My awesome grad student Shashank and I wrote this paper trying to look at broader patterns of HT in TEs. HT is happening everywhere! DNA transposons jump further than other classes! www.biorxiv.org/content/10.1...
Recent horizontal transfer of transposable elements in Drosophila
Transposable elements (TEs) are genetic elements also known as "jumping genes" that increase their copy numbers within a host through various mechanisms of transposition. TEs can also move between spe...
www.biorxiv.org
October 31, 2025 at 3:58 PM
Everybody can reply
7 reposts
11 likes
1 saves
🧠 🌟 Im very happy and grateful for receiving the Starting Grant from the Swedish Research Council. This support will allow my lab at Umeå University to further understand the role of transposons in oligodendrocyte specific human brain ageing. Looking forward to the exciting research! 🧬 🧠
October 31, 2025 at 1:21 PM
Everybody can reply
1 reposts
10 likes
The best two things in one database: Transposons and Fungi
1/ Ever needed to annotate TEs in a fungal genome, but didn't know where to start?
We have released #MycoMobilome, a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom, constructed from >4,000 fungal genomes!
www.biorxiv.org/content/10.1...
We have released #MycoMobilome, a community-focused non-redundant database of transposable element consensus sequences for the fungal kingdom, constructed from >4,000 fungal genomes!
www.biorxiv.org/content/10.1...
October 29, 2025 at 5:57 PM
Everybody can reply
4 reposts
13 likes
1 saves
Brilliant use of gfp-tagged transposons & automated scoring of kernels, combined with differential style-lengths along maize ear, to screen for genes underlying pollen competition in maize. Diana gave a banger of a presentation on this in #Zeavolution this morning. www.biorxiv.org/content/10.1...
October 29, 2025 at 3:36 PM
Everybody can reply
9 reposts
29 likes
3 saves
What caused the pink? Barbara McClintock discovered that jumping genes (aka transposons) cause color variations in maize. Could jumping genes be the story behind this pink pumpkin? We have the pumpkin genome so someone knows!?
October 25, 2025 at 11:26 PM
Everybody can reply
🌱 From junk to genius: how transposons shape gene regulation in plants
More information here ⬇️
www.ihsm.uma-csic.es/comunicacion...
More information here ⬇️
www.ihsm.uma-csic.es/comunicacion...
October 20, 2025 at 12:16 PM
Everybody can reply
1 reposts
3 likes
The 'Handler genome' of OSCs, a rare and stably growing cell line that runs a piRNA pathway to silence transposons.
Dominik (@86dominik.bsky.social) assembled the genome of this Drosophila cell line.
Besides making some cool findings, the goal was to turn this into useful resource for the field.
Dominik (@86dominik.bsky.social) assembled the genome of this Drosophila cell line.
Besides making some cool findings, the goal was to turn this into useful resource for the field.
When transposons jump, genomes diverge - even in cultured cells.
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
October 15, 2025 at 12:18 PM
Everybody can reply
7 reposts
20 likes
1 saves
🚀 The next edition of Bioinformatics of Transposable Elements with @valentinapeona.bsky.social & @ritarebollo.bsky.social is just around the corner!
🧬 Jump into the world of #transposons and level up your #bioinformatics skills
⏳ Seats are limited: www.physalia-courses.org/courses-work...
🧬 Jump into the world of #transposons and level up your #bioinformatics skills
⏳ Seats are limited: www.physalia-courses.org/courses-work...
October 15, 2025 at 9:47 AM
Everybody can reply
3 reposts
3 likes
When transposons jump, genomes diverge - even in cultured cells.
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
I am happy to share our new preprint: a chromosome-scale genome assembly for Drosophila OSC cells, one of the key model systems in the piRNA field, especially for nuclear piRNA biology. 🧬🧵 (1/12)
October 14, 2025 at 8:34 PM
Everybody can reply
23 reposts
4 quotes
65 likes
3 saves
Transposable Elements and Homotypic Niches Drive Immune Dynamics and Resistance in Melanoma Epigenetic-based immunotherapy [new]
Epi-immunotherapy: Reactivates transposons in melanoma, boosting immunity; homotypic niches resist.
Epi-immunotherapy: Reactivates transposons in melanoma, boosting immunity; homotypic niches resist.
October 10, 2025 at 9:55 PM
Everybody can reply
That would be a transposing jumping into a “color gene” or silencing it.
However, I’ve always wondered if these spots in petunia starry sky are really transposons which normally make striped sectors. These spots are more circular suggesting a mobile diffusable repressor of color… 🤔
However, I’ve always wondered if these spots in petunia starry sky are really transposons which normally make striped sectors. These spots are more circular suggesting a mobile diffusable repressor of color… 🤔
October 10, 2025 at 12:54 PM
Everybody can reply
1 likes
1 saves
A new subgroup of #CRISPR-associated transposons, V-K_V2, has been discovered in Nostocales #cyanobacteria by @cyanolab.bsky.social & colleagues 🧬. Its unique features suggest genetic mobility and V2 tracrRNAs are now included in the updated CRISPRtracrRNA tool.
buff.ly/gioIfEB
buff.ly/gioIfEB
October 8, 2025 at 11:03 AM
Everybody can reply
2 reposts
5 likes
🧬 New post on The Brownian Notion
🐸🦎 Frogs, salamanders, and jumping genes: amphibian genomes are messy, huge, and full of stories about how DNA moves, adapts, and evolves. #transposons #mobileDNA #evolution #macroevolution #genomics
https://substack.com/home/post/p-175407494
🐸🦎 Frogs, salamanders, and jumping genes: amphibian genomes are messy, huge, and full of stories about how DNA moves, adapts, and evolves. #transposons #mobileDNA #evolution #macroevolution #genomics
https://substack.com/home/post/p-175407494
Jump like a Frog: What amphibian genomes can teach us about transposable elements.
A comparative study shows that Transposable Elements can be linked to climate adaptation and other complex traits in Amphibians.
substack.com
October 7, 2025 at 4:19 PM
Everybody can reply
🧬 New post on The Brownian Notion
🐸🦎 Frogs, salamanders, and jumping genes: amphibian genomes are messy, huge, and full of stories about how DNA moves, adapts, and evolves. #transposons #mobileDNA #evolution #macroevolution #genomics
open.substack.com/pub/brownian...
🐸🦎 Frogs, salamanders, and jumping genes: amphibian genomes are messy, huge, and full of stories about how DNA moves, adapts, and evolves. #transposons #mobileDNA #evolution #macroevolution #genomics
open.substack.com/pub/brownian...
Jump like a Frog: What amphibian genomes can teach us about transposable elements.
A comparative study shows that Transposable Elements can be linked to climate adaptation and other complex traits in Amphibians.
open.substack.com
October 6, 2025 at 9:27 AM
Everybody can reply
1 likes
And this is of course what genomes are. We do know eg that some of the transposons have to be kept in order via Piwi proteins, but the fact is that our genome as a whole does its job, and even some bits that came from viruses have a role to play in that.
October 3, 2025 at 5:36 PM
Everybody can reply
The Peters lab is looking for a new team member! The role transposons play in evolution, basic mechanisms regulating transposition, and applying transposons as tools for genome modification with a special focus on guide RNA-directed transposition. cornell.wd1.myworkdayjobs.com/CornellCaree...
Technician III - Department of Microbiology
Position Summary This position will be in the lab of Dr. Joseph E. Peters in the Department of Microbiology. Research in the Peters’ lab broadly involves deciphering mechanisms in genome stability and...
cornell.wd1.myworkdayjobs.com
October 3, 2025 at 1:01 PM
Everybody can reply
21 reposts
26 likes
Discovery and protein language model-guided design of hyperactive transposases – Nature Biotechnology
Retrieval of PiggyBac transposons Complete PiggyBac transposon sequences were gathered from all available eukaryotic genomes in the NCBI database35 (31,565 genomes) and all PiggyBac elements in…
Retrieval of PiggyBac transposons Complete PiggyBac transposon sequences were gathered from all available eukaryotic genomes in the NCBI database35 (31,565 genomes) and all PiggyBac elements in…
Discovery and protein language model-guided design of hyperactive transposases – Nature Biotechnology
Retrieval of PiggyBac transposons Complete PiggyBac transposon sequences were gathered from all available eukaryotic genomes in the NCBI database35 (31,565 genomes) and all PiggyBac elements in the Dfam database (20,638). Dfam sequences were directly downloaded by selecting entries labeled as PiggyBac. NCBI eukaryotic genome-derived transposase sequences were identified using Bath36,37, with a custom hidden Markov model constructed from all active PiggyBac sequences reported in the literature. For NCBI PB retrieval, flanking regions 4 kbp upstream and downstream were included to capture the complete transposon sequence including DNA TIRs.
n24usa.com
October 2, 2025 at 11:48 AM
Everybody can reply
Our main findings:
1) Ectocarpus mobiome retains mostly recent, evol. young transposons (TEs)
2) These primarily young TEs are regulated by small RNAs in absence of canonical DNA methylation
3) Particular TE enrichment along the sex chromosomes
4) Developmental regulation of TEs through small RNAs
1) Ectocarpus mobiome retains mostly recent, evol. young transposons (TEs)
2) These primarily young TEs are regulated by small RNAs in absence of canonical DNA methylation
3) Particular TE enrichment along the sex chromosomes
4) Developmental regulation of TEs through small RNAs
October 2, 2025 at 9:06 AM
Everybody can reply
3 likes
Thank you @akankshathawani.bsky.social ! Transposons rule!
October 1, 2025 at 10:04 PM
Everybody can reply
1 likes
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons pubmed.ncbi.nlm.nih.gov/41027434/ #cryoem
October 1, 2025 at 7:34 PM
Everybody can reply
1 likes
6/8 Why did Cas12 evolve repeatedly, while Cas9/Cas13 seemingly arose only once? We discuss that the huge diversity of TnpB transposons & the high evolvability of RNA created the perfect storm for recurrent origins, a potential case of molecular contingency.
October 1, 2025 at 10:39 AM
Everybody can reply
2/8 Phylogenetic mining revealed several young Cas12 clades we call “TranCs”, i.e., nascent CRISPR systems emerging from distinct TnpB lineages. These represent multiple independent domestication events from transposons.
October 1, 2025 at 10:37 AM
Everybody can reply
2/5 🧜 TEs form discrete, repeat-rich islands that don’t correspond to centromeres. We also found an interesting enrichment in the pseudo-autosomal region of the sex chromosome, likely fueled by local hopping of DNA transposons from the sex-determining region.
October 1, 2025 at 8:18 AM
Everybody can reply
1 likes
1/5 🌊 The Ectocarpus genome harbors a high diversity of evolutionarily young TEs. DNA transposons dominate, but Gypsy elements carrying a Tudor domain caught our eye!
October 1, 2025 at 8:14 AM
Everybody can reply
1 likes
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons - ScienceDirect https://www.sciencedirect.com/science/article/pii/S0092867425010359?dgcid=rss_sd_all
Functional RNA splitting drove the evolutionary emergence of type V CRISPR-Cas systems from transposons
Transposon-encoded TnpB nucleases gave rise to type V CRISPR-Cas12 effectors through multiple independent domestication events. These systems use diff…
www.sciencedirect.com
October 1, 2025 at 12:06 AM
Everybody can reply
5 reposts
1 quotes
5 likes
2 saves