#transcriptional
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epigenometech.bsky.social
Epigenetics Update - DOT1L provides transcriptional memory through PRC1.1 antagonism go.nature.com/4qh5aXB

Chen Davidovich and Omer Gilan (Monash University) reporting in Nat Cell Biol

#Epigenetics #DOT1L #PolyComb
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Gain deeper insights into gene regulation; epigenometech.com
February 6, 2026 at 12:50 PM
giblasi.bsky.social
Our paper is now out in Proceedings of the Royal Society B 🧬🐜

Explore how tissue- and caste-specific DNA methylation relates to gene expression, while parasite-induced transcriptional changes occur independently of DNA methylation.
👉 doi.org/10.1098/rspb...

Thanks to @socialinsectlab.bsky.social
DNA methylation reflects tissue and caste identity but not parasitism-induced changes in a social insect
Abstract. The role of DNA methylation in regulating transcriptional activity and post-transcriptional modifications in insects, particularly in social inse
royalsocietypublishing.org
February 6, 2026 at 10:29 AM
prepub-singlecell.bsky.social
Scalable probe-based single-cell transcriptional profiling for virtual cell perturbation mapping and synthetic biology phenotyping #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.02.04.703058v1
February 6, 2026 at 8:00 AM
biorxiv-molbio.bsky.social
mRNA Imprinting: transcription apparatus can remotely control cytoplasmic post-transcriptional mechanisms by dozens of proteins https://www.biorxiv.org/content/10.64898/2026.02.03.703598v1
February 6, 2026 at 7:16 AM
biorxivpreprint.bsky.social
mRNA Imprinting: transcription apparatus can remotely control cytoplasmic post-transcriptional mechanisms by dozens of proteins https://www.biorxiv.org/content/10.64898/2026.02.03.703598v1
February 6, 2026 at 7:16 AM
biorxiv-physio.bsky.social
Liver-specific loss of the transcriptional coregulator ARGLU1 protects against diet-induced obesity in mice through decreased lipid absorption https://www.biorxiv.org/content/10.64898/2026.02.03.703579v1
February 6, 2026 at 6:01 AM
biorxivpreprint.bsky.social
Liver-specific loss of the transcriptional coregulator ARGLU1 protects against diet-induced obesity in mice through decreased lipid absorption https://www.biorxiv.org/content/10.64898/2026.02.03.703579v1
February 6, 2026 at 6:01 AM
aixbiobot.bsky.social
Scalable probe-based single-cell transcriptional profiling for virtual cell perturbation mapping and synthetic biology phenotyping [new]
Figure 1 Figure 2 Figure 3 Figure 4
February 6, 2026 at 3:16 AM
biorxiv-synthbio.bsky.social
Scalable probe-based single-cell transcriptional profiling for virtual cell perturbation mapping and synthetic biology phenotyping https://www.biorxiv.org/content/10.64898/2026.02.04.703058v1
February 6, 2026 at 3:02 AM
biorxivpreprint.bsky.social
Scalable probe-based single-cell transcriptional profiling for virtual cell perturbation mapping and synthetic biology phenotyping https://www.biorxiv.org/content/10.64898/2026.02.04.703058v1
February 6, 2026 at 3:02 AM
biorxiv-immuno.bsky.social
Cytokine-induced Chromatin Accessibility in Whole Blood Neutrophils Links to Sepsis Transcriptional 1 States https://www.biorxiv.org/content/10.64898/2026.02.03.703332v1
February 6, 2026 at 2:15 AM
biorxivpreprint.bsky.social
Cytokine-induced Chromatin Accessibility in Whole Blood Neutrophils Links to Sepsis Transcriptional 1 States https://www.biorxiv.org/content/10.64898/2026.02.03.703332v1
February 6, 2026 at 2:15 AM
daniela-oaks.bsky.social
El siguiente bloque de pláticas fue del grupo de @mgschiavon.bsky.social, y fue dada por Diego Morales, quien nos habló de #biestabilidad y #transcriptional #bursting #DiasAcademicos2026 @liigh-unam.bsky.social
February 5, 2026 at 8:52 PM
taghivscience.bsky.social
HIV-1 Vpr induces an NFAT-controlled transcriptional program in primary CD4+ T cells journals.asm.org/doi/10.1128/... (open access) #HIV
HIV-1 Vpr induces an NFAT-controlled transcriptional program in primary CD4+ T cells | mBio
The HIV-1 accessory protein Vpr is known for its profound effect on the host proteome. It degrades many cellular proteins, including transcription factors and DNA-associated proteins. In addition, Vpr...
journals.asm.org
February 5, 2026 at 8:45 PM
benparkerlab.bsky.social
Our #phosphoproteomics analysis of insulin signaling in bone uncovered a new mechanism of transcriptional activation via S6K phosphorylation of AFF4. It appears to play a role in regulating the expression of genes in ageing and insulin resistance. www.nature.com/articles/s41...
Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator - Nature Communications
Insulin signaling plays a crucial role in coordinating skeletal development with whole‑body energy metabolism. Here, the authors use phosphoproteomics to show insulin-signaling rewiring in aged, insul...
www.nature.com
February 5, 2026 at 6:32 PM
pluchinolab.bsky.social
Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons

academic.oup.com/nar/article/...
Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
Abstract. Heterochromatin is characterized by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However,
academic.oup.com
February 5, 2026 at 5:19 PM
prepub-singlecell.bsky.social
Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells drives neuroinflammation in SIV-infected rhesus macaques #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-8632387/latest
February 5, 2026 at 5:06 PM
laboptbio.bsky.social
Next LOB seminar: 12 Feb. 2026, 11:00AM, @xpolytechnique.bsky.social, Amphi Becquerel
Seminar of @lorenaguilarlab.bsky.social from UNAM
Title: Metabolic State as a Regulator of Transcriptional Dynamics in Human Embryonic Stem Cell Differentiation
lob.ip-paris.fr/en/events/se...
Seminar of Lorena Aguilar-Arnal, CInstituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México-UNAM Mexico
11:00am, Ecole Polytechnique, Amphi Becquerel
lob.ip-paris.fr
February 5, 2026 at 3:48 PM
plosbiology.org
HIV-1 induces #DNADamageResponse via Vpr, but does this affect the viral cycle? This study shows that Vpr-driven #DNA damage promotes epigenetic remodeling & transcriptional programs to enhance #HIV1 transcription & latency reactivation, with therapeutic potential @plosbiology.org 🧪 plos.io/4c9wVhe
Left: Virion-associated Vpr proteins induce epigenetic remodeling. Representative fluorescence microscopy images of DDR activation in HeLa and differentiated THP1 cells infected with Vpr or control viruses pre-treated with raltegravir or combination zidovudine/etravirine (n = 50 cells). For these experiments, the mCherry reporter is expressed from the viral promoter instead of being driven by CMV. This allows for tracking infection kinetics in real time to assess DDR activation from virion-associated Vpr. Right: Electrostatic surface potential of a Vpr-DCAF1 co-complex. Surfaces associated with hyperactive or DDR-deficient Vpr mutants are colored in blue and red, respectively.
February 5, 2026 at 2:02 PM
bioinfoadv.bsky.social
This study investigated transcriptional and epigenetic dysregulation of Ca2+-signaling genes in HBV-HCC using bulk RNA-seq, ChIP-seq, and DNA methylation datasets.
February 5, 2026 at 10:02 AM
bioinfoadv.bsky.social
🧬 Explore the latest from Bioinformatics Advances: “Transcriptional and epigenetic regulation of Ca2+-signaling genes in hepatitis B-derived hepatocellular carcinoma and their association with the cancer hallmarks” 

Full article available: https://doi.org/10.1093/bioadv/vbaf331
February 5, 2026 at 10:02 AM
plosbiology.org
HIV-1 induces #DNADamageResponse via Vpr, but does this affect the viral cycle? This study shows that Vpr-driven #DNA damage promotes epigenetic remodeling & transcriptional programs to enhance #HIV1 transcription & latency reactivation, with therapeutic potential @plosbiology.org 🧪 plos.io/4c9wVhe
Left: Virion-associated Vpr proteins induce epigenetic remodeling. Representative fluorescence microscopy images of DDR activation in HeLa and differentiated THP1 cells infected with Vpr or control viruses pre-treated with raltegravir or combination zidovudine/etravirine (n = 50 cells). For these experiments, the mCherry reporter is expressed from the viral promoter instead of being driven by CMV. This allows for tracking infection kinetics in real time to assess DDR activation from virion-associated Vpr. Right: Electrostatic surface potential of a Vpr-DCAF1 co-complex. Surfaces associated with hyperactive or DDR-deficient Vpr mutants are colored in blue and red, respectively.
February 5, 2026 at 9:00 AM
prepub-singlecell.bsky.social
Exploring the Transcriptional Crosstalk Between Adipose Tissue and Locoregional Recurrence in Breast Cancer Using Independent Component Analysis #SingleCell 🧪🧬🖥️
https://www.researchsquare.com/article/rs-8544684/latest
February 5, 2026 at 8:00 AM
thecovidinfoguy.bsky.social
Study: A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID

Published: 14 January 2026

www.nature.com/articles/s41...
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID - Nature Immunology
Li and colleagues describe a monocyte-specific transcriptional state along with a persistent elevation of inflammatory markers specifically found in individuals with long COVID who had mild-to-moderat...
www.nature.com
February 4, 2026 at 11:46 PM
idpseminars.bsky.social
IDPSeminas is back again TOMORROW!

Talks from Lucia Strader (@luciastrader.bsky.social) and Heather Meyer! Sign up at idpseminars.com.

Talks start at 1 pm EST / 7 PM CET!! Come learn about transcriptional adaptation and IDRs as environmental sensors and accuators!
Poster showing program for IDPSeminars on Feb 5th. Talks are: Lucia Strader: IDR sequence features of activation domains Heather Meyer: IDPs as environmental sensors and actuators in plants
February 4, 2026 at 10:14 PM