Adam Marblestone
@adammarblestone.bsky.social
Technologist, scientist. Co-founder of Convergent Research.
Reposted by Adam Marblestone
[C]Worthy has secured multi-year support from ORCA and the Patrick J. McGovern Foundation to scale open, trusted science tools for ocean-based carbon removal.
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
[C]Worthy Secures Multi-Year Support From ORCA and the Patrick J. McGovern Foundation to Scale Open-Source Marine Carbon-Removal Tools — [C]Worthy
New multi‑year awards affirm the need for infrastructure built through [C]Worthy’s approach of marrying open-source science and practical tools for industry use.
www.cworthy.org
November 24, 2025 at 4:26 PM
[C]Worthy has secured multi-year support from ORCA and the Patrick J. McGovern Foundation to scale open, trusted science tools for ocean-based carbon removal.
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
Reposted by Adam Marblestone
A global screen for magnetically induced neuronal activity in the pigeon brain www.science.org/doi/10.1126/... - so cool! 🐦🧠
A global screen for magnetically induced neuronal activity in the pigeon brain
How animals detect the Earth’s magnetic field remains a mystery in sensory biology. Despite extensive behavioral evidence, the neural circuitry and molecular mechanisms responsible for magnetic sensin...
www.science.org
November 21, 2025 at 3:07 PM
A global screen for magnetically induced neuronal activity in the pigeon brain www.science.org/doi/10.1126/... - so cool! 🐦🧠
Reposted by Adam Marblestone
Have a look if you are interested in how the team at @cultivarium.bsky.social is finding electroporation protocols for new microbes: both screening lots of conditions on a custom built electroporator concurrently, and cyclical iteration using bayesian optimization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Active learning guides automated discovery of DNA delivery via electroporation for non-model microbes
Delivery of recombinant DNA is foundational for understanding and engineering a target organism. Electroporation can be applied to any cell type, yet identification of a working protocol for new organ...
www.biorxiv.org
November 22, 2025 at 12:23 AM
Have a look if you are interested in how the team at @cultivarium.bsky.social is finding electroporation protocols for new microbes: both screening lots of conditions on a custom built electroporator concurrently, and cyclical iteration using bayesian optimization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Adam Marblestone
Announced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co.
Learn more: evebio.org/pharmome-dat...
Learn more: evebio.org/pharmome-dat...
Putting Pharmome Data in Researchers' Hands : EvE Bio
We've been busy at EvE Bio these last two years establishing the largest available pharmome mapping dataset. Now it’s making its way into the world to drive real discoveries.
evebio.org
November 18, 2025 at 3:44 PM
Announced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co.
Learn more: evebio.org/pharmome-dat...
Learn more: evebio.org/pharmome-dat...
Reposted by Adam Marblestone
Is there an academic/industry divide in attitudes about using AI to support discovery? I noticed this post has 3.6k likes on X but only 6 likes on Bluesky. It deserves more attention here!
Today, we're announcing Kosmos, our newest AI Scientist, available today. Kosmos makes fully autonomous scientific discoveries at scale by analyzing datasets and literature, and is the most powerful agent for science so far. Beta users estimate that Kosmos does 6 months of work in a single day.
November 17, 2025 at 2:32 PM
Is there an academic/industry divide in attitudes about using AI to support discovery? I noticed this post has 3.6k likes on X but only 6 likes on Bluesky. It deserves more attention here!
Reposted by Adam Marblestone
As AI collapses coordination costs, our new thesis - Scaling Trust - explores how scalable trust infrastructure could usher in a world of many AI agents, capable of mobilising, negotiating, and verifying on our behalf across digital + physical spaces ↓
link.aria.org.uk/ST-thesis-BS
link.aria.org.uk/ST-thesis-BS
Programme development | Trust Everything, Everywhere
We are in the process of building a multi-year R&D programme within this space. Our programmes are designed to advance complex, large-scale ideas that require coordinated investment and management acr...
link.aria.org.uk
November 17, 2025 at 2:50 PM
As AI collapses coordination costs, our new thesis - Scaling Trust - explores how scalable trust infrastructure could usher in a world of many AI agents, capable of mobilising, negotiating, and verifying on our behalf across digital + physical spaces ↓
link.aria.org.uk/ST-thesis-BS
link.aria.org.uk/ST-thesis-BS
Reposted by Adam Marblestone
It is actually an incredibly frustrating time to be a theoretical neuroscientist right now imo, for this reason
Same for neuroscience. The lack of ability to measure many neurons’ activity, perturb them, and measure intracellular processes and connections is what limits understanding the brain.
The key barriers are not algorithms or AI.
🧪#neuroscience 🧠🤖 #MLSky
The key barriers are not algorithms or AI.
🧪#neuroscience 🧠🤖 #MLSky
November 17, 2025 at 1:23 AM
It is actually an incredibly frustrating time to be a theoretical neuroscientist right now imo, for this reason
Reposted by Adam Marblestone
Reposted by Adam Marblestone
Cool work from our neighbors at @cultivarium.bsky.social using components from the POSSUM Toolkit! What will they (or you!) find next?
Check out the toolkit here: www.addgene.org/kits/cultiva...
Check out the toolkit here: www.addgene.org/kits/cultiva...
November 12, 2025 at 8:03 PM
Cool work from our neighbors at @cultivarium.bsky.social using components from the POSSUM Toolkit! What will they (or you!) find next?
Check out the toolkit here: www.addgene.org/kits/cultiva...
Check out the toolkit here: www.addgene.org/kits/cultiva...
Reposted by Adam Marblestone
Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
November 12, 2025 at 7:05 PM
Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
Reposted by Adam Marblestone
I am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1...
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
The songbird basal ganglia connectome
The basal ganglia (BG) play an essential role in shaping vertebrate behavior, ranging from motor learning to emotions, but comprehensive maps of their canonical synaptic architecture are missing. In m...
www.biorxiv.org
October 30, 2025 at 6:07 PM
I am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1...
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
Reposted by Adam Marblestone
Our new preprint outlining how to make 1000-plex mass tags!
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
How to design 1000-plex mass tags using the differential mass defect
Multiplexing samples in mass spectrometry-based proteomics has long been accomplished by isotopologues of small molecules. These chemically-identical "mass tags" conjugate to peptides to encode sample...
www.biorxiv.org
October 24, 2025 at 2:41 PM
Our new preprint outlining how to make 1000-plex mass tags!
Reposted by Adam Marblestone
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
How to design 1000-plex mass tags using the differential mass defect
Multiplexing samples in mass spectrometry-based proteomics has long been accomplished by isotopologues of small molecules. These chemically-identical "mass tags" conjugate to peptides to encode sample...
www.biorxiv.org
October 24, 2025 at 2:08 PM
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
Reposted by Adam Marblestone
We’re starting to look for postdocs for 2026 and beyond. Nothing official yet, but if you want to use your synbio skills and the growing Microbe-Mineral Atlas to build cutting-edge biomining technologies read more below:
docs.google.com/document/d/1...
docs.google.com/document/d/1...
Microbe-Mineral Atlas Engineering
The Barstow lab at Cornell University is looking for a new postdoc for 2026 and beyond to help us with the next phase of our Microbe-Mineral Atlas project. We plan on going from basic scientific disco...
docs.google.com
October 19, 2025 at 7:52 PM
We’re starting to look for postdocs for 2026 and beyond. Nothing official yet, but if you want to use your synbio skills and the growing Microbe-Mineral Atlas to build cutting-edge biomining technologies read more below:
docs.google.com/document/d/1...
docs.google.com/document/d/1...
Reposted by Adam Marblestone
Thanks for contributing your expertise!!
I got to editing a few clips to show how I make plant tissue culture leaf disks from leaves obtained in open air. Uploaded for your consideration to the PRISM collection. Enjoyyyyy.
prism.cultivarium.org/protocols/20...
prism.cultivarium.org/protocols/20...
prism.cultivarium.org
October 18, 2025 at 11:55 AM
Thanks for contributing your expertise!!
Reposted by Adam Marblestone
I got to editing a few clips to show how I make plant tissue culture leaf disks from leaves obtained in open air. Uploaded for your consideration to the PRISM collection. Enjoyyyyy.
prism.cultivarium.org/protocols/20...
prism.cultivarium.org/protocols/20...
prism.cultivarium.org
October 17, 2025 at 6:59 PM
I got to editing a few clips to show how I make plant tissue culture leaf disks from leaves obtained in open air. Uploaded for your consideration to the PRISM collection. Enjoyyyyy.
prism.cultivarium.org/protocols/20...
prism.cultivarium.org/protocols/20...
Reposted by Adam Marblestone
October 16, 2025 at 2:54 PM
Reposted by Adam Marblestone
8/ With semble.so and @cosmik.network we are aiming squarely at the CI space, but it is ultimately an ecosystem effort, so we’re excited to be building with the vibrant ATProto community ✨
Semble | A social knowledge network for researchers
Follow your peers' research trails. Surface and discover new connections. Built on ATProto so you own your data.
semble.so
October 15, 2025 at 10:13 PM
8/ With semble.so and @cosmik.network we are aiming squarely at the CI space, but it is ultimately an ecosystem effort, so we’re excited to be building with the vibrant ATProto community ✨
Reposted by Adam Marblestone
Excited to try this! The waiting list makes me even more curious
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 3:56 PM
Excited to try this! The waiting list makes me even more curious
Reposted by Adam Marblestone
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
October 15, 2025 at 4:17 PM
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
Reposted by Adam Marblestone
💡Did you know you can run #LeanLang in your browser without installing anything? The Lean Playground provides a full environment for experimentation, learning, and for sharing code snippets with others.
Try it out! live.lean-lang.org
Try it out! live.lean-lang.org
October 10, 2025 at 4:17 PM
💡Did you know you can run #LeanLang in your browser without installing anything? The Lean Playground provides a full environment for experimentation, learning, and for sharing code snippets with others.
Try it out! live.lean-lang.org
Try it out! live.lean-lang.org
Reposted by Adam Marblestone
Wait uh, what?? 🤩
Ballistic Microscopy (BaM) www.biorxiv.org/content/10.1101/2025.10.07.681030v1 #cryoem
October 10, 2025 at 12:56 AM
Wait uh, what?? 🤩
Reposted by Adam Marblestone
The development of new, transformative material processes has stagnated.
In our new thesis, PD Ivan Jayapurna proposes a ‘Universal Fabricator’ to rapidly discover and develop new processes for the scalable production of advanced materials. ↓
link.aria.org.uk/UF-thesis-BS
In our new thesis, PD Ivan Jayapurna proposes a ‘Universal Fabricator’ to rapidly discover and develop new processes for the scalable production of advanced materials. ↓
link.aria.org.uk/UF-thesis-BS
Manufacturing Abundance
Ages of human history are defined by materials that transformed societies and mark breakthroughs in mastery over matter. Rather than a single material, the next age will be defined by our ability to a...
link.aria.org.uk
October 10, 2025 at 11:33 AM
The development of new, transformative material processes has stagnated.
In our new thesis, PD Ivan Jayapurna proposes a ‘Universal Fabricator’ to rapidly discover and develop new processes for the scalable production of advanced materials. ↓
link.aria.org.uk/UF-thesis-BS
In our new thesis, PD Ivan Jayapurna proposes a ‘Universal Fabricator’ to rapidly discover and develop new processes for the scalable production of advanced materials. ↓
link.aria.org.uk/UF-thesis-BS
Reposted by Adam Marblestone
An Introduction to Mars Terraforming, 2025 Workshop Summary
arxiv.org/abs/2510.07344
arxiv.org/abs/2510.07344
An Introduction to Mars Terraforming, 2025 Workshop Summary
Terraforming Mars is an age old science fiction concept now worth revisiting through the lens of modern science and technology. This document serves as a summary of contemporary ideas about Mars terra...
arxiv.org
October 10, 2025 at 2:13 AM
An Introduction to Mars Terraforming, 2025 Workshop Summary
arxiv.org/abs/2510.07344
arxiv.org/abs/2510.07344