Bryan Yipp
@bryanyipp.bsky.social
MD trained scientist. Intensivist. Immunologist. Neutrophil biologist.
www.yipplab.com
www.yipplab.com
Pinned
Bryan Yipp
@bryanyipp.bsky.social
· May 30
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Sensory innervation impacts several lung diseases, but whether it influences pulmonary
fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors
leads to worsening of inflamm...
www.cell.com
Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Reposted by Bryan Yipp
I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research!
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
Hidalgo Lab | Mapping Innate Immunity
Research on neutrophil biology, innate immunity, and cardiovascular disease at Yale School of Medicine. Led by Dr. Andrés Hidalgo.
ahidalgolab.com
February 7, 2026 at 3:59 PM
I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research!
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
ahidalgolab.com
Thank you to Gerardo Barcia for his beautiful design and constant support in building it
Reposted by Bryan Yipp
Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
On the balance of knowledge - Nature Reviews Immunology
Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems.
www.nature.com
February 6, 2026 at 2:31 AM
Too much data, too little thinking.
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
A important essay from Ruslan Medzhitov on the importance of understanding data, not just generating it. A must read.
@Yale
www.nature.com/articles/s41...
Reposted by Bryan Yipp
13% success rates at #CIHR, is a really 87% fail rate for>4000 scientists. At a time when 🇨🇦 is investing millions to recruit more scientist into a broken funding environment. 🇨🇦, U need a strong science foundation 2 attract success. #CIHR, fix your science foundation, it is eroding in real time
February 3, 2026 at 11:13 PM
Reposted by Bryan Yipp
Really sorry to hear that reviewers are abusing people with diseases. Hiding behind a screen does not take courage. It is cowardice. Bully tactics.
Sad commentary on the quality of reviewers. In person review panels hold reviewers accountable.
#CIHR being back in person review panels.
Sad commentary on the quality of reviewers. In person review panels hold reviewers accountable.
#CIHR being back in person review panels.
Reviewer#3, when applicant details life threatening disease(s) as reason 4 delayed productivity, you don't have 2 point out "concern 4 lack of productivity, though applicant has had health concerns".
This comment is evil.
Empathy is a sign of humanity. Do better!
#CIHR being back F-2-F reviews.
This comment is evil.
Empathy is a sign of humanity. Do better!
#CIHR being back F-2-F reviews.
February 4, 2026 at 12:51 AM
Really sorry to hear that reviewers are abusing people with diseases. Hiding behind a screen does not take courage. It is cowardice. Bully tactics.
Sad commentary on the quality of reviewers. In person review panels hold reviewers accountable.
#CIHR being back in person review panels.
Sad commentary on the quality of reviewers. In person review panels hold reviewers accountable.
#CIHR being back in person review panels.
Reposted by Bryan Yipp
We are deeply saddened by the passing of Professor Sir Nicholas White @moru-mip.bsky.social
Nick was a visionary in #malaria treatment whose work transformed global health.
He will be remembered with great respect and affection
Read our tribute 👉 www.tropicalmedicine.ox.ac.uk/news/profess...
Nick was a visionary in #malaria treatment whose work transformed global health.
He will be remembered with great respect and affection
Read our tribute 👉 www.tropicalmedicine.ox.ac.uk/news/profess...
February 3, 2026 at 12:20 PM
We are deeply saddened by the passing of Professor Sir Nicholas White @moru-mip.bsky.social
Nick was a visionary in #malaria treatment whose work transformed global health.
He will be remembered with great respect and affection
Read our tribute 👉 www.tropicalmedicine.ox.ac.uk/news/profess...
Nick was a visionary in #malaria treatment whose work transformed global health.
He will be remembered with great respect and affection
Read our tribute 👉 www.tropicalmedicine.ox.ac.uk/news/profess...
Reposted by Bryan Yipp
Cell is hiring!
Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social
Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social
Scientific Editor, Cell
Cell has an opening for a full-time scientific editor. If you are a passionate, mission-driven team player who loves thinking broadly about science and wants to have a positive impact, we invite you t...
nam11.safelinks.protection.outlook.com
February 3, 2026 at 8:27 PM
Cell is hiring!
Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social
Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social
Reposted by Bryan Yipp
Over 100 years ago, platelets were observed to interact with neutrophils in blood clots
Eric Boilard & team now detail platelet-neutrophil interactions as more abundant in arthritic conditions, noting that neutrophils fail to migrate in the absence of platelets: doi.org/10.1172/JCI1...
Eric Boilard & team now detail platelet-neutrophil interactions as more abundant in arthritic conditions, noting that neutrophils fail to migrate in the absence of platelets: doi.org/10.1172/JCI1...
February 3, 2026 at 12:15 PM
Over 100 years ago, platelets were observed to interact with neutrophils in blood clots
Eric Boilard & team now detail platelet-neutrophil interactions as more abundant in arthritic conditions, noting that neutrophils fail to migrate in the absence of platelets: doi.org/10.1172/JCI1...
Eric Boilard & team now detail platelet-neutrophil interactions as more abundant in arthritic conditions, noting that neutrophils fail to migrate in the absence of platelets: doi.org/10.1172/JCI1...
Reposted by Bryan Yipp
I’ve joined the editorial team at the journal Science, handling papers in infectious diseases, microbiology, host-microbe interactions, and related topics. I’ll be delighted to hear from you (by email) about exciting research studies. 🦠 #microsky #immunosky #virosky www.science.org/content/page...
Meet the Editors
Meet the Editors
www.science.org
February 2, 2026 at 5:30 PM
I’ve joined the editorial team at the journal Science, handling papers in infectious diseases, microbiology, host-microbe interactions, and related topics. I’ll be delighted to hear from you (by email) about exciting research studies. 🦠 #microsky #immunosky #virosky www.science.org/content/page...
Reposted by Bryan Yipp
Pain-sensing neurons in the intestines play an important role in defending the body from threats.
New study led by the Artis Lab at @weillcornell.bsky.social shows TRPV1+ nociceptors in the gut activate tuft cells, leading to expulsion of parasites.
🔗 https://go.nature.com/4jTvO7k
New study led by the Artis Lab at @weillcornell.bsky.social shows TRPV1+ nociceptors in the gut activate tuft cells, leading to expulsion of parasites.
🔗 https://go.nature.com/4jTvO7k
January 29, 2026 at 5:55 PM
Pain-sensing neurons in the intestines play an important role in defending the body from threats.
New study led by the Artis Lab at @weillcornell.bsky.social shows TRPV1+ nociceptors in the gut activate tuft cells, leading to expulsion of parasites.
🔗 https://go.nature.com/4jTvO7k
New study led by the Artis Lab at @weillcornell.bsky.social shows TRPV1+ nociceptors in the gut activate tuft cells, leading to expulsion of parasites.
🔗 https://go.nature.com/4jTvO7k
Reposted by Bryan Yipp
In 1943, Rockefeller’s Oswald Avery, Colin MacLeod, and Maclyn McCarty demonstrated that #DNA carries an organism’s genetic information. Their discovery launched a scientific revolution that’s placed genetics at the core of modern biomedical science.
#125YearsOfRockefeller
#125YearsOfRockefeller
January 23, 2026 at 8:35 PM
In 1943, Rockefeller’s Oswald Avery, Colin MacLeod, and Maclyn McCarty demonstrated that #DNA carries an organism’s genetic information. Their discovery launched a scientific revolution that’s placed genetics at the core of modern biomedical science.
#125YearsOfRockefeller
#125YearsOfRockefeller
Reposted by Bryan Yipp
Why do some people become severely ill from infections that leave others unscathed?
go.nature.com/457vTOK
go.nature.com/457vTOK
The infection enigma: why some people die from typically harmless germs
Millions of people worldwide carry genetic mutations that weaken their immune system.
go.nature.com
January 14, 2026 at 12:49 PM
Why do some people become severely ill from infections that leave others unscathed?
go.nature.com/457vTOK
go.nature.com/457vTOK
Reposted by Bryan Yipp
@cp-immunity.bsky.social preview of IRF4-driven circuit that reshapes alveolar macrophage identity and positions them as contributors to allergic pathophysiology
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
January 13, 2026 at 6:01 PM
@cp-immunity.bsky.social preview of IRF4-driven circuit that reshapes alveolar macrophage identity and positions them as contributors to allergic pathophysiology
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
www.cell.com/immunity/ful...
Reposted by Bryan Yipp
In the strain on scientific publishing, we showed that total publications have grown out of control. A huge part of that was guest edited special issues by groups like #MDPI and #Frontiers.
This ongoing practice is the largest delegation of editorial power academia has ever seen.
2/n
This ongoing practice is the largest delegation of editorial power academia has ever seen.
2/n
The strain on scientific publishing
Abstract. Scientists are increasingly overwhelmed by the volume of articles being published. The total number of articles indexed in Scopus and Web of Science has grown exponentially in recent years; ...
direct.mit.edu
January 13, 2026 at 8:27 AM
In the strain on scientific publishing, we showed that total publications have grown out of control. A huge part of that was guest edited special issues by groups like #MDPI and #Frontiers.
This ongoing practice is the largest delegation of editorial power academia has ever seen.
2/n
This ongoing practice is the largest delegation of editorial power academia has ever seen.
2/n
Reposted by Bryan Yipp
💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons
Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...
doi.org
January 5, 2026 at 5:50 PM
💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
Reposted by Bryan Yipp
The abstract deadline for #Type2Immunity26 in Ghent, co-organized by @vibtrainconf.bsky.social and #ScienceImmunology, is this Thursday, 8 January.
Learn more: vibbio.tech/3UwmTNk
Key dates:
🗓️26 January: Early-bird deadline
🗓️23 February: Final deadline
🗓️9–10 March: Meeting
Learn more: vibbio.tech/3UwmTNk
Key dates:
🗓️26 January: Early-bird deadline
🗓️23 February: Final deadline
🗓️9–10 March: Meeting
January 5, 2026 at 7:14 PM
The abstract deadline for #Type2Immunity26 in Ghent, co-organized by @vibtrainconf.bsky.social and #ScienceImmunology, is this Thursday, 8 January.
Learn more: vibbio.tech/3UwmTNk
Key dates:
🗓️26 January: Early-bird deadline
🗓️23 February: Final deadline
🗓️9–10 March: Meeting
Learn more: vibbio.tech/3UwmTNk
Key dates:
🗓️26 January: Early-bird deadline
🗓️23 February: Final deadline
🗓️9–10 March: Meeting
The silent pneumonia: Biofilms and the neurons that should feel them
open.substack.com/pub/ansyme/p...
open.substack.com/pub/ansyme/p...
The silent pneumonia: Biofilms and the neurons that should feel them
The pneumonia your neurons can’t detect
open.substack.com
January 5, 2026 at 7:46 PM
The silent pneumonia: Biofilms and the neurons that should feel them
open.substack.com/pub/ansyme/p...
open.substack.com/pub/ansyme/p...
Reposted by Bryan Yipp
I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca
December 12, 2025 at 4:40 PM
I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca
Reposted by Bryan Yipp
What are #Neutrophils? why are there so many? how are they shaped by disease? how is it that they maintain memory despite their short lifespan?
Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇
authors.elsevier.com/a/1mFj9L7PXu...
Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇
authors.elsevier.com/a/1mFj9L7PXu...
authors.elsevier.com
December 11, 2025 at 8:39 PM
What are #Neutrophils? why are there so many? how are they shaped by disease? how is it that they maintain memory despite their short lifespan?
Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇
authors.elsevier.com/a/1mFj9L7PXu...
Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇
authors.elsevier.com/a/1mFj9L7PXu...
Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages: Immunity www.cell.com/immunity/ful...
Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages
Monocyte-derived macrophages are highly plastic, whereas tissue-resident macrophages
resist inflammatory reprogramming. Verwaerde et al. show that tissue-resident alveolar
macrophages can be reprogram...
www.cell.com
December 11, 2025 at 4:16 PM
Innate type 2 lymphocytes trigger an inflammatory switch in alveolar macrophages: Immunity www.cell.com/immunity/ful...
Anakinra restores immunological misfiring that drives influenza-associated pulmonary aspergillosis | Science Translational Medicine www.science.org/doi/10.1126/...
Anakinra restores immunological misfiring that drives influenza-associated pulmonary aspergillosis
IL-1 receptor antagonism alleviates immunological dysregulation that drives influenza-associated pulmonary aspergillosis in mice.
www.science.org
December 4, 2025 at 4:44 PM
Anakinra restores immunological misfiring that drives influenza-associated pulmonary aspergillosis | Science Translational Medicine www.science.org/doi/10.1126/...
Reposted by Bryan Yipp
Today, we see the fruit of 5+ years of teamwork. We have built a map of the neutrophil compartment (mostly in mice - but also humans). It provides a biological structure that focuses on a single immune cell lineage to discover the many ways in which neutrophils "interpret" physiology.
I’m thrilled to introduce you to the NeuMap! our latest work [email protected]. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour de force www.nature.com/articles/s41...
Architecture of the neutrophil compartment - Nature
Mapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and ...
www.nature.com
December 3, 2025 at 6:57 PM
Today, we see the fruit of 5+ years of teamwork. We have built a map of the neutrophil compartment (mostly in mice - but also humans). It provides a biological structure that focuses on a single immune cell lineage to discover the many ways in which neutrophils "interpret" physiology.
Reposted by Bryan Yipp
December 3, 2025 at 8:39 PM