Doug Dyer
@douglaspdyer.bsky.social
Immune cell recruitment, glycocalyx, chemokines and extracellular matrix at the Manchester Centre for Cell Matrix research and Lydia Becker Institute for Immunology he/him
https://www.wellcome-matrix.org/people/doug-dyer/
#glycotime
https://www.wellcome-matrix.org/people/doug-dyer/
#glycotime
Pinned
Doug Dyer
@douglaspdyer.bsky.social
· Nov 20
Airway macrophage specific expression of a dense glycocalyx and its remodelling following viral infection
The glycocalyx is best studied for its regulation of immune cell trafficking from the vasculature into inflamed tissues. The glycocalyx is composed of a range of glycans and glyco-proteins that form a...
www.biorxiv.org
Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...
Reposted by Doug Dyer
Prof Sheena Cruickshank @sheencr.bsky.social offers insight in The Guardian @theguardian.com on the science behind sneezing and what it reveals about our health #ImmunoSky
www.theguardian.com/society/2026...
www.theguardian.com/society/2026...
The sneeze secret: how much should you worry about this explosive reflex?
It is one of the most powerful involuntary actions the human body can perform. But is a big sneeze a sign of illness, pollution or something else entirely?
www.theguardian.com
February 10, 2026 at 11:26 AM
Prof Sheena Cruickshank @sheencr.bsky.social offers insight in The Guardian @theguardian.com on the science behind sneezing and what it reveals about our health #ImmunoSky
www.theguardian.com/society/2026...
www.theguardian.com/society/2026...
Reposted by Doug Dyer
You still have time to apply if you are interested in joining my lab!!
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
CELL MIGRATION LAB
We study cell migration in health and disease
cellmig.org
February 6, 2026 at 10:43 AM
You still have time to apply if you are interested in joining my lab!!
Reposted by Doug Dyer
Been on multiple search committees
For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read
For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read
You can read more about that experience here: www.nature.com/articles/s41...
Preprints as tools to advance careers - Nature Reviews Cancer
The practice of posting preprint manuscripts on servers such as bioRxiv has become increasingly common. In this Comment, Hindle and Sever explore the utility of preprints for advancing researchers…
www.nature.com
February 5, 2026 at 8:05 PM
Been on multiple search committees
For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read
For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read
Very excited to announce that registration is open for the BSMB Spring 2026 meeting in Manchester, April 13-14th. Already an amazing lineup and lots of opportunities to speak!
Register, bsmb.ac.uk/meetings/ecm... @mcrcellmatrix.bsky.social
Register, bsmb.ac.uk/meetings/ecm... @mcrcellmatrix.bsky.social
ECM biology across tissue sites. Location, location, location
bsmb.ac.uk
February 5, 2026 at 4:02 PM
Very excited to announce that registration is open for the BSMB Spring 2026 meeting in Manchester, April 13-14th. Already an amazing lineup and lots of opportunities to speak!
Register, bsmb.ac.uk/meetings/ecm... @mcrcellmatrix.bsky.social
Register, bsmb.ac.uk/meetings/ecm... @mcrcellmatrix.bsky.social
Reposted by Doug Dyer
Introducing the amazing Dr Lily Koumbas Foley 🥰📚👩🎓 @crgglasgow.bsky.social @uofgsii.bsky.social
February 4, 2026 at 8:22 PM
Introducing the amazing Dr Lily Koumbas Foley 🥰📚👩🎓 @crgglasgow.bsky.social @uofgsii.bsky.social
Reposted by Doug Dyer
Dr Alexander Clarke @ajclarke.bsky.social joins us from
@ox.ac.uk tomorrow to give a talk entitled:
“Powering the germinal centre reaction"
📆 Thursday 5th Feb
🕛 12:00 PM
📍 Michael Smith Lecture Theatre
@britsocimm.bsky.social MIG Seminar #ImmunoSky
@ox.ac.uk tomorrow to give a talk entitled:
“Powering the germinal centre reaction"
📆 Thursday 5th Feb
🕛 12:00 PM
📍 Michael Smith Lecture Theatre
@britsocimm.bsky.social MIG Seminar #ImmunoSky
February 4, 2026 at 6:02 PM
Dr Alexander Clarke @ajclarke.bsky.social joins us from
@ox.ac.uk tomorrow to give a talk entitled:
“Powering the germinal centre reaction"
📆 Thursday 5th Feb
🕛 12:00 PM
📍 Michael Smith Lecture Theatre
@britsocimm.bsky.social MIG Seminar #ImmunoSky
@ox.ac.uk tomorrow to give a talk entitled:
“Powering the germinal centre reaction"
📆 Thursday 5th Feb
🕛 12:00 PM
📍 Michael Smith Lecture Theatre
@britsocimm.bsky.social MIG Seminar #ImmunoSky
Reposted by Doug Dyer
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships to join our friendly & collaborative environment, in areas related to gene expression, mechanistic cell biology & cancer biology.
For more info 👇
sheffield.ac.uk/biosciences/...
For more info 👇
sheffield.ac.uk/biosciences/...
January 30, 2026 at 1:52 PM
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships to join our friendly & collaborative environment, in areas related to gene expression, mechanistic cell biology & cancer biology.
For more info 👇
sheffield.ac.uk/biosciences/...
For more info 👇
sheffield.ac.uk/biosciences/...
Reposted by Doug Dyer
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
January 28, 2026 at 5:45 PM
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
Reposted by Doug Dyer
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 21, 2026 at 6:06 PM
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Doug Dyer
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
CELL MIGRATION LAB
We study cell migration in health and disease
cellmig.org
January 21, 2026 at 7:57 AM
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs).
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬
Details in thread 🧵👇
#ScienceSky #Postdoc #AcademicJobs Please RT🫶
Reposted by Doug Dyer
Out now in @natchembio.nature.com: Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 🎉 www.nature.com/articles/s41... check out the press release below! #glycotime
January 20, 2026 at 11:08 AM
Out now in @natchembio.nature.com: Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 🎉 www.nature.com/articles/s41... check out the press release below! #glycotime
Reposted by Doug Dyer
Have you ever wondered how many N-Glycans or #glycoproteins there are on cells?
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
January 15, 2026 at 3:39 PM
Have you ever wondered how many N-Glycans or #glycoproteins there are on cells?
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
Reposted by Doug Dyer
#Glycans probably have more "copies/cell" than #proteins and changes in #glycosylation could potentially be remarkable biomarkers for diseases as well as targets for therapeutics. This post explores the abundance of glycans on the cell surface and it is worth a read to recognize these #biomolecules.
Have you ever wondered how many N-Glycans or #glycoproteins there are on cells?
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell!
Read the full blog post: research.bidmc.org/ncfg/blog/24...
#glycobiology #glycotime #cells #biology
January 15, 2026 at 3:52 PM
#Glycans probably have more "copies/cell" than #proteins and changes in #glycosylation could potentially be remarkable biomarkers for diseases as well as targets for therapeutics. This post explores the abundance of glycans on the cell surface and it is worth a read to recognize these #biomolecules.
Reposted by Doug Dyer
Really looking forward to speaking (for the 3rd year!) at the British Society for Immunology (@britsocimm.bsky.social) Foundations of Immunology course on 18 March 🧬
A brilliant one-day online course covering core immunology for all backgrounds 🧪
Register 👉 www.immunology.org/training/Fou...
A brilliant one-day online course covering core immunology for all backgrounds 🧪
Register 👉 www.immunology.org/training/Fou...
January 14, 2026 at 11:08 AM
Really looking forward to speaking (for the 3rd year!) at the British Society for Immunology (@britsocimm.bsky.social) Foundations of Immunology course on 18 March 🧬
A brilliant one-day online course covering core immunology for all backgrounds 🧪
Register 👉 www.immunology.org/training/Fou...
A brilliant one-day online course covering core immunology for all backgrounds 🧪
Register 👉 www.immunology.org/training/Fou...
Reposted by Doug Dyer
🚨 Job Alert! 🚨
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028
abo.rekrytointi.com
January 15, 2026 at 2:04 PM
🚨 Job Alert! 🚨
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
We have an opening at our Microscopy Core Facility in Turku 🇫🇮.
If you love imaging 🔬 and helping scientists succeed, we want you! 👇
abo.rekrytointi.com/paikat/index...
#Microscopy #ScienceJobs #CoreFacility #Imaging
@turkubioscience.bsky.social
Reposted by Doug Dyer
🥳 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐥𝐚𝐭𝐞𝐬𝐭 𝐰𝐨𝐫𝐤 𝐬𝐡𝐨𝐰𝐢𝐧𝐠 𝐡𝐨𝐰 𝐩𝐨𝐥𝐲𝐬𝐢𝐚𝐥𝐲𝐥𝐚𝐭𝐢𝐨𝐧, 𝐚 𝐫𝐚𝐫𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐦𝐨𝐝𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧, 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐦𝐨𝐧𝐨𝐜𝐲𝐭𝐞 𝐦𝐨𝐛𝐢𝐥𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐛𝐨𝐧𝐞 𝐦𝐚𝐫𝐫𝐨𝐰.
✍️ Aurélien Boyancé, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social
📖 shorturl.at/IDwza
👇 A short thread...
✍️ Aurélien Boyancé, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social
📖 shorturl.at/IDwza
👇 A short thread...
January 13, 2026 at 6:20 AM
🥳 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐥𝐚𝐭𝐞𝐬𝐭 𝐰𝐨𝐫𝐤 𝐬𝐡𝐨𝐰𝐢𝐧𝐠 𝐡𝐨𝐰 𝐩𝐨𝐥𝐲𝐬𝐢𝐚𝐥𝐲𝐥𝐚𝐭𝐢𝐨𝐧, 𝐚 𝐫𝐚𝐫𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐦𝐨𝐝𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧, 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐦𝐨𝐧𝐨𝐜𝐲𝐭𝐞 𝐦𝐨𝐛𝐢𝐥𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐛𝐨𝐧𝐞 𝐦𝐚𝐫𝐫𝐨𝐰.
✍️ Aurélien Boyancé, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social
📖 shorturl.at/IDwza
👇 A short thread...
✍️ Aurélien Boyancé, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social
📖 shorturl.at/IDwza
👇 A short thread...
Reposted by Doug Dyer
Our lab is hiring a PhD student to investigate how glycans affect antitumor immune responses in metastases and how this can be modulated to improve immunotherapy! More info here 👇
#glycotime
werkenbij.amsterdamumc.org/en/vacatures...
#glycotime
werkenbij.amsterdamumc.org/en/vacatures...
Vacatures - PhD tumor immunology of peritoneal metastasis - Amsterdam UMC
Colorectal cancer with peritoneal metastases has a particularly poor prognosis. In this KWF-funded project, you will investigate how glycan structures affect immune responses in peritoneal metastasis and whether glycan inhibition can restore anti-tumor immunity.
werkenbij.amsterdamumc.org
January 6, 2026 at 12:40 PM
Our lab is hiring a PhD student to investigate how glycans affect antitumor immune responses in metastases and how this can be modulated to improve immunotherapy! More info here 👇
#glycotime
werkenbij.amsterdamumc.org/en/vacatures...
#glycotime
werkenbij.amsterdamumc.org/en/vacatures...
Reposted by Doug Dyer
Delighted to share the latest paper from the lab
"Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers"
Amazing work driven by @follainga.bsky.social with contributions from many.
link.springer.com/article/10.1...
"Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers"
Amazing work driven by @follainga.bsky.social with contributions from many.
link.springer.com/article/10.1...
Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers - The EMBO Journal
The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an i...
link.springer.com
January 6, 2026 at 11:42 AM
Delighted to share the latest paper from the lab
"Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers"
Amazing work driven by @follainga.bsky.social with contributions from many.
link.springer.com/article/10.1...
"Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers"
Amazing work driven by @follainga.bsky.social with contributions from many.
link.springer.com/article/10.1...
Reposted by Doug Dyer
Don't miss out on your chance to attend "Fuelling the immune response IV: #UKimmunometabolismMeeting2026"
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Fuelling the immune response IV: UK immunometabolism meeting 2026 | British Society for Immunology
www.immunology.org
January 6, 2026 at 3:02 PM
Don't miss out on your chance to attend "Fuelling the immune response IV: #UKimmunometabolismMeeting2026"
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science
📆16-17th April
www.immunology.org/events/fuell...
Reposted by Doug Dyer
Major update for unilectin.unige.ch with now more than 2800 3D-structures with annotation, literature and details of interaction!! HumanLectome also up to date. Thanks to Boris Schnider at @sib.swiss and @glycoexpasy.bsky.social for super work. More exciting news soon with LectomeXplore upgrade
December 18, 2025 at 9:48 AM
Major update for unilectin.unige.ch with now more than 2800 3D-structures with annotation, literature and details of interaction!! HumanLectome also up to date. Thanks to Boris Schnider at @sib.swiss and @glycoexpasy.bsky.social for super work. More exciting news soon with LectomeXplore upgrade
Reposted by Doug Dyer
Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
www.nature.com
December 16, 2025 at 3:01 PM
Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
Reposted by Doug Dyer
🏆 Huge congratulations to our Director Professor Tracy Hussell @tracyh9494.bsky.social who has been awarded the Nature 2025 Lifetime Achievement Award for Mentoring in Science for her exceptional support of emerging scientists.
#ImmunoSky @nature.com
sites.manchester.ac.uk/lydia-becker...
#ImmunoSky @nature.com
sites.manchester.ac.uk/lydia-becker...
Professor Tracy Hussell Receives Nature Lifetime Achievement Award for Mentoring in Science
Professor Tracy Hussell receives the 2025 Nature Lifetime Achievement Award for Mentoring in Science, recognising her outstanding support of early-career researchers.
sites.manchester.ac.uk
December 10, 2025 at 1:38 PM
🏆 Huge congratulations to our Director Professor Tracy Hussell @tracyh9494.bsky.social who has been awarded the Nature 2025 Lifetime Achievement Award for Mentoring in Science for her exceptional support of emerging scientists.
#ImmunoSky @nature.com
sites.manchester.ac.uk/lydia-becker...
#ImmunoSky @nature.com
sites.manchester.ac.uk/lydia-becker...
Reposted by Doug Dyer
Beautiful talk by Matt Hepworth, so many exciting things happening at barrier surfaces. @hepworth-lab.bsky.social #BSI2025 @britsocimm.bsky.social @lydiabeckeriii.bsky.social
December 4, 2025 at 3:18 PM
Beautiful talk by Matt Hepworth, so many exciting things happening at barrier surfaces. @hepworth-lab.bsky.social #BSI2025 @britsocimm.bsky.social @lydiabeckeriii.bsky.social
