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BSI Midlands @bsi-midlands.bsky.social · Jun 20

It's today! Our #BSIMidlands25 kicks off with an overview of the history of clinical immunology in the Midlands by Dr Aarnoud Huissoon

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The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · Jun 19

We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...

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James Thaventhiran @thav-lab.bsky.social · Jun 19

Honoured to receive this prize alongside an inspiring group of scientists. This will support our work to improve mRNA therapies for precision medicine. #mRNA #immunoSky #Science

The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · Jun 19

We are very proud to introduce our brand new 2025 #ListerFellows! This year there are eight Prize recipients. lister-institute.org.uk/a-warm-welco...

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Bending Lab UK @bendinglab.bsky.social · May 15

Lovely work!

Worboys Lab @worboyslab.bsky.social · May 14

Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.

#ImmunoSky

www.biorxiv.org/content/10.1...

Inhibitory TIGIT signalling is dependent on T cell receptor activation

TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...

www.biorxiv.org

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Bending Lab UK @bendinglab.bsky.social · May 12

PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social

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Damian Maseda @dmaseda.bsky.social · May 12

Congrats to the team! Very nice study. I find it especially interesting that blocking NFAT can compensate for the effects of anti-PD1/LAG3.

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Bending Lab UK @bendinglab.bsky.social · May 12

Thank you! Yes, we have only largely looked at a few markers in the functional assays. I think as our model is very TCR signal driven (tolerogenic) it suggests it may more preferentially signal down that pathway. In terms of under co-stimulation or CD8 biology, we have not yet looked!

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Bending Lab UK @bendinglab.bsky.social · May 12

#immunosky 🧪

Bending Lab UK @bendinglab.bsky.social · May 12

We are now seeking to understand relevance of these pathways are relevant in the immune related adverse events (irAEs) space and tumour environment!

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Bending Lab UK @bendinglab.bsky.social · May 12

PD1 & Lag3 regulate TCR signal duration in tolerant CD4 T cells
•PD-1 & Lag3 exhibit layered control of CD4 T cell activation
•Co-blockade enhances NFAT-dependent TCR transcription
•NFAT inhibition reverses functional effects of anti-PD-1&Lag3
doi.org/10.1093/immadv/ltaf015
@imtadvances.bsky.social

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Eva Frickel @frickellab.bsky.social · Apr 13

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥
Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5)

Please share!

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The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · Apr 14

Our new blog post spotlights the Lister Institute's ties with @unibirmingham.bsky.social, home to Lister Fellows past and present @bendinglab.bsky.social @agagambus.bsky.social @sarahdimeloe.bsky.social sky.social @therad-lab.bsky.social @tunglejic.bsky.social lister-institute.org.uk/shining-a-li...

Shining a light on the Lister Institute’s connection to the University of Birmingham – Lister Institute

lister-institute.org.uk

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Sarah Ross @sarahhross.bsky.social · Apr 11

#Immunology out now @science.org

After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen.

buff.ly/49bKcTG

By Jobin, Seetharama, Rüttger et al.

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Rebecca Drummond 🍄 @therad-lab.bsky.social · Apr 11

Check out latest work from @bendinglab.bsky.social - new insights into IFNg regulation of TCR signalling! 🧪 #immunosky

Bending Lab UK @bendinglab.bsky.social · Apr 11

Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development

www.cell.com/iscience/ful...

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Bending Lab UK @bendinglab.bsky.social · Apr 11

#immunosky 🧪

Bending Lab UK @bendinglab.bsky.social · Apr 11

Highlights:
- A single high dose of modified self-peptide induces Tr1 cells
-Tr1 cell development is positively regulated by IFNγ
- Anti-IFNγ treatment reduces markers of strong TCR signaling and Tr1 cell frequency
- Blocking IL-27 in combination with anti-IFNγ additively reduces Tr1 cell frequency

Figure 4 from paper shows how anti-IFNg reduces markers of TCR signal strength and attenuates Tr1 cell differentiation in the Tg4 model

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Bending Lab UK @bendinglab.bsky.social · Apr 11

Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development

www.cell.com/iscience/ful...

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Waggoner Lab @labwaggoner.bsky.social · Apr 8

Noncanonical T cell responses are associated with protection from tuberculosis in mice and humans
@jem.org
rupress.org/jem/article-...

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The Lister Institute of Preventive Medicine @thelisterinstitute.bsky.social · Apr 8

A new paper from #ListerFellow @linterman.bsky.social and colleagues explores the role of tertiary lymphoid structures (TLS) in #bcell immune response. @pnas.org doi.org/10.1073/pnas...

Lung B cells in ectopic germinal centers undergo affinity maturation | PNAS

The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and...

doi.org

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Lizzy Rosser @bcellsrosser.bsky.social · Mar 28

What better way to get into that Friday feeling than reading our new paper? First author @hlpeks.bsky.social and I will be doing a tutorial on @arrdept-ucldom.bsky.social next Tuesday lunchtime for those who are interested in reading the highlights 📖

Journal of Experimental Medicine @jem.org · Mar 28

Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in humans with an XX chromosomal background. From @hlpeks.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin et al. rupress.org/jem/article/...

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Journal of Experimental Medicine @jem.org · Mar 28

Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in humans with an XX chromosomal background. From @hlpeks.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin et al. rupress.org/jem/article/...

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Fränze Progatzky @franzeprogatzky.bsky.social · Jan 23

📣 New Review Alert!

Do you think glial cells are simply neuronal support cells in the CNS?

Did you know glial cells are integral to barrier organs?

Check out our latest review exploring the fascinating crosstalk between glia and immune cells in the gut, lung and skin!
#GlialCells #ImmuneSystem

Mucosal Immunology @mucosalimmunol.bsky.social · Jan 9

Glial-immune interactions in barrier organs are reviewed by @franzeprogatzky.bsky.social and colleagues:
www.mucosalimmunology.org/article/S193...

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Daniel Utzschneider @danielutzschneider.bsky.social · Jan 31

Excited for our lab's FIRST paper #ScienceImmunology! 🎉

Led by @categraca.bsky.social & Amania Sheikh, with amazing collabs from Axel Kallies, Dane Newman, & @rickyjohnstone.bsky.social

Huge thanks to reviewers & @claireolingy.bsky.social 🙌

#Tpex #onthescoreboard

www.science.org/doi/full/10....

Stem-like memory and precursors of exhausted T cells share a common progenitor defined by ID3 expression

ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.

www.science.org

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Otto Balsiger @obalsiger.bsky.social · Jan 16

The BSI has grants available for our members who want to help get more people excited about #immunology

British Society for Immunology @britsocimm.bsky.social · Jan 16

Our Communication and Engagement Grant is open to all BSI members who want to take part in #PublicEngagement 🌟

Share your passion, build skills, and make a difference to the world of #immunology 💪

Application deadline: 1 Feb 2025 🗓️

Apply now 👉 bit.ly/3Y9j8gm

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MRC AIM DTP @mrcaimdtp.bsky.social · Jan 7

⏰ Last few days before the deadline of midday (GMT) Friday 10 January if you are thinking of applying for one of our Medical Research Council fully funded 4 year PhD studentships at our partner institutions @uniofnottingham.bsky.social @unibirmingham.bsky.social or University of Leicester 🧵

PhD Opportunities – MRC AIM

more.bham.ac.uk

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