Juan Carlos Q Vélez, MD
@juancarlosqvelez.bsky.social
🩺 Academic Nephrologist, Ochsner Health, New Orleans, LA, USA
🎓Professor of Medicine, Ochsner Clinical School - The University of Queensland, QLD, Australia
🔬Self-proclaimed Pisse Prophet
🎓Professor of Medicine, Ochsner Clinical School - The University of Queensland, QLD, Australia
🔬Self-proclaimed Pisse Prophet
Reposted by Juan Carlos Q Vélez, MD
Podocyte specific exon skipping after disease onset improves kidney pathology and function in a mouse model of #Alport syndrome pmc.ncbi.nlm.nih.gov/articles/PMC...
Podocyte specific exon skipping after disease onset improves kidney pathology and function in a mouse model of Alport syndrome
Alport syndrome (AS) is a hereditary kidney disorder caused by mutations in COL4A3, COL4A4, and COL4A5, which often lead to progressive renal failure. Although angiotensin II receptor blockers are available for symptomatic treatment, no radical or ...
pmc.ncbi.nlm.nih.gov
December 1, 2025 at 7:17 PM
Podocyte specific exon skipping after disease onset improves kidney pathology and function in a mouse model of #Alport syndrome pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Juan Carlos Q Vélez, MD
Points acknowledged but the graph allows one to see the relative changes and the shape of things that came/to come. The losartan curve is our progress vs placebo, while the others show the progress against losartan. Overall one may expect an effect similar to losartan under single agent adoption
December 1, 2025 at 2:04 AM
Points acknowledged but the graph allows one to see the relative changes and the shape of things that came/to come. The losartan curve is our progress vs placebo, while the others show the progress against losartan. Overall one may expect an effect similar to losartan under single agent adoption
Reposted by Juan Carlos Q Vélez, MD
An aldosterone synthase (CYP11B2 enzyme)–specific 18F-labeled radioligand to help lateralize in PA
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
November 28, 2025 at 3:56 PM
An aldosterone synthase (CYP11B2 enzyme)–specific 18F-labeled radioligand to help lateralize in PA
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
www.nejm.org/doi/full/10....
very cool science and technology
Any comments from the Aldo experts? @anandvaidya17.bsky.social
#NephSky #EndoSky
Reposted by Juan Carlos Q Vélez, MD
Cholemic Nephropathy aka Cholemic Nephrosis aka Bile Acid/ Bile Cast Nephropathy ca. 2024
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
November 26, 2025 at 10:43 PM
Cholemic Nephropathy aka Cholemic Nephrosis aka Bile Acid/ Bile Cast Nephropathy ca. 2024
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
#Nephpearls #NephSky
👉🏼 pubmed.ncbi.nlm.nih.gov/38649215/
Reposted by Juan Carlos Q Vélez, MD
Sibeprenlimab: First @fda.gov approved therapy targeting B cells which produce the abnormal antibodies responsible for #IgAN, addressing the fundamental cause
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
November 27, 2025 at 2:40 AM
Sibeprenlimab: First @fda.gov approved therapy targeting B cells which produce the abnormal antibodies responsible for #IgAN, addressing the fundamental cause
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
#Nephpearls #NephSky
#VisualAbstract by @nephroseeker.medsky.social
👉🏼 www.fda.gov/drugs/news-e...
👉🏼 pubmed.ncbi.nlm.nih.gov/41211929/
Reposted by Juan Carlos Q Vélez, MD
(1/2) The picture shows tissue submitted for routine immunofluorescence (fibrinogen stain is shown). Careful inspection confirms that this is an artery cross section which contains abnormal intraluminal tissue elements with numerous cleft-like spaces (see arrow).
#TeachingPoints #kidneypath #renal
#TeachingPoints #kidneypath #renal
November 25, 2025 at 5:21 PM
(1/2) The picture shows tissue submitted for routine immunofluorescence (fibrinogen stain is shown). Careful inspection confirms that this is an artery cross section which contains abnormal intraluminal tissue elements with numerous cleft-like spaces (see arrow).
#TeachingPoints #kidneypath #renal
#TeachingPoints #kidneypath #renal
Reposted by Juan Carlos Q Vélez, MD
An announcement
www.nephjc.com/news/2025/11...
#NephJC
@kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social
www.nephjc.com/news/2025/11...
#NephJC
@kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social
Taking the reigns — NephJC
In April 2014, Swapnil and I launched NephJC—and within weeks we were overwhelmed by the sheer work of running a twice-monthly, Twitter-based journal club. Fortunately, we also had a deep bench of fri...
www.nephjc.com
November 25, 2025 at 12:03 PM
An announcement
www.nephjc.com/news/2025/11...
#NephJC
@kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social
www.nephjc.com/news/2025/11...
#NephJC
@kidneyboy.bsky.social and moi hand over the @nephjc.bsky.social reigns to @nephroseeker.medsky.social & @brianrifkin.bsky.social
Reposted by Juan Carlos Q Vélez, MD
That was quick!
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
November 26, 2025 at 12:21 AM
That was quick!
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
The US FDA approves Sibeprenlimab aka Voyxact for reducing proteinuria in IgA
www.fda.gov/drugs/novel-...
#NephSky
#TopNephrology
Reposted by Juan Carlos Q Vélez, MD
even in their 2024 guidelines they downgrade the level of evidence for resistant hypertension.
Yes, spiro causes hyperK but that is easily managed with diuretics, especially in CKD.
Yes, spiro causes hyperK but that is easily managed with diuretics, especially in CKD.
November 23, 2025 at 4:08 PM
even in their 2024 guidelines they downgrade the level of evidence for resistant hypertension.
Yes, spiro causes hyperK but that is easily managed with diuretics, especially in CKD.
Yes, spiro causes hyperK but that is easily managed with diuretics, especially in CKD.
#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Sternheimer stain: WBC cast (bright field), broad RBC cast (bright), waxy cast (bright), and granular cast w/Ca Oxalate monohydrate crystals (oblique). #OchsnerNephrology #UrineMicroscopy
November 22, 2025 at 9:31 PM
#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Sternheimer stain: WBC cast (bright field), broad RBC cast (bright), waxy cast (bright), and granular cast w/Ca Oxalate monohydrate crystals (oblique). #OchsnerNephrology #UrineMicroscopy
#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Prescott-Brodie stain: RBC cast (bright field, 2 WBCs in cast), WBC cast (bright field, a few RBCs in it), lipid cast (dark field), and renal tub epi cell cast (oblique, many WBCs in blue around) #OchsnerNephrology
November 22, 2025 at 9:26 PM
#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Prescott-Brodie stain: RBC cast (bright field, 2 WBCs in cast), WBC cast (bright field, a few RBCs in it), lipid cast (dark field), and renal tub epi cell cast (oblique, many WBCs in blue around) #OchsnerNephrology
#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Sternheimer-Malbin stain: RBC cast (bright field), WBC cast (oblique illumination), fibrinous cast (dark field), and renal tub epi cell cast (oblique). #OchsnerNephrology
November 22, 2025 at 9:22 PM
#UrinarySediment from a pt with #AKI #RPGN due to suspected MPO-AAV-GN inspected with Sternheimer-Malbin stain: RBC cast (bright field), WBC cast (oblique illumination), fibrinous cast (dark field), and renal tub epi cell cast (oblique). #OchsnerNephrology
Reposted by Juan Carlos Q Vélez, MD
Commentary
Metabolic heavyweight: thick ascending limb or proximal tubule? Next round
✍️Kevin A Hurtado and Leslie S. Gewin
doi.org/10.1016/j.kint.2025.08.010
Original article: doi.org/10.1016/j.kint.2025.07.021
#MedSky #NephSky @washunephrology.bsky.social #aki #acutekidneyinjury
Metabolic heavyweight: thick ascending limb or proximal tubule? Next round
✍️Kevin A Hurtado and Leslie S. Gewin
doi.org/10.1016/j.kint.2025.08.010
Original article: doi.org/10.1016/j.kint.2025.07.021
#MedSky #NephSky @washunephrology.bsky.social #aki #acutekidneyinjury
November 21, 2025 at 9:55 PM
Commentary
Metabolic heavyweight: thick ascending limb or proximal tubule? Next round
✍️Kevin A Hurtado and Leslie S. Gewin
doi.org/10.1016/j.kint.2025.08.010
Original article: doi.org/10.1016/j.kint.2025.07.021
#MedSky #NephSky @washunephrology.bsky.social #aki #acutekidneyinjury
Metabolic heavyweight: thick ascending limb or proximal tubule? Next round
✍️Kevin A Hurtado and Leslie S. Gewin
doi.org/10.1016/j.kint.2025.08.010
Original article: doi.org/10.1016/j.kint.2025.07.021
#MedSky #NephSky @washunephrology.bsky.social #aki #acutekidneyinjury
1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:
November 21, 2025 at 5:24 PM
1/n Recently attended an international congress about Urinalysis in Santiago, Chile 🇨🇱. I was expecting a small meeting. I was wrong. Pleasantly surprised with the size of the meeting and the energy and interest from the participants. Let me share the highlights of my experience:
Reposted by Juan Carlos Q Vélez, MD
#MassSpectrometry of Minimal Change Disease and Focal Segmental Glomerulosclerosis #MCD #FSGS
#VisualAbstract by Sophia Ambruso
https://www.kireports.org/article/S2468-0249(25)00618-7/fulltext
#VisualAbstract by Sophia Ambruso
https://www.kireports.org/article/S2468-0249(25)00618-7/fulltext
November 19, 2025 at 12:00 AM
#MassSpectrometry of Minimal Change Disease and Focal Segmental Glomerulosclerosis #MCD #FSGS
#VisualAbstract by Sophia Ambruso
https://www.kireports.org/article/S2468-0249(25)00618-7/fulltext
#VisualAbstract by Sophia Ambruso
https://www.kireports.org/article/S2468-0249(25)00618-7/fulltext
Reposted by Juan Carlos Q Vélez, MD
✨ Help spread the word about SCM26 #NKFClinicals! Share with a colleague or post on social—help us spread the word about the NKF Spring Clinical Meetings!
Check it out and start sharing! ➡️ www.kidney.org/spring-clini...
Check it out and start sharing! ➡️ www.kidney.org/spring-clini...
November 16, 2025 at 8:01 PM
✨ Help spread the word about SCM26 #NKFClinicals! Share with a colleague or post on social—help us spread the word about the NKF Spring Clinical Meetings!
Check it out and start sharing! ➡️ www.kidney.org/spring-clini...
Check it out and start sharing! ➡️ www.kidney.org/spring-clini...
After a fun and productive #KidneyWk, I’m right back in ✈️ mode again, this time heading to Santiago to share and learn more within the #UrinarySediment #UrineMicroscopy South American Lab/Pathol/Nephrol community 🇵🇪🇨🇱
November 10, 2025 at 9:41 PM
After a fun and productive #KidneyWk, I’m right back in ✈️ mode again, this time heading to Santiago to share and learn more within the #UrinarySediment #UrineMicroscopy South American Lab/Pathol/Nephrol community 🇵🇪🇨🇱
I met a clever renal fellow at #KidneyWk who named his pets Ace and Arb. I’m inspired. I’ll name my next puppies Muddy and Waxy #UrinarySediment
November 8, 2025 at 11:48 PM
I met a clever renal fellow at #KidneyWk who named his pets Ace and Arb. I’m inspired. I’ll name my next puppies Muddy and Waxy #UrinarySediment
Check out thr second part of a @coreimpodcast.bsky.social podcast episode on HRS www.coreimpodcast.com/2025/10/22/h...
Hepatorenal Syndrome Part 2 on Management: 5 Pearls Segment | Core IM Podcast
Time Stamps Introduction and Overview of Hepatorenal Treatment Vasoconstrictors Focus: Terlipressin, Norepinephrine, and Midodrine Finding the Right Dose of Albumin...Read full post
www.coreimpodcast.com
November 8, 2025 at 10:57 PM
Check out thr second part of a @coreimpodcast.bsky.social podcast episode on HRS www.coreimpodcast.com/2025/10/22/h...
Reposted by Juan Carlos Q Vélez, MD
After empa-kidney, it still wasn’t clear what to do for patients with CKD without diabetes or albuminuria. This meta-analysis suggests you use flozins. #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria
This meta-analysis examines whether estimated glomerular filtration rate or degree of albuminuria, as measured by urinary albumin to creatinine ratio, modifies the effects of sodium-glucose cotranspor...
jamanetwork.com
November 8, 2025 at 12:31 AM
After empa-kidney, it still wasn’t clear what to do for patients with CKD without diabetes or albuminuria. This meta-analysis suggests you use flozins. #kidneywk
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Mandatory #KidneyWk gathering with my fellow Channeleers from Channel Your Enthusiasm podcast 🎙️ www.rosebook.club @kidneyboy.bsky.social @amyaimei.bsky.social @annagaddy.bsky.social @jwaitz.bsky.social
November 8, 2025 at 12:27 AM
Mandatory #KidneyWk gathering with my fellow Channeleers from Channel Your Enthusiasm podcast 🎙️ www.rosebook.club @kidneyboy.bsky.social @amyaimei.bsky.social @annagaddy.bsky.social @jwaitz.bsky.social
When a mentee Ochsner UQ Med Student Saleha Minhas is visited at a poster by 3 sodium rockstars (Sterns, Rodby and @kidneyboy.bsky.social) at #KidneyWk, that’s a highlight 🙌 @annagaddy.bsky.social
November 8, 2025 at 12:20 AM
When a mentee Ochsner UQ Med Student Saleha Minhas is visited at a poster by 3 sodium rockstars (Sterns, Rodby and @kidneyboy.bsky.social) at #KidneyWk, that’s a highlight 🙌 @annagaddy.bsky.social