Chekan Lab
@chekanlab.bsky.social
450 followers
170 following
4 posts
Biosynthesis and Enzymology of Natural Products at UNC Greensboro
chem.uncg.edu/chekan
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Joëlle Houriet
@joellehouriet.bsky.social
· Jul 22
Multilaboratory Untargeted Mass Spectrometry Metabolomics Collaboration to Identify Bottlenecks and Comprehensively Annotate A Single Dataset
Annotation is the process of assigning features in mass spectrometry metabolomics data sets to putative chemical structures or “analytes.” The purpose of this study was to identify challenges in the a...
pubs.acs.org
Reposted by Chekan Lab
Chekan Lab
@chekanlab.bsky.social
· Jan 16
Reposted by Chekan Lab
Doc Z
@effezeta84.bsky.social
· Jan 16
Reposted by Chekan Lab
Reposted by Chekan Lab
Marc Chevrette
@wildtypemc.bsky.social
· Dec 22
Convergent Evolution of the Antimycobacterial Lasso Peptide Triculamin
Triculamin is a ribosomally synthesized and post-translationally modified peptide (RiPP) lasso peptide with potent antimycobacterial activity, produced by an unusual, non-canonical biosynthetic gene c...
www.biorxiv.org
Reposted by Chekan Lab
Thomas Tørring
@thomastorring.bsky.social
· Dec 22
Convergent Evolution of the Antimycobacterial Lasso Peptide Triculamin
Triculamin is a ribosomally synthesized and post-translationally modified peptide (RiPP) lasso peptide with potent antimycobacterial activity, produced by an unusual, non-canonical biosynthetic gene c...
www.biorxiv.org
Reposted by Chekan Lab
Eustaquio Lab
@eustaquiolab.bsky.social
· Dec 10
Discovery of megapolipeptins by genome mining of a Burkholderiales bacteria collection
Burkholderiales bacteria have emerged as a promising source of structurally diverse natural products that are expected to play important ecological and industrial roles. This order ranks in the top th...
pubs.rsc.org
Reposted by Chekan Lab
Reposted by Chekan Lab
Reposted by Chekan Lab
Reposted by Chekan Lab
Chenxin Li, PhD
@chenxinli2.bsky.social
· Nov 21
Reposted by Chekan Lab
Andy Truman
@andytruman4.bsky.social
· Nov 14
Discovery of lydiamycin A biosynthetic gene cluster in the plant pathogen Rhodococcus fascians guides structural revision and identification of molecular target
The natural products actinonin and matlystatin feature an N-hydroxy-2-pentyl-succinamyl (HPS) chemophore that facilitates metal chelation and confers their metalloproteinase inhibitory activity. Actin...
www.biorxiv.org
Reposted by Chekan Lab
Conor McClune
@cmcclune.bsky.social
· Nov 13
Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors
Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the anti-c...
www.biorxiv.org
Chekan Lab
@chekanlab.bsky.social
· Nov 11
Reposted by Chekan Lab
Reposted by Chekan Lab
Chekan Lab
@chekanlab.bsky.social
· Oct 23
Reposted by Chekan Lab