Federico Gueli
@siamosolocani.bsky.social
Variant Spotter SC2 .
Reposted by Federico Gueli
I was very sorry to learn that Walt Dowdle, a former #CDC scientist & leader, has died. Dr. Dowdle served at CDC in several positions, including acting director.
I met him after he'd retired. A font of knowledge, he was always generous with his time. www.mclanefuneralservices.com/obituaries/w...
I met him after he'd retired. A font of knowledge, he was always generous with his time. www.mclanefuneralservices.com/obituaries/w...
Walter Reid Dowdle Obituary November 17, 2025 - McLane Funeral & Cremation Services
View Walter Reid Dowdle's obituary, send flowers, find service dates, and sign the guestbook.
www.mclanefuneralservices.com
November 23, 2025 at 3:55 PM
I was very sorry to learn that Walt Dowdle, a former #CDC scientist & leader, has died. Dr. Dowdle served at CDC in several positions, including acting director.
I met him after he'd retired. A font of knowledge, he was always generous with his time. www.mclanefuneralservices.com/obituaries/w...
I met him after he'd retired. A font of knowledge, he was always generous with his time. www.mclanefuneralservices.com/obituaries/w...
Reposted by Federico Gueli
This one spotted by @siamosolocani.bsky.social - SUCH a cool example of SARS-CoV-2 evolution! Triple strike! (this happened with Omicron as well, where it took out three serines in a triple strike too).
nextstrain.org/fetch/genome...
nextstrain.org/fetch/genome...
November 23, 2025 at 5:52 PM
This one spotted by @siamosolocani.bsky.social - SUCH a cool example of SARS-CoV-2 evolution! Triple strike! (this happened with Omicron as well, where it took out three serines in a triple strike too).
nextstrain.org/fetch/genome...
nextstrain.org/fetch/genome...
Reposted by Federico Gueli
“Two Black women said they were denied immediate medical attention despite being minutes away from giving birth.
“The incidents, which happened days apart in different states, highlight long-standing disparities in health outcomes for Black women, health experts say.”
“The incidents, which happened days apart in different states, highlight long-standing disparities in health outcomes for Black women, health experts say.”
Black mothers in Texas and Indiana say hospital staff ignored cries for care while they were in labor
“It was really a horrific situation to be treated like a dog, or not even like a dog, like less than,” mother Mercedes Wells said.
www.nbcnews.com
November 23, 2025 at 2:46 PM
“Two Black women said they were denied immediate medical attention despite being minutes away from giving birth.
“The incidents, which happened days apart in different states, highlight long-standing disparities in health outcomes for Black women, health experts say.”
“The incidents, which happened days apart in different states, highlight long-standing disparities in health outcomes for Black women, health experts say.”
Reposted by Federico Gueli
Vive la différence!
November 19, 2025 at 1:56 PM
Vive la différence!
Reposted by Federico Gueli
This is explosive stuff. Evidence that Jeffrey Epstein not only ran a child sex trafficking operation for powerful men, he also seems to have advised & supported Farage’s far right political projects in Europe and the UK, including Brexit, via Steve Bannon.
bylinetimes.com/2025/11/19/d...
bylinetimes.com/2025/11/19/d...
Dinner with Mr Brexit: Bannon’s European Revolution – Planned with Farage, Backed by Epstein
Nigel Farage was the figurehead and his partner Laure Ferrari started it. Steve Bannon and convicted sex offender Jeffrey Epstein were providing almost daily support
bylinetimes.com
November 20, 2025 at 7:41 AM
This is explosive stuff. Evidence that Jeffrey Epstein not only ran a child sex trafficking operation for powerful men, he also seems to have advised & supported Farage’s far right political projects in Europe and the UK, including Brexit, via Steve Bannon.
bylinetimes.com/2025/11/19/d...
bylinetimes.com/2025/11/19/d...
Reposted by Federico Gueli
Combined with the probable AI bubble burst... this is worrisome.
USA: Total outstanding public debt in billion $.
As off yesterday it is $2 trillion higher then on the 4th of July when the "Big Beautiful Bill" was signed, shifting the debt ceiling.
As off yesterday it is $2 trillion higher then on the 4th of July when the "Big Beautiful Bill" was signed, shifting the debt ceiling.
November 19, 2025 at 10:30 PM
Combined with the probable AI bubble burst... this is worrisome.
Reposted by Federico Gueli
Thrilled to see this finally announced - and glad to see good things still happening to good people!
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Sentinel Awarded $100 Million to Prevent Pandemics
www.macfound.org
November 18, 2025 at 10:17 PM
Thrilled to see this finally announced - and glad to see good things still happening to good people!
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Reposted by Federico Gueli
3 papers @thelancet.com today on the health dangers of ultraprocessed foods and a call for action
The health risks
www.thelancet.com/journals/lan...
The health risks
www.thelancet.com/journals/lan...
November 18, 2025 at 11:42 PM
3 papers @thelancet.com today on the health dangers of ultraprocessed foods and a call for action
The health risks
www.thelancet.com/journals/lan...
The health risks
www.thelancet.com/journals/lan...
Reposted by Federico Gueli
Cue the "progressive" Carney loyalists to rationalize Canada moving backwards on climate.
At COP30 Canada just got awarded the fossil of the day — first time since 2014 (the harper years). Clear sign of how Carney’s pro fossil fuel agenda and backsliding on climate policy is being noticed internationally.
November 19, 2025 at 1:23 AM
Cue the "progressive" Carney loyalists to rationalize Canada moving backwards on climate.
Reposted by Federico Gueli
Fascinating one. Massive increase in ACE2 binding with S:I358F according to @jbloomlab.bsky.social DMS—among the highest of any viable mutation. Seems to inhibit entry and increases vulnerability to antibodies, but with a colossal ACE2 boost like that, it could easily find other Ab-evading muts.
November 19, 2025 at 1:50 AM
Fascinating one. Massive increase in ACE2 binding with S:I358F according to @jbloomlab.bsky.social DMS—among the highest of any viable mutation. Seems to inhibit entry and increases vulnerability to antibodies, but with a colossal ACE2 boost like that, it could easily find other Ab-evading muts.
New branch spotted, it captured my attention from the first sample uploaded to Gisaid.
One GBW(US-airport surveillance) sample from Fiji Island.
With a rare mutation ( <100seqs in the pandemic) in the RBD and another a bit after the FCS region. and some interesting orf1b mutations in the tree.
One GBW(US-airport surveillance) sample from Fiji Island.
With a rare mutation ( <100seqs in the pandemic) in the RBD and another a bit after the FCS region. and some interesting orf1b mutations in the tree.
November 18, 2025 at 11:43 PM
New branch spotted, it captured my attention from the first sample uploaded to Gisaid.
One GBW(US-airport surveillance) sample from Fiji Island.
With a rare mutation ( <100seqs in the pandemic) in the RBD and another a bit after the FCS region. and some interesting orf1b mutations in the tree.
One GBW(US-airport surveillance) sample from Fiji Island.
With a rare mutation ( <100seqs in the pandemic) in the RBD and another a bit after the FCS region. and some interesting orf1b mutations in the tree.
Reposted by Federico Gueli
The Gelder Valley is the poultry-dense region where an outbreak of another HPAI subtype, H7N7, started in 2003, spreading across the Netherlands and into Germany and Belgium. It caused the deaths of approximately 30 million chickens. It also spread to at least 89 people, one of whom died. (2/3)
November 18, 2025 at 5:19 AM
The Gelder Valley is the poultry-dense region where an outbreak of another HPAI subtype, H7N7, started in 2003, spreading across the Netherlands and into Germany and Belgium. It caused the deaths of approximately 30 million chickens. It also spread to at least 89 people, one of whom died. (2/3)
Reposted by Federico Gueli
Worrisome: HIghly pathogenic avian influenza (HPAI, likely H5N1) was reported in a poultry farm (62 thousand layer hens) in Terschuur, The Netherlands. This farm is located in the poultry-dense Gelder Valley, with 195 other poultry farms in a 10-km radius. (1/3)
www.rijksoverheid.nl/actueel/nieu...
www.rijksoverheid.nl/actueel/nieu...
November 18, 2025 at 5:19 AM
Worrisome: HIghly pathogenic avian influenza (HPAI, likely H5N1) was reported in a poultry farm (62 thousand layer hens) in Terschuur, The Netherlands. This farm is located in the poultry-dense Gelder Valley, with 195 other poultry farms in a 10-km radius. (1/3)
www.rijksoverheid.nl/actueel/nieu...
www.rijksoverheid.nl/actueel/nieu...
Reposted by Federico Gueli
two new BA.3.2.2 from NSW clustering with previous samples from there, likely local circualtion has started:
nextstrain.org/fetch/genome...
nextstrain.org/fetch/genome...
nextstrain.org
November 17, 2025 at 10:31 AM
Reposted by Federico Gueli
As @siamosolocani.bsky.social has pointed out, these two sequences from Sydney are related to previous BA.3.2 collected there, indicating local spread, not a separate introduction.
Collection dates in the NSW upload ranged from Sept 20-Nov 2, w/the BA.3.2 being among the more recent: Oct 20 & 27.
Collection dates in the NSW upload ranged from Sept 20-Nov 2, w/the BA.3.2 being among the more recent: Oct 20 & 27.
November 17, 2025 at 12:03 PM
As @siamosolocani.bsky.social has pointed out, these two sequences from Sydney are related to previous BA.3.2 collected there, indicating local spread, not a separate introduction.
Collection dates in the NSW upload ranged from Sept 20-Nov 2, w/the BA.3.2 being among the more recent: Oct 20 & 27.
Collection dates in the NSW upload ranged from Sept 20-Nov 2, w/the BA.3.2 being among the more recent: Oct 20 & 27.
two new BA.3.2.2 from NSW clustering with previous samples from there, likely local circualtion has started:
nextstrain.org/fetch/genome...
nextstrain.org/fetch/genome...
nextstrain.org
November 17, 2025 at 9:27 AM
two new BA.3.2.2 from NSW clustering with previous samples from there, likely local circualtion has started:
nextstrain.org/fetch/genome...
nextstrain.org/fetch/genome...
Reposted by Federico Gueli
But the key point is it's important to not just take headline numbers at face value – especially if a method produces a negative number of cumulative excess deaths after a major pandemic.
November 16, 2025 at 10:02 AM
But the key point is it's important to not just take headline numbers at face value – especially if a method produces a negative number of cumulative excess deaths after a major pandemic.
Reposted by Federico Gueli
NIH directors have pointed to below estimates as evidence that Sweden was 'best in the world at protecting human life' for COVID (www.city-journal.org/article/nih-...). But plot doesn't show what they apparently think it shows - and there is a big red flag that immediately jumps out... 🧵
November 16, 2025 at 10:02 AM
NIH directors have pointed to below estimates as evidence that Sweden was 'best in the world at protecting human life' for COVID (www.city-journal.org/article/nih-...). But plot doesn't show what they apparently think it shows - and there is a big red flag that immediately jumps out... 🧵
Reposted by Federico Gueli
For many scientists, if they are dependant on the data for their work, they feel their backs are against the wall. It's not 'right' - but it's a cut-throat profession. Loose access to what you've but your career on, and you risk losing your entire career. That's tough to ask of anyone.
November 16, 2025 at 11:10 AM
For many scientists, if they are dependant on the data for their work, they feel their backs are against the wall. It's not 'right' - but it's a cut-throat profession. Loose access to what you've but your career on, and you risk losing your entire career. That's tough to ask of anyone.
Reposted by Federico Gueli
Particularly now, and for secure, respected, influential people in more democratic institutions, I think the excuses grow weak.
But as a limited-contract, early-career scientist who spent a lot of pandemic night awake, terrified of being targeted, I can vouch that it's a tough & shit situation.
But as a limited-contract, early-career scientist who spent a lot of pandemic night awake, terrified of being targeted, I can vouch that it's a tough & shit situation.
November 16, 2025 at 11:14 AM
Particularly now, and for secure, respected, influential people in more democratic institutions, I think the excuses grow weak.
But as a limited-contract, early-career scientist who spent a lot of pandemic night awake, terrified of being targeted, I can vouch that it's a tough & shit situation.
But as a limited-contract, early-career scientist who spent a lot of pandemic night awake, terrified of being targeted, I can vouch that it's a tough & shit situation.
Reposted by Federico Gueli
On top of that, there's stories that certain people email & call your supervisor, boss, or even dean, calling for outright termination. That's scary.
And, there's interlinking at high levels. If there's friendships at govt level above you - you may not have any choice in what you can say publicly.
And, there's interlinking at high levels. If there's friendships at govt level above you - you may not have any choice in what you can say publicly.
November 16, 2025 at 11:11 AM
On top of that, there's stories that certain people email & call your supervisor, boss, or even dean, calling for outright termination. That's scary.
And, there's interlinking at high levels. If there's friendships at govt level above you - you may not have any choice in what you can say publicly.
And, there's interlinking at high levels. If there's friendships at govt level above you - you may not have any choice in what you can say publicly.
Reposted by Federico Gueli
The file came w an agreement and/or understanding that it was for display - & requirements to comply (credit, amount of detail, GISAID logo size).
Yes, the data is still available via GISAID website - but this is prohibited by DAA from display.
So GISAID decides what tools the public get.
Yes, the data is still available via GISAID website - but this is prohibited by DAA from display.
So GISAID decides what tools the public get.
November 7, 2025 at 2:44 PM
The file came w an agreement and/or understanding that it was for display - & requirements to comply (credit, amount of detail, GISAID logo size).
Yes, the data is still available via GISAID website - but this is prohibited by DAA from display.
So GISAID decides what tools the public get.
Yes, the data is still available via GISAID website - but this is prohibited by DAA from display.
So GISAID decides what tools the public get.
Reposted by Federico Gueli
I want to spell this out in case the implications aren't clear:
This means all public tools/webapps of GISAID data (all the ones you've been used to seeing thru the pandemic, as far as we can tell) are prohibited.
The file allowed this. Cut that - cut off all tools the public & others were using.
This means all public tools/webapps of GISAID data (all the ones you've been used to seeing thru the pandemic, as far as we can tell) are prohibited.
The file allowed this. Cut that - cut off all tools the public & others were using.
On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
November 7, 2025 at 2:41 PM
I want to spell this out in case the implications aren't clear:
This means all public tools/webapps of GISAID data (all the ones you've been used to seeing thru the pandemic, as far as we can tell) are prohibited.
The file allowed this. Cut that - cut off all tools the public & others were using.
This means all public tools/webapps of GISAID data (all the ones you've been used to seeing thru the pandemic, as far as we can tell) are prohibited.
The file allowed this. Cut that - cut off all tools the public & others were using.
Reposted by Federico Gueli
BA.3.2 on the road to dominance in Western Australia? The Great Pumpkin is getting serious.
🎃🎃🎃
🎃🎃🎃
New batch from WA AUS 9/22 are BA.3.2.2
In November 8/20 samples there have been BA.3.2.2
nextstrain.org/fetch/genome...
In November 8/20 samples there have been BA.3.2.2
nextstrain.org/fetch/genome...
nextstrain.org
November 12, 2025 at 1:57 PM
BA.3.2 on the road to dominance in Western Australia? The Great Pumpkin is getting serious.
🎃🎃🎃
🎃🎃🎃
Reposted by Federico Gueli
BA.3.2 was first detected in Germany in April 2025, with a second detection in September - both single sequences (BA.3.2.2). Now 4 new sequences: EPI_ISL_20243694, EPI_ISL_20243686, EPI_ISL_20243677, and EPI_ISL_20243675.
+4 From Germany two regions BA.3.2.2 different branch from WA found by HynnSpylor github
New batch from WA AUS 9/22 are BA.3.2.2
In November 8/20 samples there have been BA.3.2.2
nextstrain.org/fetch/genome...
In November 8/20 samples there have been BA.3.2.2
nextstrain.org/fetch/genome...
November 12, 2025 at 5:58 PM
BA.3.2 was first detected in Germany in April 2025, with a second detection in September - both single sequences (BA.3.2.2). Now 4 new sequences: EPI_ISL_20243694, EPI_ISL_20243686, EPI_ISL_20243677, and EPI_ISL_20243675.