Torben Heick Jensen

Ulrich Hohmann

@hohmannulrich.bsky.social

How are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)

Molecular basis of polyadenylated RNA fate determination in the nucleus

Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

www.biorxiv.org

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Reposted by: Torben Heick Jensen

Julius Brennecke

@juliusbrennecke.bsky.social

Dream collaboration with the groups of Torben Heick Jensen (@heick.bsky.social; @au.dk) and Clemens Plaschka (@impvienna.bsky.social). Building in part on the incredible work from Ulrich Hohmann on human mRNA export.
www.biorxiv.org/content/10.1...

A molecular switch orchestrates the nuclear export of human messenger RNA

The nuclear export of messenger RNA (mRNA) is a key step in eukaryotic gene expression ([Köhler and Hurt, 2007][1]). Despite recent insights into the packaging of newly transcribed mRNAs into ribonucl...

www.biorxiv.org

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by Torben Heick Jensen

Torben Heick Jensen

@heick.bsky.social

Final call for postdoc positions in Aarhus, Denmark. Sorting of gene expression and beyond. Please get in touch for further information or apply using this link:
mbg.au.dk/en/news-and-...

A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

mbg.au.dk

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by Torben Heick Jensen

Torben Heick Jensen

@heick.bsky.social

Second call for postdoc positions in the lab. Please follow the link below to apply or get in touch for further information.
mbg.au.dk/aktuelt/ledi...

A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Ledig stilling på Aarhus Universitet

Ledig stilling ved Institut for Molekylærbiologi og Genetik - RNA-biologi og -innovation, Aarhus Universitet

mbg.au.dk

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by Torben Heick Jensen

Torben Heick Jensen

@heick.bsky.social

Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...

A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

mbg.au.dk

6 12

Reposted by: Torben Heick Jensen

William Garland

@willgarland.bsky.social

We put together a spotlight for @cp-cellchembiol.bsky.social highlighting the recent work from @baluapuri.bsky.social and @adelmanlab.bsky.social published in @cp-cell.bsky.social.

Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.

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Reposted by: Torben Heick Jensen

Peter Andersen

@germline.bsky.social

📣 🥳 🧑‍💻 Our department is hiring:

Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark

Deadline June 1st

Thanks for sharing!

mbg.au.dk/en/news-and-...

Tenure-Track Assistant Professor / Associate Professor in Bioinformatics at Aarhus University, Denmark - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - BiRC - Bioinformatics Research Center, Aarhus University

mbg.au.dk

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by Torben Heick Jensen

Torben Heick Jensen

@heick.bsky.social

Second call for a postdoc position in my lab. Please read more and apply here: mbg.au.dk/aktuelt/ledi...

Postdoc positions in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet

Ledig stilling ved Institut for Molekylærbiologi og Genetik - RNA-biologi og -innovation, Aarhus Universitet

mbg.au.dk

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by Torben Heick Jensen

Torben Heick Jensen

@heick.bsky.social

PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk

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by Torben Heick Jensen

Torben Heick Jensen

@heick.bsky.social

Postdoc positions on nuclear RNA biology available in the Heick Jensen lab. Come join us in tiny Denmark. Interested? - then follow this link: mbg.au.dk/aktuelt/ledi...

Postdoc positions in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet

Ledig stilling ved Institut for Molekylærbiologi og Genetik - RNA-biologi og -innovation, Aarhus Universitet

mbg.au.dk

1 26 23

Reposted by: Torben Heick Jensen

Olivier Duss

@olivierduss.bsky.social

First paper of our lab today @natureportfolio.bsky.social by Nussi!

We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping!

@embl.org #RNAbiology #RNASky

t.co/a24Xxcxdo0

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Reposted by: Torben Heick Jensen

Josh Mendell

@mendell-lab.bsky.social

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes

The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

www.science.org

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Reposted by: Torben Heick Jensen

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Reposted by: Torben Heick Jensen

Olivier Duss

@olivierduss.bsky.social

Exciting highlights of the recent complex life of #RNA symposium @embl.org featuring Matt Disney, Juan Valcarcel, @lapassmore.bsky.social, Herve Le Hir, Andreas Meyer, Yiliang Ding, Seitz Herve, Maria Hondele, @juliusbrennecke.bsky.social, Bahareh Torkzaban

www.embl.org/news/science...