Darin Takemoto
@dtake01.bsky.social
Weeder of woods. Interests: statistics, bioinformatics, music, games.
Reposted by Darin Takemoto
So either Trump spoke to Bolsonaro about plotting to escape to the US right before the latter got caught trying to saw off his ankle monitor, or Trump imagined a conversation he didn’t have. Both scenarios are incredibly dark
An amazing new Trump controversy, Part II of II:
- Saturday afternoon: Trump says he spoke to Bolsonaro the night before and planned to see him “in the very near future”
- Monday afternoon: The Trump White House isn’t sure whether Trump actually had the conversation he referenced two days earlier
- Saturday afternoon: Trump says he spoke to Bolsonaro the night before and planned to see him “in the very near future”
- Monday afternoon: The Trump White House isn’t sure whether Trump actually had the conversation he referenced two days earlier
White House hedges on Trump’s curious claim about his call with Brazil’s Bolsonaro White House hedges on Trump’s curious claim about his call with Brazil’s Jair Bolsonaro
Did the Republican president talk to Bolsonaro as the Brazilian plotted to escape? Trump said yes, but the White House isn’t so sure.
www.ms.now
November 25, 2025 at 7:28 PM
So either Trump spoke to Bolsonaro about plotting to escape to the US right before the latter got caught trying to saw off his ankle monitor, or Trump imagined a conversation he didn’t have. Both scenarios are incredibly dark
Reposted by Darin Takemoto
COP30 overpromised, underdelivered, empowered distractions, backtracked on issues and once again gave big oil and big ag a free pass.
Unfortunately, the suspicions of climate scientists (here in Brazil and abroad) were confirmed again.
Unfortunately, the suspicions of climate scientists (here in Brazil and abroad) were confirmed again.
November 22, 2025 at 7:47 PM
COP30 overpromised, underdelivered, empowered distractions, backtracked on issues and once again gave big oil and big ag a free pass.
Unfortunately, the suspicions of climate scientists (here in Brazil and abroad) were confirmed again.
Unfortunately, the suspicions of climate scientists (here in Brazil and abroad) were confirmed again.
Reposted by Darin Takemoto
Large language models pose privacy risks beyond data memorization, including uninformed consent, lack of privacy norms, deep inference, and widespread attribute aggregation. doi.org/hbcd8b
Five crucial ways LLMs can endanger your privacy
The privacy concerns around large language models like ChatGPT, Anthropic and Gemini are more serious than just the data the algorithms ingest, according to a Northeastern University computer science expert.
techxplore.com
November 24, 2025 at 6:30 PM
Large language models pose privacy risks beyond data memorization, including uninformed consent, lack of privacy norms, deep inference, and widespread attribute aggregation. doi.org/hbcd8b
LLMs perform markedly worse than medical school senior residents or attending physicians in script concordance testing, which is more analogous to situations found in actual clinical practice than the multiple-choice tests that LLMs excel at.
ai.nejm.org/doi/10.1056/...
ai.nejm.org/doi/10.1056/...
Assessment of Large Language Models in Clinical Reasoning: A Novel Benchmarking Study
Large language models (LLMs) are increasingly deployed for clinical decision support,
yet standard evaluations such as medical licensing exams overlook how clinicians update
decisions in dynamic co...
ai.nejm.org
November 24, 2025 at 6:45 PM
LLMs perform markedly worse than medical school senior residents or attending physicians in script concordance testing, which is more analogous to situations found in actual clinical practice than the multiple-choice tests that LLMs excel at.
ai.nejm.org/doi/10.1056/...
ai.nejm.org/doi/10.1056/...
Using evolutionary and human population data to predict pathogenicity of missense mutations. They achieve better prediction accuracy than other methods, including AlphaMissense.
doi.org/qftb
doi.org/qftb
Proteome-wide model for human disease genetics - Nature Genetics
popEVE is a proteome-wide deep generative model to identify and predict pathogenicity of missense mutations causing genetic disorders.
doi.org
November 24, 2025 at 2:53 PM
Using evolutionary and human population data to predict pathogenicity of missense mutations. They achieve better prediction accuracy than other methods, including AlphaMissense.
doi.org/qftb
doi.org/qftb
Reposted by Darin Takemoto
How can FDA allow TV ads for GLP-1 drug microdosing without any data?
Not aware of a single published study.
youtube.com/watch?v=zIbz...
Not aware of a single published study.
youtube.com/watch?v=zIbz...
Rebel Wilson goes Micro with Noom
YouTube video by Noom
youtube.com
November 22, 2025 at 5:14 PM
How can FDA allow TV ads for GLP-1 drug microdosing without any data?
Not aware of a single published study.
youtube.com/watch?v=zIbz...
Not aware of a single published study.
youtube.com/watch?v=zIbz...
Looks like Ecuador's Noboa is going to lose on all four of his referendums today. Most relevant to the US is the first question on allowing foreign (i.e. US) bases. Kinda makes you wonder how (or if) he won the election in the first place.
x.com/MashiRafael/...
x.com/MashiRafael/...
Rafael Correa on X: "Conteo rápido del propio CNE: A si 39.56%. No 60.44% B. Si 42.29%. No. 57.7% C. Si 46.91%. No. 53.09% D. Si 38.42%. No. 61.58% Gran triunfo de todo un pueblo. Fue una campaña absolutamente ciudadana y sin recursos. Recordar el paro indígena y los caídos: de" / X
Conteo rápido del propio CNE: A si 39.56%. No 60.44% B. Si 42.29%. No. 57.7% C. Si 46.91%. No. 53.09% D. Si 38.42%. No. 61.58% Gran triunfo de todo un pueblo. Fue una campaña absolutamente ciudadana y sin recursos. Recordar el paro indígena y los caídos: de
x.com
November 17, 2025 at 2:07 AM
Looks like Ecuador's Noboa is going to lose on all four of his referendums today. Most relevant to the US is the first question on allowing foreign (i.e. US) bases. Kinda makes you wonder how (or if) he won the election in the first place.
x.com/MashiRafael/...
x.com/MashiRafael/...
Reposted by Darin Takemoto
Reposted by Darin Takemoto
First opinions, 2nd opinions, analyzing lab tests, preparing for a clinic visit, helping to make difficult diagnoses, and more use cases. Its popularity will keep increasing despite lack of objective data for benefit or harm
www.nytimes.com/2025/11/16/w...
www.nytimes.com/2025/11/16/w...
Frustrated by the Medical System, Patients Turn to A.I.
www.nytimes.com
November 16, 2025 at 4:30 PM
First opinions, 2nd opinions, analyzing lab tests, preparing for a clinic visit, helping to make difficult diagnoses, and more use cases. Its popularity will keep increasing despite lack of objective data for benefit or harm
www.nytimes.com/2025/11/16/w...
www.nytimes.com/2025/11/16/w...
Reposted by Darin Takemoto
![Comic. Someone is claiming to predict the exact date of a future earthquake. Should you listen? [flowchart: start] → NO (There are big earthquakes constantly, so if anyone ever *does* figure this out, it will be immediately obvious that their method works and then the world’s seismologists will not shut up about it. You won’t need this flowchart.)](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreic7wdqg4w6qfevbqzzq4esd6237pojsnpwsrbb7gaxsxobqaiwazm@jpeg)
November 10, 2025 at 8:55 PM
Reposted by Darin Takemoto
Reposted by Darin Takemoto
Delusional thinking about healthspan and longevity, now from China
"In 5 to 10 years nobody will get cancer."
"Living to 150 is definitely realistic. In a few years this will be the reality."
www.nytimes.com/2025/11/08/w...
"In 5 to 10 years nobody will get cancer."
"Living to 150 is definitely realistic. In a few years this will be the reality."
www.nytimes.com/2025/11/08/w...
In China, the Dream of Outrunning Time
www.nytimes.com
November 9, 2025 at 3:39 PM
Delusional thinking about healthspan and longevity, now from China
"In 5 to 10 years nobody will get cancer."
"Living to 150 is definitely realistic. In a few years this will be the reality."
www.nytimes.com/2025/11/08/w...
"In 5 to 10 years nobody will get cancer."
"Living to 150 is definitely realistic. In a few years this will be the reality."
www.nytimes.com/2025/11/08/w...
Reposted by Darin Takemoto
I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...
Review of Cold Spring Harbor Laboratory’s Obituary for Dr. James Watson
James Watson, who described himself as “not a racist in a conventional way”, has died at the age of 97. Below is a review of an obituary for Dr. James Watson published by Cold Spring Ha…
liorpachter.wordpress.com
November 8, 2025 at 9:58 PM
I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...
Reposted by Darin Takemoto
In an interim analysis, sibeprenlimab, a humanized IgG2 monoclonal antibody that inhibits the proliferation-inducing ligand APRIL (a key driver of IgA nephropathy), reduced proteinuria as compared with placebo. nej.md/493Xtza
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
November 8, 2025 at 4:35 PM
In an interim analysis, sibeprenlimab, a humanized IgG2 monoclonal antibody that inhibits the proliferation-inducing ligand APRIL (a key driver of IgA nephropathy), reduced proteinuria as compared with placebo. nej.md/493Xtza
@asnkidney.bsky.social | #KidneyWk
@asnkidney.bsky.social | #KidneyWk
Reposted by Darin Takemoto
Reposted by Darin Takemoto
In case anyone is wondering if Watson was really THAT bad, @lpachter.bsky.social compiled a list of quotes that are absolutely not for the faint of heart.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
November 7, 2025 at 10:18 PM
In case anyone is wondering if Watson was really THAT bad, @lpachter.bsky.social compiled a list of quotes that are absolutely not for the faint of heart.
liorpachter.wordpress.com/2018/05/18/j...
liorpachter.wordpress.com/2018/05/18/j...
Reposted by Darin Takemoto
A Snowy Egret & Tricolored Heron for #BirdOfTheDay. It may look like a dance in the 1st photo but they are #fighting Started by the Snowy Egret dive bombing the heron as it stalked the mud flat during low tide and continued as an aerial battle into a nearby neighborhood. photos first 😉🪶 #birds
November 7, 2025 at 2:49 PM
A Snowy Egret & Tricolored Heron for #BirdOfTheDay. It may look like a dance in the 1st photo but they are #fighting Started by the Snowy Egret dive bombing the heron as it stalked the mud flat during low tide and continued as an aerial battle into a nearby neighborhood. photos first 😉🪶 #birds
Reposted by Darin Takemoto
Contrast this with the response of a president who was an actual decent human being.
November 6, 2025 at 5:51 PM
Contrast this with the response of a president who was an actual decent human being.
Reposted by Darin Takemoto
holy shit -- one of Trump's toadies just passed out and the White House event is brought to an abrupt end
November 6, 2025 at 5:38 PM
holy shit -- one of Trump's toadies just passed out and the White House event is brought to an abrupt end
A nice set of guidelines to make biomedical data resources (or any data resources) accessible
doi.org/qcv7
doi.org/qcv7
Ten simple rules for making biomedical data resources accessible
doi.org
November 7, 2025 at 1:54 PM
A nice set of guidelines to make biomedical data resources (or any data resources) accessible
doi.org/qcv7
doi.org/qcv7
Reposted by Darin Takemoto
Majestic Egret At The Wetlands by Debra Martz
Reddish Egret captured in Port Aransas, Texas.
debra-martz.pixels.com/featured/maj...
#ReddishEgret #egret ##bird #giftideas #birds #aves #avian #BirdLovers #featheredFriends #ornithology #photography #PhotographyIsArt #BuyIntoArt #AYearForArt
Reddish Egret captured in Port Aransas, Texas.
debra-martz.pixels.com/featured/maj...
#ReddishEgret #egret ##bird #giftideas #birds #aves #avian #BirdLovers #featheredFriends #ornithology #photography #PhotographyIsArt #BuyIntoArt #AYearForArt
November 4, 2025 at 1:14 PM
Majestic Egret At The Wetlands by Debra Martz
Reddish Egret captured in Port Aransas, Texas.
debra-martz.pixels.com/featured/maj...
#ReddishEgret #egret ##bird #giftideas #birds #aves #avian #BirdLovers #featheredFriends #ornithology #photography #PhotographyIsArt #BuyIntoArt #AYearForArt
Reddish Egret captured in Port Aransas, Texas.
debra-martz.pixels.com/featured/maj...
#ReddishEgret #egret ##bird #giftideas #birds #aves #avian #BirdLovers #featheredFriends #ornithology #photography #PhotographyIsArt #BuyIntoArt #AYearForArt
Reposted by Darin Takemoto
Analysis of ancient genomes shows Denisovan ancestry in Eurasia varied over 40,000 years, with early East Asians carrying the highest levels and later gene flow shaping regional differences. doi.org/g9856x
Dynamics of Denisovan ancestry in Eurasians over the past 40,000 years revealed
Modern humans inherited part of their ancestry from multiple, genetically distinct Denisovan groups through interbreeding events.
phys.org
November 4, 2025 at 4:05 PM
Analysis of ancient genomes shows Denisovan ancestry in Eurasia varied over 40,000 years, with early East Asians carrying the highest levels and later gene flow shaping regional differences. doi.org/g9856x
Reposted by Darin Takemoto
This week's @nature.com cover highlights a report of A.I.- mediated distortion
When #ChatGPT was asked to rate 40,000 résumés, it ranked the older male candidates as better quality than the younger female applicants nature.com/articles/s41...
When #ChatGPT was asked to rate 40,000 résumés, it ranked the older male candidates as better quality than the younger female applicants nature.com/articles/s41...
November 2, 2025 at 6:12 PM
This week's @nature.com cover highlights a report of A.I.- mediated distortion
When #ChatGPT was asked to rate 40,000 résumés, it ranked the older male candidates as better quality than the younger female applicants nature.com/articles/s41...
When #ChatGPT was asked to rate 40,000 résumés, it ranked the older male candidates as better quality than the younger female applicants nature.com/articles/s41...
Reposted by Darin Takemoto
A word that has become a euphemism for promoting and selling things without data or evidence
November 2, 2025 at 6:19 PM
A word that has become a euphemism for promoting and selling things without data or evidence
Reposted by Darin Takemoto
🤝 I’m forming a focus group to synergize and supercharge evidence‑based science communication on social media. Want to join? Drop a comment below or DM me. #SciComm
November 1, 2025 at 11:50 AM
🤝 I’m forming a focus group to synergize and supercharge evidence‑based science communication on social media. Want to join? Drop a comment below or DM me. #SciComm