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Christoph Kaleta @kaletalab.bsky.social · 1d

4/4 Please also be aware about the mobility rules that apply for MSCA actions - no residence in Germany for more than 12 months in the last three years.

Christoph Kaleta @kaletalab.bsky.social · 1d

3/4 Based in scenic Kiel by the Baltic Sea, we offer a competitive salary, collaborative environment, and support for work-life balance. 🌊 Ready to make a difference? Apply by November 30th, 2025, and be part of our research team! 📅 Learn more & contact us here: [email protected] #Hiring

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Christoph Kaleta @kaletalab.bsky.social · 1d

2/4 You'll apply #metabolic #modeling integrating diverse OMICs data sets to reveal how the microbiome impacts cognitive function during menopause. You'll work closely with our partners at Jena University and the entire MenoBrain consortium (www.uniklinikum-jena.de/menobrain/en/). 🌟 #ScienceJobs

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Christoph Kaleta @kaletalab.bsky.social · 1d

1/4 🌍 We are looking for a passionate #PhD student in #Metabolic #Microbiome #Modeling in the Marie Skłodowska-Curie Doctoral Network MenoBrain. Join us at one of Europe’s microbiome research hubs and push the boundaries of microbiome science! @uni-kiel.de
🔗 www.uniklinikum-jena.de/menobrain/en...

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Christoph Kaleta @kaletalab.bsky.social · 4d

Excited to share a review on metabolic modelling of host-microbiome-interactions by Natchapon Srinak (@snatchapon.bsky.social) and Jan Taubenheim from the lab: www.sciencedirect.com/science/arti...

Metabolic Modeling of Host-Microbe Interactions

Host-microbe interactions play an integral role in the function and survival of eukaryotes, influencing various processes ranging from metabolism to i…

www.sciencedirect.com

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Reposted by Christoph Kaleta

María R. Aburto @maburto.bsky.social · 14d

www.cell.com/cell-reports...

The multiomics blueprint of the individual with the most extreme lifespan

In brief, Santos-Pujol and colleagues characterize the multiomics landscape of the human with the most extreme longevity. The study enables the association of advantageous genetic variants, an engaged...

www.cell.com

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Christoph Kaleta @kaletalab.bsky.social · 18d

Excellent article on quantitative production of fermentation products by the microbiota. Key takeaway: microbial fermentation products may be more important in mice than humans, amplifying microbiome effects in mice. www.cell.com/cell/fulltex...

Quantifying the varying harvest of fermentation products from the human gut microbiota

Fermentation products are the most abundant gut microbial metabolites absorbed by the host, with important dose-dependent consequences for health. In this study, we present a systems-level analysis in...

www.cell.com

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Reposted by Christoph Kaleta

David Meyer @meyerdh.bsky.social · 22d

🕰️ Is aging driven by a programmed/programmatic mechanism, or by the unavoidable burden of imperfect maintenance? Our perspective argues that aging reflects finite maintenance and reduced evolutionary pressure🧵🧪 www.nature.com/articles/s43... @bjornschumacher.bsky.social @alexeimaklakov.bsky.social

Aging by the clock and yet without a program - Nature Aging

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

www.nature.com

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Reposted by Christoph Kaleta

Thomas Clavel @tclavel.bsky.social · 21d

Interested in the design of defined microbial communities for fundamental research and applications? Hope this work & tool will help you 👇 As always @tcahitch.bsky.social has been a driving factor ⭐⭐⭐! github.com/ClavelLab/Mi...; academic.oup.com/ismej/advanc...

Validate User

academic.oup.com

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Reposted by Christoph Kaleta

Daniel Martínez @dmartimarti.bsky.social · 29d

So, is this bacterial metabolite relevant in humans? With help from @kaletalab.bsky.social we predicted its production is significantly higher in the gut microbiomes of colorectal cancer patients. It is also present in cancer-associated microbiomes.

What does it actually do to cancer cells?

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Christoph Kaleta @kaletalab.bsky.social · 29d

Happy to have contributed!

Daniel Martínez @dmartimarti.bsky.social · 29d

Excited to share our latest work at Cabreiro lab!

Chemotherapy modulation by a cancer-associated microbiota metabolite

www.cell.com/cell-systems...

Here's what we discovered 🧵

Chemotherapy modulation by a cancer-associated microbiota metabolite

Martinez-Martinez et al. combine a host-microbe-drug-nutrient screen with multi-omics to reveal how the cancer-associated microbiota modulates chemotherapy. They identify 2-methylisocitrate, a microbi...

www.cell.com

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Reposted by Christoph Kaleta

Daniel Martínez @dmartimarti.bsky.social · 29d

Excited to share our latest work at Cabreiro lab!

Chemotherapy modulation by a cancer-associated microbiota metabolite

www.cell.com/cell-systems...

Here's what we discovered 🧵

Chemotherapy modulation by a cancer-associated microbiota metabolite

Martinez-Martinez et al. combine a host-microbe-drug-nutrient screen with multi-omics to reveal how the cancer-associated microbiota modulates chemotherapy. They identify 2-methylisocitrate, a microbi...

www.cell.com

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Reposted by Christoph Kaleta

Helena Cocheme @cochemelab.bsky.social · 29d

🚨New paper published today on cancer bugs and drugs!🚨

“Chemotherapy modulation by a cancer-associated microbiota metabolite”

Congrats to the Cabreiro lab on this exciting study!
#Cancer #Microbiome #Metabolism #Chemotherapy
#MRC_LMS #ImperialCollege #CECAD_Cologne

www.cell.com/cell-systems...

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Christoph Kaleta @kaletalab.bsky.social · 29d

Our results suggest that uropathogens may depend on a broad network of metabolic interactions during infection, potentially unlocking new treatment strategies for UTIs. (7/7)

Christoph Kaleta @kaletalab.bsky.social · 29d

A closer look at the modeled communities revealed a complex network of metabolic interactions, including compounds implicated in UTI pathogenesis like sorbitol. (6/7)

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Christoph Kaleta @kaletalab.bsky.social · 29d

Although the predicted metabolic fluxes showed mostly small differences post-metatranscriptomic data integration, we observed a notable reduction in overall flux due to the fastcore algorithm. (5/7)

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Christoph Kaleta @kaletalab.bsky.social · 29d

We simulated the bacterial community using BacArena, integrating both metabolic models and context-specific metatranscriptomic data. (4/7)

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Christoph Kaleta @kaletalab.bsky.social · 29d

Our findings reveal a diverse array of species within the uromicrobiome, extending beyond the commonly identified uropathogenic E. coli. (3/7)

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Christoph Kaleta @kaletalab.bsky.social · 29d

In this study, we combined metabolic modeling with metatranscriptomics to study the uromicrobiome's metabolic interactions during infections in women. (2/7)

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Christoph Kaleta @kaletalab.bsky.social · 29d

Delighted to share: "Metatranscriptomics-based Metabolic Modeling of Patient-Specific Urinary Microbiomes during Infection". Great work led by Jonathan Josephs-Spaulding, in collaboration with the Rupp lab. @uni-kiel.de @crc1182.bsky.social @uniluebeck.bsky.social (1/7)
rdcu.be/eFnXZ

Metatranscriptomics-based metabolic modeling of patient-specific urinary microbiome during infection

npj Biofilms and Microbiomes - Metatranscriptomics-based metabolic modeling of patient-specific urinary microbiome during infection

rdcu.be

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Reposted by Christoph Kaleta

Christian Kost @kostchristian.bsky.social · Sep 1

Only 10 days left to apply:

We are searching for a senior postdoc (3 +3 years) in the field of theoretical ecology and evolution.

The position provides the opportunity to closely interact with experimentalists and develop own research projects.

Please RT.

Details 👇:
shorturl.at/iiiOv

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Reposted by Christoph Kaleta

Christian Kost @kostchristian.bsky.social · Aug 8

I am excited to announce that the position of a senior postdoc (3 +3 years) in the field of theoretical biology is available in my group.

The position provides the opportunity to closely interact with experimentalists and develop own research projects.

Please RT.

Details 👇:
shorturl.at/iiiOv

116 FB 5 Research Assistant (m/f/d) field of Theoretical Ecology and Evolution or Computational Biology: Uni Osnabrück

shorturl.at

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Reposted by Christoph Kaleta

Sean Gibbons 🦠💩 @gibbological.bsky.social · Aug 6

💥Personalized C. difficile colonization risk prediction and probiotic therapy assessment in the human gut💥

I'm very excited about this work, driven by Alex Carr & co-supervised by @cdiener.com

@cp-cellsystems.bsky.social @isbscience.org @nitinbaliga.bsky.social

www.cell.com/cell-systems...

🧵...

Personalized Clostridioides difficile colonization risk prediction and probiotic therapy assessment in the human gut

Carr et al. show how microbial community-scale metabolic models (MCMMs) predict personalized Clostridioides difficile colonization risk and probiotic efficacy. MCMMs reveal key metabolic strategies ex...

www.cell.com

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Reposted by Christoph Kaleta

Kyojiro N Ikeda @beingkyo.bsky.social · Aug 6

Out stody Is now on National Geographic!!!

www.nationalgeographic.com/animals/arti...

This creature can 3D-print its own body parts

Bristle worms have protrusions that act like a 3D printer, helping us to understand how cells regenerate.

www.nationalgeographic.com

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