It was a real pleasure to watch this work evolve from a "what if" discussion to a @natsynth.nature.com paper
I truly appreciate being included #Chemsky
It was a real pleasure to watch this work evolve from a "what if" discussion to a @natsynth.nature.com paper
I truly appreciate being included #Chemsky
New from @darrenderksen.bsky.social, Jeffrey Van Humbeck, @wpiers.bsky.social and colleagues at @ucalgary.bsky.social.
#OpenAccess 🔓
We used the indolequinone bioreductive group to protect VHL- or CRBN-recruiting BRD4 degraders rendering them inactive. This group is removed selectively in hypoxia, revealing the active PROTAC.
We used the indolequinone bioreductive group to protect VHL- or CRBN-recruiting BRD4 degraders rendering them inactive. This group is removed selectively in hypoxia, revealing the active PROTAC.