Loren Cassin Sackett
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cassinsackett.bsky.social
Loren Cassin Sackett
@cassinsackett.bsky.social
Evolutionary biologist meets conservation geneticist meets aspiring bioinformatician. Lover of bicycles and mountains. #Fulbright🇨🇴 alum | #NatGeoExplorer
Lab website: www.cassinsackett.com
Pinned
Plague in prairie dogs is deadly, but pdogs are evolving immunity. And some of the genes showing evidence of adaptation are the same types of genes that protect Great Gerbils & humans from plague. This suggests evolution is ~predictable, & it can help us manage species facing anthropogenic threats.
A study of some of the few prairie dogs that have survived sylvatic plague identifies genes associated with immunity. One identified gene was also associated with survival in humans during the Black Death in England. In PNAS Nexus: academic.oup.com/pnasnexus/ar...
Reposted by Loren Cassin Sackett
Applications are currently being accepted for UBC's ✨️ Biodiversity Postdoctoral Fellowship ✨️ (two positions!!), due Jan. 15

Please share far and wide 🚀

(See thread)
Postdoctoral Fellowship Opportunities
Biodiversity Postdoctoral Fellowship, 2-year (2026-2028) - 2 positions OPENAt UBC, we believe that attracting and sustaining a diverse workforce is key to the successful pursuit of excellence in resea...
biodiversity.ubc.ca
November 3, 2025 at 5:25 PM
Reposted by Loren Cassin Sackett
I maintain that every one of these people should be forced to live on SNAP for a month.
Rep. Clay Higgins of Louisiana blames SNAP recipients for not stockpiling a month's worth of food.

He ends his tweet with "stop smoking crack."
October 30, 2025 at 9:21 PM
Reposted by Loren Cassin Sackett
Pleased to see published today: the Molecular Ecology special issue on "Genomics of Speciation"; many interesting papers: onlinelibrary.wiley.com/toc/1365294x...

Included in this issue is our paper on "The Distribution and Dispersal of Large Haploblocks in a Superspecies":

doi.org/10.1111/mec....
October 30, 2025 at 1:39 PM
Reposted by Loren Cassin Sackett
The Python Software Foundation got a competitive US research grant, but it came with a condition that they recant and abjure any diversity and inclusion ideas, on penalty of having to repay the money.

Obviously this is not desirable or safe, so no grant.

Donations would help them not regret this
The PSF has withdrawn $1.5 million proposal to US government grant program
In January 2025, the PSF submitted a proposal to the US government National Science Foundation under the Safety, Security, and Privacy of Open Source Ecosystems program to address structural vulnerabilities in Python and PyPI. It was the PSF’s first time applying for government funding, and navigating the intensive process was a steep learning curve for our small team to climb. Seth Larson, PSF Security Developer in Residence, serving as Principal Investigator (PI) with Loren Crary, PSF Deputy Executive Director, as co-PI, led the multi-round proposal writing process as well as the months-long vetting process. We invested our time and effort because we felt the PSF’s work is a strong fit for the program and that the benefit to the community if our proposal were accepted was considerable. We were honored when, after many months of work, our proposal was recommended for funding, particularly as only 36% of new NSF grant applicants are successful on their first attempt. We became concerned, however, when we were presented with the terms and conditions we would be required to agree to if we accepted the grant. These terms included affirming the statement that we “do not, and will not during the term of this financial assistance award, operate any programs that advance or promote DEI, or discriminatory equity ideology in violation of Federal anti-discrimination laws.” This restriction would apply not only to the security work directly funded by the grant, **but to any and all activity of the PSF as a whole**. Further, violation of this term gave the NSF the right to “claw back” previously approved and transferred funds. This would create a situation where money we’d already spent could be taken back, which would be an enormous, open-ended financial risk. Diversity, equity, and inclusion are core to the PSF’s values, as committed to in our mission statement: > _The mission of the Python Software Foundation is to promote, protect, and advance the Python programming language, and to support and facilitate the growth of**a diverse and international community** of Python programmers._ Given the value of the grant to the community and the PSF, we did our utmost to get clarity on the terms and to find a way to move forward in concert with our values. We consulted our NSF contacts and reviewed decisions made by other organizations in similar circumstances, particularly The Carpentries. In the end, however, the PSF simply can’t agree to a statement that we won’t operate any programs that “advance or promote” diversity, equity, and inclusion, as it would be a betrayal of our mission and our community. We’re disappointed to have been put in the position where we had to make this decision, because we believe our proposed project would offer invaluable advances to the Python and greater open source community, protecting millions of PyPI users from attempted supply-chain attacks. The proposed project would create new tools for automated proactive review of all packages uploaded to PyPI, rather than the current process of reactive-only review. These novel tools would rely on capability analysis, designed based on a dataset of known malware. Beyond just protecting PyPI users, the outputs of this work could be transferable for all open source software package registries, such as NPM and Crates.io, improving security across multiple open source ecosystems. In addition to the security benefits, the grant funds would have made a big difference to the PSF’s budget. The PSF is a relatively small organization, operating with an annual budget of around $5 million per year, with a staff of just 14. $1.5 million over two years would have been quite a lot of money for us, and easily the largest grant we’d ever received. Ultimately, however, the value of the work and the size of the grant were not more important than practicing our values and retaining the freedom to support every part of our community. The PSF Board voted unanimously to withdraw our application. Giving up the NSF grant opportunity—along with inflation, lower sponsorship, economic pressure in the tech sector, and global/local uncertainty and conflict—means the PSF needs financial support now more than ever. We are incredibly grateful for any help you can offer. If you're already a PSF member or regular donor, you have our deep appreciation, and we urge you to share your story about why you support the PSF. Your stories make all the difference in spreading awareness about the mission and work of the PSF. How to support the PSF: * Become a Member: When you sign up as a Supporting Member of the PSF, you become a part of the PSF. You’re eligible to vote in PSF elections, using your voice to guide our future direction, and you help us sustain what we do with your annual support. * Donate: Your donation makes it possible to continue our work supporting Python and its community, year after year. * Sponsor: If your company uses Python and isn’t yet a sponsor, send them our sponsorship page or reach out to [email protected] today. The PSF is ever grateful for our sponsors, past and current, and we do everything we can to make their sponsorships beneficial and rewarding.
pyfound.blogspot.com
October 28, 2025 at 7:16 AM
Reposted by Loren Cassin Sackett
Your daily Avian Hybrids story!

How did the Ice Ages affect three Scrubwrens in the highlands of Papua New Guinea?
avianhybrids.wordpress.com/2021/02/27/h...

#ornithology
How did the Ice Ages affect three Scrubwrens in the highlands of Papua New Guinea?
Genomic study looks for signatures of population expansion or contraction.
avianhybrids.wordpress.com
October 28, 2025 at 2:04 PM
Reposted by Loren Cassin Sackett
As part of Trump’s planned Reduction in Force (RIF) during the government shutdown, the Interior Department said it plans to lay off about 2,050 employees, including 272 from the National Park Service (NPS), 335 from the U.S. Geological Survey (USGS),
October 22, 2025 at 2:42 AM
Reposted by Loren Cassin Sackett
Major news outlets are standing together and refusing to sign. ABC News, CBS News, CNN, Fox News, and NBC News have all rejected a new Pentagon policy that would impose unprecedented restrictions on news gathering.
October 14, 2025 at 8:45 PM
Reposted by Loren Cassin Sackett
My lab is hiring a 2-yr hummingbird evolution and genomics postdoc and a 1-yr salaried research and lab tech. Both with full U. Wyoming benefits. Please spread the word! Info below. Best consideration date Nov 1, start dates early Spring 2026.
October 14, 2025 at 8:08 PM
Reposted by Loren Cassin Sackett
mammalcol is now on CRAN. Get easy access to the List of Mammal Species of Colombia using #mammalcol #R package #rstats
📦 dlizcano.github.io/mammalcol
Access to the List of Mammal Species of Colombia
The goal of mammalcol is to provide easy access to a meticulously structured dataset of Colombian mammal species in R. The 2025 update includes comprehensive, detailed species accounts, and distributi...
dlizcano.github.io
October 1, 2025 at 6:00 AM
Reposted by Loren Cassin Sackett
We just pushed a new version of the global bird phylogeny to Github. Updated topology (v1.5), and now in the most recent Clements/eBird taxonomy. We'll push to CRAN soon too, but head over and grab the most recent clootl version now. @snacktavish.bsky.social github.com/eliotmiller/...
GitHub - eliotmiller/clootl
Contribute to eliotmiller/clootl development by creating an account on GitHub.
github.com
September 13, 2025 at 8:32 PM
Reposted by Loren Cassin Sackett
I am thrilled to share this paper outlining some ideas I’ve been thinking about for a little while on a simple but powerful approach for predicting risk of inbreeding depression from long runs of homozygosity and non-ROH heterozygosity. 1/n @klohmueller.bsky.social doi.org/10.1016/j.tr...
August 4, 2025 at 5:10 PM
Plague in prairie dogs is deadly, but pdogs are evolving immunity. And some of the genes showing evidence of adaptation are the same types of genes that protect Great Gerbils & humans from plague. This suggests evolution is ~predictable, & it can help us manage species facing anthropogenic threats.
A study of some of the few prairie dogs that have survived sylvatic plague identifies genes associated with immunity. One identified gene was also associated with survival in humans during the Black Death in England. In PNAS Nexus: academic.oup.com/pnasnexus/ar...
August 12, 2025 at 1:30 PM
Reposted by Loren Cassin Sackett
10. This provision is by no means the only dreadful, counterproductive, and un-American aspect of the current executive order. But it is one that will cause extraordinary harm and may be less transparently disastrous that other elements of the order.

/fin
August 8, 2025 at 1:57 AM
Reposted by Loren Cassin Sackett
6. This makes it impossible to engage in anything other than the shortest-term, most incremental research.

Far-reaching, innovative, creative, world-changing research will no longer take place in the United States.
August 8, 2025 at 1:44 AM
Reposted by Loren Cassin Sackett
1. Federal funding for research promotes tech, biomedical, and scientific discovery in the US, and provides training for the sci/tech workforce that has brought immeasurable wealth to the US over the past 75 years.

Today's executive order includes a provision that will obliterate both functions.
Improving Oversight of Federal Grantmaking
By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal
www.whitehouse.gov
August 8, 2025 at 1:13 AM
Reposted by Loren Cassin Sackett
“This Executive Order is nothing short of obscene," said Ranking Member Zoe Lofgren (D-CA). "In what world does Donald Trump think that Americans want political appointees – who, need I remind the President, are unelected bureaucrats – making decisions on what science gets funded?”
Ranking Member Lofgren Calls Trump Out for Corrupt Executive Order Requiring Political Appointees to Approve Federal Grants | House Committee on Science, Space and Technology
The House Committee on Science, Space and Technology
democrats-science.house.gov
August 7, 2025 at 11:43 PM
Reposted by Loren Cassin Sackett
And this is what we have been seeing since Jan 20th: Vought and his Project 2025 team have been interfering with grants by meddling INSIDE the agency, inside NIH and/or HHS.
Outrageous. The White House is sidestepping Congress and halting up to $15 billion in NIH research funding, which would have gone to study diabetes, cancer & more.

The order was issued through a four-sentence email sent to NIH directors from Office of Management & Budget Director Russell Vought.
August 2, 2025 at 1:39 AM
Reposted by Loren Cassin Sackett
"At this point, women have been cleared out of all of the military’s top jobs"

By a former long-time Naval War College professor
The Administration Wants Military Women to Know Their Place
Pete Hegseth seems to be on a mission to erase women from the top ranks of the U.S. armed forces.
www.theatlantic.com
July 23, 2025 at 1:36 AM
Reposted by Loren Cassin Sackett
Today, the Environmental Protection Agency announced it will shut down its Office of Research and Development and eliminate thousands of agency jobs. According to the agency, this office has long served as the scientific backbone of its efforts to protect both public health and the environment.
July 18, 2025 at 10:51 PM
Reposted by Loren Cassin Sackett
Yesterday we posted about the Trump administration shutting down the LGBTQ+ youth crisis line, the “press 3” option on 988 is officially gone. The Trevor Project is stepping up to help fill the gap, and they could really use some support right now. If you’re able, please consider donating! 🏳️‍🌈 💛
July 18, 2025 at 11:58 PM
Reposted by Loren Cassin Sackett
5 reasons why Medicaid cuts affect everyone:

1️⃣ More ER Overcrowding
2️⃣ Higher Insurance Premiums — Hospitals shift unpaid costs to your insurance.
3️⃣ Job Loss — Fewer clinics, especially in rural areas.
4️⃣ Weaker Public Health — Less funding for services
5️⃣ Higher State Taxes or Service Cuts
July 1, 2025 at 3:40 AM
Reposted by Loren Cassin Sackett
The office of Secretary of Defense has always been held with honor and dignity. Until now. www.youtube.com/watch?v=iW6P...
Secretary of Defense
YouTube video by The Lincoln Project
www.youtube.com
July 1, 2025 at 12:10 PM
Reposted by Loren Cassin Sackett
Teachers in Oklahoma will soon be required to tell kids the 2020 election had "discrepancies" and that Christianity is the foundation of the U.S.

That’s not education. That’s propaganda.

A new lawsuit aims to stop it.

www.friendlyatheist.com/p/oklahoma-s...
Oklahoma sued over school standards that mix Christianity with right-wing lies
The lawsuit says Ryan Walters' social studies standards promote religion and conservative lies, and that he violated state law to make it happen
www.friendlyatheist.com
July 2, 2025 at 1:04 PM
Reposted by Loren Cassin Sackett
Now the Trump people have jammed political appointees — from DOGE, Vought, Trump, whomever — into the science process. These people know nothing about science. This is the way to Lysenkoism and the death of US science.

@hannahnatanson.bsky.social
June 28, 2025 at 2:24 AM