Dominique Guerrot
@dguerrot.bsky.social
Nephrology, Hypertension, ADPKD, Clinical investigation | Rouen University Hospital, France
Reposted by Dominique Guerrot
Protein Intake and Mortality in Older Adults With CKD url: jamanetwork.com/journals/jam... discovered thanks to @cyrilmousseaux.bsky.social
Protein Intake and Mortality in Older Adults With CKD
This multicohort study estimates the associations of total, animal, and plant protein intake with all-cause mortality in older adults with mild or moderate chronic kidney disease (CKD) and compares th...
jamanetwork.com
January 24, 2026 at 6:48 AM
Protein Intake and Mortality in Older Adults With CKD url: jamanetwork.com/journals/jam... discovered thanks to @cyrilmousseaux.bsky.social
Reposted by Dominique Guerrot
Meta-analysis: #SGLT2 inhibitors slow kidney decline consistently across CKD severity and albuminuria range, supporting their routine use for kidney health.
ja.ma/4pNzTve
ja.ma/4pNzTve
January 20, 2026 at 4:15 PM
Meta-analysis: #SGLT2 inhibitors slow kidney decline consistently across CKD severity and albuminuria range, supporting their routine use for kidney health.
ja.ma/4pNzTve
ja.ma/4pNzTve
Reposted by Dominique Guerrot
CKD prevalence in elderly and the eGFR inflation effect, a very important paper in the @ndt-era.bsky.social . Not just for elderly but also for the young CKD population
academic.oup.com/ndt/article/...
#nephinp
#nephrology_in_practice
academic.oup.com/ndt/article/...
#nephinp
#nephrology_in_practice
December 20, 2025 at 8:07 PM
CKD prevalence in elderly and the eGFR inflation effect, a very important paper in the @ndt-era.bsky.social . Not just for elderly but also for the young CKD population
academic.oup.com/ndt/article/...
#nephinp
#nephrology_in_practice
academic.oup.com/ndt/article/...
#nephinp
#nephrology_in_practice
Reposted by Dominique Guerrot
December 10, 2025 at 11:18 PM
Reposted by Dominique Guerrot
Dans une nouvelle étude des scientifiques de l'Inserm ont analysé comment le système lymphatique se dérègle dans l’insuffisance cardiaque. Ils ont, pour la première fois, identifié les mécanismes responsables de ce dysfonctionnement.
Lire le communiqué : presse.inserm.fr/decouverte-d...
Lire le communiqué : presse.inserm.fr/decouverte-d...
Découverte de valves au cœur du système lymphatique cardiaque et de leur rôle dans l’insuffisance cardiaque - Salle de presse de l'Inserm
Dans une nouvelle étude, des chercheurs de l’Inserm et de l’Université de Rouen Normandie, en collaboration avec une équipe de l’Université de Wurtzbourg (Allemagne), ont analysé comment le système ly...
presse.inserm.fr
December 12, 2025 at 3:41 PM
Dans une nouvelle étude des scientifiques de l'Inserm ont analysé comment le système lymphatique se dérègle dans l’insuffisance cardiaque. Ils ont, pour la première fois, identifié les mécanismes responsables de ce dysfonctionnement.
Lire le communiqué : presse.inserm.fr/decouverte-d...
Lire le communiqué : presse.inserm.fr/decouverte-d...
Reposted by Dominique Guerrot
For critically ill patients who had both severe metabolic acidemia and moderate to severe acute kidney injury, sodium bicarbonate therapy did not significantly decrease day 90 all-cause mortality.
ja.ma/4pFsAWU
ja.ma/4pFsAWU
December 10, 2025 at 3:00 PM
For critically ill patients who had both severe metabolic acidemia and moderate to severe acute kidney injury, sodium bicarbonate therapy did not significantly decrease day 90 all-cause mortality.
ja.ma/4pFsAWU
ja.ma/4pFsAWU
Well actually you wrote “renal” instead of “kidney” in a Twitter post in 2022… Access denied, sorry
Tourists may have to provide social media history to enter US
The Trump administration is considering whether to introduce harsher restrictions for travellers obtaining an Esta ⬇️
The Trump administration is considering whether to introduce harsher restrictions for travellers obtaining an Esta ⬇️
Tourists may have to provide social media history to enter US
The Trump administration is considering whether to introduce harsher restrictions for travellers obtaining an Esta
www.thetimes.com
December 11, 2025 at 12:10 AM
Well actually you wrote “renal” instead of “kidney” in a Twitter post in 2022… Access denied, sorry
Reposted by Dominique Guerrot
Hypertension, un danger silencieux : venez participer à une matinée de sensibilisation jeudi 11 décembre à Marseille. www.laprovence.com/article/sant... #santé #hypertension
Hypertension, un danger silencieux : venez participer à notre matinée de sensibilisation jeudi
Hypertension, un danger silencieux : venez participer à notre matinée de sensibilisation jeudi
www.laprovence.com
December 8, 2025 at 3:42 PM
Hypertension, un danger silencieux : venez participer à une matinée de sensibilisation jeudi 11 décembre à Marseille. www.laprovence.com/article/sant... #santé #hypertension
Reposted by Dominique Guerrot
A long delay between pre print and publication means this paper only got better and better. Congrats @rose-hill.bsky.social and all collaborators, including many in renal physiology. A role for PIEZO2 in sensing pressure in the kidney and regulating the renin pathway. www.cell.com/cell/fulltex...
Renal PIEZO2 is an essential regulator of renin
The force-sensing ion channel PIEZO2 is an essential regulator of the renin-angiotensin-aldosterone
system (RAAS), a pathway that controls blood volume. Loss of PIEZO2 in the kidney
cells that produce...
www.cell.com
December 4, 2025 at 11:27 PM
A long delay between pre print and publication means this paper only got better and better. Congrats @rose-hill.bsky.social and all collaborators, including many in renal physiology. A role for PIEZO2 in sensing pressure in the kidney and regulating the renin pathway. www.cell.com/cell/fulltex...
Reposted by Dominique Guerrot
Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study
bit.ly/3ZdrYxb #OpenAccess
#VisualAbstract #CKD
bit.ly/3ZdrYxb #OpenAccess
#VisualAbstract #CKD
November 30, 2025 at 11:00 AM
Stopping Versus Continuing Metformin in Patients With Advanced CKD: A Nationwide Scottish Target Trial Emulation Study
bit.ly/3ZdrYxb #OpenAccess
#VisualAbstract #CKD
bit.ly/3ZdrYxb #OpenAccess
#VisualAbstract #CKD
Reposted by Dominique Guerrot
I’ve called GLP-1 agents like Ozempic and Mounjaro "miracle drugs." But a new study forces me to re-evaluate that moniker.
The miracle has a problem: It ends when the prescription runs out.
Let's look at the data on the "Rebound Effect." 🧵
The miracle has a problem: It ends when the prescription runs out.
Let's look at the data on the "Rebound Effect." 🧵
November 24, 2025 at 11:27 PM
I’ve called GLP-1 agents like Ozempic and Mounjaro "miracle drugs." But a new study forces me to re-evaluate that moniker.
The miracle has a problem: It ends when the prescription runs out.
Let's look at the data on the "Rebound Effect." 🧵
The miracle has a problem: It ends when the prescription runs out.
Let's look at the data on the "Rebound Effect." 🧵
Reposted by Dominique Guerrot
Among older adults with frailty, evidence on the benefits and risks of discontinuing antihypertensive drugs is limited. Research findings from the RETREAT-FRAIL trial are summarized in a new Quick Take video. nej.md/482WnBv
#MedSky #CardioSky
#MedSky #CardioSky
November 22, 2025 at 5:02 PM
Among older adults with frailty, evidence on the benefits and risks of discontinuing antihypertensive drugs is limited. Research findings from the RETREAT-FRAIL trial are summarized in a new Quick Take video. nej.md/482WnBv
#MedSky #CardioSky
#MedSky #CardioSky
Reposted by Dominique Guerrot
Suivez le conseil du Pr Guerrot, signez et faites tourner cette pétition. On s'en fout que ce ne soit pas un outil parfait, c'est mieux que rien.
November 22, 2025 at 3:34 PM
Suivez le conseil du Pr Guerrot, signez et faites tourner cette pétition. On s'en fout que ce ne soit pas un outil parfait, c'est mieux que rien.
Reposted by Dominique Guerrot
Our recording of an excellent and educational rounds by Dominique Bertrand from Rouen is now live
www.youtube.com/watch?v=xUx3...
#Transplantation in highly sensitized recipients, with the #imlifidase experience in particular!
www.youtube.com/watch?v=xUx3...
#Transplantation in highly sensitized recipients, with the #imlifidase experience in particular!
Imlifidase for Highly Sensitized Kidney Transplant Candidates: with Dominique Bertrand
Learning Objectives:
Indications and protocol used in France
Real-world outcomes and safety considerations
Positioning vs. acceptable-mismatch and other desensitization strategies
Dr. Dominique…
www.youtube.com
November 19, 2025 at 7:27 PM
Our recording of an excellent and educational rounds by Dominique Bertrand from Rouen is now live
www.youtube.com/watch?v=xUx3...
#Transplantation in highly sensitized recipients, with the #imlifidase experience in particular!
www.youtube.com/watch?v=xUx3...
#Transplantation in highly sensitized recipients, with the #imlifidase experience in particular!
Reposted by Dominique Guerrot
Medicare for All would save $450B a year.
Every dollar spent on food stamps generates $1.50-$1.80 in economic activity.
Each dollar going to low-wage workers adds $1.20 to the economy overall.
It’s not about what this country can or can’t afford.
It’s about priorities.
Every dollar spent on food stamps generates $1.50-$1.80 in economic activity.
Each dollar going to low-wage workers adds $1.20 to the economy overall.
It’s not about what this country can or can’t afford.
It’s about priorities.
November 18, 2025 at 10:45 PM
Medicare for All would save $450B a year.
Every dollar spent on food stamps generates $1.50-$1.80 in economic activity.
Each dollar going to low-wage workers adds $1.20 to the economy overall.
It’s not about what this country can or can’t afford.
It’s about priorities.
Every dollar spent on food stamps generates $1.50-$1.80 in economic activity.
Each dollar going to low-wage workers adds $1.20 to the economy overall.
It’s not about what this country can or can’t afford.
It’s about priorities.
Reposted by Dominique Guerrot
I met a clever renal fellow at #KidneyWk who named his pets Ace and Arb. I’m inspired. I’ll name my next puppies Muddy and Waxy #UrinarySediment
November 8, 2025 at 11:48 PM
I met a clever renal fellow at #KidneyWk who named his pets Ace and Arb. I’m inspired. I’ll name my next puppies Muddy and Waxy #UrinarySediment
Reposted by Dominique Guerrot
In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
November 7, 2025 at 4:36 PM
In the PISCES trial involving participants receiving hemodialysis, fish oil (n−3 fatty acids) was compared with corn-oil placebo. The rate of serious cardiovascular events was lower with daily fish-oil supplementation. Full trial results: nej.md/49zWuqo
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
Reposted by Dominique Guerrot
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
November 6, 2025 at 6:39 PM
Highlights from my talk yesterday on Alport syndrome spectrum of disorders. (since no one posted it, I'll have to do it myself)
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Variants in type IV collagen cause a wide spectrum of disease. #KidneyWk 🧵
Reposted by Dominique Guerrot
Machine perfusion is better than just cold storage for kidneys
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
November 5, 2025 at 10:37 PM
Machine perfusion is better than just cold storage for kidneys
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
10 year follow up of the original 2009 trial in the @nejm.org
www.nejm.org/doi/full/10....
#NephSky #KidneyWk
Reposted by Dominique Guerrot
Interesting paper in @ckj-era.bsky.social - In my own practice I offer genetic testing to all my ADPKD patients now
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025
Abstract. ADPKD is the most common monogenic cause of kidney failure globally and a significant cause of morbidity and mortality. It is now recognized that
academic.oup.com
November 1, 2025 at 11:02 AM
Interesting paper in @ckj-era.bsky.social - In my own practice I offer genetic testing to all my ADPKD patients now
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Genetic Testing in Autosomal Dominant Polycystic Kidney Disease: Why It Matters in 2025 url: academic.oup.com/ckj/article/...
Reposted by Dominique Guerrot
Among participants with advanced pheochromocytoma or paraganglioma, belzutifan showed durable antitumor activity and a reduced need for antihypertensives, although most participants had treatment-related adverse events. Full LITESPARK-015 phase 2 trial results: nej.md/475bfP9
#ESMO25
#ESMO25
October 18, 2025 at 8:20 AM
Among participants with advanced pheochromocytoma or paraganglioma, belzutifan showed durable antitumor activity and a reduced need for antihypertensives, although most participants had treatment-related adverse events. Full LITESPARK-015 phase 2 trial results: nej.md/475bfP9
#ESMO25
#ESMO25
Reposted by Dominique Guerrot
🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences.
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
August 6, 2025 at 10:05 AM
🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences.
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵
Reposted by Dominique Guerrot
New—Effects of #empagliflozin on conventional and exploratory acute and chronic #kidney outcomes: an individual participant-level meta-analysis thelancet.com/journals/lan...
#SGLT2 inhibitor #CKD
#OpenAccess
#MedSky #EndoSky #RenalSky
#SGLT2 inhibitor #CKD
#OpenAccess
#MedSky #EndoSky #RenalSky
Effects of empagliflozin on conventional and exploratory acute and chronic kidney outcomes: an individual participant-level meta-analysis
SGLT2 inhibition reduces risk of acute and chronic kidney outcomes irrespective of
the size of the acute dip in eGFR. Kidney benefits are evident irrespective of diabetes
status, heart failure status,...
thelancet.com
October 10, 2025 at 10:38 PM
New—Effects of #empagliflozin on conventional and exploratory acute and chronic #kidney outcomes: an individual participant-level meta-analysis thelancet.com/journals/lan...
#SGLT2 inhibitor #CKD
#OpenAccess
#MedSky #EndoSky #RenalSky
#SGLT2 inhibitor #CKD
#OpenAccess
#MedSky #EndoSky #RenalSky
Reposted by Dominique Guerrot
SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
SGLT-2 I in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller
YouTube video by MARKUS at HOMe
youtu.be
October 10, 2025 at 6:21 PM
SGLT-2 Inhibition in ADPKD? DAPA-PKD & STOP-PKD - Prof. Emilie Cornec Le Gall & Prof. Roman-Ulrich Müller
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
youtu.be/9e-UFBnIyDI?...
@ecorneclegall.bsky.social @muellerrom.bsky.social @kronbichlerlab.bsky.social @sarahelena.bsky.social @gunnarheine.bsky.social @marcussaemann.bsky.social
Reposted by Dominique Guerrot
Mono-allelic pathogenic variants in JAG1 cause Autosomal Dominant Tubulo-interstitial Kidney Disease (ADTKD-JAG1)
doi.org/10.1016/j.kint.2025.08.033
#ckd #chronickidneydisease #MedSky #NephSky
@institutimagine.bsky.social @lafhf.bsky.social @nihrnewcastlebrc.bsky.social @ap-hp.bsky.social
doi.org/10.1016/j.kint.2025.08.033
#ckd #chronickidneydisease #MedSky #NephSky
@institutimagine.bsky.social @lafhf.bsky.social @nihrnewcastlebrc.bsky.social @ap-hp.bsky.social
October 9, 2025 at 3:17 PM
Mono-allelic pathogenic variants in JAG1 cause Autosomal Dominant Tubulo-interstitial Kidney Disease (ADTKD-JAG1)
doi.org/10.1016/j.kint.2025.08.033
#ckd #chronickidneydisease #MedSky #NephSky
@institutimagine.bsky.social @lafhf.bsky.social @nihrnewcastlebrc.bsky.social @ap-hp.bsky.social
doi.org/10.1016/j.kint.2025.08.033
#ckd #chronickidneydisease #MedSky #NephSky
@institutimagine.bsky.social @lafhf.bsky.social @nihrnewcastlebrc.bsky.social @ap-hp.bsky.social