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Reposted by Dominique Guerrot

Kidney International @kidneyint.bsky.social · 23h

Mono-allelic pathogenic variants in JAG1 cause Autosomal Dominant Tubulo-interstitial Kidney Disease (ADTKD-JAG1)

doi.org/10.1016/j.kint.2025.08.033

#ckd #chronickidneydisease #MedSky #NephSky
@institutimagine.bsky.social @lafhf.bsky.social @nihrnewcastlebrc.bsky.social @ap-hp.bsky.social

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Reposted by Dominique Guerrot

F. Perry Wilson, MD @fperrywilson.bsky.social · 23d

Childhood obesity has quadrupled since the 1960s. Now over 20% of kids meet the definition (>95th percentile of BMI).
This is driving type 2 diabetes in children, and increases the risk of other diseases as adults.
We need to talk about weight-loss drugs for kids. 🧵

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Reposted by Dominique Guerrot

PKD International @pkdinternational.bsky.social · 28d

In this video, Professor Dominique Guerrot presents the DAPA-PKD study, a collaborative research effort he co-leads with Professor Emilie Cornec-Le Gall (Brest). This important study will evaluate the potential of SGLT2 inhibitors, such as dapagliflozin, in the treatment of #ADPKD.

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Reposted by Dominique Guerrot

markusathome @markusathome.bsky.social · 27d

Tonight it's all about ADPKD!

KDIGO Guidelines / ERA Genes & Kidney Working Group - Prof. Roser Torra, Prof. Roman-Ulrich Müller

youtu.be/qjnYDsYbx0Q?...

@rosertorra.bsky.social @muellerrom.bsky.social @dguerrot.bsky.social @gunnarheine.bsky.social @kronbichlerlab.bsky.social

ADPKD: KDIGO GL / ERA Genes & Kidney WG - Prof. Roser Torra, Prof. Roman-Ulrich Müller

YouTube video by MARKUS at HOMe

youtu.be

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Reposted by Dominique Guerrot

FlexNP @rnflex.bsky.social · 28d

I have a feeling sales of home blood pressure cuffs are going to spike because people working in Primary Care like myself are going to be telling patients to confirm what the Apple watch is telling them with an actual blood pressure cuff.

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Reposted by Dominique Guerrot

Adrian Liston @labliston.bsky.social · Sep 3

🧵How to write and manage your first research budgets

The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.

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Reposted by Dominique Guerrot

Dominique Guerrot @dguerrot.bsky.social · Aug 6

📚 The 2025 #KDIGO Guidelines recommend ambitious BP targets to manage hypertension in ADPKD:
🎯 ≤110/75 mmHg (HBPM) for adults <50 y with preserved renal function (G1–G2),
🎯 <120 mmHg systolic (office BP) in older adults, if tolerated.

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Dominique Guerrot @dguerrot.bsky.social · Aug 24

@lucilefigueres.bsky.social @antoinelanot.bsky.social @lemoinesandrine.bsky.social

Dominique Guerrot @dguerrot.bsky.social · Aug 24

#NephrOdio podcasts 🎧
🚀 Half a million downloads !

https://open.spotify.com/show/2UBeBVbxnfv8F9S82GENGa?si=JHcAmscnTPq3c25152duxw

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Dominique Guerrot @dguerrot.bsky.social · Aug 22

@clemencebechade.bsky.social 👏🏻

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Reposted by Dominique Guerrot

Jordy Cohen @jordybc.bsky.social · Aug 14

New 2025 AHA/ACC Hypertension Guideline dropped!

www.jacc.org/doi/10.1016/...

#hypertension #medsky #nephsky

2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College o...

www.jacc.org

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Reposted by Dominique Guerrot

NEJM.org @nejm.org · Aug 13

CONFIDENCE trial: For patients with both chronic kidney disease and type 2 diabetes, whether combination therapy with finerenone and empagliflozin would improve outcomes over single-drug therapy is unclear. Research findings are summarized in a new Quick Take video. nej.md/40Szhuy

A visual representation of a patient with both chronic kidney disease and type 2 diabetes and finerenone + empagliflozin for treatment.

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Reposted by Dominique Guerrot

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Jun 29

In the introduction, @johngreensbluesky.bsky.social drops some TB facts

Annually more than a million people die of TB

Overall, more than a *billion* people have died of TB in last 2 centuries

That’s also something like 1 in 7 people who have ever lived 🤯

#NephJCBookClub

TB deaths from Our World in Data blob:https://ourworldindata.org/9c8bbafc-201d-482c-9f4c-17decf723a36

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Dominique Guerrot @dguerrot.bsky.social · Aug 6

📖 To go deeper:
Review article by our team in Kidney International @theisn.org
👉 doi.org/10.1016/j.ki...

Redirecting

doi.org

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Dominique Guerrot @dguerrot.bsky.social · Aug 6

🧠 Bottom line:
Controlling BP in ADPKD is not optional.
It’s essential for reducing risks to the heart, the brain (notably aneurysms), and probably the kidneys themselves.

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Dominique Guerrot @dguerrot.bsky.social · Aug 6

💊 First-line treatment: RAAS blockade (#ACEi or #ARB).
Other drugs can be added depending on context:
• thiazide(-like) diuretics
• calcium channel blockers
• β-blockers
→ Adapted based on comorbidities, side effects, or tolvaptan use.

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Dominique Guerrot @dguerrot.bsky.social · Aug 6

⚠️ These targets may be difficult to achieve or poorly tolerated in practice.
🧩 In such cases, the ESH (#EuropeanSocietyofHypertension) guideline target — <130/80 mmHg — may be a reasonable alternative, aiming for long-term adherence and safety. (Personal opinion)

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Dominique Guerrot @dguerrot.bsky.social · Aug 6

📚 The 2025 #KDIGO Guidelines recommend ambitious BP targets to manage hypertension in ADPKD:
🎯 ≤110/75 mmHg (HBPM) for adults <50 y with preserved renal function (G1–G2),
🎯 <120 mmHg systolic (office BP) in older adults, if tolerated.

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Dominique Guerrot @dguerrot.bsky.social · Aug 6

🔬 Before kidney function declines, 2 disease-specific mechanisms drive early #hypertension in #ADPKD:
📍 Local ischemia due to kidney #cyst expansion → RAAS activation
📍 Loss of polycystin function in blood vessels → primary #endothelial dysfunction
→ This sets ADPKD apart from other forms of CKD

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Dominique Guerrot @dguerrot.bsky.social · Aug 6

🫀 #Hypertension in autosomal dominant polycystic kidney disease: unique pathways, common consequences.
In #ADPKD, high blood pressure is often the first clinical sign and not just a complication of the kidney disease.
Actually its mechanisms differ markedly from other CKD-related hypertension... 🧵

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Dominique Guerrot @dguerrot.bsky.social · Aug 4

Interesting. Still surprising to me that nowadays nephrologists are not involved in kidney biopsy and dialysis catheter placement in some countries. Clearly reduces the interest of choosing the speciality IMO

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Reposted by Dominique Guerrot

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · Jul 31

should we screen for CKD in the general population?

Finally, flozins, finerenone and GLP1s allow a good cost-effectiveness case

www.nephjc.com/news/2025/7/... for #NephJC shorts

Time to stop just being dialysis-ologists and flozinate, glipinate!

#NephSky