🥊 Knocking out MNN11 glycosyltransferase in #yeast = ⬆︎ taxadiene synthase expression & boosts taxadiene yield. New #YeastResearch shows endogenous glycosylation modifications can limit heterologous protein function in #pharmaceutical precursor production.
🧬 #SGD
www.yeastgenome.org/reference/S1...
🧬 #SGD
www.yeastgenome.org/reference/S1...
January 23, 2026 at 10:46 PM
🥊 Knocking out MNN11 glycosyltransferase in #yeast = ⬆︎ taxadiene synthase expression & boosts taxadiene yield. New #YeastResearch shows endogenous glycosylation modifications can limit heterologous protein function in #pharmaceutical precursor production.
🧬 #SGD
www.yeastgenome.org/reference/S1...
🧬 #SGD
www.yeastgenome.org/reference/S1...
Enzyme research accelerates growth in the Glycosyltransferase Market. www.marketresearchfuture.com/reports/glyc... #Biotechnology
Glycosyltransferase Market Size, Share, Trends Report 2035
Glycosyltransferase Market growth is projected to reach USD 3.72 Million, at a 5.48% CAGR by driving industry size, share, top company analysis, segments research, trends and forecast report 2025 to 2...
www.marketresearchfuture.com
January 23, 2026 at 1:01 PM
Enzyme research accelerates growth in the Glycosyltransferase Market. www.marketresearchfuture.com/reports/glyc... #Biotechnology
The polyphenol trade-off: leaf protection vs fruit attraction in apples driven by the phlorizin glycosyltransferase PGGT1
Yan et al.
nph.onlinelibrary.wiley.com/share/U4HVUR...
Yan et al.
nph.onlinelibrary.wiley.com/share/U4HVUR...
January 22, 2026 at 6:09 PM
The polyphenol trade-off: leaf protection vs fruit attraction in apples driven by the phlorizin glycosyltransferase PGGT1
Yan et al.
nph.onlinelibrary.wiley.com/share/U4HVUR...
Yan et al.
nph.onlinelibrary.wiley.com/share/U4HVUR...
A putative GtrB-like glycosyltransferase modulates cation-dependent BCP8-2 phage infection and cell surface structure in Bacillus cereus https://www.biorxiv.org/content/10.64898/2026.01.14.699495v1
January 15, 2026 at 1:16 AM
A putative GtrB-like glycosyltransferase modulates cation-dependent BCP8-2 phage infection and cell surface structure in Bacillus cereus https://www.biorxiv.org/content/10.64898/2026.01.14.699495v1
A putative GtrB-like glycosyltransferase modulates cation-dependent BCP8-2 phage infection and cell surface structure in Bacillus cereus https://www.biorxiv.org/content/10.64898/2026.01.14.699495v1
January 15, 2026 at 1:16 AM
A putative GtrB-like glycosyltransferase modulates cation-dependent BCP8-2 phage infection and cell surface structure in Bacillus cereus https://www.biorxiv.org/content/10.64898/2026.01.14.699495v1
A single catalytic domain residue regulates the substrate specificity of a mucin-type O-glycosyltransferase in salivary gland function
#Drosophila
#Drosophila
A single catalytic domain residue regulates the substrate specificity of a mucin-type O-glycosyltransferase in salivary gland function
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
January 9, 2026 at 12:23 PM
A single catalytic domain residue regulates the substrate specificity of a mucin-type O-glycosyltransferase in salivary gland function
#Drosophila
#Drosophila
A single catalytic domain residue regulates the substrate specificity of a mucin-type O-glycosyltransferase in salivary gland function https://www.biorxiv.org/content/10.64898/2025.12.22.695686v1
December 24, 2025 at 5:45 PM
A single catalytic domain residue regulates the substrate specificity of a mucin-type O-glycosyltransferase in salivary gland function https://www.biorxiv.org/content/10.64898/2025.12.22.695686v1
A single catalytic domain residue regulates the substrate specificity of a mucin-type O-glycosyltransferase in salivary gland function https://www.biorxiv.org/content/10.64898/2025.12.22.695686v1
December 24, 2025 at 5:45 PM
A single catalytic domain residue regulates the substrate specificity of a mucin-type O-glycosyltransferase in salivary gland function https://www.biorxiv.org/content/10.64898/2025.12.22.695686v1
Expanded UDP-glycosyltransferase gene clusters underlie insecticide detoxification in Spodoptera frugiperda
#Drosophila
#Drosophila
Expanded UDP-glycosyltransferase gene clusters underlie insecticide detoxification in Spodoptera frugiperda
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
December 11, 2025 at 6:23 AM
Expanded UDP-glycosyltransferase gene clusters underlie insecticide detoxification in Spodoptera frugiperda
#Drosophila
#Drosophila
I'm happy to share that our work describing the #cryoEM #structure of the glycosyltransferase ArnC from Salmonella enterica has been published in Nature Communications. #membrane #protein #PetrouLab
The article is open access and available at:
www.nature.com/articles/s41...
The article is open access and available at:
www.nature.com/articles/s41...
Structural basis of undecaprenyl phosphate glycosylation leading to polymyxin resistance in Gram-negative bacteria - Nature Communications
The study reveals the structure of ArnC, a membrane glycosyltransferase that modifies undecaprenyl phosphate with aminoarabinose (L-Ara4N), leading to polymyxin resistance. The structure of ArnC in tw...
www.nature.com
December 9, 2025 at 9:56 PM
I'm happy to share that our work describing the #cryoEM #structure of the glycosyltransferase ArnC from Salmonella enterica has been published in Nature Communications. #membrane #protein #PetrouLab
The article is open access and available at:
www.nature.com/articles/s41...
The article is open access and available at:
www.nature.com/articles/s41...
About a decade ago we began to look at the walls of stem cells by systematically analysing the expression patterns of glycosyltransferase (GTs) genes and polysaccharide composition in the shoot apical meristem (SAM） (www.cell.com/current-biol....
December 6, 2025 at 10:11 AM
About a decade ago we began to look at the walls of stem cells by systematically analysing the expression patterns of glycosyltransferase (GTs) genes and polysaccharide composition in the shoot apical meristem (SAM） (www.cell.com/current-biol....
Identification of a novel O-glycosyltransferase PgGT2 for catalyzing the first glycosylation step of saponin synthesis in Platycodon grandiflorum https://pubmed.ncbi.nlm.nih.gov/41313913/
November 30, 2025 at 3:09 PM
Identification of a novel O-glycosyltransferase PgGT2 for catalyzing the first glycosylation step of saponin synthesis in Platycodon grandiflorum https://pubmed.ncbi.nlm.nih.gov/41313913/
Mutation c.548A>G (p.Asp183Gly) in the gene encoding A-glycosyltransferase results in the A(weak) trait by reducing the number of hydrogen bonds, which leads to decreased protein stability.
tinyurl.com/apj2c6m3
#glycotime
tinyurl.com/apj2c6m3
#glycotime
November 25, 2025 at 10:44 AM
Mutation c.548A>G (p.Asp183Gly) in the gene encoding A-glycosyltransferase results in the A(weak) trait by reducing the number of hydrogen bonds, which leads to decreased protein stability.
tinyurl.com/apj2c6m3
#glycotime
tinyurl.com/apj2c6m3
#glycotime
In a study published in Horticulture Research, researchers identified the peach UDP-glycosyltransferase PpUGT74F2 as a major enzyme involved in SA metabolism.
#SA metabolism #UDP-glycosyltransferase
Details: doi.org/10.1093/hr/uhaf049
#SA metabolism #UDP-glycosyltransferase
Details: doi.org/10.1093/hr/uhaf049
November 23, 2025 at 2:40 PM
In a study published in Horticulture Research, researchers identified the peach UDP-glycosyltransferase PpUGT74F2 as a major enzyme involved in SA metabolism.
#SA metabolism #UDP-glycosyltransferase
Details: doi.org/10.1093/hr/uhaf049
#SA metabolism #UDP-glycosyltransferase
Details: doi.org/10.1093/hr/uhaf049
Structural insight into glycosyltransferase function
ARC Centre for Cryo-EM of Membrane Proteins
youtu.be/jPy4l4M-xQ4?...
ARC Centre for Cryo-EM of Membrane Proteins
youtu.be/jPy4l4M-xQ4?...
Structural insight into glycosyltransferase function
YouTube video by ARC Centre for Cryo-EM of Membrane Proteins
youtu.be
November 11, 2025 at 9:38 AM
Structural insight into glycosyltransferase function
ARC Centre for Cryo-EM of Membrane Proteins
youtu.be/jPy4l4M-xQ4?...
ARC Centre for Cryo-EM of Membrane Proteins
youtu.be/jPy4l4M-xQ4?...
CCeMMP Seminar alert! ⏰ We welcome Assistant Prof. Rie Nygaard, Weill Cornell Medicine,
New York City, USA. “Structural insight into glycosyltransferase function”
More info and register: ccemmp.org/events/ccemm...
New York City, USA. “Structural insight into glycosyltransferase function”
More info and register: ccemmp.org/events/ccemm...
November 9, 2025 at 3:15 AM
CCeMMP Seminar alert! ⏰ We welcome Assistant Prof. Rie Nygaard, Weill Cornell Medicine,
New York City, USA. “Structural insight into glycosyltransferase function”
More info and register: ccemmp.org/events/ccemm...
New York City, USA. “Structural insight into glycosyltransferase function”
More info and register: ccemmp.org/events/ccemm...
Ryan Griffiths et al.: A structural basis for the strain-dependent UDP-sugar specificity of glycosyltransferase C from the Limosilactobacillus reuteri accessory secretion system ##CrystalStructure@uniofeastanglia...##IUCrhttps://journals.iucr.org/paper?S2059798325008782
A structural basis for the strain-dependent UDP-sugar specificity of glycosyltransferase C from the Limosilactobacillus reuteri accessory secretion system
X-ray crystal structures of glycosyltransferase C from the Limosilactobacillus reuteri 100-23 (LrGtfC100-23) accessory secretion system were determined in its apo form and in complexes with UDP and with UDP-N-acetylglucosamine, which revealed candidate residues involved in strain-specific recognition of UDP-sugars. Site-directed mutagenesis of these residues led to a switch of the UDP-sugar binding specificities of LrGtfC100-23 and the highly homologous LrGtfC from L. reuteri ATCC 53608.
journals.iucr.org
November 6, 2025 at 1:00 AM
Ryan Griffiths et al.: A structural basis for the strain-dependent UDP-sugar specificity of glycosyltransferase C from the Limosilactobacillus reuteri accessory secretion system ##CrystalStructure@uniofeastanglia...##IUCrhttps://journals.iucr.org/paper?S2059798325008782
UDP-glycosyltransferase confers anthranilic diamide resistance in Bemisia tabaci
#Drosophila
#Drosophila
UDP-glycosyltransferase confers anthranilic diamide resistance in Bemisia tabaci
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 5, 2025 at 5:23 AM
UDP-glycosyltransferase confers anthranilic diamide resistance in Bemisia tabaci
#Drosophila
#Drosophila
We identified O-glycosylation of STAT1 (Ser499/Thr510) as critical for maintaining Th1 effector function. Inhibiting O-glycosyltransferase or mutating these sites disrupted STAT1 activity and Th1 differentiation.
Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation
T helper (Th) cell lineages are linked to metabolism, but precise mechanisms in human Th1 cells remain unclear. We addressed this question by in vitro stimulation and CRISPR/Cas9-mediated gene editing...
www.life-science-alliance.org
November 4, 2025 at 9:48 AM
We identified O-glycosylation of STAT1 (Ser499/Thr510) as critical for maintaining Th1 effector function. Inhibiting O-glycosyltransferase or mutating these sites disrupted STAT1 activity and Th1 differentiation.
The O-glycosyltransferase SECRET AGENT Participates in Abscisic Acid-Induced Microtubule Remodeling and Stomatal Closure in Arabidopsis thaliana https://www.biorxiv.org/content/10.1101/2025.10.29.683829v1
October 31, 2025 at 5:02 PM
The O-glycosyltransferase SECRET AGENT Participates in Abscisic Acid-Induced Microtubule Remodeling and Stomatal Closure in Arabidopsis thaliana https://www.biorxiv.org/content/10.1101/2025.10.29.683829v1
The O-glycosyltransferase SECRET AGENT Participates in Abscisic Acid-Induced Microtubule Remodeling and Stomatal Closure in Arabidopsis thaliana https://www.biorxiv.org/content/10.1101/2025.10.29.683829v1
October 31, 2025 at 5:02 PM
The O-glycosyltransferase SECRET AGENT Participates in Abscisic Acid-Induced Microtubule Remodeling and Stomatal Closure in Arabidopsis thaliana https://www.biorxiv.org/content/10.1101/2025.10.29.683829v1
Tracking down the aberrant septa phenotype, we discovered that a non-essential orphan class B PBP called PBP3 plays a non-catalytic regulatory role in promoting PBP1 function (and causes TPase* PBP1 to synthesize too many septa) likely by over-activating PBP1’s glycosyltransferase activity
October 28, 2025 at 1:25 AM
Tracking down the aberrant septa phenotype, we discovered that a non-essential orphan class B PBP called PBP3 plays a non-catalytic regulatory role in promoting PBP1 function (and causes TPase* PBP1 to synthesize too many septa) likely by over-activating PBP1’s glycosyltransferase activity
Researchers isolated phage-resistant mutants and used whole-genome sequencing to identify a glycosyltransferase gene within the rgp locus responsible for the biosynthesis of the cell wall-associated rhamnose-glucose polysaccharide (RGP).
October 27, 2025 at 8:55 PM
Researchers isolated phage-resistant mutants and used whole-genome sequencing to identify a glycosyltransferase gene within the rgp locus responsible for the biosynthesis of the cell wall-associated rhamnose-glucose polysaccharide (RGP).
By leveraging protecting-group control, glycosyltransferase selectivity, and glyco-epitope blocking, the researchers precisely installed unique branches and terminal epitopes.
October 15, 2025 at 3:15 AM
By leveraging protecting-group control, glycosyltransferase selectivity, and glyco-epitope blocking, the researchers precisely installed unique branches and terminal epitopes.