@grahamabra.bsky.social
Nephrologist @StanfordNeph, Chair @HDAE_Official, Director Social Media @HemodialysisInt, Defender of the 4 nephrons.
Cool paper
Genetics of AMKD getting deeper…
Genetics of AMKD getting deeper…
Prevalence of the M1 Modifier p.N264K in APOL1 Among Individuals With Kidney Disease Undergoing Commercial Genetic Testing in the United States
bit.ly/48PB2xk (FREE)
bit.ly/48PB2xk (FREE)
November 26, 2025 at 12:32 AM
Cool paper
Genetics of AMKD getting deeper…
Genetics of AMKD getting deeper…
Reposted
An announcement
www.nephjc.com/news/2025/11...
#NephJC
@kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social
www.nephjc.com/news/2025/11...
#NephJC
@kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social
Taking the reigns — NephJC
In April 2014, Swapnil and I launched NephJC—and within weeks we were overwhelmed by the sheer work of running a twice-monthly, Twitter-based journal club. Fortunately, we also had a deep bench of fri...
www.nephjc.com
November 25, 2025 at 12:03 PM
An announcement
www.nephjc.com/news/2025/11...
#NephJC
@kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social
www.nephjc.com/news/2025/11...
#NephJC
@kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social
Reposted
That was quick!
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
November 26, 2025 at 12:21 AM
That was quick!
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
Reposted
I did not know it was this bad
Look at the mortality in younger females (versus males) in CKD 5
jamanetwork.com/journals/jam... in @jamainternalmed.com from Alberta
#NephSky #GenderDisparities
Look at the mortality in younger females (versus males) in CKD 5
jamanetwork.com/journals/jam... in @jamainternalmed.com from Alberta
#NephSky #GenderDisparities
November 25, 2025 at 7:14 PM
I did not know it was this bad
Look at the mortality in younger females (versus males) in CKD 5
jamanetwork.com/journals/jam... in @jamainternalmed.com from Alberta
#NephSky #GenderDisparities
Look at the mortality in younger females (versus males) in CKD 5
jamanetwork.com/journals/jam... in @jamainternalmed.com from Alberta
#NephSky #GenderDisparities
Reposted
1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:
November 21, 2025 at 5:24 PM
1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:
Reposted
6/ 📖 Intro
⚡ SGLT2 inhibitors, first made for glucose control, surprised us with strong renal + CV protection 💥 Their small, reversible eGFR dip (like RASi) hinted at the mechanism: more Na⁺ to the macula densa → restored tubuloglomerular feedback → ⬇️ glomerular pressure → nephroprotection. 🧬
⚡ SGLT2 inhibitors, first made for glucose control, surprised us with strong renal + CV protection 💥 Their small, reversible eGFR dip (like RASi) hinted at the mechanism: more Na⁺ to the macula densa → restored tubuloglomerular feedback → ⬇️ glomerular pressure → nephroprotection. 🧬
November 20, 2025 at 6:47 PM
6/ 📖 Intro
⚡ SGLT2 inhibitors, first made for glucose control, surprised us with strong renal + CV protection 💥 Their small, reversible eGFR dip (like RASi) hinted at the mechanism: more Na⁺ to the macula densa → restored tubuloglomerular feedback → ⬇️ glomerular pressure → nephroprotection. 🧬
⚡ SGLT2 inhibitors, first made for glucose control, surprised us with strong renal + CV protection 💥 Their small, reversible eGFR dip (like RASi) hinted at the mechanism: more Na⁺ to the macula densa → restored tubuloglomerular feedback → ⬇️ glomerular pressure → nephroprotection. 🧬
Reposted
Up next: It might seem a little fishy, but was a great catch 🎣 #NephJC
PISCES, the use of fish oil to decrease mortality in dialysis patients.
www.pubmed.ncbi.nlm....
PISCES, the use of fish oil to decrease mortality in dialysis patients.
www.pubmed.ncbi.nlm....
November 19, 2025 at 2:58 AM
Up next: It might seem a little fishy, but was a great catch 🎣 #NephJC
PISCES, the use of fish oil to decrease mortality in dialysis patients.
www.pubmed.ncbi.nlm....
PISCES, the use of fish oil to decrease mortality in dialysis patients.
www.pubmed.ncbi.nlm....
Reposted
The latest #FreelyFiltered episode has dropped
www.nephjc.com/freelyfilter...
With pinch hitters Brian Rifkin and Anna Gaddy
www.nephjc.com/freelyfilter...
With pinch hitters Brian Rifkin and Anna Gaddy
FF 85 Live! From Houston, the #KidneyWk Draft — NephJC
FF 85 Live! From Houston, the #KidneyWk Draft
www.nephjc.com
November 19, 2025 at 2:33 PM
The latest #FreelyFiltered episode has dropped
www.nephjc.com/freelyfilter...
With pinch hitters Brian Rifkin and Anna Gaddy
www.nephjc.com/freelyfilter...
With pinch hitters Brian Rifkin and Anna Gaddy
Reposted
The #NephJC summary and VA are live
www.nephjc.com/news/atacice...
Excellent fast work from @notjustdialysis.bsky.social and @salinesolut.bsky.social
Atacicept in IgAN
www.nephjc.com/news/atacice...
Excellent fast work from @notjustdialysis.bsky.social and @salinesolut.bsky.social
Atacicept in IgAN
Attacking the Origin of IgAN: ORIGIN3 and Atacicept — NephJC
This week, we will discuss the phase 3 ORIGIN3 trial of atacicept, an APRIL/BAFF inhibitor for use in IgAN.
www.nephjc.com
November 18, 2025 at 11:31 AM
The #NephJC summary and VA are live
www.nephjc.com/news/atacice...
Excellent fast work from @notjustdialysis.bsky.social and @salinesolut.bsky.social
Atacicept in IgAN
www.nephjc.com/news/atacice...
Excellent fast work from @notjustdialysis.bsky.social and @salinesolut.bsky.social
Atacicept in IgAN
Reposted
Reposted
ATTN Fellows!!! Apply to be in the 3rd annual NephMadness NIT Fellows debate at NKF SCM in New Orleans
Application here
form.jotform.com/252084341700...
Application here
form.jotform.com/252084341700...
November 18, 2025 at 3:46 AM
ATTN Fellows!!! Apply to be in the 3rd annual NephMadness NIT Fellows debate at NKF SCM in New Orleans
Application here
form.jotform.com/252084341700...
Application here
form.jotform.com/252084341700...
Reposted
Interesting molecule - Troxerutin as an osmotic agent for PD
academic.oup.com/ndt/advance-...
in @ndt-era.bsky.social
It seems it’s a flavonol from the Japanese pagoda tree en.wikipedia.org/wiki/Troxeru...
#PDSky #NephSky
academic.oup.com/ndt/advance-...
in @ndt-era.bsky.social
It seems it’s a flavonol from the Japanese pagoda tree en.wikipedia.org/wiki/Troxeru...
#PDSky #NephSky
November 13, 2025 at 6:19 PM
Interesting molecule - Troxerutin as an osmotic agent for PD
academic.oup.com/ndt/advance-...
in @ndt-era.bsky.social
It seems it’s a flavonol from the Japanese pagoda tree en.wikipedia.org/wiki/Troxeru...
#PDSky #NephSky
academic.oup.com/ndt/advance-...
in @ndt-era.bsky.social
It seems it’s a flavonol from the Japanese pagoda tree en.wikipedia.org/wiki/Troxeru...
#PDSky #NephSky
Reposted
A novel system to continuously estimate intradialytic blood pressure in real time
More info: academic.oup.com/ndt/article/...
@ndt-era.bsky.social, @hjanders.bsky.social
More info: academic.oup.com/ndt/article/...
@ndt-era.bsky.social, @hjanders.bsky.social
A novel system to continuously estimate intradialytic blood pressure in real time
ABSTRACTBackground. Intradialytic hypotension (IDH) is a common complication of haemodialysis that is associated with adverse patient outcomes. We have dev
academic.oup.com
November 12, 2025 at 3:08 PM
A novel system to continuously estimate intradialytic blood pressure in real time
More info: academic.oup.com/ndt/article/...
@ndt-era.bsky.social, @hjanders.bsky.social
More info: academic.oup.com/ndt/article/...
@ndt-era.bsky.social, @hjanders.bsky.social
Reposted
Reposted
Should obesity remain a contraindication for a kidney transplant?
www.ajkd.org/article/S027...
In @ajkd.bsky.social
Sure it’s a risk factor for graft failure - but so is DM, CAD - which are worse and those are not contraindications!
#NephSky #Transplant
www.ajkd.org/article/S027...
In @ajkd.bsky.social
Sure it’s a risk factor for graft failure - but so is DM, CAD - which are worse and those are not contraindications!
#NephSky #Transplant
Access to Kidney Transplantation in Adults With Severe Obesity: A Population-Based Retrospective Cohort Study
International guidelines do not consider moderate or severe obesity to be contraindications
to kidney transplantation, but clinical practice suggests otherwise. This study sought
to evaluate the likel...
www.ajkd.org
November 12, 2025 at 10:11 PM
Should obesity remain a contraindication for a kidney transplant?
www.ajkd.org/article/S027...
In @ajkd.bsky.social
Sure it’s a risk factor for graft failure - but so is DM, CAD - which are worse and those are not contraindications!
#NephSky #Transplant
www.ajkd.org/article/S027...
In @ajkd.bsky.social
Sure it’s a risk factor for graft failure - but so is DM, CAD - which are worse and those are not contraindications!
#NephSky #Transplant
Reposted
I realize folks have probably heard this elsewhere, but it looks like the shutdown will likely end very soon, if not tonight then tomorrow. The good health policy news is that the telehealth flexibilities will be extended until January 30 and made retroactive back to October 1. (1)
November 12, 2025 at 2:24 PM
I realize folks have probably heard this elsewhere, but it looks like the shutdown will likely end very soon, if not tonight then tomorrow. The good health policy news is that the telehealth flexibilities will be extended until January 30 and made retroactive back to October 1. (1)
Community house HD continues to be a great example of patient centered care and creative thinking
Dialysis model saves lives and millions
https://www.newsbeep.com/241229/
A world-first South Auckland dialysis model is being praised for saving lives, restoring dignity, and easing pressure on…
https://www.newsbeep.com/241229/
A world-first South Auckland dialysis model is being praised for saving lives, restoring dignity, and easing pressure on…
Dialysis model saves lives and millions - News Beep
A world-first South Auckland dialysis model is being praised for saving lives, restoring dignity, and easing pressure on Middlemore Hospital, but its future
www.newsbeep.com
November 10, 2025 at 2:35 PM
Community house HD continues to be a great example of patient centered care and creative thinking
Reposted
In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
November 7, 2025 at 4:36 PM
In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
Reposted
a conservative dialysis strategy in possibly recovering AKI helps people recover faster!
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury
This trial examines whether a conservative dialysis strategy can improve recovery of kidney function for patients with acute kidney injury who require dialysis.
jamanetwork.com
November 7, 2025 at 6:50 PM
a conservative dialysis strategy in possibly recovering AKI helps people recover faster!
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
jamanetwork.com/journals/jam...
in @jama.com from #KidneyWk
Like STARRT-AKi et al, at the other end? Small trial - needs replication or this is common sense?
Reposted
large cohort study of
CDK 4/6
BRAF
EGFR
VEGF
and other cancer treatments
#OncoNephrology #NephSky #KidneyWk
jamanetwork.com/journals/jam... from Shuchi Anand et al from @stanfordmedicine.bsky.social
CDK 4/6
BRAF
EGFR
VEGF
and other cancer treatments
#OncoNephrology #NephSky #KidneyWk
jamanetwork.com/journals/jam... from Shuchi Anand et al from @stanfordmedicine.bsky.social
November 6, 2025 at 10:30 PM
large cohort study of
CDK 4/6
BRAF
EGFR
VEGF
and other cancer treatments
#OncoNephrology #NephSky #KidneyWk
jamanetwork.com/journals/jam... from Shuchi Anand et al from @stanfordmedicine.bsky.social
CDK 4/6
BRAF
EGFR
VEGF
and other cancer treatments
#OncoNephrology #NephSky #KidneyWk
jamanetwork.com/journals/jam... from Shuchi Anand et al from @stanfordmedicine.bsky.social
Reposted
We are 2 for 2 with positive trials so far. LIBERATE-D shows benefit with a conservative vs conventional dialysis strategy in AKI-D. The difference in mortality is concerning though? Simultaneous pub 👇🏾 #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
November 7, 2025 at 5:10 PM
We are 2 for 2 with positive trials so far. LIBERATE-D shows benefit with a conservative vs conventional dialysis strategy in AKI-D. The difference in mortality is concerning though? Simultaneous pub 👇🏾 #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
November 6, 2025 at 6:39 PM
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Reposted
ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
November 6, 2025 at 2:55 PM
ORIGIN phase 3 trial: In an interim analysis of a clinical trial, atacicept, a fusion protein that binds and inhibits two cytokines thought to be central to the pathophysiology of IgA nephropathy, significantly reduced proteinuria. nej.md/3JEq8QL
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
