science.org
December 30, 2025 at 6:50 AM
CRISPRa-mediated disentanglement of the Dux-MERVL axis in the 2C-like state, totipotency, and cell death
Science Advances
www.science.org/doi/10.1126/...
Science Advances
www.science.org/doi/10.1126/...
Biochemical binding and cellular functional studies reveal that fortilin interacts with CTNNA3 (α-T-catenin), protecting it from phosphorylation, ubiquitination, and proteasome-mediated degradation, promoting cell survival and preventing apoptosis.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Fortilin binds CTNNA3 and protects it against phosphorylation, ubiquitination, and proteasomal degradation to guard cells against apoptosis - Communications Biology
Biochemical binding and cellular functional studies reveal that fortilin interacts with CTNNA3 (α-T-catenin), protecting it from phosphorylation, ubiquitination, and proteasome-mediated degradation, p...
www.nature.com
December 29, 2025 at 6:35 PM
Biochemical binding and cellular functional studies reveal that fortilin interacts with CTNNA3 (α-T-catenin), protecting it from phosphorylation, ubiquitination, and proteasome-mediated degradation, promoting cell survival and preventing apoptosis.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
💩 FODMAPs cause increased colonic permeability in diarrhea-predominant #IBS (IBS-D) via LPS-mediated colonic mast cell activation. Low FODMAP diet improves these pathological changes in IBS-D. Read more at https://ow.ly/HgAN50XLLGr
December 29, 2025 at 5:30 PM
💩 FODMAPs cause increased colonic permeability in diarrhea-predominant #IBS (IBS-D) via LPS-mediated colonic mast cell activation. Low FODMAP diet improves these pathological changes in IBS-D. Read more at https://ow.ly/HgAN50XLLGr
Levamisole-Mediated Suppression of B-Cell Proliferation and Antibody Production Reveals Mechanistic Insights into Idiopathic Nephrotic Syndrome Therapy https://www.biorxiv.org/content/10.64898/2025.12.23.695947v1
December 27, 2025 at 8:15 PM
Levamisole-Mediated Suppression of B-Cell Proliferation and Antibody Production Reveals Mechanistic Insights into Idiopathic Nephrotic Syndrome Therapy https://www.biorxiv.org/content/10.64898/2025.12.23.695947v1
Levamisole-Mediated Suppression of B-Cell Proliferation and Antibody Production Reveals Mechanistic Insights into Idiopathic Nephrotic Syndrome Therapy https://www.biorxiv.org/content/10.64898/2025.12.23.695947v1
December 27, 2025 at 8:15 PM
Levamisole-Mediated Suppression of B-Cell Proliferation and Antibody Production Reveals Mechanistic Insights into Idiopathic Nephrotic Syndrome Therapy https://www.biorxiv.org/content/10.64898/2025.12.23.695947v1
Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
December 26, 2025 at 3:37 PM
Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1
www.frontiersin.org/journals/imm...
www.frontiersin.org/journals/imm...
Plant Science Research Weekly -- Trehalose-mediated reprograming: metabolic crosstalk in plant-insect interactions (Plant, Cell & Environment) (Summary by Ching Chan) buff.ly/hJAJotk
#PlantaePSRW
#PlantaePSRW
Trehalose-mediated reprograming: metabolic crosstalk in plant-insect interactions | Plantae
In nature, plants often face multiple attackers simultaneously, giving rise to complex three-way interactions that can reshape defense outcomes in unexpected ways. An intriguing example comes from…
buff.ly
December 26, 2025 at 2:15 PM
Plant Science Research Weekly -- Trehalose-mediated reprograming: metabolic crosstalk in plant-insect interactions (Plant, Cell & Environment) (Summary by Ching Chan) buff.ly/hJAJotk
#PlantaePSRW
#PlantaePSRW
cGAS/STING-mediated γδ T cell recruitment drives radioresistance: implications for improving radioimmunotherapy outcomes: doi.org/10.1172/JCI2...
Brooke C. Braman & David R. Raleigh comment on Yue Deng et al. doi.org/10.1172/JCI1...
Brooke C. Braman & David R. Raleigh comment on Yue Deng et al. doi.org/10.1172/JCI1...
December 26, 2025 at 2:01 PM
cGAS/STING-mediated γδ T cell recruitment drives radioresistance: implications for improving radioimmunotherapy outcomes: doi.org/10.1172/JCI2...
Brooke C. Braman & David R. Raleigh comment on Yue Deng et al. doi.org/10.1172/JCI1...
Brooke C. Braman & David R. Raleigh comment on Yue Deng et al. doi.org/10.1172/JCI1...
#Research
Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression doi.org/10.1186/s435...
#NSCLC #ArginineMono_methylation #SOX9 #PRMT7 #R160 #FBXW7 #KEAP1
Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression doi.org/10.1186/s435...
#NSCLC #ArginineMono_methylation #SOX9 #PRMT7 #R160 #FBXW7 #KEAP1
Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression - Molecular Biomedicine
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, underscoring the need for deeper insights into its molecular mechanisms. The SRY-box transcription fac...
doi.org
December 26, 2025 at 6:20 AM
#Research
Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression doi.org/10.1186/s435...
#NSCLC #ArginineMono_methylation #SOX9 #PRMT7 #R160 #FBXW7 #KEAP1
Protein arginine methyltransferase 7-mediated arginine mono-methylation stabilizes SRY-box transcription factor 9 to promote non-small cell lung cancer progression doi.org/10.1186/s435...
#NSCLC #ArginineMono_methylation #SOX9 #PRMT7 #R160 #FBXW7 #KEAP1
A comparison of dermatomyositis and lupus skin revealed that dermatomyositis is characterized by monocyte-mediated endothelial cell dysfunction
www.science.org/doi/10.1126/... @kahlenberglab.bsky.social @umich.edu
www.science.org/doi/10.1126/... @kahlenberglab.bsky.social @umich.edu
December 26, 2025 at 2:44 AM
A comparison of dermatomyositis and lupus skin revealed that dermatomyositis is characterized by monocyte-mediated endothelial cell dysfunction
www.science.org/doi/10.1126/... @kahlenberglab.bsky.social @umich.edu
www.science.org/doi/10.1126/... @kahlenberglab.bsky.social @umich.edu
Congratulations to my team, Carter Craig,Tabitha Boeringer, Mia Pardo and Ashley Del Pozo for their latest paper, 'GPCR-Mediated Cell Intelligence, a Critical Function for Survival and Long-Term Health' out now as a Preprint.
www.preprints.org/manuscript/2...
www.preprints.org/manuscript/2...
December 25, 2025 at 4:26 PM
Congratulations to my team, Carter Craig,Tabitha Boeringer, Mia Pardo and Ashley Del Pozo for their latest paper, 'GPCR-Mediated Cell Intelligence, a Critical Function for Survival and Long-Term Health' out now as a Preprint.
www.preprints.org/manuscript/2...
www.preprints.org/manuscript/2...
Plant Science Research Weekly -- Reprogramming trees: hairy root-mediated transformation unlocks genetic engineering in poplar (Plant Cell Environ.) (Summary by Ching Chan) buff.ly/77LZTaG
#PlantaePSRW
#PlantaePSRW
Reprogramming trees: Hairy root-mediated transformation unlocks genetic engineering in poplar | Plantae
Agrobacterium tumefaciens, through its natural capacity to deliver foreign DNA into plant genomes, has enabled efficient transformation across many plant species and cultivars.
buff.ly
December 24, 2025 at 2:15 PM
Plant Science Research Weekly -- Reprogramming trees: hairy root-mediated transformation unlocks genetic engineering in poplar (Plant Cell Environ.) (Summary by Ching Chan) buff.ly/77LZTaG
#PlantaePSRW
#PlantaePSRW
"NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus"
Interesting work by James McLaren's lab on NK cell responses to superantigens and during blodstream infections.
6/9
Interesting work by James McLaren's lab on NK cell responses to superantigens and during blodstream infections.
6/9
NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus
Abstract. Natural killer (NK) cells are specialized lymphocytes that help protect against viruses and cancer. However, in the context of bacterial infectio
academic.oup.com
December 24, 2025 at 8:23 AM
"NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus"
Interesting work by James McLaren's lab on NK cell responses to superantigens and during blodstream infections.
6/9
Interesting work by James McLaren's lab on NK cell responses to superantigens and during blodstream infections.
6/9
"It has been postulated that the demyelination occurring secondary to VLCFA incorporation into cell membranes liberates abnormal lipids that may act as triggers in ALD to initiate the cascade of inflammatory demyelination that appears to be both cytokine and T cell mediated" it is wicked
I have mastered to stop the first phase but now this second phase is there since 2020 for unknown reasons. That is the reason why I have all these problems. It is the inflammatory phase. Normally people die in 1-2 years.
"It begins with an initial noninflammatory dysmyelination similar to that described for the adrenal and testicular dysfunction. The initial dysmyelination is associated with a mild macrophage response. This can progress at some point to a secondary phase of confluent inflammatory demyelination"
December 24, 2025 at 8:07 AM
"It has been postulated that the demyelination occurring secondary to VLCFA incorporation into cell membranes liberates abnormal lipids that may act as triggers in ALD to initiate the cascade of inflammatory demyelination that appears to be both cytokine and T cell mediated" it is wicked
Efficient Generation of Humanized Cloned Cattle via Embryonic Stem Cell-Mediated Dual-Round Site-Specific Editing https://www.biorxiv.org/content/10.64898/2025.12.20.695363v1
December 23, 2025 at 9:46 PM
Efficient Generation of Humanized Cloned Cattle via Embryonic Stem Cell-Mediated Dual-Round Site-Specific Editing https://www.biorxiv.org/content/10.64898/2025.12.20.695363v1
Efficient Generation of Humanized Cloned Cattle via Embryonic Stem Cell-Mediated Dual-Round Site-Specific Editing https://www.biorxiv.org/content/10.64898/2025.12.20.695363v1
December 23, 2025 at 9:46 PM
Efficient Generation of Humanized Cloned Cattle via Embryonic Stem Cell-Mediated Dual-Round Site-Specific Editing https://www.biorxiv.org/content/10.64898/2025.12.20.695363v1
Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood, say Gabrielle LeBlanc, Adam Sobel, Michael Constantinides (@mikerobe.bsky.social) and colleagues @scripps.edu: rupress.org/jem/article/...
#InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome
#InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome
December 23, 2025 at 9:30 PM
Antibiotic use in early life impairs MAIT cell–mediated immunity in adulthood, say Gabrielle LeBlanc, Adam Sobel, Michael Constantinides (@mikerobe.bsky.social) and colleagues @scripps.edu: rupress.org/jem/article/...
#InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome
#InfectiousDisease #HostDefense #MucosalImmunology #LymphocyteBiology #Microbiome