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Hellerschmied Lab

@hellerschmiedlab.bsky.social

280 followers 400 following 12 posts

Biochemistry and cell biology lab @unidue-zmb.bsky.social Excited about secretory pathway and #Golgi #proteostasis mechanisms funded by AvHStiftung, part of @crc1430.bsky.social (tweets by PI)

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Hellerschmied Lab @hellerschmiedlab.bsky.social · Jul 15

Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social

Nature Structural & Molecular Biology @natsmb.nature.com · Jul 14

New online: Conformational plasticity of a BiP–GRP94 chaperone complex

Conformational plasticity of a BiP–GRP94 chaperone complex

Nature Structural & Molecular Biology, Published online: 14 July 2025; doi:10.1038/s41594-025-01619-0BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.

go.nature.com

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André Nadler @nadlerlab.bsky.social · 2d

This is going to be fun - we are really pleased with the program - there is some really exciting science on the menu! Do sign up!

GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · 2d

Registration open: 77. Mosbacher Kolloquium "More than lipidic barriers - New horizons in membrane biology" from March 25-28, 2026
lnkd.in/dgsW4c3

Scientific Organizers: Britta Brügger, Robert Ernst, André Nadler, Christian Ungermann
Early registration & poster abstracts until January 31, 2026

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Center of Medical Biotechnology @unidue-zmb.bsky.social · 2d

🏆 #LabOlympics 2025 at the ZMB are over — congratulations to the 'Ehrmännchen'! 🎉
They didn’t just take home the trophy, but also the honor of hosting the 2026 edition!
A big thanks to @hellerschmiedlab.bsky.social, @icce-unidue.bsky.social and all other participants for their amazing team spirit!

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satooze.bsky.social @satooze.bsky.social · 2d

Explore emerging research with field leaders @keystoneSymposia.bsky.social #Autophagy : Mechanisms to Therapy, this February in Keystone! keysym.us/KSAutophagy26 #KSAutophagy26 www.keystonesymposia.org/conferences/...

Autophagy: Mechanisms to Therapy | Keystone Symposia

Join us at the Keystone Symposia on Autophagy: Mechanisms to Therapy, February 2026, in Keystone, with field leaders!

keysym.us

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Ewan Birney @ewanbirney.bsky.social · 2d

A reminder that the PhD program for EMBL is open for winter recruitment round. If you want to understand life at a molecular level and have a quantitative science (you don't have to have done biology - we love our mathematicians/physcists/chemists!) apply www.embl.org/about/info/e...

Application – EMBL International PhD Programme

www.embl.org

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Ishier Raote @ishier.bsky.social · 11d

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...

Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology

Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.

www.nature.com

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Universität zu Köln @unicologne.bsky.social · 9d

🧬Ubiquitin Precursor: A Key to Healthy Aging?
Scientists @cecad.bsky.social and @hhu.de have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging opening up potentially new perspectives for the treatment of cancer and age-related diseases. uni.koeln/BLXJA

A quiet ally: a ubiquitin precursor promotes stress resistance and longevity

In response to cellular stress, the protein CxUb is activated to identify damaged proteins, thereby maintaining cellular health. The discovery could lead to ways to improve the treatment of cancer and...

uni.koeln

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Wojciech Pokrzywa @wpokrzywa.bsky.social · 5d

Preprint alert! 🚨
We reveal molecular switches that enable the nucleolus to reorganise into a proteostasis hub - coordinating protein quality control with ribosome biogenesis and cross-talk with other stress-responsive organelles.
A big tour de force by the team 💪
www.biorxiv.org/content/10.1...

CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub

The nucleolus, classically dedicated to ribosome biogenesis, also acts as a stress-responsive proteostasis hub. During heat shock, misfolded proteins accumulate in its granular component (GC), but whe...

www.biorxiv.org

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IMPRS for Living Matter @imprs-lm.bsky.social · 19d

The Sacca' lab investigates the behavior of molecular motors within engineered DNA origami nano-compartments to understanding of how nanoscale confinements influence biochemical processes and energy conversion. Interested? Then apply to @imprs-lm.bsky.social

#IMPRS #PhDposition #Syntheticbiology

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IMPRS for Living Matter @imprs-lm.bsky.social · Sep 3

Are you eager to join an international community of scientists to tackle novel and exciting research projects in the areas of #biochemistry, #structuralbiology, #biophysics, #cellbiology, #chemicalbiology and #syntheticbiology? Apply NOW for a #fullyfunded #PhDpositions @IMPRS-LM.

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IMPRS for Living Matter @imprs-lm.bsky.social · 15d

If you would like to contribute to uncover the mechanisms by which proteolytic enzymes in the ubiquitin system operate and exploit these insights for novel therapeutic approaches, then apply to the Gersch lab @maltegersch.bsky.social #IMPRS-LM.

#IMPRS #PhDposition #PhDprogram #ChemicalBiology

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Virtual ChemBioTalks @chembiotalks.bsky.social · 18d

The 5th Virtual @chembiotalks.bsky.social on September 30th are one week away. We have an exciting program including our keynotes Sarah O'Connor (@oconnorlab.bsky.social) and @craigmcrews.bsky.social.

Make sure to register for free: web.cvent.com/event/...
#ChemSky #ChemBio

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Verena Cmentowski @vcmentowski.bsky.social · 25d

Excited to share our new paper! 🎉
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
www.science.org/doi/10.1126/...
Very thankful to @andrea-musacchio.bsky.social for his mentorship and support over the years.

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona

The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.

www.science.org

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Andrea Musacchio @andrea-musacchio.bsky.social · 26d

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...

Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle

The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona

The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.

www.science.org

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Rune Busk Damgaard @rbdamgaard.bsky.social · 25d

A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight!

chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

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Max-Planck-Gesellschaft @maxplanck.de · 26d

Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

Graphic with a blue background and light green dots. The text 'call for applications' appears in green, and 'Ausschreibung' in white. A white arrow on the right points diagonally upward.

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Franz Narberhaus @franznarberhaus.bsky.social · Sep 3

jobs.ruhr-uni-bochum.de/jobposting/b...

W1TTW2 Professorship in Biology of Microorganisms (m/f/d)

jobs.ruhr-uni-bochum.de

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Max-Planck-Gesellschaft @maxplanck.de · Sep 9

Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer

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Jasmeen Oberoi @jasmeenoberoi.bsky.social · Sep 9

🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.

📅 Deadline: 29th September 2025.

🙏 Please share with anyone who might be interested.

Research Technician – Protein Biochemistry at University of Sussex

Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

www.jobs.ac.uk

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FMI science @fmiscience.bsky.social · Sep 8

🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...

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Katherine A Donovan @katherinedonovan.bsky.social · Sep 8

Just a few days until our annual hybrid TPD event! In-person registration is full, but you can still join us live on Zoom via our regular biweekly link.

Register for the Zoom stream here: dfci.zoom.us/webinar/regi...

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Eric Chevet @ericchevet.bsky.social · Sep 7

This week selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation www.nature.com/articles/s42...

bims-proteo 2025-09-07 papers

biomed.news

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Women in Autophagy @womeninautophagy.bsky.social · Sep 3

📅 Less than 2 weeks left to submit your abstract for our 6th Annual Symposium Webinar!

🎉Don’t miss this chance to share your work, hear the latest advances in autophagy research, and connect with a vibrant community! 🎉

The link for abstraction submission is below 👇

forms.office.com/r/wZbTvPePwR

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Cell Biology J-Club @cellclub.bsky.social · Sep 3

www.biorxiv.org/content/10.1...

Mechanical forces stimulate Golgi export

Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...

www.biorxiv.org

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Journal of Cell Biology @jcb.org · Sep 3

Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...

#Reproducibility

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delladavid-lab.bsky.social @delladavid-lab.bsky.social · Sep 2

Exciting news📣: #ProteostasisUK is hiring a network manager to help drive an ambitious, #BBSRC funded initiative connecting and expanding #Proteostasis research across the UK. Position initially for 3 years. Deadline September 28th. More info: tinyurl.com/f83rp673 & proteostasisuk.co.uk Please RT

hireful.

tinyurl.com

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