Alice Braun
@alicebraun.bsky.social
Statistical geneticist interested in complex traits @ripkelab.bsky.social and @broadinstitute.org 🧬⚔️
Professional dungeon master @home
Professional dungeon master @home
Reposted by Alice Braun
Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...
July 21, 2025 at 7:01 PM
Our project, looking at the genetic relationships between immune diseases and psychiatric disorders, has finally been published! Now with gene expression analyses as well as additional sensitivity analyses, thanks to reviewers. Find the full article here: www.nature.com/articles/s41...
Reposted by Alice Braun
Wonderful thread about mentors. @nature.com ‘s mentorship award is open for noms now: www.nature.com/nature/award...
June 8, 2025 at 7:33 PM
Wonderful thread about mentors. @nature.com ‘s mentorship award is open for noms now: www.nature.com/nature/award...
Reposted by Alice Braun
Why do children with Type 1 Diabetes (T1D) often have parents with autoimmune diseases?
Our new study shows parental autoimmune conditions affect offspring’s T1D risk through complex genetic factors, including both HLA and non-HLA variants.
🔗 www.cell.com/cell-genomic...
Our new study shows parental autoimmune conditions affect offspring’s T1D risk through complex genetic factors, including both HLA and non-HLA variants.
🔗 www.cell.com/cell-genomic...
Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms
Leveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen,
Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring
T1D. Their creative and r...
www.cell.com
April 25, 2025 at 6:34 PM
Why do children with Type 1 Diabetes (T1D) often have parents with autoimmune diseases?
Our new study shows parental autoimmune conditions affect offspring’s T1D risk through complex genetic factors, including both HLA and non-HLA variants.
🔗 www.cell.com/cell-genomic...
Our new study shows parental autoimmune conditions affect offspring’s T1D risk through complex genetic factors, including both HLA and non-HLA variants.
🔗 www.cell.com/cell-genomic...
The Ripke lab has worked on a new stable release of RICOPILI! Updates include compatibility with GRCh38 and imputation using Minimac4. A software tarball and YAML file are provided to help resolve dependency issues:
github.com/Ripkelab/ric...
Any feedback is highly welcome!
@pgcgenetics.bsky.social
github.com/Ripkelab/ric...
Any feedback is highly welcome!
@pgcgenetics.bsky.social
GitHub - Ripkelab/ricopili: Main ricopili repo for public releases
Main ricopili repo for public releases. Contribute to Ripkelab/ricopili development by creating an account on GitHub.
github.com
March 12, 2025 at 5:03 PM
The Ripke lab has worked on a new stable release of RICOPILI! Updates include compatibility with GRCh38 and imputation using Minimac4. A software tarball and YAML file are provided to help resolve dependency issues:
github.com/Ripkelab/ric...
Any feedback is highly welcome!
@pgcgenetics.bsky.social
github.com/Ripkelab/ric...
Any feedback is highly welcome!
@pgcgenetics.bsky.social
Reposted by Alice Braun
A tour de force review of the connections between between the nervous and immune systems
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 12, 2025 at 4:29 PM
A tour de force review of the connections between between the nervous and immune systems
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alice Braun
Incredibly proud to see our latest work out in Nature Genetics: www.nature.com/articles/s41...
Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥
Special thanks to @daniposthu.bsky.social
A full thread describing findings below!
Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥
Special thanks to @daniposthu.bsky.social
A full thread describing findings below!
Prioritizing effector genes at trait-associated loci using multimodal evidence
Nature Genetics - FLAMES is a machine learning approach combining variant fine-mapping, SNP-to-gene annotations and convergence-based gene prioritization scores to identify candidate effector genes...
rdcu.be
February 11, 2025 at 9:58 AM
Incredibly proud to see our latest work out in Nature Genetics: www.nature.com/articles/s41...
Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥
Special thanks to @daniposthu.bsky.social
A full thread describing findings below!
Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥
Special thanks to @daniposthu.bsky.social
A full thread describing findings below!
Reposted by Alice Braun
impressive, superhelpful review listing 100s tools for GWAS analysis, with important focus on summary data interpretation
biodatamining.biomedcentral.com/articles/10....
biodatamining.biomedcentral.com/articles/10....
The goldmine of GWAS summary statistics: a systematic review of methods and tools - BioData Mining
Genome-wide association studies (GWAS) have revolutionized our understanding of the genetic architecture of complex traits and diseases. GWAS summary statistics have become essential tools for various...
biodatamining.biomedcentral.com
January 23, 2025 at 10:03 PM
impressive, superhelpful review listing 100s tools for GWAS analysis, with important focus on summary data interpretation
biodatamining.biomedcentral.com/articles/10....
biodatamining.biomedcentral.com/articles/10....
Reposted by Alice Braun
We're hiring a postdoc to help shape our autism research program; please consider applying.
www.23andme.com/careers/jobs...
www.23andme.com/careers/jobs...
Postdoc - Autism Research – 23andMe Careers
Read about our mission-based culture, look up open positions and check out the perks of working here.
www.23andme.com
January 21, 2025 at 6:21 PM
We're hiring a postdoc to help shape our autism research program; please consider applying.
www.23andme.com/careers/jobs...
www.23andme.com/careers/jobs...
Congrats everyone!!!
1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in @cellpress.bsky.social.
www.cell.com/cell/fulltex...
A thread 🧵:
www.cell.com/cell/fulltex...
A thread 🧵:
January 14, 2025 at 9:22 PM
Congrats everyone!!!
Reposted by Alice Braun
Last work tweet of 2024 (maybe 😉): I, Ken Kendler, Brad Verhulst, @jorsmo.bsky.social and @andrewgrotzinger.bsky.social et al in the Psychiatric Genomics Consortium Cross Disorder Group (PGC-CDG) wrote a review on challenges studying cross disorder (psych) genetics: www.nature.com/articles/s41...
Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research - Molecular Psychiatry
Molecular Psychiatry - Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research
www.nature.com
December 27, 2024 at 4:28 PM
Last work tweet of 2024 (maybe 😉): I, Ken Kendler, Brad Verhulst, @jorsmo.bsky.social and @andrewgrotzinger.bsky.social et al in the Psychiatric Genomics Consortium Cross Disorder Group (PGC-CDG) wrote a review on challenges studying cross disorder (psych) genetics: www.nature.com/articles/s41...
Reposted by Alice Braun
🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.
GitHub - MichelNivard/awesome-complex-trait-genetics: A list of awesome tools for complex trait genetics.
A list of awesome tools for complex trait genetics. - MichelNivard/awesome-complex-trait-genetics
github.com
November 28, 2024 at 9:21 AM
🚨 This will become a curated list of awesome tools for complex trait genetics, **add yours**! it may become a review in which case those who contribute are invited as co-authors.
Reposted by Alice Braun
Thanks for the valued colleague award @pgcgenetics.bsky.social, which traveled all the way from Singapore to Berlin!
December 3, 2024 at 1:10 PM
Thanks for the valued colleague award @pgcgenetics.bsky.social, which traveled all the way from Singapore to Berlin!
Reposted by Alice Braun
NOW HIRING
#postdocjobs
NIH funding for a #postdoc with interest in complex genetics / computation / analysis
#GWAS #rarevariants #polygenicriskscores
in multiple research contexts:
psychiatric genomics; cognitive genomics; embryo screening...
acnp.org/wp-content/u...
#postdocjobs
NIH funding for a #postdoc with interest in complex genetics / computation / analysis
#GWAS #rarevariants #polygenicriskscores
in multiple research contexts:
psychiatric genomics; cognitive genomics; embryo screening...
acnp.org/wp-content/u...
https://acnp.org/wp-content/uploads/2021/09/Postdoc_listing-_Lencz_polygenic.pdf…
November 25, 2024 at 5:31 PM
NOW HIRING
#postdocjobs
NIH funding for a #postdoc with interest in complex genetics / computation / analysis
#GWAS #rarevariants #polygenicriskscores
in multiple research contexts:
psychiatric genomics; cognitive genomics; embryo screening...
acnp.org/wp-content/u...
#postdocjobs
NIH funding for a #postdoc with interest in complex genetics / computation / analysis
#GWAS #rarevariants #polygenicriskscores
in multiple research contexts:
psychiatric genomics; cognitive genomics; embryo screening...
acnp.org/wp-content/u...