Dorian McILROY
dmcilroy.bsky.social
Dorian McILROY
@dmcilroy.bsky.social
1.4K followers 66 following 350 posts
Virology lecturer at Nantes University. Interested in polyomaviruses, particularly capsid interactions with antibodies and host receptors.
Posts Media Videos Starter Packs
This happens every year. The day after the email goes out at my university, all the slots for flu vaccine shots are fully booked.
Reposted by Dorian McILROY
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
Reposted by Dorian McILROY
A word that has become a euphemism for promoting and selling things without data or evidence
Reposted by Dorian McILROY
I've been asked about this paper (www.nature.com/articles/s41...) enough times that I finally had to read it.

The basic claim is that mRNA vaccines had huge synergistic benefit with checkpoint blockade against lung cancer melanoma.

tl;dr it's glam-slop & everyone involved should be embarrassed
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature
mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
www.nature.com
Reposted by Dorian McILROY
@isv-news.bsky.social #ISV2025
Alec Freyn, Moderna presenting ISV Paper of the Year 2025 - quadrivalent mRNA vaccine against a broad spectrum of orthopoxviruses.
Reposted by Dorian McILROY
this figure would be such a good inclusion for an introduction to immunology
So sorry you have to read such evil lies. Remember that you are an inspiration to many, many people.
Reposted by Dorian McILROY
Acute and chronic viral infections, including Herpes Zoster (Shingles), Hepatitis C, HIV, CMV, influenza, and SARS-CoV-2, are linked with a substantial increased risk of cardiovascular events, from a systematic review. Figure for SARS-CoV-2 below
newsroom.heart.org/news/some-ac...
This is the difference between science and charlatanism. Only by honestly testing what works, and what doesn't, can we advance.
Couple of comments/thoughts on this paper. 1/ Serum antibody maintained at 100-200 ng/mL at least 72 weeks is pretty impressive. 2/ with HIV-specific bNAbs, could it rival lenacapavir ?
Reposted by Dorian McILROY
Here are some highlight clips from my very enjoyable chat with Decoding the gurus about my book

Full video here: www.youtube.com/watch?v=zrsV...

Chris of course with the most important raised eyebrow:
Why did I do it?

Was it because I am a shill for EcoHealth Alliance? :)
Hear below

1/
Now this is really, really interesting. Seems like every single fundamental process in eukaryotes has its origins in bacteria.
1/10 Genome maintenance by telomerase is a fundamental process in nearly all eukaryotes. But where does it come from?

Today, we report the discovery of telomerase homologs in a family of antiviral RTs, revealing an unexpected evolutionary origin in bacteria.
www.biorxiv.org/content/10.1...
Antiviral reverse transcriptases reveal the evolutionary origin of telomerase
Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection. However, much of DRT family diversity remains ...
www.biorxiv.org
This is worth sharing again
Fourth: play our funny guessing game #DiscoverOrMDPI.

Can you outguess marketing operatives from publishers by telling apart MDPI from Discover journals?

We wrote the game and the blog, and cannot win.

pagoba.shinyapps.io/publi_guess/
Now that is an excellent question. Current levels of anti-vaccine sentiment make me doubt whether it would be possible to eradicate smallpox now.
Sponsored by Austrian FPO. Right wing anti-science blood and soil type party.
Reposted by Dorian McILROY
Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...

PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
Isolation, engineering and ecology of temperate phages from the human gut - Nature
Human host-associated cellular products may act as induction agents for bacteriophages.
nature.com
Reposted by Dorian McILROY
Persistent viral #infections in #insects are not as harmless as once believed. @salehlabparis.bsky.social &co show how such infections in #FruitFlies alter survival, reproduction, behavior & gene expression, revealing the hidden costs of #viral persistence @plosbiology.org 🧪 plos.io/4olpuXm
Hey what about the follow-up study on the association between bed/waking time and hospital visits, earning power, and mental abilities?