Nicholas Mancuso
@nmancuso.bsky.social
Associate Professor at USC. Genetics/Stats/ML. Husband and father. GA➡️CA. He/him. Views are mine.
www.mancusolab.com
www.mancusolab.com
Pinned
Nicholas Mancuso
@nmancuso.bsky.social
· Nov 17
a cartoon character with a skull on his face
ALT: a cartoon character with a skull on his face
media.tenor.com
Who dares to disturb my slumber
Reposted by Nicholas Mancuso
Blog post: A Missing Heritability Update. Three legs and other problems. I follow up on the recent excellent post on the subject by @sashagusevposts.bsky.social. ericturkheimer.substack.com/p/missing-he...
Missing Heritability Revisited
Following up on Sasha
ericturkheimer.substack.com
November 25, 2025 at 3:04 PM
Blog post: A Missing Heritability Update. Three legs and other problems. I follow up on the recent excellent post on the subject by @sashagusevposts.bsky.social. ericturkheimer.substack.com/p/missing-he...
Reposted by Nicholas Mancuso
Good context here on the heritability discussion that steps back from dispassionate itemizing
Blog post: A Missing Heritability Update. Three legs and other problems. I follow up on the recent excellent post on the subject by @sashagusevposts.bsky.social. ericturkheimer.substack.com/p/missing-he...
Missing Heritability Revisited
Following up on Sasha
ericturkheimer.substack.com
November 26, 2025 at 12:15 AM
Good context here on the heritability discussion that steps back from dispassionate itemizing
I'm kind of addicted to my kids capri suns?
November 25, 2025 at 3:40 AM
I'm kind of addicted to my kids capri suns?
He got that vermut in em
November 23, 2025 at 12:11 AM
He got that vermut in em
Folks acting like MTG opening up a possibility in an already tenuous balance in the house :
I encourage you to visit Acworth GA. As someone with family there, It's a mix of recent wealthy mansion owners and historically poor white folks. I don't think it's gonna flip anytime soon.
I encourage you to visit Acworth GA. As someone with family there, It's a mix of recent wealthy mansion owners and historically poor white folks. I don't think it's gonna flip anytime soon.
November 22, 2025 at 11:44 PM
Folks acting like MTG opening up a possibility in an already tenuous balance in the house :
I encourage you to visit Acworth GA. As someone with family there, It's a mix of recent wealthy mansion owners and historically poor white folks. I don't think it's gonna flip anytime soon.
I encourage you to visit Acworth GA. As someone with family there, It's a mix of recent wealthy mansion owners and historically poor white folks. I don't think it's gonna flip anytime soon.
Reposted by Nicholas Mancuso
Chekov’s Gundam
November 22, 2025 at 6:43 AM
Chekov’s Gundam
Smh these olives don't even fit on my fingers
November 22, 2025 at 10:27 PM
Smh these olives don't even fit on my fingers
Reposted by Nicholas Mancuso
So there you have it, twin study estimates were greatly inflated, and molecular data sets the record straight. I walk through possible counter-arguments, but ultimately the uncomfortable truth is that genes contribute to traits much less than we always thought.
November 21, 2025 at 10:34 PM
So there you have it, twin study estimates were greatly inflated, and molecular data sets the record straight. I walk through possible counter-arguments, but ultimately the uncomfortable truth is that genes contribute to traits much less than we always thought.
Reposted by Nicholas Mancuso
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
My life has been in shambles these past few months since King Gizzard and the Lizard Wizard has been off Spotify
November 22, 2025 at 4:28 AM
My life has been in shambles these past few months since King Gizzard and the Lizard Wizard has been off Spotify
Everybody Wants to Rule the Word
YouTube video by Release - Topic
www.youtube.com
November 21, 2025 at 4:56 PM
Reposted by Nicholas Mancuso
Last month I wrote about two new papers presenting the new Taiwan Precision Medicine Initiative (TPMI), a resource with genetic and EHR data from about half a million participants.
This was special as my mom went to NTU & worked in some of these medical centers. 🇹🇼
www.nature.com/articles/d41...
This was special as my mom went to NTU & worked in some of these medical centers. 🇹🇼
www.nature.com/articles/d41...
Taiwan invests in genetic resource for health
A large biobanking effort captures genetic and health data from half a million people in Taiwan, widening the diversity of genomes used to predict disease risk.
www.nature.com
November 20, 2025 at 9:03 PM
Last month I wrote about two new papers presenting the new Taiwan Precision Medicine Initiative (TPMI), a resource with genetic and EHR data from about half a million participants.
This was special as my mom went to NTU & worked in some of these medical centers. 🇹🇼
www.nature.com/articles/d41...
This was special as my mom went to NTU & worked in some of these medical centers. 🇹🇼
www.nature.com/articles/d41...
Reposted by Nicholas Mancuso
fav version of this
November 21, 2025 at 6:01 AM
fav version of this
Reposted by Nicholas Mancuso
It was a three-man team that took the Grok hardpoint that day, and two of us were just there to guard the poet.Whistler was a sonnet slinger fresh from the Guatemalan meter wars, still waking up with the taste of a bloody metonym on his tongue.
November 20, 2025 at 8:29 PM
It was a three-man team that took the Grok hardpoint that day, and two of us were just there to guard the poet.Whistler was a sonnet slinger fresh from the Guatemalan meter wars, still waking up with the taste of a bloody metonym on his tongue.
👇👇👇👇👇In light of some recent folks trying to find common ground with that bullshit NRO article
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
November 20, 2025 at 6:54 PM
👇👇👇👇👇In light of some recent folks trying to find common ground with that bullshit NRO article
Reposted by Nicholas Mancuso
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
November 19, 2025 at 9:48 PM
I really hate it when scientists keep saying that “we need to rebuild trust in science,” because it implies that scientists are to blame for the mistrust rather than the millions of dollars of dark money that have funded political attacks on science in order to advance a far right agenda.
Reposted by Nicholas Mancuso
squirrel: *points gun*
me: what do you want me to do?
squirrel: *gestures at sign*
me: alright, i get it *opens book drop*
squirrel: *makes hurry-up motion*
me: NOT A SQUIRREL!
squirrel: *disappears into book drop*
me: *whispers* forgive me, keith
me: what do you want me to do?
squirrel: *gestures at sign*
me: alright, i get it *opens book drop*
squirrel: *makes hurry-up motion*
me: NOT A SQUIRREL!
squirrel: *disappears into book drop*
me: *whispers* forgive me, keith
November 19, 2025 at 1:41 PM
squirrel: *points gun*
me: what do you want me to do?
squirrel: *gestures at sign*
me: alright, i get it *opens book drop*
squirrel: *makes hurry-up motion*
me: NOT A SQUIRREL!
squirrel: *disappears into book drop*
me: *whispers* forgive me, keith
me: what do you want me to do?
squirrel: *gestures at sign*
me: alright, i get it *opens book drop*
squirrel: *makes hurry-up motion*
me: NOT A SQUIRREL!
squirrel: *disappears into book drop*
me: *whispers* forgive me, keith
Reposted by Nicholas Mancuso
Me, a sane person: Surely you fascists can't blame *everything* on illegal immigration!
Fascist, cracking knuckles: Watch.
Fascist, cracking knuckles: Watch.
this defies parody. also helps explain why Sec Bessent bizarrely blamed immigrants when confronted with a question about high beef prices
November 20, 2025 at 5:26 PM
Me, a sane person: Surely you fascists can't blame *everything* on illegal immigration!
Fascist, cracking knuckles: Watch.
Fascist, cracking knuckles: Watch.
Reposted by Nicholas Mancuso
@hakha.bsky.social and I wrote a Research Briefing (with a lay summary + "behind the scenes") of our paper on how genes are prioritized by GWAS and rare variant burden tests. 🧬🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
How do genetic association studies rank genes?
Genome-wide association studies and rare-variant burden tests reveal complementary aspects of trait biology.
www.nature.com
November 19, 2025 at 6:43 PM
@hakha.bsky.social and I wrote a Research Briefing (with a lay summary + "behind the scenes") of our paper on how genes are prioritized by GWAS and rare variant burden tests. 🧬🧪
www.nature.com/articles/d41...
www.nature.com/articles/d41...
This is what really baffles me. These companies claim to not use input data for downstream training, but why should we believe them at all? They've consistently lied about this very aspect!
Why should we be hooking up sensitive systems to companies that are largely unregulated? This is insane
Why should we be hooking up sensitive systems to companies that are largely unregulated? This is insane
Intuit is integrating ChatGPT into their TurboTax, QuickBooks, Credit Karma, & Mailchimp services, & vice versa. Which is to say, I think a SHIT TON of people are about to get audited.
They also claiming no bleedover btwn your financial data & ChatGPT, which… okayy… 😬
www.cnbc.com/2025/11/18/i...
They also claiming no bleedover btwn your financial data & ChatGPT, which… okayy… 😬
www.cnbc.com/2025/11/18/i...
November 19, 2025 at 4:51 AM
This is what really baffles me. These companies claim to not use input data for downstream training, but why should we believe them at all? They've consistently lied about this very aspect!
Why should we be hooking up sensitive systems to companies that are largely unregulated? This is insane
Why should we be hooking up sensitive systems to companies that are largely unregulated? This is insane
I cannot emphasize enough that yall should be drinking sweet (but not too much sweet) vermouth with an olive and orange twist
November 19, 2025 at 3:46 AM
I cannot emphasize enough that yall should be drinking sweet (but not too much sweet) vermouth with an olive and orange twist
I believe you misheard me, being me ALL ur olives.
November 19, 2025 at 2:58 AM
I believe you misheard me, being me ALL ur olives.