Josette Schoenmakers
@josetteschoenma.bsky.social
Reposted by Josette Schoenmakers
Fascinating 🧵. The grotesquely mutated spike of this NJ Cryptic binds ACE2 very tightly.
It raises a broader question: Can cryptic wastewater-like lineages transmit?
YES
We knew it happened once. Now we know it's happened at least twice. The results in both cases were not pretty. 1/15
It raises a broader question: Can cryptic wastewater-like lineages transmit?
YES
We knew it happened once. Now we know it's happened at least twice. The results in both cases were not pretty. 1/15
This is wild.
Remember the NJ crytic lineage?
I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out.
Some colleagues took me up on it.
Guess what they found?
1/
Remember the NJ crytic lineage?
I posted 18 months ago that the Spike was too divergent to predict ACE2 binding, and asked if someone else could figure it out.
Some colleagues took me up on it.
Guess what they found?
1/
November 22, 2025 at 7:19 PM
Fascinating 🧵. The grotesquely mutated spike of this NJ Cryptic binds ACE2 very tightly.
It raises a broader question: Can cryptic wastewater-like lineages transmit?
YES
We knew it happened once. Now we know it's happened at least twice. The results in both cases were not pretty. 1/15
It raises a broader question: Can cryptic wastewater-like lineages transmit?
YES
We knew it happened once. Now we know it's happened at least twice. The results in both cases were not pretty. 1/15
Reposted by Josette Schoenmakers
Tv-programma zet verwijderde panelen naast begraafplaats Margraten neer
Tv-programma zet verwijderde panelen naast begraafplaats Margraten neer
De twee panelen met informatie over zwarte Amerikaanse militairen werden onthuld in het bijzijn van nazaten.
nos.nl
November 23, 2025 at 3:06 AM
Tv-programma zet verwijderde panelen naast begraafplaats Margraten neer
Reposted by Josette Schoenmakers
1/ 🚀 Exciting news: we’ve just released the first Nextclade dataset for Enterovirus D68 (EV-D68), developed in collaboration with the European Non-Polio Enterovirus Network (ENPEN).
👉🏻 Check out the dataset on Nextclade! clades.nextstrain.org?dataset-name...
#EVD68 #Enterovirus #OpenData
👉🏻 Check out the dataset on Nextclade! clades.nextstrain.org?dataset-name...
#EVD68 #Enterovirus #OpenData
November 20, 2025 at 12:49 PM
1/ 🚀 Exciting news: we’ve just released the first Nextclade dataset for Enterovirus D68 (EV-D68), developed in collaboration with the European Non-Polio Enterovirus Network (ENPEN).
👉🏻 Check out the dataset on Nextclade! clades.nextstrain.org?dataset-name...
#EVD68 #Enterovirus #OpenData
👉🏻 Check out the dataset on Nextclade! clades.nextstrain.org?dataset-name...
#EVD68 #Enterovirus #OpenData
Reposted by Josette Schoenmakers
Worrisome: HIghly pathogenic avian influenza (HPAI, likely H5N1) was reported in a poultry farm (62 thousand layer hens) in Terschuur, The Netherlands. This farm is located in the poultry-dense Gelder Valley, with 195 other poultry farms in a 10-km radius. (1/3)
www.rijksoverheid.nl/actueel/nieu...
www.rijksoverheid.nl/actueel/nieu...
November 18, 2025 at 5:19 AM
Worrisome: HIghly pathogenic avian influenza (HPAI, likely H5N1) was reported in a poultry farm (62 thousand layer hens) in Terschuur, The Netherlands. This farm is located in the poultry-dense Gelder Valley, with 195 other poultry farms in a 10-km radius. (1/3)
www.rijksoverheid.nl/actueel/nieu...
www.rijksoverheid.nl/actueel/nieu...
Reposted by Josette Schoenmakers
Overstromingen zetten tentenkampen Gaza blank: 'Blote voeten en natte dekens'
Overstromingen zetten tentenkampen Gaza blank: 'Blote voeten en natte dekens'
"Het regende maar een paar minuten, een half uurtje. Toen stonden de tenten al helemaal onder water", zegt een journalist van Al Jazeera vanuit Gaza.
nos.nl
November 16, 2025 at 8:41 AM
Overstromingen zetten tentenkampen Gaza blank: 'Blote voeten en natte dekens'
Reposted by Josette Schoenmakers
#JustPublished:
Detection of wild poliovirus in wastewater in Germany: risk and recommendations.
Germany has reported the detection of wild #poliovirus type 1 (WPV1) in a wastewater sample from Hamburg. 𝗡𝗼 𝗵𝘂𝗺𝗮𝗻 𝗰𝗮𝘀𝗲𝘀 𝗵𝗮𝘃𝗲 𝗯𝗲𝗲𝗻 𝗶𝗱𝗲𝗻𝘁𝗶𝗳𝗶𝗲𝗱, 𝗮𝗻𝗱 𝗘𝘂𝗿𝗼𝗽𝗲 𝗿𝗲𝗺𝗮𝗶𝗻𝘀 𝗽𝗼𝗹𝗶𝗼-𝗳𝗿𝗲𝗲.
#Polio #IDsky #EpiSky
Detection of wild poliovirus in wastewater in Germany: risk and recommendations.
Germany has reported the detection of wild #poliovirus type 1 (WPV1) in a wastewater sample from Hamburg. 𝗡𝗼 𝗵𝘂𝗺𝗮𝗻 𝗰𝗮𝘀𝗲𝘀 𝗵𝗮𝘃𝗲 𝗯𝗲𝗲𝗻 𝗶𝗱𝗲𝗻𝘁𝗶𝗳𝗶𝗲𝗱, 𝗮𝗻𝗱 𝗘𝘂𝗿𝗼𝗽𝗲 𝗿𝗲𝗺𝗮𝗶𝗻𝘀 𝗽𝗼𝗹𝗶𝗼-𝗳𝗿𝗲𝗲.
#Polio #IDsky #EpiSky
Detection of wild poliovirus in wastewater in Germany: risk and recommendations
Germany’s health authorities have reported the detection of wild poliovirus type 1 in one wastewater sample in Hamburg.
bit.ly
November 13, 2025 at 8:36 PM
#JustPublished:
Detection of wild poliovirus in wastewater in Germany: risk and recommendations.
Germany has reported the detection of wild #poliovirus type 1 (WPV1) in a wastewater sample from Hamburg. 𝗡𝗼 𝗵𝘂𝗺𝗮𝗻 𝗰𝗮𝘀𝗲𝘀 𝗵𝗮𝘃𝗲 𝗯𝗲𝗲𝗻 𝗶𝗱𝗲𝗻𝘁𝗶𝗳𝗶𝗲𝗱, 𝗮𝗻𝗱 𝗘𝘂𝗿𝗼𝗽𝗲 𝗿𝗲𝗺𝗮𝗶𝗻𝘀 𝗽𝗼𝗹𝗶𝗼-𝗳𝗿𝗲𝗲.
#Polio #IDsky #EpiSky
Detection of wild poliovirus in wastewater in Germany: risk and recommendations.
Germany has reported the detection of wild #poliovirus type 1 (WPV1) in a wastewater sample from Hamburg. 𝗡𝗼 𝗵𝘂𝗺𝗮𝗻 𝗰𝗮𝘀𝗲𝘀 𝗵𝗮𝘃𝗲 𝗯𝗲𝗲𝗻 𝗶𝗱𝗲𝗻𝘁𝗶𝗳𝗶𝗲𝗱, 𝗮𝗻𝗱 𝗘𝘂𝗿𝗼𝗽𝗲 𝗿𝗲𝗺𝗮𝗶𝗻𝘀 𝗽𝗼𝗹𝗶𝗼-𝗳𝗿𝗲𝗲.
#Polio #IDsky #EpiSky
Reposted by Josette Schoenmakers
Met een knoop in m’n maag volg ik de rechtszaak over het Vlaardingse pleegmeisje. Wat een gruwelijkheden heeft zij doorstaan.
Gisteren kreeg ik de vraag wat politiek Den Haag doet om het stelsel te verbeteren.
Het antwoord: weinig. Kamer en Kabinet laten het keihard afweten.
Gisteren kreeg ik de vraag wat politiek Den Haag doet om het stelsel te verbeteren.
Het antwoord: weinig. Kamer en Kabinet laten het keihard afweten.
November 6, 2025 at 4:27 PM
Met een knoop in m’n maag volg ik de rechtszaak over het Vlaardingse pleegmeisje. Wat een gruwelijkheden heeft zij doorstaan.
Gisteren kreeg ik de vraag wat politiek Den Haag doet om het stelsel te verbeteren.
Het antwoord: weinig. Kamer en Kabinet laten het keihard afweten.
Gisteren kreeg ik de vraag wat politiek Den Haag doet om het stelsel te verbeteren.
Het antwoord: weinig. Kamer en Kabinet laten het keihard afweten.
Reposted by Josette Schoenmakers
🚨 NEW: The majority holder of the world's genetic sequence data is a bad actor who can cut off access to critics and competing services. We've tolerated this for years, and now it threatens the pandemic treaty. Time for WHO to step in. With @ctrlalttim.com: www.thinkglobalhealth.org/article/to-f...
To Finish the Pandemic Agreement, WHO Needs a Trustworthy Viral Database | Think Global Health
Online platforms for sharing virus sequences are in disarray. The World Health Organization has a chance to build something new
www.thinkglobalhealth.org
November 5, 2025 at 3:31 PM
🚨 NEW: The majority holder of the world's genetic sequence data is a bad actor who can cut off access to critics and competing services. We've tolerated this for years, and now it threatens the pandemic treaty. Time for WHO to step in. With @ctrlalttim.com: www.thinkglobalhealth.org/article/to-f...
Reposted by Josette Schoenmakers
BA.3.2 has arrived in the UK. One BA.3.2.2, collected October 5, was uploaded from Scotland today.
Same branch as recent BA.3.2.2 from Germany & Slovenia.
It has a few errors (S:ins214:ASDT is misread & ORF1a:E4388K is an artifact). Ignoring those, the one notable new mutation is N:N126K.
Same branch as recent BA.3.2.2 from Germany & Slovenia.
It has a few errors (S:ins214:ASDT is misread & ORF1a:E4388K is an artifact). Ignoring those, the one notable new mutation is N:N126K.
November 7, 2025 at 12:10 PM
BA.3.2 has arrived in the UK. One BA.3.2.2, collected October 5, was uploaded from Scotland today.
Same branch as recent BA.3.2.2 from Germany & Slovenia.
It has a few errors (S:ins214:ASDT is misread & ORF1a:E4388K is an artifact). Ignoring those, the one notable new mutation is N:N126K.
Same branch as recent BA.3.2.2 from Germany & Slovenia.
It has a few errors (S:ins214:ASDT is misread & ORF1a:E4388K is an artifact). Ignoring those, the one notable new mutation is N:N126K.
Reposted by Josette Schoenmakers
Closing these public analyses puts the world more in the dark and concretely harms surveillance as it becomes more difficult for variant spotters to contribute to global situational awareness. 4/5
November 6, 2025 at 9:46 PM
Closing these public analyses puts the world more in the dark and concretely harms surveillance as it becomes more difficult for variant spotters to contribute to global situational awareness. 4/5
Reposted by Josette Schoenmakers
On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
November 6, 2025 at 9:46 PM
On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
Reposted by Josette Schoenmakers
Hebben jullie dit rapport gelezen?
Carbon credits als moderne vorm van kolonialisme!
Bedrijven die hiermee de traditie van Keniaanse en Tanzaniaanse Maasai willen beïnvloeden voor eigen gewin.
H/t yuritangondi op het andere platform
assets.survivalinternational.org/documents/24...
Carbon credits als moderne vorm van kolonialisme!
Bedrijven die hiermee de traditie van Keniaanse en Tanzaniaanse Maasai willen beïnvloeden voor eigen gewin.
H/t yuritangondi op het andere platform
assets.survivalinternational.org/documents/24...
assets.survivalinternational.org
November 5, 2025 at 2:12 PM
Hebben jullie dit rapport gelezen?
Carbon credits als moderne vorm van kolonialisme!
Bedrijven die hiermee de traditie van Keniaanse en Tanzaniaanse Maasai willen beïnvloeden voor eigen gewin.
H/t yuritangondi op het andere platform
assets.survivalinternational.org/documents/24...
Carbon credits als moderne vorm van kolonialisme!
Bedrijven die hiermee de traditie van Keniaanse en Tanzaniaanse Maasai willen beïnvloeden voor eigen gewin.
H/t yuritangondi op het andere platform
assets.survivalinternational.org/documents/24...
Reposted by Josette Schoenmakers
EU-landen mogen vanaf nu carbon credits gebruiken om hun klimaatdoelen te halen. Dat besloot de EU vandaag na lange onderhandelingen. Met die credits kunnen landen laten zien dat ergens anders ter wereld CO₂ uit de lucht is gehaald. Maar de klimaatimpact daarvan wordt grof overschat.
De EU kiest met carbon credits voor afzwakken klimaatdoelen
Na lange onderhandelingen besloot de Europese Unie vandaag om haar klimaatdoelen af te zwakken door het toelaten van ‘carbon credits’. Dat zijn papieren die laten zien dat ergens anders ter wereld CO₂...
www.ftm.nl
November 5, 2025 at 1:17 PM
EU-landen mogen vanaf nu carbon credits gebruiken om hun klimaatdoelen te halen. Dat besloot de EU vandaag na lange onderhandelingen. Met die credits kunnen landen laten zien dat ergens anders ter wereld CO₂ uit de lucht is gehaald. Maar de klimaatimpact daarvan wordt grof overschat.
Slovenia just uploaded a BA.3.2.2 to GISAID.
It is most closely linked to the 2 German BA.3.2.2 from April and september and (a bit more distant) to a South African one from September.
It is most closely linked to the 2 German BA.3.2.2 from April and september and (a bit more distant) to a South African one from September.
November 5, 2025 at 9:32 AM
Slovenia just uploaded a BA.3.2.2 to GISAID.
It is most closely linked to the 2 German BA.3.2.2 from April and september and (a bit more distant) to a South African one from September.
It is most closely linked to the 2 German BA.3.2.2 from April and september and (a bit more distant) to a South African one from September.
Reposted by Josette Schoenmakers
GISAID is now blocking genomic sequencing access to critical resources like Nextstrain, Covspectrum, Outbreak-info, & others.
This makes us less safe, as live tracking of viral evolution remains critical for assessment of emerging threats. This needs to be escalated.
This makes us less safe, as live tracking of viral evolution remains critical for assessment of emerging threats. This needs to be escalated.
Bad. No justification, no communication, no standard procedures for making changes—just arbitrary pronouncements cutting off access to some of the most valuable resources we have.
And now NextStrain as well.
Next up, will GISAID start charging open-source community tools to have access?
That would completely shaft users who contributed to GISAID, where we never agreed to that and assumed GISAID would be good custodians of the data we contributed. They're not.
Next up, will GISAID start charging open-source community tools to have access?
That would completely shaft users who contributed to GISAID, where we never agreed to that and assumed GISAID would be good custodians of the data we contributed. They're not.
October 30, 2025 at 10:53 PM
GISAID is now blocking genomic sequencing access to critical resources like Nextstrain, Covspectrum, Outbreak-info, & others.
This makes us less safe, as live tracking of viral evolution remains critical for assessment of emerging threats. This needs to be escalated.
This makes us less safe, as live tracking of viral evolution remains critical for assessment of emerging threats. This needs to be escalated.
Reposted by Josette Schoenmakers
And now NextStrain as well.
Next up, will GISAID start charging open-source community tools to have access?
That would completely shaft users who contributed to GISAID, where we never agreed to that and assumed GISAID would be good custodians of the data we contributed. They're not.
Next up, will GISAID start charging open-source community tools to have access?
That would completely shaft users who contributed to GISAID, where we never agreed to that and assumed GISAID would be good custodians of the data we contributed. They're not.
October 16, 2025 at 7:48 PM
And now NextStrain as well.
Next up, will GISAID start charging open-source community tools to have access?
That would completely shaft users who contributed to GISAID, where we never agreed to that and assumed GISAID would be good custodians of the data we contributed. They're not.
Next up, will GISAID start charging open-source community tools to have access?
That would completely shaft users who contributed to GISAID, where we never agreed to that and assumed GISAID would be good custodians of the data we contributed. They're not.
Reposted by Josette Schoenmakers
NZ wastewater COVID19 surveillance dashboard update. poops.nz The levels detected are relatively low and there is a mixed bag of variants tracked and reported, including the first detection of BA.3.2 in NZ (albeit just in one sample a few weeks ago & hasn’t been detected since.
October 30, 2025 at 6:11 PM
NZ wastewater COVID19 surveillance dashboard update. poops.nz The levels detected are relatively low and there is a mixed bag of variants tracked and reported, including the first detection of BA.3.2 in NZ (albeit just in one sample a few weeks ago & hasn’t been detected since.
Reposted by Josette Schoenmakers
🦠Heads up. BA.3.2 has arrived in NZ
BA.3.2 detected in Aotearoa New Zealand wastewater
3.2% for the week to 5 October
BA.3.2 is not shown in the fortnight to 19 Oct. However, variants with a national percentage of < 1% are not included so BA.3.2 is likely to still be circulating
BA.3.2 detected in Aotearoa New Zealand wastewater
3.2% for the week to 5 October
BA.3.2 is not shown in the fortnight to 19 Oct. However, variants with a national percentage of < 1% are not included so BA.3.2 is likely to still be circulating
October 30, 2025 at 4:06 AM
🦠Heads up. BA.3.2 has arrived in NZ
BA.3.2 detected in Aotearoa New Zealand wastewater
3.2% for the week to 5 October
BA.3.2 is not shown in the fortnight to 19 Oct. However, variants with a national percentage of < 1% are not included so BA.3.2 is likely to still be circulating
BA.3.2 detected in Aotearoa New Zealand wastewater
3.2% for the week to 5 October
BA.3.2 is not shown in the fortnight to 19 Oct. However, variants with a national percentage of < 1% are not included so BA.3.2 is likely to still be circulating
Reposted by Josette Schoenmakers
Dit doet gewoon pijn aan je oren. How low can you go? Proberen een puntje te scoren over de rug van een vrouw. Goed dat de presentator het benoemt voor wat het is: onversneden seksisme.
October 27, 2025 at 6:16 PM
Dit doet gewoon pijn aan je oren. How low can you go? Proberen een puntje te scoren over de rug van een vrouw. Goed dat de presentator het benoemt voor wat het is: onversneden seksisme.
Reposted by Josette Schoenmakers
One more BA.3.2.1 from netherlands
cc @snpoehlm.bsky.social @ryanhisner.bsky.social @josetteschoenma.bsky.social ( i m apparently blocked by X, likely it doesn't like intl law)
cc @snpoehlm.bsky.social @ryanhisner.bsky.social @josetteschoenma.bsky.social ( i m apparently blocked by X, likely it doesn't like intl law)
October 23, 2025 at 3:36 PM
One more BA.3.2.1 from netherlands
cc @snpoehlm.bsky.social @ryanhisner.bsky.social @josetteschoenma.bsky.social ( i m apparently blocked by X, likely it doesn't like intl law)
cc @snpoehlm.bsky.social @ryanhisner.bsky.social @josetteschoenma.bsky.social ( i m apparently blocked by X, likely it doesn't like intl law)
Reposted by Josette Schoenmakers
Dit is waarom het 2e Woonprotest door de Kalverstraat liep; er staan 240 woningen leeg, midden in het centrum van onze hoofdstad, en er kraait geen haan naar...
October 22, 2025 at 7:11 AM
Dit is waarom het 2e Woonprotest door de Kalverstraat liep; er staan 240 woningen leeg, midden in het centrum van onze hoofdstad, en er kraait geen haan naar...
In Nederland lijkt de recombinant XGA opkomend. Het zijn er nog niet heel veel, maar hij is al wel in 6 provincies gevonden.
Hij komt tot nog toe voornamelijk in West-Europa voor, zoals in België, Frankrijk en Spanje.
Hij komt tot nog toe voornamelijk in West-Europa voor, zoals in België, Frankrijk en Spanje.
October 17, 2025 at 9:25 PM
In Nederland lijkt de recombinant XGA opkomend. Het zijn er nog niet heel veel, maar hij is al wel in 6 provincies gevonden.
Hij komt tot nog toe voornamelijk in West-Europa voor, zoals in België, Frankrijk en Spanje.
Hij komt tot nog toe voornamelijk in West-Europa voor, zoals in België, Frankrijk en Spanje.
Not a majority for PE.1.4 in the NSW samples uploaded to GISAID, but close.
A second BA.3.2.2, which wasn't mentioned in the report.
A second BA.3.2.2, which wasn't mentioned in the report.
October 16, 2025 at 10:56 AM
Not a majority for PE.1.4 in the NSW samples uploaded to GISAID, but close.
A second BA.3.2.2, which wasn't mentioned in the report.
A second BA.3.2.2, which wasn't mentioned in the report.
Emergence of COVID-19 Variant XFG not linked to Higher Rates of Sore Throat or altered severity: Evidence from participatory surveillance in The Netherlands @rivm-nl.bsky.social
www.rivm.nl/documenten/e...
www.rivm.nl/documenten/e...
Emergence of COVID-19 Variant XFG not linked to Higher Rates of Sore Throat or altered severity: Evidence from participatory surveillance in The Netherlands | RIVM
www.rivm.nl
October 16, 2025 at 9:58 AM
Emergence of COVID-19 Variant XFG not linked to Higher Rates of Sore Throat or altered severity: Evidence from participatory surveillance in The Netherlands @rivm-nl.bsky.social
www.rivm.nl/documenten/e...
www.rivm.nl/documenten/e...
PE.1.4 has now reached majority in New South Wales/Australia.
Cases not up (yet?).
Cases not up (yet?).
October 16, 2025 at 5:07 AM
PE.1.4 has now reached majority in New South Wales/Australia.
Cases not up (yet?).
Cases not up (yet?).