Ralph Abraham did not publicly respond to a whooping cough outbreak in Louisiana earlier this year for 2 months.

The US now has almost 1,800 measles cases.

Researchers at the SFU Faculty of Health Sciences surveyed Canadian Long COVID patients, and found that many people with the condition consider virtual care "lifesaving and essential," while also noti...

Long COVID, or postacute sequelae of COVID-19 from SARS-CoV-2 infection, is a persistent debilitating disease affecting multiple systems and organs. Long COVID pathophysiology is a complex and not fully established process. One prevailing theory is that the formation of fibrin amyloid microclots (fibrinaloids), due to SARS-CoV-2 infection, can induce persistent inflammation and capillary blockage. An association between the amyloidogenic Spike protein of SARS-CoV-2 and impaired fibrinolysis was made when it was observed that fibrin clots formed in the presence of a mixture of amyloid fibrils from the spike protein mediated resistance to plasmin lysis. Here, we use purified components from the coagulation cascade to investigate the molecular processes of impaired fibrinolysis using seven amyloidogenic SARS-COV-2 Spike peptides. Five of seven Spike amyloid fibrils appeared not to substantially interfere with the fibrinogen–fibrin–fibrinolysis process in vitro, while two spike fibrils were active in different ways. Spike601 amyloid fibrils (sequence 601–620) impaired thrombin-mediated fibrin formation by binding and sequestering fibrinogen but did not affect fibrinolysis. On the contrary, fibrin clots formed in the presence of Spike685 amyloid fibrils (sequence 685–701) exhibited a marked resistance to plasmin-mediated fibrinolysis. We conclude that Spike685 amyloid fibrils can induce dense fibrin clot networks as well as incorporate fibrin into aggregated structures that resist fibrinolysis. Our study proposes a molecular mechanism for how the Spike protein of SARS-CoV-2 could contribute to the formation of fibrinolysis-resistant microclots observed in long COVID.

The US now has almost 1,800 measles cases.

The current Surgeon General of Louisiana has made headlines recently, including for allegedly burying a whooping cough outbreak.

The head of the Center for Communicable Disease Control at the Iranian Health Ministry has warned of a high-speed spread of Influenza A, H3N2 subtype, noting that the virus has undergone some changes ...

Long COVID has exposed both the limits of current clinical science and the challenges of pharmaceutical strategy

Researchers discover spike protein can shift states and hide from antibodies.

Public Comments to the CDC’s ACIP vaccine committee closes Monday, Nov 24 at 11:59 pm EST. Children must be protected from infectious diseases through access to vaccines.

A recording from Jeremy Faust, MD's live video

CDC ACIP’s December meeting: demand vaccines.

Long COVID has exposed both the limits of current clinical science and the challenges of pharmaceutical strategy

Five years later, the greatest basic science failure in generations caused the pandemic harms highlighted by people across the political spectrum, and broke our social cohesion.

Despite having plagued humans for millennia, typhoid fever is rarely considered a threat in developed countries today.