Jim Hurley
@jimhurley.bsky.social
membranes, autophagy, lysosomes, cryo-EM and -ET, Parkinson's
Reposted by Jim Hurley
New pre-print out on the stepwise recruitment to membrane of the #autophagy ULK1 complex from the @mito911.bsky.social from @martenslab.bsky.social Ian Ganley @hummerlab.bsky.social @jimhurley.bsky.social labs
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
Reconstitution of multistep recruitment of ULK1 to membranes in autophagy
The ULK1 complex (ULK1C) and the class III phosphatidylinositol 3-kinase complex I (PI3KC3-C1) act together to initiate autophagy. Human ULK1C consists of ULK1 itself, FIP200, and the HORMA domain het...
doi.org
November 10, 2025 at 7:06 AM
New pre-print out on the stepwise recruitment to membrane of the #autophagy ULK1 complex from the @mito911.bsky.social from @martenslab.bsky.social Ian Ganley @hummerlab.bsky.social @jimhurley.bsky.social labs
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
with the generous support of @asapresearch.parkinsonsroadmap.org
doi.org/10.1101/2025...
Membrane dynamics, repair and disease Keystone symposium this February in Colorado. The real, true, final abstract deadline is tonight so the organizers can start picking the short talks tomorrow! www.keystonesymposia.org/conferences/...
Membrane Dynamics, Repair and Disease | Keystone Symposia
Join us at the Keystone Symposia on Membrane Dynamics, Repair and Disease, February 2026, in Keystone, with field leaders!
www.keystonesymposia.org
November 6, 2025 at 11:28 PM
Membrane dynamics, repair and disease Keystone symposium this February in Colorado. The real, true, final abstract deadline is tonight so the organizers can start picking the short talks tomorrow! www.keystonesymposia.org/conferences/...
Reposted by Jim Hurley
Collaborative. Creative. Impactful. Come join us in Ann Arbor! For more information and application link see jobs.sciencecareers.org/job/675674/f...
October 19, 2025 at 5:53 PM
Collaborative. Creative. Impactful. Come join us in Ann Arbor! For more information and application link see jobs.sciencecareers.org/job/675674/f...
Reposted by Jim Hurley
Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social
Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...
Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...
2026 Autophagy in Stress, Development and Disease Conference GRC
The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.
www.grc.org
October 17, 2025 at 7:26 PM
Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social
Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...
Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...
Reposted by Jim Hurley
Early-career scientists - last call! ⏰ Submit your short talk abstract or scholarship app by Oct 8 (11:59 pm MDT) for Autophagy: Mechanisms to Therapy. Join @annesimonsen.bsky.social, Dan Baird & others!
🔗 keysym.us/KSAutophagy26
🎥 youtu.be/4Y6YvL-unAM
#KSAutophagy26 #autophagy #mitophagy
🔗 keysym.us/KSAutophagy26
🎥 youtu.be/4Y6YvL-unAM
#KSAutophagy26 #autophagy #mitophagy
KSQA: Dr. Dan Baird (Autophagy)
YouTube video by KeystoneSymposia
youtu.be
October 6, 2025 at 10:27 PM
Early-career scientists - last call! ⏰ Submit your short talk abstract or scholarship app by Oct 8 (11:59 pm MDT) for Autophagy: Mechanisms to Therapy. Join @annesimonsen.bsky.social, Dan Baird & others!
🔗 keysym.us/KSAutophagy26
🎥 youtu.be/4Y6YvL-unAM
#KSAutophagy26 #autophagy #mitophagy
🔗 keysym.us/KSAutophagy26
🎥 youtu.be/4Y6YvL-unAM
#KSAutophagy26 #autophagy #mitophagy
Reposted by Jim Hurley
📣 Don't miss out on the upcoming mito911 #webinar featuring Karin Reinisch, PhD, from the Yale School of Medicine.
👇 Reserve your spot using the link below.
📅 October 20
⏰ 11:00 AM ET
RSVP: bit.ly/4gPqCjo
👇 Reserve your spot using the link below.
📅 October 20
⏰ 11:00 AM ET
RSVP: bit.ly/4gPqCjo
October 6, 2025 at 3:52 PM
📣 Don't miss out on the upcoming mito911 #webinar featuring Karin Reinisch, PhD, from the Yale School of Medicine.
👇 Reserve your spot using the link below.
📅 October 20
⏰ 11:00 AM ET
RSVP: bit.ly/4gPqCjo
👇 Reserve your spot using the link below.
📅 October 20
⏰ 11:00 AM ET
RSVP: bit.ly/4gPqCjo
Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.
September 20, 2025 at 12:53 PM
Position available! Team @mito911.bsky.social needs a new scientific program manager to take over from legendary super-PM @doroteaartscience.bsky.social, who is moving on to bigger things. This is a Berkeley-based position. Apply at aprecruit.berkeley.edu/JPF05103.
Reposted by Jim Hurley
Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
Structural basis for mTORC1 activation on the lysosomal membrane - Nature
Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...
www.nature.com
September 17, 2025 at 9:35 PM
Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
Reposted by Jim Hurley
RFK Jr. rolled out that old chestnut again about how healthy Americans were in the 60’s, so here’s a fact check.
In 1965:
-42% of American adults smoked; it’s 11% now.
-The infant morality rate was 24.7/1000; it’s 5.6/1000 now.
-Overall life expectancy was 70 years; it's about 77 years now.
In 1965:
-42% of American adults smoked; it’s 11% now.
-The infant morality rate was 24.7/1000; it’s 5.6/1000 now.
-Overall life expectancy was 70 years; it's about 77 years now.
September 4, 2025 at 6:46 PM
RFK Jr. rolled out that old chestnut again about how healthy Americans were in the 60’s, so here’s a fact check.
In 1965:
-42% of American adults smoked; it’s 11% now.
-The infant morality rate was 24.7/1000; it’s 5.6/1000 now.
-Overall life expectancy was 70 years; it's about 77 years now.
In 1965:
-42% of American adults smoked; it’s 11% now.
-The infant morality rate was 24.7/1000; it’s 5.6/1000 now.
-Overall life expectancy was 70 years; it's about 77 years now.
Reposted by Jim Hurley
📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin.
👇 Reserve your spot using the link below.
📅 September 8
⏰ 11:00 AM EST
RSVP: bit.ly/4mUJeAc
👇 Reserve your spot using the link below.
📅 September 8
⏰ 11:00 AM EST
RSVP: bit.ly/4mUJeAc
September 2, 2025 at 5:03 PM
📣 Don't miss out on the upcoming @mito911.bsky.social webinar featuring Katie Drerup, PhD, from the University of Wisconsin.
👇 Reserve your spot using the link below.
📅 September 8
⏰ 11:00 AM EST
RSVP: bit.ly/4mUJeAc
👇 Reserve your spot using the link below.
📅 September 8
⏰ 11:00 AM EST
RSVP: bit.ly/4mUJeAc
Reposted by Jim Hurley
🧪 And House appropriators say: no cuts to NIH budget!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
September 1, 2025 at 10:37 PM
🧪 And House appropriators say: no cuts to NIH budget!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
House subcommittee version just came out (link below). Holds NIH flat at $48 billion.
To be clear: this is far from over. But a good sign that science still matters across both sides of aisle.
YOUR VOICE MATTERS!!
Reposted by Jim Hurley
BREAKING: Big moment as CDC staff stage a mass walkout.
They have lined the street outside its HQ to greet and salute the four top officials who have resigned in protest at RFK Jr’s attack on the agency’s science base.
(🎥 AP)
They have lined the street outside its HQ to greet and salute the four top officials who have resigned in protest at RFK Jr’s attack on the agency’s science base.
(🎥 AP)
August 28, 2025 at 7:42 PM
BREAKING: Big moment as CDC staff stage a mass walkout.
They have lined the street outside its HQ to greet and salute the four top officials who have resigned in protest at RFK Jr’s attack on the agency’s science base.
(🎥 AP)
They have lined the street outside its HQ to greet and salute the four top officials who have resigned in protest at RFK Jr’s attack on the agency’s science base.
(🎥 AP)
Reposted by Jim Hurley
BIG NEWS!! We will be hiring a new professor with 25 years of endowed funding at the @biozentrum.unibas.ch @unibas.ch, focused on using biophysics and structural biology to explore climate-related fundamental science topics. Come start an innovative research cluster with us! 🧪🔬🧶🧬🌾🌍
🧪 The University of Basel is setting up a new endowed professorship in #ClimateBiophysics at the @biozentrum.unibas.ch, funded by the Georg H. Endress Foundation. This new professorship strengthens climate research @unibas.ch. www.biozentrum.unibas.ch/news/detail/...
New endowed professorship strengthens climate research at the University of Basel
The University of Basel is setting up a new endowed professorship at the Biozentrum to make fundamental discoveries at the interface between biophysics and climate-relevant environmental biology. This...
www.biozentrum.unibas.ch
August 26, 2025 at 9:32 PM
BIG NEWS!! We will be hiring a new professor with 25 years of endowed funding at the @biozentrum.unibas.ch @unibas.ch, focused on using biophysics and structural biology to explore climate-related fundamental science topics. Come start an innovative research cluster with us! 🧪🔬🧶🧬🌾🌍
Reposted by Jim Hurley
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa
August 27, 2025 at 3:27 AM
Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!
Reposted by Jim Hurley
We're Hiring! Assistant Professor of Molecular Therapeutics in MCB. Learn more and apply online:
aprecruit.berkeley.edu/JPF05098
aprecruit.berkeley.edu/JPF05098
August 20, 2025 at 10:44 PM
We're Hiring! Assistant Professor of Molecular Therapeutics in MCB. Learn more and apply online:
aprecruit.berkeley.edu/JPF05098
aprecruit.berkeley.edu/JPF05098
So happy to see @doroteaartscience.bsky.social 's art on the cover!
🏖️Our August issue's out!
Cover: Flexibility of #autophagy initiation
👉🏼Review on #metabolism in #embryogenesis #devbio
👉🏼Review on #DNArepair
🔬 #ribosomes #neurodevelopment #mitophagy #ferroptosis #stemcells #epigenetics #leukemia #antitumor immunity & more!
www.nature.com/ncb/volumes/...
Cover: Flexibility of #autophagy initiation
👉🏼Review on #metabolism in #embryogenesis #devbio
👉🏼Review on #DNArepair
🔬 #ribosomes #neurodevelopment #mitophagy #ferroptosis #stemcells #epigenetics #leukemia #antitumor immunity & more!
www.nature.com/ncb/volumes/...
August 12, 2025 at 7:53 PM
So happy to see @doroteaartscience.bsky.social 's art on the cover!
Reposted by Jim Hurley
New research reports the identification of a Mitophagic Stress Response ("MitoSR" - mmm, catchy!) activated by mitochondrial damage in neurons & operating in parallel to canonical Pink1/Parkin-dependent mitophagy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 10, 2025 at 11:38 AM
New research reports the identification of a Mitophagic Stress Response ("MitoSR" - mmm, catchy!) activated by mitochondrial damage in neurons & operating in parallel to canonical Pink1/Parkin-dependent mitophagy
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Jim Hurley
Animal cell biology per gpt5:
August 8, 2025 at 10:04 PM
Animal cell biology per gpt5:
Want to share your work at the premiere meeting of the minds between basic membrane biology and therapeutics? Short talk deadline is coming up Oct. 8, 2025. www.keystonesymposia.org/conferences/...
August 4, 2025 at 7:10 PM
Want to share your work at the premiere meeting of the minds between basic membrane biology and therapeutics? Short talk deadline is coming up Oct. 8, 2025. www.keystonesymposia.org/conferences/...
Reposted by Jim Hurley
New Online! Lysosomal membrane homeostasis and its importance in physiology and disease
Lysosomal membrane homeostasis and its importance in physiology and disease
Nature Reviews Molecular Cell Biology, Published online: 04 August 2025; doi:10.1038/s41580-025-00873-wLysosomes degrade cellular components, and their membrane is an important signalling hub. Recent insights into the mechanisms that maintain lysosomal membrane homeostasis — including the interplay between membrane damage, repair, lysophagy and lysosome biogenesis — highlight their importance in physiology, in disease and during ageing.
bit.ly
August 4, 2025 at 6:47 PM
New Online! Lysosomal membrane homeostasis and its importance in physiology and disease
Reposted by Jim Hurley
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.
August 1, 2025 at 9:06 AM
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.
Reposted by Jim Hurley
The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.
With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency
Republicans on spending committee push back against proposed reorganization and overhead cuts
scim.ag
July 31, 2025 at 9:37 PM
The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.
Congratulations @kev-in-situ-et.bsky.social and the whole team on in situ cryo-ET images of OA-induced mitochondria damage and Parkin-dependent mitophagy out now tinyurl.com/25b82cp4. We couldn't have done it without in situ guru @wilflinglab.bsky.social and mito guru @samlewis.bsky.social .
July 31, 2025 at 7:02 PM
Congratulations @kev-in-situ-et.bsky.social and the whole team on in situ cryo-ET images of OA-induced mitochondria damage and Parkin-dependent mitophagy out now tinyurl.com/25b82cp4. We couldn't have done it without in situ guru @wilflinglab.bsky.social and mito guru @samlewis.bsky.social .
Reposted by Jim Hurley
First highlight...
Senator Capito started of the discussion saying that the bill contains AN INCREASE for NIH.
The details are not available, but the bill will be released ofter the hearing.
This is not a done-deal, but it does show where the Senate is on a bipartisan basis.
Senator Capito started of the discussion saying that the bill contains AN INCREASE for NIH.
The details are not available, but the bill will be released ofter the hearing.
This is not a done-deal, but it does show where the Senate is on a bipartisan basis.
July 31, 2025 at 4:12 PM
First highlight...
Senator Capito started of the discussion saying that the bill contains AN INCREASE for NIH.
The details are not available, but the bill will be released ofter the hearing.
This is not a done-deal, but it does show where the Senate is on a bipartisan basis.
Senator Capito started of the discussion saying that the bill contains AN INCREASE for NIH.
The details are not available, but the bill will be released ofter the hearing.
This is not a done-deal, but it does show where the Senate is on a bipartisan basis.