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Eric Thompson

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H-index: 32
Economics 26%
Political science 24%
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by Eric Thompson

azbiomarkers.bsky.social
Apologies - the decision support interpretation isn’t quite there outside of these Rx ( e.g. DPYD for fluoropyrimidines).
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by Eric Thompson

azbiomarkers.bsky.social
There are a couple of instances in cancer Rx when it is crucial, but the decision support interpretation isn’t quite there. I have these conversations all the time - en route to some now. Polite is all we can ask. We have to bring the science.
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by Eric Thompson

azbiomarkers.bsky.social
Think I saw a recent announcement of a company re-entering this space. Have not checked their science.
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by Eric Thompson

azbiomarkers.bsky.social
There is not enough data spanning the entire ADME enzymatic system to integrate findings into clinical decisions. There is not a monetary incentive to create these data. Until this is solved you are correct. The data existing often are not used (e.g. warfarin, irinoteca).
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Reposted by: Eric Thompson

ascopost.bsky.social
Phase II LUNAR Trial: PSMA-targeted radiopharmaceutical plus SBRT improved PFS in pts with oligometastatic prostate cancer (18 vs 7 mo), which helped to delay ADT by 24 months

Presented by Amar U. Kishan, MD, at the ASTRO Annual Meeting @astro-org.bsky.social

ascopost.com/news/septemb...
Prostate Cancer: Radiopharmaceutical Plus SBRT Delays Progression in Patients With Limited Metastatic Disease
In prostate cancer, radiopharmaceuticals typically target PSMA, delivering precise doses of radiation directly to tumors; these medicines are currently approved for later-stage prostate cancer. The LU...
ascopost.com
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Reposted by: Eric Thompson

natrevdrugdiscov.nature.com
Today's Nobel Prize for Physiology or Medicine relates to research on regulatory T cells www.nobelprize.org/prizes/medic...

For readers interested in harnessing the biology of regulatory T cells to treat disease, here's a comprehensive review www.nature.com/articles/s41...
rdcu.be/eJHU8
Regulatory T cell biology
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Reposted by: Eric Thompson

nature.com
This year’s Nobel Prize in Physiology or Medicine has been awarded to three scientists for discovering a class of immune cells that help to prevent the body from attacking its own tissues

go.nature.com/3VNrH1s
Medicine Nobel goes to scientists who revealed secrets of immune system ‘regulation’
Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.
go.nature.com
2 40 120

Reposted by: Eric Thompson, Melissa Sweet

scinews.bsky.social
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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by Eric Thompson

azbiomarkers.bsky.social
Could be revolutionary if reproducible. EP2 GPCR. www.nature.com/articles/s41...
Targeting prostaglandin E2 receptor 2 in Schwann cells inhibits inflammatory pain but not inflammation - Nature Communications
Non-steroidal anti-inflammatory drugs (NSAIDs) are known to alleviate pain by reducing inflammation. To the contrary, here, the authors show that selective inhibition of the prostaglandin E2 receptor (EP2) in Schwann cells eliminates pain without disrupting the protective and healing functions of inflammation.
www.nature.com
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Reposted by: Eric Thompson

c0nc0rdance.bsky.social
You're watching 12 hrs of live cell imaging compressed into a GIF.

A multi-nucleated mouse pre-adipocyte tries to undergo mitosis, triggers a checkpoint because it has too much DNA, & undergoes apoptosis.

The last stage is called "blebbing", which is wonderfully descriptive.

(🔬: NanoLive Imaging)
3 18 86

by Eric J. Topol — Reposted by: Eric Thompson

erictopol.bsky.social
New: The link between air pollution and aortic dissection/aneurysm, adds to genetic susceptibility
www.nature.com/articles/s44...
Association of air pollution exposure and genetic susceptibility with increased risk of thoracic aortic aneurysm and dissection - Nature Cardiovascular Research
Ma et al. demonstrate that air pollution is associated with an increased risk of thoracic aortic aneurysm and dissection (TAAD), and that genetic susceptibility to TAAD amplifies this risk through multiplicative and additive interactions.
www.nature.com
2 39 120

by Eric J. Topol — Reposted by: Eric Thompson

erictopol.bsky.social
Where are the Covid nasal vaccines for the US to block infections and transmission?
Here's yet another with a very good profile in people for mucosal immunity and high neutralizing antibodies in all participants (from China)
www.nature.com/articles/s41...
Intranasal vaccine combining adenovirus and trimeric subunit protein provides superior immunity against SARS-CoV-2 Omicron variant - Nature Biomedical Engineering
A combination of adenovirus-vectored and subunit protein intranasal vaccine enhances immune response against SARS-CoV-2 variants in animal models and humans.
www.nature.com
10 97 320

Reposted by: Eric Thompson

natbiotech.nature.com
In Brief: @novonordisk.bsky.social's #Wegovy gains accelerated FDA approval for treating metabolic dysfunction-associated steatohepatitis (MASH), also known as fatty liver disease www.nature.com/articles/s41...
rdcu.be/eHgPo
Wegovy approved for MASH - Nature Biotechnology
Nature Biotechnology - Wegovy approved for MASH
www.nature.com
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Reposted by: Eric Thompson

jco-asco.bsky.social
We're thrilled to be here on BlueSky to bring you the latest practice-changing oncology research from all six JCO Journals! Follow-us for great content from #JCO, #JCOOP, #JCOGO, #JCOPO, #JCOCCI, & #JCOOA.
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by Eric Thompson

azbiomarkers.bsky.social
Unless GINA is strengthened to include many more insurance utility cases this data will be sought by underwriters. It is their business model to accurately model risk, and these data can be a help for them. The harm to the subject is actually a win in this business setting. We need to expand GINA.
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Reposted by: Eric Thompson

labwaggoner.bsky.social
Molecular subtypes of human skeletal muscle in cancer cachexia @nature.com
nature.com/articles/s41...
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by Eric Thompson

azbiomarkers.bsky.social
The juxtaposition was remarkable. Perseverance is the key attribute in science.
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Reposted by: Eric Thompson

compoundchem.com
As summer fades, dahlias are blooming. This graphic looks at the chemical cause of their colours and why you won't spot a blue one! www.compoundchem.com/2021/09/12/d...
#ChemSky 🧪
Infographic on the chemistry of dahlia flower colours. The colours of dahlias are a result of anthocyanin-, chalcone- and aurone-derived pigments. Colourless sflavones also interact with and stabilise anthocyanin pigments. Chalcones and aurones lead to yellow and orange dahlias, while anthocyanins play a part in orange, pink, red and black dahlias. Blue dahlias aren't seen because dahlias lack an enzyme for making delphinidin, the anthocyanin which leads to blue flowers.
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by Eric Thompson

azbiomarkers.bsky.social
www.nature.com/articles/s41...
The mutagenic forces shaping the genomes of lung cancer in never smokers - Nature
An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as ...
www.nature.com

Reposted by: Eric Thompson

obenaufa.bsky.social
Anyone working in metastasis research – the BEUG Foundation has once again opened the call for their Metastasis Research Prize.
This prize is a wonderful recognition of innovative contributions and supports excellence in metastasis research across Europe.
www.beugstiftung-metastase.de/apply-now/
Apply now – Beugstiftung
www.beugstiftung-metastase.de
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by Eric Thompson

azbiomarkers.bsky.social
Interesting data on the long term impact of air pollution on cancer risk - telomere shortening and gene mutations associated with exposures to industrial air pollution.

www.nature.com/articles/s41...
The mutagenic forces shaping the genomes of lung cancer in never smokers - Nature
An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as air pollution and passive smoking.
www.nature.com

by Eric Thompson

azbiomarkers.bsky.social
I wonder how many tons of Coccidioidomycosis (Valley Fever)spores got distributed in that. Is there any indication of a spike in cases after a haboob?
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by Eric Thompson

azbiomarkers.bsky.social
I’d second that - tenacity is the key. Many don’t have the stamina to follow through on a problem for years. The tenacity to make it through the negative results is key.
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Reposted by: Eric Thompson, Urška Demšar

richardsever.bsky.social
"why [would] anyone intelligent enough to be a scientist choose to be one [given] the unfavorable risk-to-reward ratio "?

One of the most intelligent people you could meet offers some answers: having ideas, watching them develop, and sharing them journals.biologists.com/jcs/article/...
Why would anyone want to be a scientist?
It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...
journals.biologists.com
5 40 120

Reposted by: Eric Thompson

natrevcancer.nature.com
#ResearchHighlight 🚨
In a recent study, the Nussenzweig lab investigated the mechanisms underlying #cytarabine-induced neurotoxicity and provide a mechanistic explanation for the differing neurotoxicity profiles of #gemcitabine.
📖⬇️
Same same but different - Nature Reviews Cancer
In a recent study published in Nature, Liu, Wang, et al. investigate the mechanisms underlying cytarabine-induced neurotoxicity and provide a mechanistic explanation for the differing neurotoxicity profiles of other nucleoside analogues, such as gemcitabine.
www.nature.com
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by Eric Thompson

azbiomarkers.bsky.social
You might find this interesting: journals.sagepub.com/doi/abs/10.1...

The Pen Is Mightier Than the Keyboard: Advantages of Longhand Over Laptop Note Taking
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by Eric Thompson

azbiomarkers.bsky.social
Slightly diminish a band:

HVAC/DC
Aluminum Maiden
A Sabbath
Motley Cruise
Warranty
Nice Company
Proper English
Led Brick
The Whos of Whoville
Lewis and the News
Crocus
The Zoo Animals
White Bread
Rob Cadaver
.38 Common
Picodeath

by Eric Thompson

azbiomarkers.bsky.social
Seems to echo the findings in this preprint:
arxiv.org/abs/2506.08872

Use it or lose it seems to be fairly universal so far.
Your Brain on ChatGPT: Accumulation of Cognitive Debt when Using an AI Assistant for Essay Writing Task
This study explores the neural and behavioral consequences of LLM-assisted essay writing. Participants were divided into three groups: LLM, Search Engine, and Brain-only (no tools). Each completed thr...
arxiv.org
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by Eric Thompson

azbiomarkers.bsky.social
Seems to echo the findings in this preprint: doi.org/10.48550/arX...

Use it or lose it seems to be fairly universal so far.
Your Brain on ChatGPT: Accumulation of Cognitive Debt when Using an AI Assistant for Essay Writing Task
This study explores the neural and behavioral consequences of LLM-assisted essay writing. Participants were divided into three groups: LLM, Search Engine, and Brain-only (no tools). Each completed thr...
doi.org
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by Eric Thompson

azbiomarkers.bsky.social
and some of us pine for the $.59/.69/.79 menu of our glory years... although my diet is much more healthy due in part to the inflation we've felt since.

References

Fields & subjects

Updated 1m