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LadyDEADtera32 🍁😷🌈💀

@ladylettera32.bsky.social

2.9K followers 770 following 19K posts

Canadian novelist-in-progress. Dorkasaurus Rex & existential meat sack. Doing okay (allegedly). No one is coming to save us. We have to save each other. Wear a respirator. AI is built on stolen art.

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LadyDEADtera32 🍁😷🌈💀 @ladylettera32.bsky.social · 2d

PSA to check your child’s candy this Halloween. There might be raisins in there and no one deserves that.

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Dr Toby Driver @drtobydriver.bsky.social · 2h

Gazing in awe & wonder 😮

Inside the spectacular Little Woodbury house at @butserancientfarm.co.uk where the great soot-blackened roof stands without central posts

An incredible family house from Late Iron Age Britain

With @durotrigesdig.bsky.social
@theduncanmackay.bsky.social

📷 My own, Sept

Duncan & Miles inside a roundhouse gazing up at the roof

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𝙱𝚊𝚋𝚎 𝚁𝚞𝚝𝚑𝚕𝚎𝚜𝚜 @unfitz.bsky.social · 2d

The camera doesn’t lie, but Photoshop is one deceitful motherfucker.

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Geriatric Petunia @klodovik.bsky.social · 2h

Why not name the retailer, especially if "many shoppers actually want this technology in stores". They could have surge of shoppers who just love that their faces are being recorded and kept in who knows what databases

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Ryan Nanni @celebrityhottub.bsky.social · 7h

baseball is the best preparation for death because it does not come with a clock that tells you when your suffering will end one way or the other

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Merriam-Webster @merriam-webster.com · 21h

Printing presses kept their letters in cases.

Capital letters went in the upper case.
Smaller letters went in the lower case.

This is why we say ‘UPPER CASE’ and ‘lower case.’

Ok, but what did we call them before the invention of the printing press?

MAJUSCULE and minuscule.

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John A Dracula Cullen @nellucnhoj.bsky.social · 2h

Here's a good alternative by @hedgehogsafety.bsky.social

The moderation list "A Very British Bigotry" by hedgehogsafety.bsky.social

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John A Dracula Cullen @nellucnhoj.bsky.social · 2h

Oh, I was wondering why I no longer had the option to report TERFs to a moderation list I was subbed to.

Description of a moderation list --now titled as "Hidden list"-- made by brainnotonyet.bsky.social

The description reads "trans exclusionary radical feminists who are using rightwing language to attack minority groups."

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Angry Redhead @sidherian.bsky.social · 2h

This creates a plausible pathway for motor neuron degeneration, though causality is not yet proven.
We need long-term studies tracking SARS-CoV-2 survivors, neurodegeneration markers, and MND incidence.
The virus’s neurological reach may be wider than we realise.”

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Angry Redhead @sidherian.bsky.social · 2h

Bottom line:
SARS-CoV-2 delivers multiple hits to motor neurons: infection, inflammation, vascular compromise, protein aggregation.

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Angry Redhead @sidherian.bsky.social · 2h

Multiple hits = cumulative vulnerability. This shows how environmental exposures, lifestyle factors, & viral infections can converge on the same neurodegenerative pathways. SARS-CoV-2 may not create MND from scratch, but it could push already vulnerable neurons over the edge.

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Angry Redhead @sidherian.bsky.social · 2h

including motor neuron disease (MND).
Chronic neuronal stress and inflammation can prime cells for degeneration. Conceptually, prior neuronal injury (e.g. from TBI) could lower the threshold for SARS-CoV-2–induced neuronal damage increasing MND risk or hastening its onset.

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Angry Redhead @sidherian.bsky.social · 2h

Systemic immune activation can lead to autoimmune or bystander neuronal injury.
In genetically susceptible people, this could trigger or worsen MND.
Traumatic brain injury (TBI), including repeated concussions from sports like rugby, is a known risk factor for neurodegenerative diseases

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Angry Redhead @sidherian.bsky.social · 2h

Vascular and metabolic stress:
SARS-CoV-2 can cause microthrombi, hypoxia and endothelial dysfunction. Motor neurons are highly metabolically active, so even mild oxygen or nutrient deficits can accelerate degeneration.
Immune-mediated damage:

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Angry Redhead @sidherian.bsky.social · 2h

which can promote TDP-43 aggregation, a hallmark of ALS, leading to neuron dysfunction & death.

ER is responsible for folding & processing proteins properly.

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Angry Redhead @sidherian.bsky.social · 2h

Neuroinflammation:
Infected neurons trigger microglial activation & astrocyte dysfunction, creating chronic inflammation.
Neuroinflammation is a known driver of MND, especially ALS.
Protein misfolding:
Viral infection causes ER (Endoplasmic Reticulum) stress and oxidative stress,

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Angry Redhead @sidherian.bsky.social · 2h

Let’s break down the neuropathology.
Direct infection of motor neurons:
SARS-CoV-2 enters via ACE2, NRP1, CD147 receptors and can replicate inside neurons.
These long, metabolically demanding cells are highly vulnerable to injury.

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Angry Redhead @sidherian.bsky.social · 2h

Via @jamesthrot (pseudonym) Consultant Neuropathologist UK

“Since I’m a neuropathologist, I’ll put my two cents into this MND discussion.

SARS-CoV-2 isn’t just a respiratory virus. Emerging evidence shows it can infect human motor neurons. Could this link to motor neuron disease (MND)?

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LadyDEADtera32 🍁😷🌈💀 @ladylettera32.bsky.social · 1h

Get vaxxed, push for clean (HEPA filtered) air, and for fuck’s sake cover your germ-y gob 😷

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LadyDEADtera32 🍁😷🌈💀 @ladylettera32.bsky.social · 1h

*SQUEEEEEEEE* omg it’s so CUTE and WEE 💖

Sardonicus @sardonicus.eu · 3h

Pantogram’s miniature binary typewriter
spoon-tamago.com/pantograph-i...

tiny typewriter with two keys 0 and 1 the paper in it is covered with 0's and 1's

LadyDEADtera32 🍁😷🌈💀 @ladylettera32.bsky.social · 1h

Yah whenever I feel stuck I switch gears to get unstuck. Sometimes that means trying a story idea from my notebook and sometimes that means doing the dishes, cleaning the bathroom, reading a book etc. and leaving my story to simmer on the back burner of my mind till I figure out how to move forward

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Kari Dru @karidru.bsky.social · 11h

And sometimes you need to do something similar that contains less pressure as practice.

This often looks like goofing off but it isn't.

And if uou say to the machine "do this scene transition for me", you now don't become the writer who could have written that scenr transition.

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Kari Dru @karidru.bsky.social · 12h

Sometimes people commission an art and get mad when they see the artist working on other stuff. This is probably also a step in getting to the comm.

I'm not saying nobody's a slacker, just that a lot of the time, something needs to steep in the back of your brain for a while...

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Kari Dru @karidru.bsky.social · 12h

Staring at the wall, doing the dishes, getting to inbox zero, writing the thing that is not the thing you're supposed to be writing, all count as writing and also are not a skippable step.

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Kari Dru @karidru.bsky.social · 12h

I feel like people who don't do art don't really understand the ongoing joke about how we don't wanna write/draw/etc.

We do actually really want to. In fact, it is not possible to stop us.

It's just that a lot of the creative process looks a lot like doing the dishes or staring at the wall.

Faine Greenwood @faineg.bsky.social · 1d

there’s this weird idea a lot of people seem to have about how all of us writers and artists must secretly want to use AI and are merely resisting temptation for ethical reasons, and like, no, it’s not hard for me to resist drinking the bowl of Piss With Glass In It actually

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Kari Dru @karidru.bsky.social · 6h

The twisted thing about it is he's definitely only alive because he's getting presidential health care, AND ALSO the job, even to the extent he's doing it, is killing him.

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