Thames water want to make at deal with Ofwat, to pollute illegally for 15 years

YouTube video by Jillian Angeline

Antimicrobial resistance is a massive threat, but it can take decades to develop a new antibiotic. That time could be drastically reduced if we were able to anticipate desirable properties of a chemic...

Background: Amyloidogenic proteins play a central role in a range of pathological conditions, yet their presence in thrombi has only recently been recognized. Whether computational prediction tools ca...

Bacteria can be killed very effectively by targeting their first line of protection. The cell membranes (outer and inner membranes) of Gram-negative bacteria are directly targeted by antibiotics, such as polymyxins, via electrostatic interactions with their lipopolysaccharide (LPS) fraction. The downstream effects - preceding the cell death - of the disruptions of the bacterial membranes upon the intercalation of these antibiotics are unknown. By screening a set of E. coli membrane protein knockouts, three membrane transporters were shown to mediate the growth-inhibitory effects of colistin. This was corroborated with growth assays on gain-of-function strains, cytotoxic assays and in vivo infections in an invertebrate animal model. This is first-time evidence that the disruption caused to membrane proteins, such as the chloride channel ClcB, the sugar transport system component PtsI and the hypothetical Glutamate:GABA antiporter YcaM, is part of the cytotoxic pathway that follows or is concomitant to the electrostatic intercalations of polymyxins with the Gram-negative bacteria membrane. ### Competing Interest Statement The authors have declared no competing interest.

Michael Gove’s ex on her compassionate pieces for the Daily Mail, struggling to survive on an MP’s salary, doing Sam Cam’s ironing and becoming a laughing stock after Brexit

The Trump administration’s “Make America Healthy Again” report misinterprets some studies and cites others that don’t exist, according to the listed authors.

Jeff Bridges is sharing some good news pertaining to his health.

This will hurt so many students—and destroy Harvard.