Andrew Ellisdon
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drellisdon.bsky.social
Andrew Ellisdon
@drellisdon.bsky.social
730 followers 480 following 20 posts
Structural biology and protein engineering at Monash University. Cryo-EM and AI/ML-guided structural biology of cancer and immune complexes.

https://t.co/5JwsAwTSH5
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drellisdon.bsky.social
Andrew Ellisdon @drellisdon.bsky.social · Nov 20
Our latest study is now online at Science Advances! We report the structure of the gigantic TSC:WIPI3 complex revealing new insights into lysosomal docking and dysregulation in disease. #cryoEM #mTOR 🧪

www.science.org/doi/10.1126/...
Reposted by Andrew Ellisdon
science.org
A new study reveals a signaling loop that drives metastasis in triple-negative breast cancer, discoveries about amylin receptor subunits could inform future drug design, and more this week in #ScienceSignaling. https://scim.ag/3HH1ePw
The image shows a stained section of an invasive ductal carcinoma in a mammary gland.
August 19, 2025 at 9:00 PM
drellisdon.bsky.social
Hox-C12 coordinates β2-adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer | Science Signaling www.science.org/doi/10.1126/...
Hox-C12 coordinates β2-adrenoceptor coupling to a cAMP/calcium feedforward loop to drive invasion in triple-negative breast cancer
A GPCR and a moonlighting transcription factor together drive metastasis in breast cancer.
www.science.org
August 19, 2025 at 8:09 PM
drellisdon.bsky.social
Exciting times for structural biology @monashuniversity.bsky.social from cryo-EM to therapeutic development of new AI-guided therapeutics.

www.theage.com.au/technology/n...
Nvidia supercomputer marks ‘new era’ for Australian AI
The world’s most valuable company is building an Australia-first supercomputer that will initially tackle cancer research.
www.theage.com.au
August 15, 2025 at 11:26 PM
Reposted by Andrew Ellisdon
brettcollins.bsky.social
@lorneproteins.bsky.social Meeting with the Lorne Protein Committee to plan for the 2026 and future meetings!
@wehi-research.bsky.social
July 23, 2025 at 3:57 AM
Reposted by Andrew Ellisdon
eugenevalkov.bsky.social
Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky

www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications
Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay - Nature Communications
Intracellular pathogens hijack host gene expression to subvert cellular processes. Here, the authors show that Legionella pneumophila’s PieF effector inhibits the human CCR4-NOT deadenylation machiner...
www.nature.com
July 13, 2025 at 3:59 AM
Reposted by Andrew Ellisdon
charlesbj.bsky.social
Nice review on #TSC and #mTORC highlighting our cryoEM structure of TSC. Phosphorylation mechanisms that modulate TSC activity still remain unknown. TBC1D7 function largely a mystery, but important in brain development / megalencephaly.
July 9, 2025 at 2:43 AM
Reposted by Andrew Ellisdon
bdmanning.bsky.social
Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!
July 9, 2025 at 12:38 AM
Reposted by Andrew Ellisdon
sylviecallegari.bsky.social
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...

@wehi-research.bsky.social @komanderlab.bsky.social
March 13, 2025 at 7:20 PM
Reposted by Andrew Ellisdon
kevinmgill.bsky.social
Deep in Saturn’s northern hexagon is a 2,000 kilometer (1,250 mile) wide high-wind vortex, seen here in infrared false color. Imaged by Cassini.

flic.kr/p/2g5dxDw
flic.kr/p/2g4xyyQ
Saturn’s northern hexagon in infrared false color. NASA/JPL-Caltech/SSI/CICLOPS/Kevin M. Gill Saturn’s northern vortex of terror in infrared false color. NASA/JPL-Caltech/SSI/CICLOPS/Kevin M. Gill
March 4, 2025 at 2:21 AM
drellisdon.bsky.social
Great to see this study published. Congrats to Roger Daly and team! www.nature.com/articles/s41...
Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer - Nature Communications
The PEAK family of pseudokinases is known to play oncogenic roles in poor-prognosis triple negative breast cancer (TNBC). Here this group identifies the role of calcium/calmodulin-dependent prote...
www.nature.com
February 23, 2025 at 11:29 PM
Reposted by Andrew Ellisdon
korolchuklab.bsky.social
#Autophagy and #mTOR papers from last week, there’s always something to every taste, enjoy thanks to @Bims_BiomedNews pre-selection.

biomed.news/bims-auttor/...
a man in a gucci jacket is sitting on a couch and saying over and over again
ALT: a man in a gucci jacket is sitting on a couch and saying over and over again
media.tenor.com
February 23, 2025 at 12:52 AM
Reposted by Andrew Ellisdon
kevinkaichuang.bsky.social
All-atom fixed backbone protein sequence design with FAMPNN

@richardshuai.bsky.social Talal Widatalla @possuhuanglab.bsky.social @brianhie.bsky.social

www.biorxiv.org/content/10.1...
FAMPNN architecture
February 21, 2025 at 10:37 PM
Reposted by Andrew Ellisdon
niclag.bsky.social
Our paper is out!
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity | Science Immunology www.science.org/doi/10.1126/...
LCK–co-receptor association ensures T cell lineage fidelity and maximizes epitope-specific TCR diversity
LCK-mutant mice help define the role of LCK–co-receptor association in T cell development and immune responses.
www.science.org
February 21, 2025 at 10:32 PM
Reposted by Andrew Ellisdon
thamlab.bsky.social
Interested in #malaria transmission and fertilisation? Check out our new work using cryo-EM of ENDOGENOUS sexual stage parasites to determine the Pfs230-Pfs48/45 fertilisation complex - please read & share!

structures| nanobodies |human immune responses | mRNA-LNP

www.biorxiv.org/content/10.1...
www.biorxiv.org
February 17, 2025 at 7:23 AM
Reposted by Andrew Ellisdon
adzebill.bsky.social
The Internet Archive has to date downloaded 500 terabytes of US government websites, which it crawls at the end of every presidential term. The whole archive is fully searchable. This effort's housed by a donation-funded nonprofit, not a branch of the US government. blog.archive.org/2024/05/08/e...
End of Term Web Archive – Preserving the Transition of a Nation | Internet Archive Blogs
blog.archive.org
February 1, 2025 at 12:58 AM
Reposted by Andrew Ellisdon
karaswisher.bsky.social
Must read for California www.nytimes.com/2025/01/25/o...
Opinion | California, We Feel Your Pain Here in Australia
In California’s fire-stoked debate over how aggressively to manage both nature and urban sprawl, Australia can share both empathy and insight.
www.nytimes.com
January 26, 2025 at 5:48 AM
Reposted by Andrew Ellisdon
drellisdon.bsky.social
Thanks Brett! A few more for the list

re-solute.eu/resources/da... (SLCs)
www.flyrnai.org/tools/fly_pr... (excellent)
www.ebi.ac.uk/complexporta...
prodata.swmed.edu/humanPPI/ (excellent)
honiglab.c2b2.columbia.edu/PrePPI/ (unsure)
predictomes.org (small target number)

Any others we've missed?
November 10, 2024 at 8:28 AM
Reposted by Andrew Ellisdon
johnrubinstein.bsky.social
Come be my boss!
We're looking for a new Program Head for the Molecular Medicine Program at the Hospital for Sick Children.
Toronto, Canada
(the deadline has been extended from Jan 31)
Please Re-post.
jobs.sciencecareers.org/job/667223/p...
Program Head - Molecular Medicine, The Hospital for Sick Children Research Institute - Toronto (City), Ontario (CA) job with The Hospital for Sick Children (SickKids) Research Institute | 667223
Provide leadership and mentorship to members of the Molecular Medicine Program and influence the scientific direction of the Research Institute
jobs.sciencecareers.org
January 24, 2025 at 11:02 PM
Reposted by Andrew Ellisdon
drshanerrr.bsky.social
It was perfectly clear last night until about 11pm which allowed me to finally have a good look at the Horsehead Nebula. Here is the result of 61 minutes of data (366 stacked images) from the Seestar S50. Slight enhancement in Lightroom.
January 24, 2025 at 8:21 PM
Reposted by Andrew Ellisdon
harvardcellbio.bsky.social
New work from Coon Lab (Wisconsin), @harperlabhms.bsky.social & Gygi Lab @harvardcellbio.bsky.social reports global proteomics/lipidomics of > 2 dozen Lysosomal Storage Disease mutant cells & reveals iron defects associated with mitochondrial defects in NPC2 mutants www.science.org/doi/10.1126/...
Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST
A nanoflow multiomic workflow reveals how lysosomal dysfunction disrupts autophagy and mitochondrial homeostasis in LSD mutants.
www.science.org
January 22, 2025 at 7:43 PM
Reposted by Andrew Ellisdon
reikawatanabe.bsky.social
High-resolution cryo-EM using a common LaB6 120-keV
electron microscope equipped with a sub–200-keV
direct electron detector!
www.science.org
January 5, 2025 at 2:22 PM
Reposted by Andrew Ellisdon
frezzalab.bsky.social
Good morning, all. The first curated issue of papers in #cancermetabolism and #mitochondrialbiology of 2025 is ready and full of exciting findings. Don't miss it, check it here:

biomed.news/bims-camemi/...

@biomednews.bsky.social

"I am a book I neither wrote nor read."-Delmore Schwartz
January 5, 2025 at 7:04 AM
Reposted by Andrew Ellisdon
charlesbj.bsky.social
The PDBs for our TSC structure are now available!

To put the size of TSC in perspective, here's a ribosome... this thing is enormous. 🤩

#cryoEM #mTORC1 #TSC

rcsb.org/3d-view/9CE3
science.org/doi/10.1126/sciadv.adr5807
@luptoncj.bsky.social
December 7, 2024 at 3:33 AM