RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
@aribio.bsky.social
In Ribosome we Trust!!!
Ferreira-Cerca group at the Structural Biology of the Cell laboratory (BIOC) @CNRS / @École polytechnique
More information available at https://ferreiracercalab.com/
#archaea #Ribosome #RNA
Ferreira-Cerca group at the Structural Biology of the Cell laboratory (BIOC) @CNRS / @École polytechnique
More information available at https://ferreiracercalab.com/
#archaea #Ribosome #RNA
Pinned
RNase W, a conserved ribonuclease family with a novel active site
Abstract. Ribosome biogenesis is a complex process requiring multiple precursor ribosomal RNA (rRNA) cleavage steps. In archaea, the full set of ribonuclea
academic.oup.com
Check out our latest publication: academic.oup.com/nar/advance-...
#archaea #ribosome #RNA #Ribonuclease
#archaea #ribosome #RNA #Ribonuclease
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Our paper is out! Analysis of 30K+ genomes revealed that CPR bacteria assemble their ribosomes in unconventional ways, and that these assembly processes appear to have co-evolved with ribosome structure. doi.org/10.1093/molb... #Ribosome #Evolution #Patescibacteria #MBE
November 24, 2025 at 1:15 PM
Our paper is out! Analysis of 30K+ genomes revealed that CPR bacteria assemble their ribosomes in unconventional ways, and that these assembly processes appear to have co-evolved with ribosome structure. doi.org/10.1093/molb... #Ribosome #Evolution #Patescibacteria #MBE
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Histones and nucleoid-associated proteins in Methanosarcina acetivorans mediate recovery from stress and stasis https://www.biorxiv.org/content/10.1101/2025.11.24.690127v1
November 25, 2025 at 3:17 AM
Histones and nucleoid-associated proteins in Methanosarcina acetivorans mediate recovery from stress and stasis https://www.biorxiv.org/content/10.1101/2025.11.24.690127v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Computational design of cysteine proteases https://www.biorxiv.org/content/10.1101/2025.11.21.689808v1
November 22, 2025 at 2:45 PM
Computational design of cysteine proteases https://www.biorxiv.org/content/10.1101/2025.11.21.689808v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Our study on ribonucleotides incorporation the genomes of Haloferax volcanii and Thermococcus barophilus is new published in #NAR #ribonucleasesH
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Validate User
academic.oup.com
November 22, 2025 at 11:01 AM
Our study on ribonucleotides incorporation the genomes of Haloferax volcanii and Thermococcus barophilus is new published in #NAR #ribonucleasesH
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
An archaeal genetic code with all TAG codons as pyrrolysine www.science.org/doi/abs/10.1... #jcampubs
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
www.science.org
November 21, 2025 at 4:20 PM
An archaeal genetic code with all TAG codons as pyrrolysine www.science.org/doi/abs/10.1... #jcampubs
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
November 19, 2025 at 11:22 PM
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Hundred-Picolitre Droplet on Demand Tape Drive and XES Prototypes for Time-Resolved Serial Crystallography at VMXi, Diamond Light Source https://www.biorxiv.org/content/10.1101/2025.11.19.689295v1
November 20, 2025 at 3:53 PM
Hundred-Picolitre Droplet on Demand Tape Drive and XES Prototypes for Time-Resolved Serial Crystallography at VMXi, Diamond Light Source https://www.biorxiv.org/content/10.1101/2025.11.19.689295v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Equipositioning of Chromosomes in the Polyploid Archaeon Haloferax volcanii by HpaAB https://www.biorxiv.org/content/10.1101/2025.11.19.689047v1
November 19, 2025 at 4:18 PM
Equipositioning of Chromosomes in the Polyploid Archaeon Haloferax volcanii by HpaAB https://www.biorxiv.org/content/10.1101/2025.11.19.689047v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases www.science.org/doi/abs/10.1... #jcampubs
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
www.science.org
November 13, 2025 at 8:58 PM
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases www.science.org/doi/abs/10.1... #jcampubs
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Thermophiles don’t just survive heat, they thrive in it. 🔥
They provide heat-stable enzymes, insights into early Earth, and tools for biotech.
Our new thematic issue in #FEMSMicrobiolEcol captures how diverse this field is. Explore the collection👉 buff.ly/kD8fmOL
They provide heat-stable enzymes, insights into early Earth, and tools for biotech.
Our new thematic issue in #FEMSMicrobiolEcol captures how diverse this field is. Explore the collection👉 buff.ly/kD8fmOL
November 14, 2025 at 7:00 AM
Thermophiles don’t just survive heat, they thrive in it. 🔥
They provide heat-stable enzymes, insights into early Earth, and tools for biotech.
Our new thematic issue in #FEMSMicrobiolEcol captures how diverse this field is. Explore the collection👉 buff.ly/kD8fmOL
They provide heat-stable enzymes, insights into early Earth, and tools for biotech.
Our new thematic issue in #FEMSMicrobiolEcol captures how diverse this field is. Explore the collection👉 buff.ly/kD8fmOL
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Phylogenetic reconciliation supports a methanogenic ancestor of the Archaea and a derived origin for host-associated lineages https://www.biorxiv.org/content/10.1101/2025.11.11.687807v1
November 12, 2025 at 11:32 PM
Phylogenetic reconciliation supports a methanogenic ancestor of the Archaea and a derived origin for host-associated lineages https://www.biorxiv.org/content/10.1101/2025.11.11.687807v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
The halophilic archaeon Halogranum roseipondis sp. nov. is susceptible to a virus carrying an exceptionally high number of viral tRNA genes https://www.biorxiv.org/content/10.1101/2025.11.07.687168v1
November 8, 2025 at 2:18 AM
The halophilic archaeon Halogranum roseipondis sp. nov. is susceptible to a virus carrying an exceptionally high number of viral tRNA genes https://www.biorxiv.org/content/10.1101/2025.11.07.687168v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
The SPATA5-SPATA5L1-CINP-C1ORF109 complex is essential for cytoplasmic pre-60S ribosome maturation https://www.biorxiv.org/content/10.1101/2025.11.07.687187v1
November 8, 2025 at 2:45 AM
The SPATA5-SPATA5L1-CINP-C1ORF109 complex is essential for cytoplasmic pre-60S ribosome maturation https://www.biorxiv.org/content/10.1101/2025.11.07.687187v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
The evolution lifecycle of ribosome hibernation factors https://www.biorxiv.org/content/10.1101/2025.11.04.686544v1
November 5, 2025 at 1:18 AM
The evolution lifecycle of ribosome hibernation factors https://www.biorxiv.org/content/10.1101/2025.11.04.686544v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
In @nature.com: Using AI and other cutting-edge techniques, the Klinge lab has captured the first near-continuous "molecular movie" of ribosome formation—revealing, frame by frame, how cells build the protein factories that make life possible.
More here: https://bit.ly/3LbHTaF
More here: https://bit.ly/3LbHTaF
October 29, 2025 at 5:22 PM
In @nature.com: Using AI and other cutting-edge techniques, the Klinge lab has captured the first near-continuous "molecular movie" of ribosome formation—revealing, frame by frame, how cells build the protein factories that make life possible.
More here: https://bit.ly/3LbHTaF
More here: https://bit.ly/3LbHTaF
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Transcription profiling and functional analysis of spRNAs and their corresponding asRNAs in Methanosarcina mazei https://www.biorxiv.org/content/10.1101/2025.10.28.685009v1
October 29, 2025 at 2:18 AM
Transcription profiling and functional analysis of spRNAs and their corresponding asRNAs in Methanosarcina mazei https://www.biorxiv.org/content/10.1101/2025.10.28.685009v1
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying
it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing
modifications to support...
www.cell.com
October 27, 2025 at 1:19 PM
How to become a "hot RNA" 🌡️? The answers were kindly provided by hyperthermophilic archaea: rRNA modifications are key! Check out this new publication presenting pan-modification profiling of the epitranscriptome. www.cell.com/cell/fulltex.... (1/3)
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome #rnasky #microsky www.cell.com/cell/abstrac...
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying
it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing
modifications to support...
www.cell.com
October 25, 2025 at 7:52 AM
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome #rnasky #microsky www.cell.com/cell/abstrac...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
Amazing paper from collaborators Schraga Schwartz and Moran Shalev-Benami at Weizmann. Nucleotide resolution sequencing of 16 RNA modifications from diverse organisms cultured under basal and 'extreme' conditions + enzymology, structure, synthesis, and biophysics.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying
it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing
modifications to support...
www.cell.com
October 24, 2025 at 5:20 PM
Amazing paper from collaborators Schraga Schwartz and Moran Shalev-Benami at Weizmann. Nucleotide resolution sequencing of 16 RNA modifications from diverse organisms cultured under basal and 'extreme' conditions + enzymology, structure, synthesis, and biophysics.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by RNA & Ribosome Homeostasis Lab @École Polytechnique / @CNRS
WE ARE BACK!!! Archaea Power Hour will return this coming WEDNESDAY, Oct. 22nd at 10AM EST/4PM CET. Check your email for the Zoom link (coming soon) or register here: forms.gle/6QvCjHH2H4pxro…. Take a look at the exciting talks we have planned to kick off our fall seminar series:
October 17, 2025 at 3:50 PM
WE ARE BACK!!! Archaea Power Hour will return this coming WEDNESDAY, Oct. 22nd at 10AM EST/4PM CET. Check your email for the Zoom link (coming soon) or register here: forms.gle/6QvCjHH2H4pxro…. Take a look at the exciting talks we have planned to kick off our fall seminar series: