Alan Bince Jacob
@alanbince.bsky.social
Doctoral Candidate - Dept. of Neuropsychology & Psychopharmacology, Maastricht University | Neuroscience in Human Movement | Research: Cognitive Control, Predictive Coding, Posture/Gait | Personal views only
Pinned
Alan Bince Jacob
@alanbince.bsky.social
· Dec 23
Reduced belief updating impairs adaptive step initiation in older adults
Ageing is associated with declines in mobility and balance that threaten independence and increase the risk of falls. Although these changes are often attributed to deterioration of muscular and senso...
doi.org
✨ My first preprint from my PhD with @tjeerdwboonstra.bsky.social is live ! We reveal reduced precision weighting of prediction errors in older adults during step initiation using Go/No-Go stepping paradigm and Hierarchical Gaussian Filter 👇
doi.org/10.64898/202...
doi.org/10.64898/202...
Reposted by Alan Bince Jacob
Paper is out by @harikalidindi.bsky.social : feedback control model of neural population activity
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Feedback control of random networks as a model of flexible motor cortical dynamics across tasks
Kalidindi and Crevecoeur develop a computational framework linking feedback-controlled
networks to limb dynamics. They demonstrate that optimal control of fixed network
reproduces key motor cortical d...
www.cell.com
February 13, 2026 at 12:14 PM
Paper is out by @harikalidindi.bsky.social : feedback control model of neural population activity
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Alan Bince Jacob
Please share: I am recruiting a PhD student to join my lab in Oslo!
For this project, we will investigate the role of striatal interneurons during action selection, using a combination of behavior, in vivo voltage imaging, and slice ephys.
www.jobbnorge.no/en/available...
#NeuroJobs #NeuroSkyence
For this project, we will investigate the role of striatal interneurons during action selection, using a combination of behavior, in vivo voltage imaging, and slice ephys.
www.jobbnorge.no/en/available...
#NeuroJobs #NeuroSkyence
February 13, 2026 at 2:34 PM
Please share: I am recruiting a PhD student to join my lab in Oslo!
For this project, we will investigate the role of striatal interneurons during action selection, using a combination of behavior, in vivo voltage imaging, and slice ephys.
www.jobbnorge.no/en/available...
#NeuroJobs #NeuroSkyence
For this project, we will investigate the role of striatal interneurons during action selection, using a combination of behavior, in vivo voltage imaging, and slice ephys.
www.jobbnorge.no/en/available...
#NeuroJobs #NeuroSkyence
Tone deaf af. More AI slop.
Jim Ratcliffe has issued a bland and generic statement about economic policy which does not engage at all with what he got wrong, or why saying the UK has been colonised has been legitimately criticised. Nor does he seem to retract his language of colonisation in gesturing towards a semi-apology
February 12, 2026 at 2:07 PM
Tone deaf af. More AI slop.
Not surprised by this comment. Stinks of ignorance. Comes from a billionaire who’s depending on public money to rebuild a football stadium for a club that he owns partially (28.94%).
just billionaire Sir Jim Ratcliffe throwing out some serious made-up numbers on TV
February 11, 2026 at 9:30 PM
Not surprised by this comment. Stinks of ignorance. Comes from a billionaire who’s depending on public money to rebuild a football stadium for a club that he owns partially (28.94%).
Reposted by Alan Bince Jacob
Breakthrough @nature.com study showcases new non-invasive treatment for Parkinson’s Disease that targets the somato-cognitive action network (SCAN) with personalized neuromodulation, for superior outcomes. www.nature.com/articles/s41...
February 8, 2026 at 4:16 AM
Breakthrough @nature.com study showcases new non-invasive treatment for Parkinson’s Disease that targets the somato-cognitive action network (SCAN) with personalized neuromodulation, for superior outcomes. www.nature.com/articles/s41...
Reposted by Alan Bince Jacob
Job alert 🚨 Fully funded PhD position available in our Maastricht lab! Are you interested in the relationship between memory and prediction, and have a track record of neuroimaging/decoding? Please apply! #NeuroJobs
www.academictransfer.com/nl/jobs/3576...
www.academictransfer.com/nl/jobs/3576...
PhD Candidate: Cognitive Computational Neuroscience of Memory and Prediction
Welcome to Maastricht University! Are you fascinated by how the brain remembers and predicts information, and how it can tell apart representations of past and future? At Maastricht University, you wi...
www.academictransfer.com
January 7, 2026 at 11:22 AM
Job alert 🚨 Fully funded PhD position available in our Maastricht lab! Are you interested in the relationship between memory and prediction, and have a track record of neuroimaging/decoding? Please apply! #NeuroJobs
www.academictransfer.com/nl/jobs/3576...
www.academictransfer.com/nl/jobs/3576...
Wishing you all a happy new year. May this year bring you many success.
December 31, 2025 at 1:15 PM
Wishing you all a happy new year. May this year bring you many success.
✨ My first preprint from my PhD with @tjeerdwboonstra.bsky.social is live ! We reveal reduced precision weighting of prediction errors in older adults during step initiation using Go/No-Go stepping paradigm and Hierarchical Gaussian Filter 👇
doi.org/10.64898/202...
doi.org/10.64898/202...
Reduced belief updating impairs adaptive step initiation in older adults
Ageing is associated with declines in mobility and balance that threaten independence and increase the risk of falls. Although these changes are often attributed to deterioration of muscular and senso...
doi.org
December 23, 2025 at 11:35 AM
✨ My first preprint from my PhD with @tjeerdwboonstra.bsky.social is live ! We reveal reduced precision weighting of prediction errors in older adults during step initiation using Go/No-Go stepping paradigm and Hierarchical Gaussian Filter 👇
doi.org/10.64898/202...
doi.org/10.64898/202...
Reposted by Alan Bince Jacob
this looks pretty cool from Jirsa lab
"A deformable attractor manifold organizes
human resting-state brain dynamics"
www.biorxiv.org/content/bior...
"A deformable attractor manifold organizes
human resting-state brain dynamics"
www.biorxiv.org/content/bior...
www.biorxiv.org
December 18, 2025 at 11:08 AM
this looks pretty cool from Jirsa lab
"A deformable attractor manifold organizes
human resting-state brain dynamics"
www.biorxiv.org/content/bior...
"A deformable attractor manifold organizes
human resting-state brain dynamics"
www.biorxiv.org/content/bior...
Reposted by Alan Bince Jacob
The Nobel Prize committee should announce the World Cup winner tomorrow
December 6, 2025 at 4:29 AM
The Nobel Prize committee should announce the World Cup winner tomorrow
Reposted by Alan Bince Jacob
During an interesting discussion yesterday with @philosophyshepherd.bsky.social and our Representations Group (www.tcd.ie/Neuroscience...), I mentioned the idea of thinking of our motor systems as embodying a generative model of possible movements. Some members objected...
December 4, 2025 at 11:47 AM
During an interesting discussion yesterday with @philosophyshepherd.bsky.social and our Representations Group (www.tcd.ie/Neuroscience...), I mentioned the idea of thinking of our motor systems as embodying a generative model of possible movements. Some members objected...
Reposted by Alan Bince Jacob
*13th MindBrainBody Symposium*
📆 Mar 9-11, 2026
🏠 #Berlin & virtual
(deadline: Jan 8, 2026)
Keynotes:
- @ulrikebingel.bsky.social
- Karl Friston (online)
- @tinalonsdorf.bsky.social
- Sonja Kotz
- Julian Thayer
...& so much more: prizes, posters, talks, food, drinks, encounters.
Let's meet!
📆 Mar 9-11, 2026
🏠 #Berlin & virtual
(deadline: Jan 8, 2026)
Keynotes:
- @ulrikebingel.bsky.social
- Karl Friston (online)
- @tinalonsdorf.bsky.social
- Sonja Kotz
- Julian Thayer
...& so much more: prizes, posters, talks, food, drinks, encounters.
Let's meet!
December 1, 2025 at 7:28 AM
*13th MindBrainBody Symposium*
📆 Mar 9-11, 2026
🏠 #Berlin & virtual
(deadline: Jan 8, 2026)
Keynotes:
- @ulrikebingel.bsky.social
- Karl Friston (online)
- @tinalonsdorf.bsky.social
- Sonja Kotz
- Julian Thayer
...& so much more: prizes, posters, talks, food, drinks, encounters.
Let's meet!
📆 Mar 9-11, 2026
🏠 #Berlin & virtual
(deadline: Jan 8, 2026)
Keynotes:
- @ulrikebingel.bsky.social
- Karl Friston (online)
- @tinalonsdorf.bsky.social
- Sonja Kotz
- Julian Thayer
...& so much more: prizes, posters, talks, food, drinks, encounters.
Let's meet!
Reposted by Alan Bince Jacob
Insular neural interfaces
Cognitive error signals in the anterior insula propagate toward prefrontal cortex when a BCI fails to follow the user’s intention. Real-time integration enables a self-correcting neural interface that compensates for its own decoder misclassifications
#neuroskyence
Cognitive error signals in the anterior insula propagate toward prefrontal cortex when a BCI fails to follow the user’s intention. Real-time integration enables a self-correcting neural interface that compensates for its own decoder misclassifications
#neuroskyence
Insular error network enables self-correcting intracranial brain-computer interface
Error recognition is fundamental to adaptive behavior, enabling rapid compensatory action when outcomes deviate from expectations. Central to this function are neural circuits for performance monitori...
www.biorxiv.org
November 27, 2025 at 9:40 AM
Insular neural interfaces
Cognitive error signals in the anterior insula propagate toward prefrontal cortex when a BCI fails to follow the user’s intention. Real-time integration enables a self-correcting neural interface that compensates for its own decoder misclassifications
#neuroskyence
Cognitive error signals in the anterior insula propagate toward prefrontal cortex when a BCI fails to follow the user’s intention. Real-time integration enables a self-correcting neural interface that compensates for its own decoder misclassifications
#neuroskyence
Reposted by Alan Bince Jacob
Reposted by Alan Bince Jacob
New preprint:
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
November 9, 2025 at 9:33 PM
New preprint:
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Neural manifolds that orchestrate walking and stopping
Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:
www.biorxiv.org/content/10.1...
Reposted by Alan Bince Jacob
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Sensory expectations shape neural population dynamics in motor circuits
Nature - Experiments with human volunteers and macaques show that expectations produced by probabilistic cueing of future sensory inputs shape motor circuit dynamics in order to increase the...
www.nature.com
October 29, 2025 at 4:11 PM
Thrilled that our paper is out today in Nature!
www.nature.com/articles/s4...
www.nature.com/articles/s4...
Reposted by Alan Bince Jacob
Here at #Indian academy of #neuroscience meeting in the beautiful city of Kovalam in Kerala share.google/EzLqUeTwCeDw... ♥️
@sbaulac.bsky.social is giving the opening talk on brain mosaicism in epilepsy and cortical malformations #epilepsy.
@sbaulac.bsky.social is giving the opening talk on brain mosaicism in epilepsy and cortical malformations #epilepsy.
share.google
share.google
October 29, 2025 at 8:41 AM
Here at #Indian academy of #neuroscience meeting in the beautiful city of Kovalam in Kerala share.google/EzLqUeTwCeDw... ♥️
@sbaulac.bsky.social is giving the opening talk on brain mosaicism in epilepsy and cortical malformations #epilepsy.
@sbaulac.bsky.social is giving the opening talk on brain mosaicism in epilepsy and cortical malformations #epilepsy.
Reposted by Alan Bince Jacob
The Farage Factor.
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Racist incidents against UK nurses surge by 55%
Royal College of Nursing calls on government to stop using anti-migrant rhetoric, which it says emboldens racist behaviour
www.theguardian.com
October 27, 2025 at 8:56 AM
The Farage Factor.
www.theguardian.com/society/2025...
www.theguardian.com/society/2025...
Reposted by Alan Bince Jacob
We were honoured to award Prof Bradford McFadyen @bjmcfadyen.bsky.social ISPGR's Honorary Membership at our 2025 World Congress. Prof McFadyen reflects on this award - and what it takes to make a meaningful career in posture and gait research - in our latest #ISPGRBlog.
tinyurl.com/5n7ces5h
tinyurl.com/5n7ces5h
A Lifetime Member's reflections on making a meaningful career in posture and gait research - ISPGR
tinyurl.com
October 28, 2025 at 8:27 AM
We were honoured to award Prof Bradford McFadyen @bjmcfadyen.bsky.social ISPGR's Honorary Membership at our 2025 World Congress. Prof McFadyen reflects on this award - and what it takes to make a meaningful career in posture and gait research - in our latest #ISPGRBlog.
tinyurl.com/5n7ces5h
tinyurl.com/5n7ces5h
Reposted by Alan Bince Jacob
Revised-TLDR:
Using the hidden multivariate pattern method we show how we capture 5 (!) recurrent EEG topographies in participants' decisions.
We show how these events parse the single-trial reaction time into:
- sensory processes
- attention orientation
- evidence accumulation
- motor execution
Using the hidden multivariate pattern method we show how we capture 5 (!) recurrent EEG topographies in participants' decisions.
We show how these events parse the single-trial reaction time into:
- sensory processes
- attention orientation
- evidence accumulation
- motor execution
October 27, 2025 at 10:09 AM
Revised-TLDR:
Using the hidden multivariate pattern method we show how we capture 5 (!) recurrent EEG topographies in participants' decisions.
We show how these events parse the single-trial reaction time into:
- sensory processes
- attention orientation
- evidence accumulation
- motor execution
Using the hidden multivariate pattern method we show how we capture 5 (!) recurrent EEG topographies in participants' decisions.
We show how these events parse the single-trial reaction time into:
- sensory processes
- attention orientation
- evidence accumulation
- motor execution
Reposted by Alan Bince Jacob
April and I finished The Pitt last night, and man...what an amazing show. I can't speak to the medical accuracy, which I've heard is good, but I can speak to the depictions of PTSD/anxiety. I also want to give a shout out to a scene in the final episode between Noah Wyle and Shawn Hatosy that
October 13, 2025 at 3:12 PM
April and I finished The Pitt last night, and man...what an amazing show. I can't speak to the medical accuracy, which I've heard is good, but I can speak to the depictions of PTSD/anxiety. I also want to give a shout out to a scene in the final episode between Noah Wyle and Shawn Hatosy that
Reposted by Alan Bince Jacob
Started watching The Pitt finally. Hot damn, it’s great. I miss this kind of episodic TV.
October 24, 2025 at 7:54 AM
Started watching The Pitt finally. Hot damn, it’s great. I miss this kind of episodic TV.
Reposted by Alan Bince Jacob
Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects.
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics
Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid an...
pubs.acs.org
October 24, 2025 at 12:17 PM
Big week for all you second-gen psychedelics and non-hallucinatory neuroplastogens fans! New results from Zalsupindole - promotes greater neuroplasticity than ketamine, psilocybin, or DMT, without any of the pesky psychedelic side (fun?) effects.
pubs.acs.org/doi/abs/10.1...
pubs.acs.org/doi/abs/10.1...
Reposted by Alan Bince Jacob
@dotproduct.bsky.social's first first author paper is finally out in @sfnjournals.bsky.social! Her findings show that content-specific predictions fluctuate with alpha frequencies, suggesting a more specific role for alpha oscillations than we may have thought. With @jhaarsma.bsky.social. 🧠🟦 🧠🤖
Contents of visual predictions oscillate at alpha frequencies
Predictions of future events have a major impact on how we process sensory signals. However, it remains unclear how the brain keeps predictions online in anticipation of future inputs. Here, we combin...
www.jneurosci.org
October 21, 2025 at 11:05 AM
@dotproduct.bsky.social's first first author paper is finally out in @sfnjournals.bsky.social! Her findings show that content-specific predictions fluctuate with alpha frequencies, suggesting a more specific role for alpha oscillations than we may have thought. With @jhaarsma.bsky.social. 🧠🟦 🧠🤖
Reposted by Alan Bince Jacob
Please RT! 🙏🙏🙏
1/3 How do you correct for multiple comparisons? Do you take into account *all* comparisons that can render the paper publishable? Most of us don’t. In this NHB piece, Yoav Benjamini, Yoav Zeevi and I argue that it’s time to change our practices >>
www.nature.com/articles/s41...
1/3 How do you correct for multiple comparisons? Do you take into account *all* comparisons that can render the paper publishable? Most of us don’t. In this NHB piece, Yoav Benjamini, Yoav Zeevi and I argue that it’s time to change our practices >>
www.nature.com/articles/s41...
Correction for multiple comparisons should be ubiquitous - Nature Human Behaviour
Nature Human Behaviour - Correction for multiple comparisons should be ubiquitous
www.nature.com
October 16, 2025 at 5:28 PM
Please RT! 🙏🙏🙏
1/3 How do you correct for multiple comparisons? Do you take into account *all* comparisons that can render the paper publishable? Most of us don’t. In this NHB piece, Yoav Benjamini, Yoav Zeevi and I argue that it’s time to change our practices >>
www.nature.com/articles/s41...
1/3 How do you correct for multiple comparisons? Do you take into account *all* comparisons that can render the paper publishable? Most of us don’t. In this NHB piece, Yoav Benjamini, Yoav Zeevi and I argue that it’s time to change our practices >>
www.nature.com/articles/s41...