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Reposted by Garvin SUMO Biology Lab

Pedro Beltrao @pedrobeltrao.bsky.social · 1d

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

The functional landscape of the human ubiquitinome

Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...

www.biorxiv.org

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Aga Gambus @agagambus.bsky.social · 3d

We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...

Senior Research Technician at University of Birmingham

Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.

www.jobs.ac.uk

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Marco Saponaro @m-saponaro.bsky.social · 3d

3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries
lnkd.in/etU3yydb

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Sarah Moser @sarahmoser.bsky.social · 25d

Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊

Histone Recycling Promotes PARP Inhibitor Resistance

Major Finding: PARP inhibition induces eviction of histones, and the chaperone NASP is required to recycle these histones to prevent DNA damage and promote resistance. Concept: Histone recycling repre...

aacrjournals.org

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The EMBO Journal @embojournal.org · 25d

Xingzhi Xu, Shunichi Takeda and collaborators show that UFL1-dependent #UFMylation of MCM5 promotes CMG replicative helicase formation and replication fork progression
www.embopress.org/doi/full/10....

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Faculty of Biological Sciences @bioscienceleeds.bsky.social · 25d

🔬 What are plasmodesmata, and why are they important?

In this new case study, discover how the Faculty's Professor Yoselin Benitez-Alfonso's research into microscopic plant pores could help tackle climate change and global food insecurity.

bit.ly/4pocNvX

@researchleeds.bsky.social

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Marcin J. Suskiewicz @msuskiewicz.bsky.social · 24d

Sharing once again - and highly recommending - the postdoc positions with Antoni. One of the projects is a collaboration with us and the postdoc will include a sojourn in our lab.

Antoni Wrobel @agwrobel.bsky.social · Sep 8

Dear scientific community,

I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.

my.corehr.com/pls/uoxrecru...

my.corehr.com/pls/uoxrecru...

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Julie @rna-julie.bsky.social · Sep 10

Looking forward to another great day at Ribosome biogenesis meeting @embo.org Great conversations yesterday and lively to catch up with colleagues!

Barbara hepworh sculpture in Churchill College gardens

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Terry Suk @terryrsuk.bsky.social · Mar 28

We’re happy to share that our labs first #ALS and #FTD study “A stress-dependent TDP-43 SUMOylation program preserves neuronal function” is now online at Molecular Neurodegeneration! doi.org/10.1186/s130...

A stress-dependent TDP-43 SUMOylation program preserves neuronal function - Molecular Neurodegeneration

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are overwhelmingly linked to TDP-43 dysfunction. Mutations in TDP-43 are rare, indicating that the progressive accumulation of exo...

doi.org

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Uli Rass @u-rass.bsky.social · Sep 3

My first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social

DNA2 enables growth by restricting recombination-restarted replication - Nature

DNA2 suppresses recombination-restarted replication and checkpoint activation at stalled forks, and its loss triggers recombination-dependent synthesis, checkpoint signalling and cell-cycle exit, high...

www.nature.com

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Lorenz Lab @sonjalorenzlab.bsky.social · Sep 2

Delighted to share our work on cellular ubiquitination of drug-like compounds by HUWE1 - a surprising journey! Kudos to all contributors & first authors, Barbara Orth and Pavel Pohl. Sincere thanks to @ireserra.bsky.social ‬ #NatCommun for expertly guiding the winding publishing path.
rdcu.be/eDzPk

Selective ubiquitination of drug-like small molecules by the ubiquitin ligase HUWE1

Nature Communications - Ubiquitination is a versatile modification system in eukaryotic cells. Here, the authors unveil that the ubiquitin ligase HUWE1 can modify drug-like small-molecule...

rdcu.be

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Chowdhury Lab @chowdhurylab.bsky.social · Sep 2

Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function.
www.cell.com/cell-chemica...

Pharmacologic interrogation of USP28 cellular function in p53 signaling

Bratt, Kilgas et al. describe the SAR-driven design of CAS-010, a selective USP28 probe, alongside a control compound and an inhibitor-resistant mutant. They show that USP28 inhibition mimics p53 path...

www.cell.com

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The EMBO Journal @embojournal.org · Aug 26

What is the basis & significance of SUMO1 vs SUMO2/3 conjugation preference? Jo Morris et al find that mitotic deacetylation biases SUMO E1 SAE2 towards #SUMO1 conjugation onto NuMA to ensure faithful chromosome segregation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....

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Hartmut Vodermaier @hvodermaier.bsky.social · Sep 2

Was fun to work on this manuscript - never would have thought that an E1 enzyme could be involved in selecting a particular #ubiquitin -like protein isoform over another!

The EMBO Journal @embojournal.org · Aug 26

What is the basis & significance of SUMO1 vs SUMO2/3 conjugation preference? Jo Morris et al find that mitotic deacetylation biases SUMO E1 SAE2 towards #SUMO1 conjugation onto NuMA to ensure faithful chromosome segregation
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....

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Marcin J. Suskiewicz @msuskiewicz.bsky.social · Sep 1

We are happy to have contributed a protocol to a book on SUMO methods (work mainly by postdoc El Hadji Cisse and engineer Stéphane Goffinont): link.springer.com/protocol/10....

Production and Purification of SUMO-UBC9 and SUMO-RANGAP1CTD

SUMOylation is a post-translational modification catalyzed by a multi-step enzymatic cascade. To gain structural biology insights into the last step of this process, where SUMO is transferred from a S...

link.springer.com

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The Groth lab @grothlab.bsky.social · Aug 28

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Image of Niels Mejlgaar (CEO of DNRF), Anja Groth (EpiC director) & Jesper Fisker (CEO of DCS).

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Oded Rechavi @odedrechavi.bsky.social · Aug 29

Opening a "Decision on your Manuscript" email

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Andrii Gorelik @andriigorelik.bsky.social · Aug 28

Happy to share that my first-author paper from my postdoc at Imperial @imperialcollegeldn.bsky.social and The Francis Crick Institute @crick.ac.uk is now published in Cell Reports!

www.sciencedirect.com/science/arti...

MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition

Human N-myristoyltransferases (NMTs) catalyze N-terminal protein N-myristoylation and are promising targets in cancer, with an emerging mechanistic ra…

www.sciencedirect.com

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Daniel Durocher @durocher1.bsky.social · Aug 28

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

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Garvin SUMO Biology Lab @garvinlab.bsky.social · Aug 21

Very happy to see this one out from @themorrislab.bsky.social. It turns out that the SUMO E1 enzyme can discriminate between SUMO isoforms by using an acetylation/deacetylation switch during mitosis. www.embopress.org/doi/full/10....

HDAC6-dependent deacetylation of SAE2 enhances SUMO1 conjugation for mitotic integrity | The EMBO Journal

imageimageThe basis and significance of SUMO1 vs SUMO2/3 conjugation preference remains incompletely understood. Here, deacetylation of SAE2, the SUMO-activating E1 enzyme, during mitosis is found to ...

www.embopress.org

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Elton Zeqiraj @zeqiraj.bsky.social · Mar 17

Amazing efforts from first author @francescachandler.bsky.social and collaborators Roger Greenberg, Joseph Salvino, Francesco Del Galdo and their teams. @pennmedicine.bsky.social @wistar.org @astburycentre.bsky.social @astbury-bsl.bsky.social
@antoncalabrese.bsky.social
@bioscienceleeds.bsky.social

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Jacqueline Jacobs @jacqjacobs.bsky.social · Aug 15

Aspiring PhD students, this is your chance to join us at the NKI to work on genomic instability and telomeres!: www.werkenbijavl.nl/vacatures/ph...

PhD student to study the mechanisms and therapeutic potential of genomic instability

www.werkenbijavl.nl

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Faculty of Biological Sciences @bioscienceleeds.bsky.social · Aug 13

Research that could change lives: A new paper led by Leeds researchers shows DNA by-products may be 'early warning system' for relapse in childhood leukaemia.

Read it in Nature: bit.ly/41zW927

@cclguk.bsky.social @littleprincesses.bsky.social
@bloodcanceruk.bsky.social @ljrusselllab.bsky.social

Excised DNA circles from V(D)J recombination promote relapsed leukaemia

Nature - Excised signal circles are circular DNA by-products of V(D)J recombination that form a complex with the V(D)J recombinase, and when increased in abundance, result in increased mutagenesis,...

bit.ly

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Astbury Biostructure Laboratory @astbury-bsl.bsky.social · Aug 11

🚨 We’re hiring! 🚨

We’re looking for a Correlative Imaging Scientist to join our EM team at ABSL!

You will be developing and supporting cryo-EM & cryo-CLEM workflows across multiple imaging platforms (FIB-SEM, cryo-confocal, cryo-EM).

Any questions? Get in touch!

jobs.leeds.ac.uk/Vacancy.aspx...

Job Opportunity at University of Leeds: Correlative Imaging Scientist

Are you a creative postdoctoral-scientist keen to explore novel in-situ biology with cryogenic electron tomography? Do you have a background in imaging technologies and/or image processing?We are look...

jobs.leeds.ac.uk

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Grant Stewart @profstewartlab.bsky.social · Aug 7

Great paper by the Vaziri lab about the role of RNF25 regulating the DDR independently of its E3 ligase activity!

www.nature.com/articles/s41...

The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling - Nature Communications

DNA replication stress is a driver of genome instability. Here, the authors identify a role of the E3 ligase RNF25 in promoting replication stress tolerance. Mechanistically, RNF25 recruits the fork p...

www.nature.com

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