Nayan Arora
@captainchloride.bsky.social
Associate Professor and APD @pdxkidney.bsky.social | Cardiorenal enthusiast | Whisky drinker, runner, dad | Filtrate on Freely Filtered 🎙️
Pinned
Nayan Arora
@captainchloride.bsky.social
· Nov 17
When was the last time you were paged about a serum Cl- level? Probably never.
Despite being the most abundant anion in the body, Cl- is under appreciated
🔥Here’s why it matters (esp in heart failure!)
#tweetorial #medtwitter #nephtwitter #cardiotwitter #NSMC
Despite being the most abundant anion in the body, Cl- is under appreciated
🔥Here’s why it matters (esp in heart failure!)
#tweetorial #medtwitter #nephtwitter #cardiotwitter #NSMC
Reposted by Nayan Arora
as far as I know the fish oil craze started with bad math over an Icelandic or Greenland study, and has been a cesspit of bad science since then and this finding reminds me of what my mom said:
if it is to good to be true, it is
if it is to good to be true, it is
November 8, 2025 at 12:50 AM
as far as I know the fish oil craze started with bad math over an Icelandic or Greenland study, and has been a cesspit of bad science since then and this finding reminds me of what my mom said:
if it is to good to be true, it is
if it is to good to be true, it is
Reposted by Nayan Arora
Agreed - already have some proactive DMI folks on Finerenone - has been safe and lowers proteinuria in my hands
November 7, 2025 at 8:13 PM
Agreed - already have some proactive DMI folks on Finerenone - has been safe and lowers proteinuria in my hands
We are 2 for 2 with positive trials so far. LIBERATE-D shows benefit with a conservative vs conventional dialysis strategy in AKI-D. The difference in mortality is concerning though? Simultaneous pub 👇🏾 #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
November 7, 2025 at 5:10 PM
We are 2 for 2 with positive trials so far. LIBERATE-D shows benefit with a conservative vs conventional dialysis strategy in AKI-D. The difference in mortality is concerning though? Simultaneous pub 👇🏾 #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Shocking first high impact trial of the day. Fish oil reduces CV events in dialysis patients! #Pisces #kidneywk
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
November 7, 2025 at 4:45 PM
Shocking first high impact trial of the day. Fish oil reduces CV events in dialysis patients! #Pisces #kidneywk
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Simultaneous pub in NEJM
www.nejm.org/doi/full/10....
Reposted by Nayan Arora
For finerenone in type 1 DKD I think albuminuria is OK
For Atacicept - this is preliminary data which gets them accelerated FDA approval and a few months of making 💰until the GFR slope analysis comes through?
#KidneyWk
For Atacicept - this is preliminary data which gets them accelerated FDA approval and a few months of making 💰until the GFR slope analysis comes through?
#KidneyWk
November 6, 2025 at 8:57 PM
For finerenone in type 1 DKD I think albuminuria is OK
For Atacicept - this is preliminary data which gets them accelerated FDA approval and a few months of making 💰until the GFR slope analysis comes through?
#KidneyWk
For Atacicept - this is preliminary data which gets them accelerated FDA approval and a few months of making 💰until the GFR slope analysis comes through?
#KidneyWk
Reposted by Nayan Arora
While I agree, here in Australia the drugs will not get funded by the govt without the harder endpoints unless of course the price is okay which of course is not going to happen. It’s exciting to see all these new therapeutics but unless the cost comes down I doubt we will see them in Australia soon
November 6, 2025 at 8:41 PM
While I agree, here in Australia the drugs will not get funded by the govt without the harder endpoints unless of course the price is okay which of course is not going to happen. It’s exciting to see all these new therapeutics but unless the cost comes down I doubt we will see them in Australia soon
@sophia-kidney.bsky.social is working really hard at this conference #kidneywk
November 6, 2025 at 7:37 PM
@sophia-kidney.bsky.social is working really hard at this conference #kidneywk
@sophia-kidney.bsky.social got shoved into a corner by ASN but well
worth the trek to check out her poster and try out abcKidney #kidneywk
worth the trek to check out her poster and try out abcKidney #kidneywk
November 6, 2025 at 4:58 PM
@sophia-kidney.bsky.social got shoved into a corner by ASN but well
worth the trek to check out her poster and try out abcKidney #kidneywk
worth the trek to check out her poster and try out abcKidney #kidneywk
Small trial of lysine chloride in euvolemic patients with heart failure. Median furosemide dose was 80mg. Chloride supplementation reduced plasma volume and improved diuretic response. Interesting but maybe not the population I would use it in? #kidneywk
November 6, 2025 at 4:07 PM
Small trial of lysine chloride in euvolemic patients with heart failure. Median furosemide dose was 80mg. Chloride supplementation reduced plasma volume and improved diuretic response. Interesting but maybe not the population I would use it in? #kidneywk
We have a new therapy for type 1 diabetes! FINE-ONE with significant proteinuria reduction compared to placebo on a background of RASi with an acceptable safety profile. Where’s the simultaneous pub?? Sglt2 inhibitors are next…#kidneywk
November 6, 2025 at 3:26 PM
We have a new therapy for type 1 diabetes! FINE-ONE with significant proteinuria reduction compared to placebo on a background of RASi with an acceptable safety profile. Where’s the simultaneous pub?? Sglt2 inhibitors are next…#kidneywk
Interim analysis of atacicept (dual BAFF/APRIL inhibitor) shows successful proteinuria reduction vs placebo. Also reduced Gd-IgA1 levels. Adding to the IgA armamentarium. Simultaneous pub 👇🏾 #kidneywk
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
November 6, 2025 at 3:21 PM
Interim analysis of atacicept (dual BAFF/APRIL inhibitor) shows successful proteinuria reduction vs placebo. Also reduced Gd-IgA1 levels. Adding to the IgA armamentarium. Simultaneous pub 👇🏾 #kidneywk
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Reposted by Nayan Arora
New episode of Freely Filtered with @brendonneuen.bsky.social @hswapnil.medsky.social @captainchloride.bsky.social @sophia-kidney.bsky.social and author Muth Vaduganathan discussing the CONVINCE trial
www.nephjc.com/freelyfilter...
With chapters, refs, and pictures
www.nephjc.com/freelyfilter...
With chapters, refs, and pictures
October 21, 2025 at 12:11 PM
New episode of Freely Filtered with @brendonneuen.bsky.social @hswapnil.medsky.social @captainchloride.bsky.social @sophia-kidney.bsky.social and author Muth Vaduganathan discussing the CONVINCE trial
www.nephjc.com/freelyfilter...
With chapters, refs, and pictures
www.nephjc.com/freelyfilter...
With chapters, refs, and pictures
Reposted by Nayan Arora
Going to add this to my lecture slides.
August 26, 2025 at 6:05 PM
Going to add this to my lecture slides.
Interesting diuretic resistance study. Adunctive thiazides take the lead over loop intensification? Nice discussion on mechanisms of DR, both practical and hypothetical. #nephsky
journals.lww.com/jasn/abstrac...
journals.lww.com/jasn/abstrac...
Loop Diuretic Dose Intensification versus Adjuvant Thiazide ... : Journal of the American Society of Nephrology
g diuretic resistance mechanism could optimize diuretic response.
Methods:
Patients hospitalized with heart failure and diuretic resistance (6-hour cumulative natriuresis <100 mmol after IV loop di...
journals.lww.com
September 17, 2025 at 8:15 PM
Interesting diuretic resistance study. Adunctive thiazides take the lead over loop intensification? Nice discussion on mechanisms of DR, both practical and hypothetical. #nephsky
journals.lww.com/jasn/abstrac...
journals.lww.com/jasn/abstrac...
Reposted by Nayan Arora
Latest episode of @freelyfiltered.bsky.social is live! This one on the two RCTs of DDAVP to prevent renal biopsy bleeding. We had special guest Vandana Niyyar join us. @medpeedskidneys.bsky.social @captainchloride.bsky.social
www.nephjc.com/freelyfilter...
www.nephjc.com/freelyfilter...
FF 82 DDAVP up the nose to prevent biopsy bleeding — NephJC
Nasal DDAVP to prevent bleeding complications from renal biopsy, the results of two randoized, placebo controlled, trials.
www.nephjc.com
August 8, 2025 at 3:13 PM
Latest episode of @freelyfiltered.bsky.social is live! This one on the two RCTs of DDAVP to prevent renal biopsy bleeding. We had special guest Vandana Niyyar join us. @medpeedskidneys.bsky.social @captainchloride.bsky.social
www.nephjc.com/freelyfilter...
www.nephjc.com/freelyfilter...
Thank you to @asnpublications.bsky.social #JASN for letting us write this. Important topic that's unfortunately devoid of robust data for many of our patients. #nephsky
journals.lww.com/jasn/abstrac...
journals.lww.com/jasn/abstrac...
Remote Measurement of Volume Status in Heart Failure : Journal of the American Society of Nephrology
ed with telemedicine services, have failed to improve outcomes. Implantable hemodynamic monitors allow clinicians to obtain meaningful, objective data, with an opportunity for early intervention to im...
journals.lww.com
August 6, 2025 at 4:26 PM
Thank you to @asnpublications.bsky.social #JASN for letting us write this. Important topic that's unfortunately devoid of robust data for many of our patients. #nephsky
journals.lww.com/jasn/abstrac...
journals.lww.com/jasn/abstrac...
Interesting study in pts w/T1D w/ or w/out flozins and comp. With healthy controls. Less glomerulomegaly on routine biopsies. Flozins impacted metabolic transcripts throughout the nephron - ie the effect wasn’t isolated to the proximal tubule. Showing they are powerful metabolic drugs. #nephsky
July 21, 2025 at 10:08 PM
Interesting study in pts w/T1D w/ or w/out flozins and comp. With healthy controls. Less glomerulomegaly on routine biopsies. Flozins impacted metabolic transcripts throughout the nephron - ie the effect wasn’t isolated to the proximal tubule. Showing they are powerful metabolic drugs. #nephsky
If you're applying to a Nephrology fellowship, let @glaucomflecken.bsky.social tell you why you need to come to @pdxkidney.bsky.social. Then let us tell you what makes it such a great and unique training program! #nephsky
July 17, 2025 at 4:41 PM
If you're applying to a Nephrology fellowship, let @glaucomflecken.bsky.social tell you why you need to come to @pdxkidney.bsky.social. Then let us tell you what makes it such a great and unique training program! #nephsky
Congratulations to all our incredible graduating fellows! Excited to see what comes next for these wonderful individuals.
June 19, 2025 at 8:40 PM
Reposted by Nayan Arora
ICYMI
@captainchloride.bsky.social on the art of decongestion in heart failure
Embracing hypercreatininemia
Flozins or Acetazolamide
How to use Urine Na+
Do we believe the Italian HTS RCTs?
www.youtube.com/watch?v=3m2b...
#NephGR
@captainchloride.bsky.social on the art of decongestion in heart failure
Embracing hypercreatininemia
Flozins or Acetazolamide
How to use Urine Na+
Do we believe the Italian HTS RCTs?
www.youtube.com/watch?v=3m2b...
#NephGR
The Art of Decongestion with Dr. Nayan Arora
YouTube video by Ottawa Nephrology
www.youtube.com
May 27, 2025 at 11:41 AM
ICYMI
@captainchloride.bsky.social on the art of decongestion in heart failure
Embracing hypercreatininemia
Flozins or Acetazolamide
How to use Urine Na+
Do we believe the Italian HTS RCTs?
www.youtube.com/watch?v=3m2b...
#NephGR
@captainchloride.bsky.social on the art of decongestion in heart failure
Embracing hypercreatininemia
Flozins or Acetazolamide
How to use Urine Na+
Do we believe the Italian HTS RCTs?
www.youtube.com/watch?v=3m2b...
#NephGR
Reposted by Nayan Arora
Listening to @captainchloride.bsky.social presenting about decongestion strategies, while escalating all the steps to ultrafiltration 🌊 #NephGR
🌊🌊 Oliguric, overhidrated pt, with an SBP of 270 mmHg, a bit of respiratory alkalosis, and Na 133
@hswapnil.medsky.social
🌊🌊 Oliguric, overhidrated pt, with an SBP of 270 mmHg, a bit of respiratory alkalosis, and Na 133
@hswapnil.medsky.social
May 15, 2025 at 12:53 PM
Listening to @captainchloride.bsky.social presenting about decongestion strategies, while escalating all the steps to ultrafiltration 🌊 #NephGR
🌊🌊 Oliguric, overhidrated pt, with an SBP of 270 mmHg, a bit of respiratory alkalosis, and Na 133
@hswapnil.medsky.social
🌊🌊 Oliguric, overhidrated pt, with an SBP of 270 mmHg, a bit of respiratory alkalosis, and Na 133
@hswapnil.medsky.social