Scholar

Pablo Pelegrı́n

Videos
H-index: 62
Biology 65%
Medicine 26%
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Reposted by: Pablo Pelegrı́n

jkagan1.bsky.social
An NLRP3 stimulatory universal influenza vaccine.
We report an NLRP3 stimulus that generates hyperactive dendritic cells (hDCs).
journals.asm.org/doi/10.1128/...
An NLRP3-stimulatory adjuvant improves the immunogenicity of influenza virus vaccines in mice and non-human primates | mBio
The generation of vaccines that stimulate T cell activities is an unmet need for the scientific community, as T cells are the primary mediators of immune memory. In this study, we report a new vaccine...
journals.asm.org
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by Pablo Pelegrı́n

ppelegrin.bsky.social
Looking for passionate candidate to apply to PhD fellowship to University of Murcia call:

www.um.es/documents/d/...

Interested students contact me!
www.um.es
3 1

by Pablo Pelegrı́n

ppelegrin.bsky.social
www.linkedin.com/posts/albert...
Intrahepatic donor microbiota-based metataxonomic signature detected in organ preservation solution enables prediction of short-term liver transplant outcomes | Alberto Baroja-Mazo
Thrilled to share that our latest work has just been published in Gut 🚀 We show that donor intrahepatic microbial DNA signatures, detected in organ preservation solution, can predict post-transplant o...
www.linkedin.com

Reposted by: Pablo Pelegrı́n

jem.org
Cheng, Qiu et al @jhu.edu provide new insights into the molecular mechanism of #phagosome maturation and the dynamics of host defense response following phagosome-mediated bacterial degradation in peritoneal #macrophages. rupress.org/jem/article/...

#InnateImmunity #inflammation #InfectiousDisease
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Reposted by: Pablo Pelegrı́n

jem.org
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
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Reposted by: Pablo Pelegrı́n

lozanzi.bsky.social
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
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Reposted by: Pablo Pelegrı́n

labwaggoner.bsky.social
Review @natimmunol.nature.com
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets
www.nature.com/articles/s41...
2 7

Reposted by: Pablo Pelegrı́n

malvinapiz.bsky.social
🚨It’s out @embojournal.org 🚨
Cardiolipin inhibits Caspase-4/11!
Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.
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Reposted by: Pablo Pelegrı́n

inflammasomelab.bsky.social
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies!
Link: rdcu.be/d2mjm
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells
Nature Immunology - Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate...
rdcu.be
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