Doug Dyer
@douglaspdyer.bsky.social
Immune cell recruitment, glycocalyx, chemokines and extracellular matrix at the Manchester Centre for Cell Matrix research and Lydia Becker Institute for Immunology he/him
https://www.wellcome-matrix.org/people/doug-dyer/
#glycotime
https://www.wellcome-matrix.org/people/doug-dyer/
#glycotime
Pinned
Airway macrophage specific expression of a dense glycocalyx and its remodelling following viral infection
The glycocalyx is best studied for its regulation of immune cell trafficking from the vasculature into inflamed tissues. The glycocalyx is composed of a range of glycans and glyco-proteins that form a...
www.biorxiv.org
Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...
Reposted by Doug Dyer
🧬 A new study by Dr Alex Eckersley and @tracyh9494.bsky.social uncovers why severe viral infections can cause long-term breathlessness & fatigue.
Damage to the lung’s basement membrane may persist long after recovery - offering new targets for future therapies.
#ImmunoSky
tinyurl.com/2zddsj63
Damage to the lung’s basement membrane may persist long after recovery - offering new targets for future therapies.
#ImmunoSky
tinyurl.com/2zddsj63
Study unravels puzzle of how viruses can cause long-term lung damage
Researchers at The University of Manchester reveal how severe viral infections like flu and long COVID cause long-term lung damage by disrupting basement membranes, offering new targets for future the...
tinyurl.com
November 26, 2025 at 6:41 PM
🧬 A new study by Dr Alex Eckersley and @tracyh9494.bsky.social uncovers why severe viral infections can cause long-term breathlessness & fatigue.
Damage to the lung’s basement membrane may persist long after recovery - offering new targets for future therapies.
#ImmunoSky
tinyurl.com/2zddsj63
Damage to the lung’s basement membrane may persist long after recovery - offering new targets for future therapies.
#ImmunoSky
tinyurl.com/2zddsj63
Reposted by Doug Dyer
🔬 New research led by @douglaspdyer.bsky.social shows that CCR2-mediated monocyte recruitment is essential for limiting radiotherapy-induced intestinal toxicity - pointing to new strategies for reducing off-target tissue damage. @cruk-mi.bsky.social #ImmunoSky #Cancer #RadNet
tinyurl.com/34uu4nr9
tinyurl.com/34uu4nr9
Key Immune Cells Found to Protect the Gut During Radiotherapy
New research reveals how CCR2-driven monocyte recruitment protects the gut from radiotherapy damage, offering potential pathways to reduce treatment side effects.
tinyurl.com
November 26, 2025 at 7:43 PM
🔬 New research led by @douglaspdyer.bsky.social shows that CCR2-mediated monocyte recruitment is essential for limiting radiotherapy-induced intestinal toxicity - pointing to new strategies for reducing off-target tissue damage. @cruk-mi.bsky.social #ImmunoSky #Cancer #RadNet
tinyurl.com/34uu4nr9
tinyurl.com/34uu4nr9
Reposted by Doug Dyer
Reposted by Doug Dyer
Last stretch for these positions, as the deadline for this is on Sunday!
employment.ku.dk/faculty/?sho...
Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Postdoc at the Copenhagen Center for Glycocalyx Research at the Department of Cellular and Molecular Medicine
employment.ku.dk
November 25, 2025 at 4:02 AM
Last stretch for these positions, as the deadline for this is on Sunday!
Reposted by Doug Dyer
Hello #glycotime! GlycoShape makes its debut on bsky today 🦋🎉 Follow us for news, updates and fun-facts (I take full responsibility for those, Ojas @ojas-singh.bsky.social 😆) below ⬇️
Hello bsky 🦋 GlycoShape is now here to give you updates on our glycan 3D database, toolbox, glyco fun-facts and news!
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
We just updated server, so clear your browser's cache, and build some glycoproteins with us 🍬
We'll have great new tools coming up soon, so follow us for some exciting #glycotime
a close up of a feather on a rock with the words `` hello '' written in white letters .
ALT: a close up of a feather on a rock with the words `` hello '' written in white letters .
media.tenor.com
November 24, 2025 at 4:53 PM
Hello #glycotime! GlycoShape makes its debut on bsky today 🦋🎉 Follow us for news, updates and fun-facts (I take full responsibility for those, Ojas @ojas-singh.bsky.social 😆) below ⬇️
Reposted by Doug Dyer
Love a story where the environment wins the argument every single time
This is also an elegant dissection of how the microenvironment cues, differentiation pathways, and inflammatory signals converge to shape the glycocalyx
Thanks for sharing @douglaspdyer.bsky.social
This is also an elegant dissection of how the microenvironment cues, differentiation pathways, and inflammatory signals converge to shape the glycocalyx
Thanks for sharing @douglaspdyer.bsky.social
November 22, 2025 at 7:03 PM
Love a story where the environment wins the argument every single time
This is also an elegant dissection of how the microenvironment cues, differentiation pathways, and inflammatory signals converge to shape the glycocalyx
Thanks for sharing @douglaspdyer.bsky.social
This is also an elegant dissection of how the microenvironment cues, differentiation pathways, and inflammatory signals converge to shape the glycocalyx
Thanks for sharing @douglaspdyer.bsky.social
Reposted by Doug Dyer
Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...
Airway macrophage specific expression of a dense glycocalyx and its remodelling following viral infection
The glycocalyx is best studied for its regulation of immune cell trafficking from the vasculature into inflamed tissues. The glycocalyx is composed of a range of glycans and glyco-proteins that form a...
www.biorxiv.org
November 20, 2025 at 8:13 PM
Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...
Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...
Airway macrophage specific expression of a dense glycocalyx and its remodelling following viral infection
The glycocalyx is best studied for its regulation of immune cell trafficking from the vasculature into inflamed tissues. The glycocalyx is composed of a range of glycans and glyco-proteins that form a...
www.biorxiv.org
November 20, 2025 at 8:13 PM
Delighted to share our new pre-print from PhD student Ziyun Zhang joint with @tracyh9494.bsky.social demonstrating that lung alveolar macrophages have a dense glycocalyx and interstitial macrophages do not, @mcrcellmatrix.bsky.social @lydiabeckeriii.bsky.social www.biorxiv.org/content/10.1...
Reposted by Doug Dyer
Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair
Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammatio…
www.sciencedirect.com
November 19, 2025 at 5:09 PM
Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Doug Dyer
- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
Are you looking for a postdoc?
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
I will be looking for 2-4 people after the summer to join the lab !!
Do not hesitate to reach out and disseminate !!
July 1, 2025 at 4:46 AM
- A postdoc to work on cancer extravasation (4-year project).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
- A postdoc help in completing Filopodia-related lab projects (2-year).
- Multiple Marie Curie postdoc positions that will open in the fall.
- We will open a 5-year position to cover my teaching (70% research and 30% teaching).
Reposted by Doug Dyer
Less than 3 weeks until our final report launch event
9th Dec. (London) 10am
We will be welcoming a fantastic panel:
🌟Jo O'Leary (UKRI)
🌟Sara Mole (UCL)
🌟John Tregoning (Imperial)
🌟Katie Perry (Daphne Trust)
🌟Jennie Evans (BSI)
🌟Ilaria Meazzini (RSC)
Register here: www.carersinstemm.co.uk
9th Dec. (London) 10am
We will be welcoming a fantastic panel:
🌟Jo O'Leary (UKRI)
🌟Sara Mole (UCL)
🌟John Tregoning (Imperial)
🌟Katie Perry (Daphne Trust)
🌟Jennie Evans (BSI)
🌟Ilaria Meazzini (RSC)
Register here: www.carersinstemm.co.uk
November 19, 2025 at 8:52 AM
Less than 3 weeks until our final report launch event
9th Dec. (London) 10am
We will be welcoming a fantastic panel:
🌟Jo O'Leary (UKRI)
🌟Sara Mole (UCL)
🌟John Tregoning (Imperial)
🌟Katie Perry (Daphne Trust)
🌟Jennie Evans (BSI)
🌟Ilaria Meazzini (RSC)
Register here: www.carersinstemm.co.uk
9th Dec. (London) 10am
We will be welcoming a fantastic panel:
🌟Jo O'Leary (UKRI)
🌟Sara Mole (UCL)
🌟John Tregoning (Imperial)
🌟Katie Perry (Daphne Trust)
🌟Jennie Evans (BSI)
🌟Ilaria Meazzini (RSC)
Register here: www.carersinstemm.co.uk
Reposted by Doug Dyer
Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field.
1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis
2. Proteins are a source of glycans found in preparations of glycoRNA
1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis
2. Proteins are a source of glycans found in preparations of glycoRNA
#glycotime We hope our b2b publications serve as a heads-up for the #glycoRNA community, and drive the field forward constructively. Links👇
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
Kim et al. rdcu.be/eP4GQ
@nathanaelbkegel.bsky.social Kegel et al. nature.com/articles/s12276-025-01575-1 (Stefan Bauer lab)
November 17, 2025 at 8:35 AM
Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field.
1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis
2. Proteins are a source of glycans found in preparations of glycoRNA
1. RNA-associated glycoconjugates highlight potential
ambiguities in glycoRNA analysis
2. Proteins are a source of glycans found in preparations of glycoRNA
Reposted by Doug Dyer
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
November 12, 2025 at 10:16 AM
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
Reposted by Doug Dyer
Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!
employment.ku.dk/faculty/?sho...
Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Hi all! We’re hiring at our brand new Center for Glycocalyx Research, across all areas - but I am also looking for postdocs to join my group specifically!
Postdoc at the Copenhagen Center for Glycocalyx Research at the Department of Cellular and Molecular Medicine
employment.ku.dk
November 11, 2025 at 8:38 AM
Another bump for the postdoc and PhD positions still open at the center and postdoc specifically within my group (same link to apply). We’re looking for wet/dry lab, and I’m specifically after people who do magic with computers!
Reposted by Doug Dyer
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
#Biochemistry #Trafficking #CellSignaling #Wnt
November 10, 2025 at 7:45 PM
B4GALT1 and Wntless collaborate to block LRP5/6 translocation from #Golgi to cell surface, say Xinyang Li, Yue Hua, Xiaoqing Gan and colleagues (Fudan University): rupress.org/jcb/article/...
#Biochemistry #Trafficking #CellSignaling #Wnt
#Biochemistry #Trafficking #CellSignaling #Wnt
Reposted by Doug Dyer
Don’t miss this work on CCR2 monocyte recruitment from @douglaspdyer.bsky.social and colleagues - online now! www.mucosalimmunology.org/article/S193...
November 10, 2025 at 1:52 PM
Don’t miss this work on CCR2 monocyte recruitment from @douglaspdyer.bsky.social and colleagues - online now! www.mucosalimmunology.org/article/S193...
Reposted by Doug Dyer
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
November 5, 2025 at 2:01 PM
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
Well done @nabinapun.bsky.social getting your Radnet @cruk-mi.bsky.social @lydiabeckeriii.bsky.social @mcrcnews.bsky.social @mcrcellmatrix.bsky.social PhD work out
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
November 10, 2025 at 2:59 PM
Well done @nabinapun.bsky.social getting your Radnet @cruk-mi.bsky.social @lydiabeckeriii.bsky.social @mcrcnews.bsky.social @mcrcellmatrix.bsky.social PhD work out
Reposted by Doug Dyer
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...
What Rosalind Franklin truly contributed to the discovery of DNA’s structure
Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.
www.nature.com
November 8, 2025 at 7:32 AM
If you believe either that Franklin discovered the double helix, and / or Watson and Crick stole her data, ask yourself how you know this. Then take a read of this article.
Reposted by Doug Dyer
It’s a new immunology 101 to brighten your weekend cos your weekend can’t get started until you have marvelled over monoclonal antibodies. Its a reach I know but still hope you find time to read and enjoy 🧪
Immunology 101: Monoclonal antibodies
What monoclonals are and how we use them therapeutically.
open.substack.com
November 7, 2025 at 6:42 PM
It’s a new immunology 101 to brighten your weekend cos your weekend can’t get started until you have marvelled over monoclonal antibodies. Its a reach I know but still hope you find time to read and enjoy 🧪
Reposted by Doug Dyer
New findings in #ScienceSignaling show that cells called leukocytes have a surface “coating” that can be modified during inflammatory conditions, such as #psoriasis, revealing how immune cells are recruited to sites of inflammation. https://scim.ag/4osBp5U
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.
scim.ag
November 7, 2025 at 4:00 PM
New findings in #ScienceSignaling show that cells called leukocytes have a surface “coating” that can be modified during inflammatory conditions, such as #psoriasis, revealing how immune cells are recruited to sites of inflammation. https://scim.ag/4osBp5U
Thanks so much for inviting me, it was a great day and a particularly impressive group of students!!
Day 2 of the Matrix Biology PhD course and we’re in the new Fælleshuset building starting our group work brain storming. Thanks to @douglaspdyer.bsky.social and @tranejoan.bsky.social for laying the foundations of ECM biology in yesterday’s lectures!
November 6, 2025 at 7:59 AM
Thanks so much for inviting me, it was a great day and a particularly impressive group of students!!
Reposted by Doug Dyer
Day 2 of the Matrix Biology PhD course and we’re in the new Fælleshuset building starting our group work brain storming. Thanks to @douglaspdyer.bsky.social and @tranejoan.bsky.social for laying the foundations of ECM biology in yesterday’s lectures!
November 6, 2025 at 7:54 AM
Day 2 of the Matrix Biology PhD course and we’re in the new Fælleshuset building starting our group work brain storming. Thanks to @douglaspdyer.bsky.social and @tranejoan.bsky.social for laying the foundations of ECM biology in yesterday’s lectures!
Reposted by Doug Dyer
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.
www.science.org
November 4, 2025 at 10:35 PM
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
Reposted by Doug Dyer
Don’t miss this week’s issue of #ScienceSignaling!
New discoveries about an enigmatic, cancer-linked mutation could redefine understanding of the kinome, a study reveals how immune cells are recruited to inflammatory sites in psoriasis, and more. https://scim.ag/3LkFGtC
New discoveries about an enigmatic, cancer-linked mutation could redefine understanding of the kinome, a study reveals how immune cells are recruited to inflammatory sites in psoriasis, and more. https://scim.ag/3LkFGtC
November 4, 2025 at 10:00 PM
Don’t miss this week’s issue of #ScienceSignaling!
New discoveries about an enigmatic, cancer-linked mutation could redefine understanding of the kinome, a study reveals how immune cells are recruited to inflammatory sites in psoriasis, and more. https://scim.ag/3LkFGtC
New discoveries about an enigmatic, cancer-linked mutation could redefine understanding of the kinome, a study reveals how immune cells are recruited to inflammatory sites in psoriasis, and more. https://scim.ag/3LkFGtC