Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
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Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
Shahbaz et al. find that female long COVID patients with ME/CFS exhibit heightened
inflammation, altered hematopoiesis, disrupted hormone levels, and neuroinflammatory
gene signatures. In parallel, our study identifies sex-specific immune and hormonal
biomarkers that correlate with clinical symptoms, supporting the need for tailored
therapeutic strategies, including consideration of hormone replacement therapy.
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November 10, 2025 at 3:17 PM
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
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scCellFie is a computational framework that infers metabolic activities from both single-cell and spatial transcriptomic data, enabling large-scale, interpretable analyses across cell atlases.
November 10, 2025 at 3:16 PM
scCellFie is a computational framework that infers metabolic activities from both single-cell and spatial transcriptomic data, enabling large-scale, interpretable analyses across cell atlases.
Integrated Cross-Organ Transcriptomic Analysis Uncovers Conserved Gene Signatures Predictive of Allograft Rejection https://www.biorxiv.org/content/10.1101/2025.11.07.687316v1
November 10, 2025 at 4:08 AM
Integrated Cross-Organ Transcriptomic Analysis Uncovers Conserved Gene Signatures Predictive of Allograft Rejection https://www.biorxiv.org/content/10.1101/2025.11.07.687316v1
Integrated Cross-Organ Transcriptomic Analysis Uncovers Conserved Gene Signatures Predictive of Allograft Rejection https://www.biorxiv.org/content/10.1101/2025.11.07.687316v1
November 10, 2025 at 4:08 AM
Integrated Cross-Organ Transcriptomic Analysis Uncovers Conserved Gene Signatures Predictive of Allograft Rejection https://www.biorxiv.org/content/10.1101/2025.11.07.687316v1
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS - Shahbaz et al.
"Hormonal analysis shows reduced testosterone in [females] and estradiol in [males]."
www.s4me.info/threads/inte...
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"Hormonal analysis shows reduced testosterone in [females] and estradiol in [males]."
www.s4me.info/threads/inte...
www.cell.com/cell-reports...
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS, 2025, Shahbaz et al.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00522-1
Highlights
• Female long COVID (LC) patients show heightened immune activation and inflammation
• Disrupted sex hormone lev...
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November 10, 2025 at 3:15 AM
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS - Shahbaz et al.
"Hormonal analysis shows reduced testosterone in [females] and estradiol in [males]."
www.s4me.info/threads/inte...
www.cell.com/cell-reports...
"Hormonal analysis shows reduced testosterone in [females] and estradiol in [males]."
www.s4me.info/threads/inte...
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Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
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Screenshot from latest Science for ME weekly update
#LongCovid #MEcfs
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
www.cell.com/cell-reports...
Screenshot from latest Science for ME weekly update
#LongCovid #MEcfs
![Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS — Shima Shahbaz et al.
"Hormonal analysis shows reduced testosterone in [females] and estradiol in [males]. Transcriptomic data reveal neuroinflammatory signatures in [females], potentially explaining cognitive symptoms. We also identify biomarkers that distinguish [females] from [males] and correlate with sex-specific clinical symptoms."](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:43rudsv62fuwsmnk7oppgtdy/bafkreihbyqpykkh7phqxds2mujmw3f26ymnvkkpdwvau5g2aphlbgtzq7i@jpeg)
November 10, 2025 at 1:26 AM
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Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
www.cell.com/cell-reports...
Screenshot from latest Science for ME weekly update
#LongCovid #MEcfs
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
www.cell.com/cell-reports...
Screenshot from latest Science for ME weekly update
#LongCovid #MEcfs
Online now: Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
Shahbaz et al. find that female long COVID patients with ME/CFS exhibit heightened inflammation, altered hematopoiesis, disrupted hormone levels, and neuroinflammatory gene signatures. In parallel, our study identifies sex-specific immune and hormonal biomarkers that correlate with clinical symptoms, supporting the need for tailored therapeutic strategies, including consideration of hormone replacement therapy.
dlvr.it
November 9, 2025 at 8:19 PM
Online now: Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
Transcriptomic profiling revealed significant gene expression changes, particularly for the 18-demethylated analog, suggesting modulation of key signaling pathways.
November 9, 2025 at 2:16 PM
Transcriptomic profiling revealed significant gene expression changes, particularly for the 18-demethylated analog, suggesting modulation of key signaling pathways.
Transcriptomic Profiling of scWAT Reveals Reduced Lipid-Associated Macrophage Signatures in Long-Term Endurance- and Resistance-Trained Athletes https://www.biorxiv.org/content/10.1101/2025.11.07.687158v1
November 9, 2025 at 5:02 AM
Transcriptomic Profiling of scWAT Reveals Reduced Lipid-Associated Macrophage Signatures in Long-Term Endurance- and Resistance-Trained Athletes https://www.biorxiv.org/content/10.1101/2025.11.07.687158v1
Transcriptomic Profiling of scWAT Reveals Reduced Lipid-Associated Macrophage Signatures in Long-Term Endurance- and Resistance-Trained Athletes https://www.biorxiv.org/content/10.1101/2025.11.07.687158v1
November 9, 2025 at 5:02 AM
Transcriptomic Profiling of scWAT Reveals Reduced Lipid-Associated Macrophage Signatures in Long-Term Endurance- and Resistance-Trained Athletes https://www.biorxiv.org/content/10.1101/2025.11.07.687158v1
Nature research paper: Transcriptomic and spatial organization of telencephalic GABAergic neurons
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Transcriptomic and spatial organization of telencephalic GABAergic neurons - Nature
Long-distance migration and dispersion is a common characteristic of nearly all classes of telencephalic GABAergic neurons, which diversify extensively after birth in the cortex and striatum, but show limited postnatal changes in the septum, preoptic area and pallidum.
go.nature.com
November 8, 2025 at 12:24 PM
Nature research paper: Transcriptomic and spatial organization of telencephalic GABAergic neurons
go.nature.com/43fLcE5
go.nature.com/43fLcE5
1️⃣0️⃣📖 Paper: Shahbaz et al., Cell Reports Medicine (2025)
“Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in Long Covid patients with ME/CFS.”
www.cell.com/cell-reports...
“Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in Long Covid patients with ME/CFS.”
www.cell.com/cell-reports...
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
Shahbaz et al. find that female long COVID patients with ME/CFS exhibit heightened
inflammation, altered hematopoiesis, disrupted hormone levels, and neuroinflammatory
gene signatures. In parallel, ou...
www.cell.com
November 8, 2025 at 11:47 AM
1️⃣0️⃣📖 Paper: Shahbaz et al., Cell Reports Medicine (2025)
“Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in Long Covid patients with ME/CFS.”
www.cell.com/cell-reports...
“Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in Long Covid patients with ME/CFS.”
www.cell.com/cell-reports...
Transcriptomic and proteomic analyses revealed gene and protein networks associated with these pathological changes. Further, RECK depletion led to elevated levels of inflammatory markers and enhanced EGFR signaling, suggesting a potential therapeutic target.
November 8, 2025 at 8:46 AM
Transcriptomic and proteomic analyses revealed gene and protein networks associated with these pathological changes. Further, RECK depletion led to elevated levels of inflammatory markers and enhanced EGFR signaling, suggesting a potential therapeutic target.
Sample-multiplexed FACS-preprocessing of PBMCs enables scalable scRNA-seq without compromising transcriptomic or cellular integrity #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.11.06.687014v1
https://www.biorxiv.org/content/10.1101/2025.11.06.687014v1
November 8, 2025 at 8:00 AM
Sample-multiplexed FACS-preprocessing of PBMCs enables scalable scRNA-seq without compromising transcriptomic or cellular integrity #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.1101/2025.11.06.687014v1
https://www.biorxiv.org/content/10.1101/2025.11.06.687014v1
Sample-multiplexed FACS-preprocessing of PBMCs enables scalable scRNA-seq without compromising transcriptomic or cellular integrity https://www.biorxiv.org/content/10.1101/2025.11.06.687014v1
November 8, 2025 at 3:35 AM
Sample-multiplexed FACS-preprocessing of PBMCs enables scalable scRNA-seq without compromising transcriptomic or cellular integrity https://www.biorxiv.org/content/10.1101/2025.11.06.687014v1
Sample-multiplexed FACS-preprocessing of PBMCs enables scalable scRNA-seq without compromising transcriptomic or cellular integrity https://www.biorxiv.org/content/10.1101/2025.11.06.687014v1
November 8, 2025 at 3:35 AM
Sample-multiplexed FACS-preprocessing of PBMCs enables scalable scRNA-seq without compromising transcriptomic or cellular integrity https://www.biorxiv.org/content/10.1101/2025.11.06.687014v1
Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infections https://www.biorxiv.org/content/10.1101/2025.11.07.687132v1
November 8, 2025 at 3:16 AM
Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infections https://www.biorxiv.org/content/10.1101/2025.11.07.687132v1
Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infections https://www.biorxiv.org/content/10.1101/2025.11.07.687132v1
November 8, 2025 at 3:16 AM
Immune transcriptomic differences in paediatric patients with SARS-CoV-2 compared to other lower respiratory tract infections https://www.biorxiv.org/content/10.1101/2025.11.07.687132v1
But it's taken me weeks of time to do quality control exercises and confirm mapping quality, using a transcriptomic alignment method featuring bowtie2 as before, but instead of genomic alignment. And there's some stupid issues. Just stupid...
November 8, 2025 at 2:13 AM
But it's taken me weeks of time to do quality control exercises and confirm mapping quality, using a transcriptomic alignment method featuring bowtie2 as before, but instead of genomic alignment. And there's some stupid issues. Just stupid...
Cell Reports Medicine: 'Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS'
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
Shahbaz et al. find that female long COVID patients with ME/CFS exhibit heightened
inflammation, altered hematopoiesis, disrupted hormone levels, and neuroinflammatory
gene signatures. In parallel, ou...
www.cell.com
November 7, 2025 at 10:33 PM
Cell Reports Medicine: 'Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS'
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Peripheral transcriptomic signature of chronic antibody-mediated rejection in kidney transplantation: a dual effect for MMP9 over time https://www.medrxiv.org/content/10.1101/2025.11.06.25339648v1
November 7, 2025 at 10:14 PM
Peripheral transcriptomic signature of chronic antibody-mediated rejection in kidney transplantation: a dual effect for MMP9 over time https://www.medrxiv.org/content/10.1101/2025.11.06.25339648v1
Transcriptomic and functional comparison of cells isolated from healthy and degenerated ovine intervertebral discs https://www.biorxiv.org/content/10.1101/2025.11.06.686904v1
November 7, 2025 at 9:30 PM
Transcriptomic and functional comparison of cells isolated from healthy and degenerated ovine intervertebral discs https://www.biorxiv.org/content/10.1101/2025.11.06.686904v1
Transcriptomic and functional comparison of cells isolated from healthy and degenerated ovine intervertebral discs https://www.biorxiv.org/content/10.1101/2025.11.06.686904v1
November 7, 2025 at 9:30 PM
Transcriptomic and functional comparison of cells isolated from healthy and degenerated ovine intervertebral discs https://www.biorxiv.org/content/10.1101/2025.11.06.686904v1
-Hormonal analysis shows reduced testosterone in LCF and estradiol in LCM. -Transcriptomic data reveal #neuroinflammatory signatures in LCF, potentially explaining cognitive symptoms.
The study also identify biomarkers that distinguish LCF from LCM and correlate with sex-specific clinical symptoms.
The study also identify biomarkers that distinguish LCF from LCM and correlate with sex-specific clinical symptoms.
November 7, 2025 at 7:08 PM
-Hormonal analysis shows reduced testosterone in LCF and estradiol in LCM. -Transcriptomic data reveal #neuroinflammatory signatures in LCF, potentially explaining cognitive symptoms.
The study also identify biomarkers that distinguish LCF from LCM and correlate with sex-specific clinical symptoms.
The study also identify biomarkers that distinguish LCF from LCM and correlate with sex-specific clinical symptoms.
Direct link to the research mentioned in the post above:
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS (Nov 7, 2025)
www.cell.com/cell-reports...
[ FREE PDF available ]
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS (Nov 7, 2025)
www.cell.com/cell-reports...
[ FREE PDF available ]
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS
Shahbaz et al. find that female long COVID patients with ME/CFS exhibit heightened
inflammation, altered hematopoiesis, disrupted hormone levels, and neuroinflammatory
gene signatures. In parallel, ou...
www.cell.com
November 7, 2025 at 7:06 PM
Direct link to the research mentioned in the post above:
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS (Nov 7, 2025)
www.cell.com/cell-reports...
[ FREE PDF available ]
Integrated immune, hormonal, and transcriptomic profiling reveals sex-specific dysregulation in long COVID patients with ME/CFS (Nov 7, 2025)
www.cell.com/cell-reports...
[ FREE PDF available ]