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Reposted by Cristian Pattaro

Nicholas Mancuso @nmancuso.bsky.social · 2d

5 YEARS of HGG Advances! Mike, Jessica, Sara, and so many others have done such a fantastic job in shaping and expanding the journal.

Please consider submitting your work in genetics/genomics with us!

Human Genetics and Genomics Advances @hggadvances.bsky.social · 3d

Our October issue is online!
Check out the amazing cover from @comfortandadam.bsky.social to commemorate 5 YEARS of HGG Advances!

www.cell.com/hgg-advances...

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Cristian Pattaro @cpattaro.bsky.social · 2d

"a polygenic score, by design, is acausal. It is a correlation accumulator"

Eric Turkheimer @ent3c.bsky.social · Aug 9

New blog post: The New Eugenics Companies
(Oops, I meant to say generational health and embryo selection)

The New Eugenics Companies

Oops, I meant to say generational health and embryo selection

ericturkheimer.substack.com

Cristian Pattaro @cpattaro.bsky.social · 2d

"dependence is the modal human condition"

Kathryn Paige Harden @kph3k.bsky.social · Aug 19

I wrote about the Don't Die biohackers who want to live forever, Viviana Zelizer's sociological history of the life insurance industry, and Ira, the cute nurse who fixed my grandmother's IV at 1 AM:

open.substack.com/pub/kathrynp...

Don't Die

Thoughts on aging, fragility, and care from my grandmother's hospital room

open.substack.com

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Cristian Pattaro @cpattaro.bsky.social · 2d

Thx for writing this. So deeply human.

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Cristian Pattaro @cpattaro.bsky.social · 3d

Agree. This struck me. Also thinking to the work reviewers have put on that.

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Cristian Pattaro @cpattaro.bsky.social · 3d

Massive #retraction of #Mendelianrandomization papers @ Skin Res Technol, >30 papers retracted in a single issue

Unclear biological rationale supporting valid application of MR to the research question 😶

Decision by journal+publisher. Authors disagree

onlinelibrary.wiley.com/toc/16000846...

Skin Research and Technology: Vol 31, No 10

Click on the title to browse this issue

onlinelibrary.wiley.com

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Reposted by Cristian Pattaro

Tuuli Lappalainen @tuuliel.bsky.social · 4d

We're hiring! My team at @nygenome.org is looking for a statistical genetics postdoc to decipher functional architecture of complex diseases from cutting-edge CRISPR+scRNA-seq data, with @nevillesanjana.bsky.social lab. Happy to meet at #ASHG25, apply here
jobs.silkroad.com/NYGenome/Car...

Postdoctoral Research Associate, Lappalainen & Sanjana Labs - 101 Avenue of the Americas, 7th Floor, New York, New York - New York Genome Center

Find a career with New York Genome Center

jobs.silkroad.com

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Reposted by Cristian Pattaro

Janne Pott @pottj.bsky.social · 6d

📣Preprint alert - a tricky one, as there are no significant results (and we all know null-results are hard to publish)
Do PCSK9 levels affect survival in breast cancer patients?
We tried to replicate findings in cell lines and mouse model using 3 Mendelian Randomization approaches, but failed.

medRxivpreprint @medrxivpreprint.bsky.social · 7d

PCSK9 and breast cancer survival: a Mendelian Randomization study https://www.medrxiv.org/content/10.1101/2025.10.03.25337270v1

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Cristian Pattaro @cpattaro.bsky.social · 6d

Towards race-free predictive formulas: a path that should not be abandoned

www.nejm.org/doi/full/10....

The Race-Correction Debates — Progress, Tensions, and Future Directions | NEJM

Many race-adjusted clinical tools have recently been scrutinized and replaced with race-neutral versions — efforts that have faced obstacles and generated contentious debate about the use of race i...

www.nejm.org

Cristian Pattaro @cpattaro.bsky.social · 6d

reflections on #sociogenomics

#popgen

www.cell.com/trends/genet...

A tale of two sociogenomics: shall the twain ever meet?

How does the social environment ‘get under the skin’ to influence the behavior of individual animals and humans and the activity of their genomes? And, conversely, how do genetic variants influence so...

www.cell.com

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Cristian Pattaro @cpattaro.bsky.social · 7d

Very nice application of factor analysis #stats

Simon Fisher @profsimonfisher.bsky.social · 11d

"Earlier- & later-diagnosed autism have different developmental trajectories & genetic profiles. The findings have important implications for how we conceptualize autism & provide a model to explain some of its diversity." @vw1234.bsky.social & an international team report today in @nature.com: 👇🧪

Polygenic and developmental profiles of autism differ by age at diagnosis - Nature

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

www.nature.com

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Reposted by Cristian Pattaro

Mike Inouye @mikeinouye.bsky.social · 9d

Not unrelated... I've recently updated the Research page on our lab's website (first time in nearly 10 years!) www.inouyelab.org/home/research

and we are now recruiting PhD students for autumn 2026 @dphpc.bsky.social @cam.ac.uk - feel free to get in touch!

Inouye Lab - Research

Background Technological advances have continued to drive the study of biology towards the statistical and computational sciences. We are now able to differentiate and quantify biomolecules at levels ...

www.inouyelab.org

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Cristian Pattaro @cpattaro.bsky.social · 9d

keywords for innovative science: rookie & diversity
www.nature.com/articles/d41...

Want to do disruptive science? Include more rookie researchers

Papers from research teams with a substantial number of beginners are highly disruptive and innovative, study shows.

www.nature.com

Cristian Pattaro @cpattaro.bsky.social · 10d

the Trials within Cohort (TwiC) design:
www.jclinepi.com/article/S089...

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bioRxiv Genetics @biorxiv-genetic.bsky.social · 11d

SAFE-LD: A novel method for the estimation of linkage disequilibrium from summary statistics https://www.biorxiv.org/content/10.1101/2025.09.29.679154v1

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Guido Valverde @guido-valverde.bsky.social · 11d

Why scientists should take more coffee breaks
www.science.org/content/arti...

Why scientists should take more coffee breaks

Grad students should make time for casual conversations with peers, this Ph.D. student writes

www.science.org

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Reposted by Cristian Pattaro

Andrea Ganna @andganna.bsky.social · 12d

🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much.

Our new study in Nature Genetics including 9 disease and 7 biobanks shows:

• Susceptibility variants ≠ survival
• PRSs for onset weak at predicting progression
• Lifespan PRS predicts survival better

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Reposted by Cristian Pattaro

Karsten Suhre @ksuhre.bsky.social · 11d

A pretty comprehensive comparison of most actual #proteomics platforms:

Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery

www.nature.com/articles/s42...

Current landscape of plasma proteomics from technical innovations to biological insights and biomarker discovery - Communications Chemistry

Plasma proteome profiling has surged as a promising avenue for biomarker discovery, yet comprehensive platform comparisons remain scarce. Here, the authors evaluate eight proteomics platforms, revealing key differences and complementary strengths, providing crucial insights for researchers into coverage trade-offs and implicating biomarker discovery and clinical applications.

www.nature.com

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Cristian Pattaro @cpattaro.bsky.social · 16d

"ignoring political issues that affect health means ignoring real barriers to care"
www.thelancet.com/journals/lan...

Gaza's healthocide: medical societies must not stay silent

The catastrophic humanitarian crisis in Gaza, with the apparent deliberate targeting of health-care infrastructure and personnel, has highlighted a profound challenge to the global medical community. ...

www.thelancet.com

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Reposted by Cristian Pattaro

Sasha Gusev @sashagusevposts.bsky.social · Aug 27

I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:

Beneath the surface of the sum

When genetic interactions matter and when they don't

open.substack.com

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Lori O'Brien @llobrienlab.bsky.social · 16d

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

Image of a fluorescently labeled adult mouse kidney showing AQP2 staining of collecting ducts and connecting segment in green and alpha SMA staining of the arterial tree in magenta. The collecting ducts look like squiggly branches.

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American Statistical Association History of Statistics @hos-asa.bsky.social · 16d

#OTD 1876 Edith Abbott b (d 28 Jul 1957) ASA Fellow 1945. One of the 1st F deans in the US, she pioneered statistical methods applied to policy development for welfare, education & protections for immigrants, working women & children

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Nicola Pirastu @npirastu.bsky.social · 17d

The Health Data Science Centre at
@humantechnopole.bsky.social is looking for an outstanding Postdoc to work on Generative Machine Learning for biomedical data.
If you are passionate about ML and real-world health data, this is the position for you!
info: [email protected]
tinyurl.com/5n8yy7xp

Human Technopole hiring Postdoc in Generative Machine Learning for Biomedical Data in Milan, Lombardy, Italy | LinkedIn

Posted 3:54:30 PM. APPLICATION CLOSING DATE: October 9th 2025Job descriptionHuman Technopole (HT) is an…See this and similar jobs on LinkedIn.

tinyurl.com

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Jeffrey Barrett @jeffbarrett.eu · 18d

1. e.g. pmc.ncbi.nlm.nih.gov/articles/PMC...

2. jamanetwork.com/journals/jam...

For expert advice on using tylenol during pregnancy:
www.acog.org/clinical/cli...

Acetaminophen Use in Pregnancy and Neurodevelopmental Outcomes

www.acog.org

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Reposted by Cristian Pattaro

Chris Wallace @chr1sw.bsky.social · 19d

In modern datasets, very large sample sizes combined with slight differences in information across SNPs (eg die to imputation) can mislead fine mapping algorithms, and in turn colocalisation.

Stephen Burgess @stevesphd.bsky.social · 19d

A pre-print for Chris Wallace's colocPropTest method for proportional colocalization is available online: www.biorxiv.org/content/10.1... @chr1sw.bsky.social

Variable information across SNPs in GWAS data can cause false rejections of colocalisation which can be resolved by proportional colocalisation tests

Fine-mapping is now a standard post-GWAS analysis, but it has been shown to be potentially inaccurate for large meta-analysis GWAS. We show how this can be caused by variable amounts of statistical in...

www.biorxiv.org

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