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Reposted by Nicholas Mancuso

Anne Carpenter @drannecarpenter.bsky.social · 5h

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further

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Jessica Kant @jessdkant.bsky.social · 18h

So when I hear of students being encouraged to use GPT in college I don’t hear innovation. I hear cognitive atrophy, the inability to think critically for oneself, and total dependence on vulnerable centralized repositories of data for knowledge without ever understanding how knowledge is generated.

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Nicholas Mancuso @nmancuso.bsky.social · 3h

Just arrived this week direct from CSH. Looking forward to reading!

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John Greally @greally.bsky.social · 3h

My book on Epigenetics: History, Molecules and Diseases

www.amazon.com/Epigenetics-...

#EpigeneticsBook #Epigenetics

Epigenetics: History, Molecules, and Diseases

Buy Epigenetics: History, Molecules, and Diseases on Amazon.com ✓ FREE SHIPPING on qualified orders

www.amazon.com

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Reposted by Nicholas Mancuso

Human Genetics and Genomics Advances @hggadvances.bsky.social · 4h

Will you be at #ASHG25 next week? Come chat each day 3-4pm at ASHG Central!

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Nicholas Mancuso @nmancuso.bsky.social · 4h

YES LFG

CalMatters @calmatters.org · 6h

After weeks of waiting, California's governor signed a bill that will allow mid-rise apartment buildings near major transit stops in California's biggest metro areas. https://cal.news/4n3hzge

📝 @frombenc.bsky.social
📸 Ray Chavez

Passengers look on as a BART train didn’t stop at the Rockridge BART station due to a systemwide closure that affected all BART stations, in Oakland on March 9, 2025. Photo by Ray Chavez, Bay Area News Group

Hed: Breaking: Gov. Newsom signs massive California housing overhaul

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Reposted by Nicholas Mancuso

Kerstin Ludwig @kuludwig.bsky.social · 4h

I finally made (it on) my first cover 🤣 🥳!!
Congratulations to @hggadvances.bsky.social, and all my fellow co-editors, for establishing a great genomics journal. And to all authors: if your manuscript still needs a home, consider submitting with us. We would be delighted to handle your paper 🫶 💪.

Human Genetics and Genomics Advances @hggadvances.bsky.social · 1d

Our October issue is online!
Check out the amazing cover from @comfortandadam.bsky.social to commemorate 5 YEARS of HGG Advances!

www.cell.com/hgg-advances...

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Nicholas Mancuso @nmancuso.bsky.social · 6h

5 YEARS of HGG Advances! Mike, Jessica, Sara, and so many others have done such a fantastic job in shaping and expanding the journal.

Please consider submitting your work in genetics/genomics with us!

Human Genetics and Genomics Advances @hggadvances.bsky.social · 1d

Our October issue is online!
Check out the amazing cover from @comfortandadam.bsky.social to commemorate 5 YEARS of HGG Advances!

www.cell.com/hgg-advances...

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Reposted by Nicholas Mancuso

Alan Burdick @alanburdick.bsky.social · 1d

A new NYT as-told-to series, "Lost Science," documents the work of researchers who have lost their jobs or funding after cuts by the Trump administration. Share your story with us!

www.nytimes.com/2025/10/08/c...

Has Your Scientific Work Been Cut? We Want to Hear.

www.nytimes.com

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Jeffrey Ross-Ibarra @jrossibarra.bsky.social · 1d

PEQG website live! genetics-gsa.org/peqg-2026/

Homepage - 2026 Population, Evolutionary, and Quantitative Genetics Conference

Visit our website to learn more.

genetics-gsa.org

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Reposted by Nicholas Mancuso

Inigo Martincorena @imartincorena.bsky.social · 2d

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Somatic mutation and selection at population scale - Nature

A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

www.nature.com

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Nicholas Mancuso @nmancuso.bsky.social · 1d

Which bars, I need these bars

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Nicholas Mancuso @nmancuso.bsky.social · 2d

Tax incentives for folks who have children directly support those children bc, again, kids cannot work. Comparing children to owning property says more about you than any other weird links u try to dredge up

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Nicholas Mancuso @nmancuso.bsky.social · 2d

There was some standup that popped into my insta feed that was similar to this. "I wike peanut butter n beef. Wanna see my muscles?" Can't seem to find it, but the 6-year old voice sold it.

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Nicole Chung @nicolechung.bsky.social · 2d

Young lives cut short on an unimaginable scale: the 18,457 children on Gaza’s list of war dead

Every name on a list compiled by health authorities in Gaza of the child victims of Israel’s offensive

www.theguardian.com

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April Wei @aprilwei.bsky.social · 2d

Excited to preprint our latest work (w/ Drew DeHaas, Zhibai Jia, Leo Speidel) on using ARGs for demographic inference. w/ applications using data from 1000 Genomes Project. www.biorxiv.org/content/10.1...

Inference of complex demographic history using composite likelihood based on whole-genome genealogies

Accurate parametric inference on complex demographic models is a continuing challenge in population genetics. Ancestral recombination graphs (ARGs) provide richer information than simple population ge...

www.biorxiv.org

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Reposted by Nicholas Mancuso

April Wei @aprilwei.bsky.social · 2d

Method works from simple and complex scenarios in jointly estimating epoch time, population size, migration rate (symmetric or asymmetric), growth rate, and admixture proportion. Software integrated with msprime, demes, tsinfer/tsdate, relate, and singer. github.com/aprilweilab/...

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Nicholas Mancuso @nmancuso.bsky.social · 2d

Hey Tom, do children incur extra financial costs? Also, can children work? Thx.

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PUMPKIN SPICE SLUGGO @saintsluggo.bsky.social · 2d

Holy shit, AI can do my job after all. I work in retail and I lie to people all the time to make them stop bothering me.

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ghost malone ergo propter malone @proptermalone.bsky.social · 2d

New Normal Men! @golikehellmachine.com returns to tell us about Portland, we break down the shutdown, and @ed3d.net talks @rickywlmsbong.bsky.social into buying Hades 2.

Episode 27 - Frog in the Streets and a Freak in the Sheets

Podcast Episode · Normal Men · 10/08/2025 · 1h 2m

podcasts.apple.com

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Don Moynihan @donmoyn.bsky.social · 2d

The elimination of USAID is a moral atrocity and all involved made a choice to enable, and then lie about, ending the lives of some of the most vulnerable people in the world.

MAE SOT, Thailand (AP) - Mohammed Taher clutched the lifeless body of his 2-year-old son and wept. Ever since his family's food rations stopped arriving at their internment camp in Myanmar in April, the father had watched helplessly as his once-vibrant baby boy weakened, suffering from diarrhea and begging for food.
On May 21, exactly two weeks after Taher's little boy died, U.S. Secretary of State Marco Rubio sat before Congress and declared: "No one has died" because of his government's decision to gut its foreign aid program. Rubio also insisted: "No children are dying on my watch."
That, Taher says, "is a lie."

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Nicholas Mancuso @nmancuso.bsky.social · 3d

Right? The blog does an -excellent- job of walking through results.

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Nicholas Mancuso @nmancuso.bsky.social · 3d

This paper is bananas and shows there is still so much to be learned about gradient descent behavior. [ODEs are so hot right now]

centralflows.github.io

Understanding Optimization in Deep Learning with Central Flows

centralflows.github.io

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Nicholas Mancuso @nmancuso.bsky.social · 3d

Yesterday's Academic Senate meeting was amazing. Zoom was at capacity, and once I was finally able to join, I was met with a unified front and consistent message from faculty. We fully reject this compact!

I'm sure the board of trustees will recc the right decision

www.latimes.com/california/s...

USC faculty members denounce Trump compact that would shift university to the right

The USC Academic Senate held a special meeting to discuss the Trump administration's education compact, which was presented to the school last week.

www.latimes.com

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Reposted by Nicholas Mancuso

Siva @sivav.bsky.social · 3d

I wrote about the “compact” for higher education

newrepublic.com/article/2013...

Why This Essay Could Cause the University of Virginia to Shut Down

How Linda McMahon’s latest “compact” would do deep and permanent harm to American higher education

newrepublic.com

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