Nicholas Mancuso
@nmancuso.bsky.social
Associate Professor at USC. Genetics/Stats/ML. Husband and father. GA➡️CA. He/him. Views are mine.
www.mancusolab.com
www.mancusolab.com
Pinned
Nicholas Mancuso
@nmancuso.bsky.social
· Nov 17
a cartoon character with a skull on his face
ALT: a cartoon character with a skull on his face
media.tenor.com
Who dares to disturb my slumber
Reposted by Nicholas Mancuso
Interesting, but of course: "It’s worth noting that a C compiler is a near-ideal task for semi-autonomous AI model coding: The specification is decades old and well-defined, comprehensive test suites already exist, and there’s a known-good reference compiler to check against."
February 6, 2026 at 11:46 PM
Interesting, but of course: "It’s worth noting that a C compiler is a near-ideal task for semi-autonomous AI model coding: The specification is decades old and well-defined, comprehensive test suites already exist, and there’s a known-good reference compiler to check against."
Reposted by Nicholas Mancuso
Polygenic scores are useful for early detection, but also early prevention!
New paper shows people with high genetic risk of T2D have 3x more risk of developing it by age 35. Early detection could trigger lifestyle changes, metformin prescription...
doi.org/10.1038/s414...
New paper shows people with high genetic risk of T2D have 3x more risk of developing it by age 35. Early detection could trigger lifestyle changes, metformin prescription...
doi.org/10.1038/s414...
Preventing premature deaths through polygenic risk scores - Nature Communications
Via an integrative modelling approach that combines population and clinical trial data, the authors find that polygenic risk score-based screening would reduce premature mortality across seven commonl...
doi.org
February 6, 2026 at 5:34 PM
Polygenic scores are useful for early detection, but also early prevention!
New paper shows people with high genetic risk of T2D have 3x more risk of developing it by age 35. Early detection could trigger lifestyle changes, metformin prescription...
doi.org/10.1038/s414...
New paper shows people with high genetic risk of T2D have 3x more risk of developing it by age 35. Early detection could trigger lifestyle changes, metformin prescription...
doi.org/10.1038/s414...
Reposted by Nicholas Mancuso
Pour one out for every professional political pundit, writer, consultant whatever that has spent the last decade trying to pretend that the Trump phenomenon was about trade or opiates and not a big chunk of white america losing its mind over having a black president bsky.app/profile/kyle...
A screenshot from a video posted on Trump's Truth Social account: truthsocial.com/@realDonaldT...
February 6, 2026 at 9:28 AM
Pour one out for every professional political pundit, writer, consultant whatever that has spent the last decade trying to pretend that the Trump phenomenon was about trade or opiates and not a big chunk of white america losing its mind over having a black president bsky.app/profile/kyle...
the dustbuster
February 6, 2026 at 12:06 AM
the dustbuster
Reposted by Nicholas Mancuso
they want catharsis, not action
February 5, 2026 at 2:36 PM
they want catharsis, not action
this person would rather congratulate the trump administration on "stiffing ICE" than -anything- dems propose
Couple that with the fact that in a shutdown most recently, the admin went out of their way not to pay employees they legally had to pay. Putting it simply, That money done already spent, hun, and I guarantee you their first step would be stiffing the boots on the ground. They are already doing it!
February 5, 2026 at 5:41 PM
this person would rather congratulate the trump administration on "stiffing ICE" than -anything- dems propose
Reposted by Nicholas Mancuso
"Getting DHS binned off from the rest of the govt in some amazing legislative jiu-jitsu to maximize leverage on getting restrictions into DHS annual approps was bad, actually"
Maybe not a significant enough hostage anymore.
But of course that's also Dem leadership's fault for separating this out instead of blocking the whole damn minibus.
The trajectory of voter opinion was clearly towards actionable outrage. There will be more footage of atrocities.
But of course that's also Dem leadership's fault for separating this out instead of blocking the whole damn minibus.
The trajectory of voter opinion was clearly towards actionable outrage. There will be more footage of atrocities.
February 5, 2026 at 5:27 PM
"Getting DHS binned off from the rest of the govt in some amazing legislative jiu-jitsu to maximize leverage on getting restrictions into DHS annual approps was bad, actually"
Me trying to be smart, "ya that's def a Mott the Hoople fallacy"
February 5, 2026 at 4:26 PM
Me trying to be smart, "ya that's def a Mott the Hoople fallacy"
GRANT MUSIC REENGAGED, WAIT ITS DUE IN LIKE AN HOUR
GRANT WRITING MUSIC ENGAGED www.youtube.com/watch?v=0D-G...
Stepping Into Tomorrow
YouTube video by Donald Byrd - Topic
www.youtube.com
February 5, 2026 at 3:06 PM
GRANT MUSIC REENGAGED, WAIT ITS DUE IN LIKE AN HOUR
The 'do something!' faction really needs to log off, say, indefinitely. Or at a minimum follow more lawyers and reputable journalists, good grief...
February 5, 2026 at 3:05 PM
The 'do something!' faction really needs to log off, say, indefinitely. Or at a minimum follow more lawyers and reputable journalists, good grief...
Reposted by Nicholas Mancuso
“Your mountainish inhumanity”
We’re doing this to ourselves
We’re doing this to ourselves
Ian McKellen performs “The Strangers’ Case” speech from “Sir Thomas More” on Colbert.
February 5, 2026 at 1:59 PM
“Your mountainish inhumanity”
We’re doing this to ourselves
We’re doing this to ourselves
GRANT WRITING MUSIC ENGAGED www.youtube.com/watch?v=0D-G...
Stepping Into Tomorrow
YouTube video by Donald Byrd - Topic
www.youtube.com
February 5, 2026 at 6:12 AM
GRANT WRITING MUSIC ENGAGED www.youtube.com/watch?v=0D-G...
Reposted by Nicholas Mancuso
2029 ruling: 15th Supreme Court Justice Stancil writing for the affirmative
February 5, 2026 at 12:40 AM
2029 ruling: 15th Supreme Court Justice Stancil writing for the affirmative
Reposted by Nicholas Mancuso
when we talk about DEI, structural racism, critical race theory, and all the other bugaboos, this is what we mean:
it is unjust to have people whose blood, organs, and other tissues we'll gladly accept as must-have therapeutics while denying them equal access and merit as recipients
it is unjust to have people whose blood, organs, and other tissues we'll gladly accept as must-have therapeutics while denying them equal access and merit as recipients
Apparently we can't always offer life-saving care to undocumented patients, but we can always ask the family to consent to organ donation when they die.
My heart hurts so much, I think I'm going to throw up.
My heart hurts so much, I think I'm going to throw up.
February 5, 2026 at 5:29 AM
when we talk about DEI, structural racism, critical race theory, and all the other bugaboos, this is what we mean:
it is unjust to have people whose blood, organs, and other tissues we'll gladly accept as must-have therapeutics while denying them equal access and merit as recipients
it is unjust to have people whose blood, organs, and other tissues we'll gladly accept as must-have therapeutics while denying them equal access and merit as recipients
wait how have i not seen this, ed harris, george romero!?!
February 5, 2026 at 5:26 AM
wait how have i not seen this, ed harris, george romero!?!
Reposted by Nicholas Mancuso
They have been in general obeying court orders, all of this would make those orders much easier to issue and maintain on appeal
this is simultaneously much more than i expected and not nearly enough. IF the Reps abided by this it would make things LESS awful but i just don't see why we'd expect them to abide by any agreement they make once they have cash in hand
Schumer & Jeffries lay out the Democratic demands for a DHS funding deal in a letter to the top Republican leaders
February 5, 2026 at 4:54 AM
They have been in general obeying court orders, all of this would make those orders much easier to issue and maintain on appeal
Reposted by Nicholas Mancuso
Jeffries and Schumer are actually pretty good at counting votes so I’m legitimately curious to see where this goes
Schumer & Jeffries lay out the Democratic demands for a DHS funding deal in a letter to the top Republican leaders
February 5, 2026 at 4:56 AM
Jeffries and Schumer are actually pretty good at counting votes so I’m legitimately curious to see where this goes
Reposted by Nicholas Mancuso
once again: lawyers are morally responsible for their professional decisions. people get really mad about this but … you picked the job. you took the money. you own what you’ve done.
A bizarre number of people have stepped up to defend Julie Le. What you see in that transcript is an attorney who chose to do evil work—deporting people for ICE then moving over to DOJ in early Jan. specifically to fight these habeas petitions—being called to the carpet. She's desperate, not heroic.
If you want to read the transcript of the February 3 hearing where Julie Le had her "this job sucks" meltdown, now you can:
drive.google.com/file/d/1FnY2...
drive.google.com/file/d/1FnY2...
February 5, 2026 at 4:02 AM
once again: lawyers are morally responsible for their professional decisions. people get really mad about this but … you picked the job. you took the money. you own what you’ve done.
Whys his head look like a baked ham
February 5, 2026 at 4:00 AM
Whys his head look like a baked ham
Reposted by Nicholas Mancuso
44 years ago today
Bad Brains is the debut studio album by the American hardcore punk band Bad Brains, recorded in 1981 and released on the cassette-only label ROIR on this day in 1982
#punk #punks #punkrock #badbrains #hardcorepunk #history #punkrockhistory #otd
Bad Brains is the debut studio album by the American hardcore punk band Bad Brains, recorded in 1981 and released on the cassette-only label ROIR on this day in 1982
#punk #punks #punkrock #badbrains #hardcorepunk #history #punkrockhistory #otd
February 5, 2026 at 3:43 AM
44 years ago today
Bad Brains is the debut studio album by the American hardcore punk band Bad Brains, recorded in 1981 and released on the cassette-only label ROIR on this day in 1982
#punk #punks #punkrock #badbrains #hardcorepunk #history #punkrockhistory #otd
Bad Brains is the debut studio album by the American hardcore punk band Bad Brains, recorded in 1981 and released on the cassette-only label ROIR on this day in 1982
#punk #punks #punkrock #badbrains #hardcorepunk #history #punkrockhistory #otd
Reposted by Nicholas Mancuso
And, finally, WE ARE WINNING. They're crumbling, and the full firepower of the Minnesota bar isn't close to online yet. The combined might of our state's attorneys will soon be able to double, triple, 10x, the number of filings. They can't cope.
February 4, 2026 at 10:11 PM
And, finally, WE ARE WINNING. They're crumbling, and the full firepower of the Minnesota bar isn't close to online yet. The combined might of our state's attorneys will soon be able to double, triple, 10x, the number of filings. They can't cope.
🫡 thats my rep!
Today I joined House Democrats at ICE headquarters in DC to demand Kristi Noem's impeachment & voted NO on funding for DHS. Not a dollar more until DHS ends its violence & abuse of power.
Trump's federal agents killed two Americans in broad daylight. We are not backing down.
Trump's federal agents killed two Americans in broad daylight. We are not backing down.
February 4, 2026 at 11:31 PM
🫡 thats my rep!
Reposted by Nicholas Mancuso
I think this would have the opposite effect of what is intended. Instead of supressing the vote you’re going to end up with angry people even more determined to cast a ballot bsky.app/profile/marc...
🚨BREAKING: Steve Bannon said Tuesday that the federal government is planning to send Immigration and Customs Enforcement (ICE) officers to patrol polling stations during this year’s midterm elections. www.democracydocket.com/news-alerts/...
Steve Bannon says ICE will ‘surround the polls’ as Trump doubles down on taking over elections
Trump doubled down on his comments to nationalize voting Tuesday during an Oval Office press conference. “If you think about it, a state is an agent for the federal government in elections,” Trump sai...
www.democracydocket.com
February 4, 2026 at 7:29 PM
I think this would have the opposite effect of what is intended. Instead of supressing the vote you’re going to end up with angry people even more determined to cast a ballot bsky.app/profile/marc...