Lightnews — Scholar-powered news

Reposted by Adam Marblestone

Nicole Rust @nicolecrust.bsky.social · 1d

Please spread the word! I am recruiting a PhD student this cycle (Fall 2026 start) to join my team in a new venture: the neuroscience of mood.

If you are curious to learn more, this short talk provides a good overview of why, what and how.

www.youtube.com/watch?v=gjIK...

Nicole Rust - The representation of mood in the primate insula (May 6, 2025)

YouTube video by Simons Foundation

www.youtube.com

1 38 56

Reposted by Adam Marblestone

Derek Lowe @dereklowe.bsky.social · 17h

I don’t think I’ve ever had more fun in the lab than when I was making MOFs myself (and trying to use them for small-molecule X-ray structure determination). So let me celebrate by posting a few of the MOF crystals I prepared:

Bright green transparent metal-organic framework crystals prepared with copper and a “multipronged” carboxylic acid ligand. The crystals formed blocky roughly rectangular pieces with some very large emerald-like chunks.

Pink/red transparent metal-organic framework crystals prepared with cobalt and a “multipronged” carboxylic acid ligand. The crystals formed as a mixture of long rectangular types and aggregated chunks.

Purple transparent metal-organic framework crystals prepared with cobalt and a “multipronged” carboxylic acid ligand. The crystals formed long slightly blocky needles.

Clear transparent metal-organic framework crystals prepared with zirconium and a “multipronged” carboxylic acid ligand. The crystals formed chunky hexagons.

3 22 93

Reposted by Adam Marblestone

Timothy Bredy @twbredy.bsky.social · 1d

Say what? 👍

Ryan Flynn @raflynn5.bsky.social · 1d

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells

The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

www.biorxiv.org

2 4

Reposted by Adam Marblestone

Eugene Vinitsky 🍒 @eugenevinitsky.bsky.social · 1d

Soooooo when is bluesky deploying bridging systems
arxiv.org/abs/2301.09976

Bridging Systems: Open Problems for Countering Destructive Divisiveness across Ranking, Recommenders, and Governance

Divisiveness appears to be increasing in much of the world, leading to concern about political violence and a decreasing capacity to collaboratively address large-scale societal challenges. In this wo...

arxiv.org

1 2 17

Reposted by Adam Marblestone

Sarah Lempriere @sarahlempriere.bsky.social · 4d

I love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...

Hidden networks in the brain

Dendritic nanotubes extend brain connectivity beyond synapses

www.science.org

16 54

Reposted by Adam Marblestone

Ryan Flynn @raflynn5.bsky.social · 2d

Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

1 19 41

Reposted by Adam Marblestone

Greg Jefferis @jefferis.bsky.social · 3d

Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live for exploration. Find out more at the landing page hosted by our Janelia FlyEM collaborators www.janelia.org/project-team....

Male CNS Connectome

A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system —a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the ...

www.janelia.org

2 64 130

Reposted by Adam Marblestone

Neuroengineering @neuroengineering.bsky.social · 4d

Precision Neuroscience published their high-density ECoG in Nature Biomed. Eng.

The startup shows a 1,024-channel grid implanted through a cortical slit in pigs, and intraoperative neural recordings and stimulation in five humans at sub-mm resolution.

#neuroskyence @precisionneuro.bsky.social

Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation - Nature Biomedical Engineering

A 1,024-channel microelectrode array is delivered to the brain cortex via a minimally invasive incision in the skull and dura, and allows recording, stimulation and neural decoding across large portions of the brain in porcine models and human neurosurgical patients.

www.nature.com

7 27

Reposted by Adam Marblestone

Nikolai Slavov @slavov-n.bsky.social · 5d

Earlier this year, @parallelsq.bsky.social hosted a research fest.

We began with a broad perspective:
◾️ A century of remarkable progress! Proteomics drove conceptual discoveries and medical treatments.

Listen to what's next!

Proteomics: The arc of progress
youtu.be/Sc2QLXb84XI?...

4 7

Reposted by Adam Marblestone

Onur Dagliyan @onurdagliyan.bsky.social · 6d

🤯

www.science.org/doi/10.1126/...

Intercellular communication in the brain through a dendritic nanotubular network

Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dend...

www.science.org

4 6

Reposted by Adam Marblestone

Anders Sandberg @arenamontanus.bsky.social · 6d

Announcing ALLFED's new study in Earth System Dynamics: Even modest crop declines from nuclear war or infrastructure collapse could trigger cascading food trade disruptions. Global food systems are more fragile than we think. allfed.info/research/pub...

Food trade disruption after global catastrophes

Jehn et. al (2024) highlight the vulnerability of the global food trade system to major disruptions caused by global catastrophic risks (GCR), such as an Abrupt Sunlight Reduction Scenario (ASRS) resu...

allfed.info

1 2

Reposted by Adam Marblestone

Ed Boyden @eboyden3.bsky.social · 6d

Wonderful to collaborate with, and to support as an advisor, E11 Bio - and to announce PRISM, a technology for mapping brains in a self-correcting way, by barcoding neurons followed by expansion microscopy! Thread below by E11 Bio CEO Andrew Payne, with preprint at, www.biorxiv.org/content/10.1...

Andrew Payne @andrewcpayne.bsky.social · 7d

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

3 26

Reposted by Adam Marblestone

Joergen Kornfeld @jmrko.bsky.social · 7d

Long story short: PRISM has the potential to solve the connectomics reconstruction bottleneck for good. Fantastic collaboration with E11, MIT, and the Crick!

Andrew Payne @andrewcpayne.bsky.social · 7d

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

1 5

Reposted by Adam Marblestone

kathleen leeper @kathleen-leeper.bsky.social · 7d

hello, we are working on brain mapping and now you can read about it! it has beautiful neurons (shout out to cell 1492), cool multiplexing tricks, and cell barcodes. there are live data links, my first addgene collection and much much more

Andrew Payne @andrewcpayne.bsky.social · 7d

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

1 1 1

Reposted by Adam Marblestone

Sven Truckenbrodt @sventruckenbrodt.bsky.social · 16d

The Molecular Brain Mapping group at the MRC-LMB is hiring! 🌈🧠

I'm looking for people who are excited about developing multimodal analysis and visualization tools to capture the "hidden connectome," in a highly intersectional environment exploring ideas in meta-science.

mrc.tal.net/vx/mobile-0/...

Imaging Data Engineer - Neurobiology - Dr Sven Truckenbrodt - LMB 2697 - Medical Research Council

Location: Cambridge. Vacancy: Imaging Data Engineer - Neurobiology - Dr Sven Truckenbrodt - LMB 2697. Closing Date: 09/10/2025, 23:55

mrc.tal.net

4 4

Reposted by Adam Marblestone

Sven Truckenbrodt @sventruckenbrodt.bsky.social · 7d

E11's self-correcting neuron barcoding technology PRISM is getting us closer to scalable connectomics — this will enable connectomics research we've been dreaming of for decades 🌈🧠🔬

Andrew Payne @andrewcpayne.bsky.social · 7d

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

1 4

Reposted by Adam Marblestone

Sumner L. Norman @sumnerln.bsky.social · 7d

Our sister FRO E11 Bio is well on their way to mapping every neuron in the brain. Check out their work on PRISM out today!

Andrew Payne @andrewcpayne.bsky.social · 7d

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

1 5

Reposted by Adam Marblestone

Addgene @addgene.bsky.social · 7d

New AAV tools from @e11bio.bsky.social! PRISM uses protein-tag barcodes for high-throughput reconstruction of neurons and other cell-labeling applications. https://twp.ai/4iruEB

A 3D rendering of a network of neurons from a rectangular volume. Each neuron is filled with a slightly different color, making each cell body and its projections distinct from its neighbors.

3 10

Reposted by Adam Marblestone

Konrad Kording @kordinglab.bsky.social · 7d

Such a cool achievement!

Andrew Payne @andrewcpayne.bsky.social · 7d

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

1 12

Reposted by Adam Marblestone

Andrew Payne @andrewcpayne.bsky.social · 7d

Preprint: www.biorxiv.org/content/10.1...

Portal and gallery: www.e11.bio/tech

Addgene constructs: www.addgene.org/depositor-co...

Volara: github.com/e11bio/volara

Open data: github.com/e11bio/e11-o...

Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context

Mapping nanoscale neuronal morphology with molecular annotations is critical for understanding healthy and dysfunctional brain circuits. Current methods are constrained by image segmentation errors an...

www.biorxiv.org

1 4

Reposted by Adam Marblestone

Andrew Payne @andrewcpayne.bsky.social · 7d

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

1 28 54

Adam Marblestone @adammarblestone.bsky.social · 7d

Proud of @e11bio.bsky.social's early progress here, and excited for so much more to come (that I've seen previews of as a FRO board member 😍).

Optics + expansion + barcoding + AI + molecules = beginning of infinity for scalable brain circuit mapping, with wide implications across science.

Andrew Payne @andrewcpayne.bsky.social · 7d

E11 Bio is excited to unveil PRISM technology for mapping brain wiring with simple light microscopes. Today, brain mapping in humans and other mammals is bottlenecked by accurate neuron tracing. PRISM uses molecular ID codes and AI to help neurons trace themselves.

Read more: e11.bio/blog/prism

3 9

Reposted by Adam Marblestone

Sean Carroll @seanmcarroll.bsky.social · Aug 6

Sobering physics-of-democracy finding: attractors in social-media dynamics seem to be "networks of outrage."

Petter Törnberg @pettertornberg.com · Aug 6

We built the simplest possible social media platform. No algorithms. No ads. Just LLM agents posting and following.

It still became a polarization machine.

Then we tried six interventions to fix social media.

The results were… not what we expected.

arxiv.org/abs/2508.03385

Can We Fix Social Media? Testing Prosocial Interventions using Generative Social Simulation

Social media platforms have been widely linked to societal harms, including rising polarization and the erosion of constructive debate. Can these problems be mitigated through prosocial interventions?...

arxiv.org

9 20 78

Reposted by Adam Marblestone

Sean Carroll @seanmcarroll.bsky.social · 20d

Certainly rooting for this particular cosmological anomaly to hold up...

Alexandre Adler @bachpropagate.bsky.social · 20d

arxiv.org/abs/2509.13654
More CMB birefringence hints! Might become the main discovery space in a few years... 🧪🔭 #cosmology

Cosmic Birefringence from the Atacama Cosmology Telescope Data Release 6

The polarized light of the cosmic microwave background is sensitive to new physics that violates parity symmetry. For example, the interaction of photons with the fields of elusive dark matter and dar...

arxiv.org

3 2 44

Reposted by Adam Marblestone

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 10d

Combinatorial protein barcodes enable self-correcting neuron tracing with nanoscale molecular context https://www.biorxiv.org/content/10.1101/2025.09.26.678648v1

5 7