Adam Marblestone
@adammarblestone.bsky.social
Technologist, scientist. Co-founder of Convergent Research.
Reposted by Adam Marblestone
A special opportunity for lovers of mass spectrometry proteomics to join a like-minded team at PTI.
Join a collaborative initiative to enable direct protein analysis at unprecedented scale, in partnership with leading instrument developers, academics, and industry leaders.
1/2
Join a collaborative initiative to enable direct protein analysis at unprecedented scale, in partnership with leading instrument developers, academics, and industry leaders.
1/2
February 4, 2026 at 1:00 PM
A special opportunity for lovers of mass spectrometry proteomics to join a like-minded team at PTI.
Join a collaborative initiative to enable direct protein analysis at unprecedented scale, in partnership with leading instrument developers, academics, and industry leaders.
1/2
Join a collaborative initiative to enable direct protein analysis at unprecedented scale, in partnership with leading instrument developers, academics, and industry leaders.
1/2
Reposted by Adam Marblestone
So you sequenced a billion+ bases. That don’t impress me much.
JERBOA is a toolkit to figure out what genes do at scale. We've used it to unlock 43 non-model microbes across 12 different phyla.
JERBOA is a toolkit to figure out what genes do at scale. We've used it to unlock 43 non-model microbes across 12 different phyla.
February 3, 2026 at 5:43 PM
So you sequenced a billion+ bases. That don’t impress me much.
JERBOA is a toolkit to figure out what genes do at scale. We've used it to unlock 43 non-model microbes across 12 different phyla.
JERBOA is a toolkit to figure out what genes do at scale. We've used it to unlock 43 non-model microbes across 12 different phyla.
Reposted by Adam Marblestone
Light-microscopy brain mapping was picked as one of 7 technologies to watch in 2026 by Nature!
Hear from E11's CEO @andrewcpayne.bsky.social: www.nature.com/articles/d41...
Hear from E11's CEO @andrewcpayne.bsky.social: www.nature.com/articles/d41...
From quantum computing to mRNA therapeutics: seven technologies to watch in 2026
Nature’s round-up of innovations that are poised to make a splash in the year ahead.
www.nature.com
January 29, 2026 at 4:44 PM
Light-microscopy brain mapping was picked as one of 7 technologies to watch in 2026 by Nature!
Hear from E11's CEO @andrewcpayne.bsky.social: www.nature.com/articles/d41...
Hear from E11's CEO @andrewcpayne.bsky.social: www.nature.com/articles/d41...
Reposted by Adam Marblestone
Synaptic MEMOIR: mapping individual synapses of neurons with protein barcodes https://www.biorxiv.org/content/10.1101/2025.11.25.690442v1
November 26, 2025 at 8:16 AM
Synaptic MEMOIR: mapping individual synapses of neurons with protein barcodes https://www.biorxiv.org/content/10.1101/2025.11.25.690442v1
Reposted by Adam Marblestone
It's been an incredibly exciting year in metascience at large, and for us at Convergent.
Last week, the NSF announced their Tech Labs Initiative.
www.essentialtechnology.blog/p/the-future...
Last week, the NSF announced their Tech Labs Initiative.
www.essentialtechnology.blog/p/the-future...
The Future of Focused Research Organizations:
Working with Convergent on the NSF Tech Labs Initiative
www.essentialtechnology.blog
December 23, 2025 at 9:12 PM
It's been an incredibly exciting year in metascience at large, and for us at Convergent.
Last week, the NSF announced their Tech Labs Initiative.
www.essentialtechnology.blog/p/the-future...
Last week, the NSF announced their Tech Labs Initiative.
www.essentialtechnology.blog/p/the-future...
Reposted by Adam Marblestone
Dim Red Dot
Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time.
It lies beyond the Affectable Universe.
Let me explain…
1/🧵
Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time.
It lies beyond the Affectable Universe.
Let me explain…
1/🧵
December 18, 2025 at 11:17 AM
Dim Red Dot
Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time.
It lies beyond the Affectable Universe.
Let me explain…
1/🧵
Scientists have just released a photo featuring a dim red dot. It is the light of a single star exploding in a galaxy so far far away that that nothing we do could ever affect it — even in the very fullness of time.
It lies beyond the Affectable Universe.
Let me explain…
1/🧵
Reposted by Adam Marblestone
Last Friday, the @NSF released an RFI for a new Tech Labs Initiative, to "build and scale next-gen independent research organizations to advance science."
December 16, 2025 at 4:06 PM
Last Friday, the @NSF released an RFI for a new Tech Labs Initiative, to "build and scale next-gen independent research organizations to advance science."
Reposted by Adam Marblestone
A Vision of Metascience; How does the culture of science change and improve?
We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science
https://pllqt.it/Qg2rOs
We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science
https://pllqt.it/Qg2rOs
December 1, 2024 at 12:27 PM
A Vision of Metascience; How does the culture of science change and improve?
We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science
https://pllqt.it/Qg2rOs
We need metascience entrepreneurs, seeking to achieve a scalable improvement in the social processes of science
https://pllqt.it/Qg2rOs
Reposted by Adam Marblestone
To mark the occasion, FAS CEO Daniel Correa spoke with @sgrodriques.bsky.social and @adammarblestone.bsky.social about how best to run a Tech Lab/FRO-style org, what they've learned, and the role federal funding can play:
fas.org/publication/...
fas.org/publication/...
NSF Wants To Supercharge FROs. We Spoke With the Scientists Who Proposed Them.
We recently spoke with Adam Marblestone and Sam Rodriques, former FAS fellows who developed the idea for FROs and advocated for their use in a 2020 policy memo.
fas.org
December 12, 2025 at 4:49 PM
To mark the occasion, FAS CEO Daniel Correa spoke with @sgrodriques.bsky.social and @adammarblestone.bsky.social about how best to run a Tech Lab/FRO-style org, what they've learned, and the role federal funding can play:
fas.org/publication/...
fas.org/publication/...
If you've been interested in FROs, you'll want to see this from NSF:
sam.gov/opp/7332ade9...
"sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."
sam.gov/opp/7332ade9...
"sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."
December 12, 2025 at 4:19 PM
If you've been interested in FROs, you'll want to see this from NSF:
sam.gov/opp/7332ade9...
"sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."
sam.gov/opp/7332ade9...
"sustained... support to... independent organizational structures operating outside of existing academic, start-up, and industry constraints... a dedicated, full-time team... operational independence..."
Reposted by Adam Marblestone
A genetic platform for a biocementation bacterium https://www.biorxiv.org/content/10.64898/2025.12.05.692644v1
December 7, 2025 at 2:02 AM
A genetic platform for a biocementation bacterium https://www.biorxiv.org/content/10.64898/2025.12.05.692644v1
Reposted by Adam Marblestone
[C]Worthy has secured multi-year support from ORCA and the Patrick J. McGovern Foundation to scale open, trusted science tools for ocean-based carbon removal.
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
[C]Worthy Secures Multi-Year Support From ORCA and the Patrick J. McGovern Foundation to Scale Open-Source Marine Carbon-Removal Tools — [C]Worthy
New multi‑year awards affirm the need for infrastructure built through [C]Worthy’s approach of marrying open-source science and practical tools for industry use.
www.cworthy.org
November 24, 2025 at 4:26 PM
[C]Worthy has secured multi-year support from ORCA and the Patrick J. McGovern Foundation to scale open, trusted science tools for ocean-based carbon removal.
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
We can’t scale what we can’t measure—this funding accelerates our MRV models + datasets.
Full announcement: www.cworthy.org/media/cworth...
Reposted by Adam Marblestone
A global screen for magnetically induced neuronal activity in the pigeon brain www.science.org/doi/10.1126/... - so cool! 🐦🧠
A global screen for magnetically induced neuronal activity in the pigeon brain
How animals detect the Earth’s magnetic field remains a mystery in sensory biology. Despite extensive behavioral evidence, the neural circuitry and molecular mechanisms responsible for magnetic sensin...
www.science.org
November 21, 2025 at 3:07 PM
A global screen for magnetically induced neuronal activity in the pigeon brain www.science.org/doi/10.1126/... - so cool! 🐦🧠
Reposted by Adam Marblestone
Have a look if you are interested in how the team at @cultivarium.bsky.social is finding electroporation protocols for new microbes: both screening lots of conditions on a custom built electroporator concurrently, and cyclical iteration using bayesian optimization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Active learning guides automated discovery of DNA delivery via electroporation for non-model microbes
Delivery of recombinant DNA is foundational for understanding and engineering a target organism. Electroporation can be applied to any cell type, yet identification of a working protocol for new organ...
www.biorxiv.org
November 22, 2025 at 12:23 AM
Have a look if you are interested in how the team at @cultivarium.bsky.social is finding electroporation protocols for new microbes: both screening lots of conditions on a custom built electroporator concurrently, and cyclical iteration using bayesian optimization
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Adam Marblestone
Announced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co.
Learn more: evebio.org/pharmome-dat...
Learn more: evebio.org/pharmome-dat...
Putting Pharmome Data in Researchers' Hands : EvE Bio
We've been busy at EvE Bio these last two years establishing the largest available pharmome mapping dataset. Now it’s making its way into the world to drive real discoveries.
evebio.org
November 18, 2025 at 3:44 PM
Announced today: @evebio.bsky.social's pharmome-mapping dataset - the largest public map of how compounds do or don’t touch druggable targets - is now live on DrugBank's knowledgebase and available programmatically + interactively on Hugging Face, @hf.co.
Learn more: evebio.org/pharmome-dat...
Learn more: evebio.org/pharmome-dat...
Reposted by Adam Marblestone
Is there an academic/industry divide in attitudes about using AI to support discovery? I noticed this post has 3.6k likes on X but only 6 likes on Bluesky. It deserves more attention here!
Today, we're announcing Kosmos, our newest AI Scientist, available today. Kosmos makes fully autonomous scientific discoveries at scale by analyzing datasets and literature, and is the most powerful agent for science so far. Beta users estimate that Kosmos does 6 months of work in a single day.
November 17, 2025 at 2:32 PM
Is there an academic/industry divide in attitudes about using AI to support discovery? I noticed this post has 3.6k likes on X but only 6 likes on Bluesky. It deserves more attention here!
Reposted by Adam Marblestone
As AI collapses coordination costs, our new thesis - Scaling Trust - explores how scalable trust infrastructure could usher in a world of many AI agents, capable of mobilising, negotiating, and verifying on our behalf across digital + physical spaces ↓
link.aria.org.uk/ST-thesis-BS
link.aria.org.uk/ST-thesis-BS
Programme development | Trust Everything, Everywhere
We are in the process of building a multi-year R&D programme within this space. Our programmes are designed to advance complex, large-scale ideas that require coordinated investment and management acr...
link.aria.org.uk
November 17, 2025 at 2:50 PM
As AI collapses coordination costs, our new thesis - Scaling Trust - explores how scalable trust infrastructure could usher in a world of many AI agents, capable of mobilising, negotiating, and verifying on our behalf across digital + physical spaces ↓
link.aria.org.uk/ST-thesis-BS
link.aria.org.uk/ST-thesis-BS
Reposted by Adam Marblestone
It is actually an incredibly frustrating time to be a theoretical neuroscientist right now imo, for this reason
Same for neuroscience. The lack of ability to measure many neurons’ activity, perturb them, and measure intracellular processes and connections is what limits understanding the brain.
The key barriers are not algorithms or AI.
🧪#neuroscience 🧠🤖 #MLSky
The key barriers are not algorithms or AI.
🧪#neuroscience 🧠🤖 #MLSky
November 17, 2025 at 1:23 AM
It is actually an incredibly frustrating time to be a theoretical neuroscientist right now imo, for this reason
Reposted by Adam Marblestone
Reposted by Adam Marblestone
Cool work from our neighbors at @cultivarium.bsky.social using components from the POSSUM Toolkit! What will they (or you!) find next?
Check out the toolkit here: www.addgene.org/kits/cultiva...
Check out the toolkit here: www.addgene.org/kits/cultiva...
November 12, 2025 at 8:03 PM
Cool work from our neighbors at @cultivarium.bsky.social using components from the POSSUM Toolkit! What will they (or you!) find next?
Check out the toolkit here: www.addgene.org/kits/cultiva...
Check out the toolkit here: www.addgene.org/kits/cultiva...
Reposted by Adam Marblestone
Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
November 12, 2025 at 7:05 PM
Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.