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Reposted by Madeline Lancaster

Simon Fisher @profsimonfisher.bsky.social · 1d

New paper alert! Rare DNA changes in the SETBP1 gene are linked to speech problems & diverse syndromes affecting brain development. Work led by ace postdoc @maggiemkwong.bsky.social uncovered impact of different gene variants, coupling clinical/speech evaluation to molecular & cellular readouts.🧬🗣️🔬🧪

SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder - Nature Communications

Different types of SETBP1 variants cause variable developmental syndromes with only partial clinical and functional overlaps. Here, the authors report that SETBP1 variants outside the degron region impair DNA-binding, transcription, and neuronal differentiation capacity and morphologies.

www.nature.com

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Reposted by Madeline Lancaster

Julius Brennecke @juliusbrennecke.bsky.social · 7d

The Vienna BioCenter PhD Program application deadline is approaching: October 10!

Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!

training.vbc.ac.at/phd-program/

#PhD #LifeSciences

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Reposted by Madeline Lancaster

Denis Jabaudon @djabaudon.bsky.social · 7d

Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT

neuro-unige.ch/news/csf-mee...

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Madeline Lancaster @lancasterlab.bsky.social · 9d

No, I don’t have it! I know, I really MUST read it!

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Madeline Lancaster @lancasterlab.bsky.social · 9d

Cool, thanks for sharing! Another good example of this is the change in timing of expression of ZEB2 in human versus ape neural progenitors. It’s about timing of its expression but the protein itself isn’t different. I think this is much more common as an evolutionary mechanism.

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Reposted by Madeline Lancaster

Alessandro Gozzi @gozziale.bsky.social · Sep 10

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f

Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience

➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism?

Check out what we found!
🧵1/n

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Reposted by Madeline Lancaster

Carl T. Bergstrom @carlbergstrom.com · Sep 1

Nine former CDC directors, from Bill Foege onward, speak out about the incalculable harm that RFK, Jr. is doing to public health in the US and around the world.

Gift link.

Opinion | We Ran the C.D.C.: Kennedy Is Endangering Every American’s Health

www.nytimes.com

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Madeline Lancaster @lancasterlab.bsky.social · Aug 10

Amazing work! The Silver lab is on a roll!

Debby Silver @debbysilver.bsky.social · Aug 10

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

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Madeline Lancaster @lancasterlab.bsky.social · Aug 2

This new preprint looks pretty interesting. Human neurons take up to 4 decades to fully mature!

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Aug 1

Human neurons undergo protracted functional maturation into adulthood https://www.biorxiv.org/content/10.1101/2025.08.01.668139v1

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Madeline Lancaster @lancasterlab.bsky.social · Jun 7

I can’t wait to try this! It’s such a huge issue in the field, and we haven’t been happy with any of the solutions out there so far. Thanks Yoav!

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Reposted by Madeline Lancaster

Stefan Schoenfelder @stefanschoenfelder.bsky.social · Jun 2

Delighted & excited to share our latest preprint on non-canonical enhancers in human pluripotent stem cells, the result of a fantastic and fun collaboration with @guenesdoganlab.bsky.social‬:
www.biorxiv.org/content/10.1...

🧵 below

Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells

Enhancers are key gene regulatory elements that ensure the precise spatiotemporal execution of developmental gene expression programmes. However recent findings indicate that approaches to identify en...

www.biorxiv.org

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Madeline Lancaster @lancasterlab.bsky.social · May 29

This is amazing. Really interesting science made accessible to non experts. I recommend tuning in if you can, even for a little while

Hank Green @hankgreen.bsky.social · May 28

200+ scientists are in the middle of a marathon livestream to show why weather and climate science is so important and needs all our help to continue.

It is here: wclivestream.com/watch

Redirecting to: https://www.youtube.com/@wclivestream/live

wclivestream.com

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Reposted by Madeline Lancaster

Jen MacKinnon @jenmackinnon.bsky.social · May 28

Hi friends - In the face of unprecedented cuts to the basic research science funding, climate scientists are staging an 100-hour live stream of why science matters. There will be many talks on all sorts of things (I'm Saturday at 12:30 PT). Please share widely! wcstreamathon.netlify.app. 🌊🧪

The Weather & Climate Livestream

Join us starting May 28th, as meteorologists and climate scientists from across the US share their research and answer your questions.

wcstreamathon.netlify.app

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Reposted by Madeline Lancaster

Denis Jabaudon @djabaudon.bsky.social · May 28

Still openings, check it out!

Denis Jabaudon @djabaudon.bsky.social · Feb 2

🧠Job Opening!🧠

We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.

Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!

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Madeline Lancaster @lancasterlab.bsky.social · May 26

FWIW, not every single SCB talks that way. @djabaudon.bsky.social and I discussed what the differences (not failures) of organoids can teach us about what cells are capable of if given the opportunity (if in vivo constraints are removed) in this article many years back: doi.org/10.1242/dev....

Exploring landscapes of brain morphogenesis with organoids

Summary: This Spotlight summarizes the themes that emerged from a recent workshop organized by The Company of Biologists on ‘Thinking beyond the dish: taking in vitro neural differentiation to the nex...

doi.org

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Reposted by Madeline Lancaster

James Briscoe @jamesbriscoe.bsky.social · May 19

New Faraday Fellowships for international applicants moving to the UK

Up to £4 million per researcher over 5-10 years

Fast-track option for mid-career researchers looking to relocate to the UK

The Royal Society @royalsociety.org · May 19

Today we've announced the new Faraday Fellowship accelerated international route, which will grant up to £30 million in funding over the next two years to attract global talent and support the development of world-leading research groups in the UK: #RSGrants royalsociety.org/news/2025/05...

Royal Society announces £30m fund to attract global talent over next two years | Royal Society

International recruitment scheme comes amid announcement of Government principles for 10-year research funding

royalsociety.org

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Madeline Lancaster @lancasterlab.bsky.social · May 20

This is so cool! It’s beautiful to see exactly the kind of elegant genetic locus swapping experiments I’ve been hoping to see in the field 🤩 Nice work Debby and team!

Debby Silver @debbysilver.bsky.social · May 14

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

www.nature.com

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Madeline Lancaster @lancasterlab.bsky.social · May 20

Check out this impressive work from the Jabaudon lab exploring an age old question: how does the forebrain grow more than the rest of the brain?

Denis Jabaudon @djabaudon.bsky.social · May 5

Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...

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Madeline Lancaster @lancasterlab.bsky.social · May 20

So many exciting papers and preprints in the past few weeks. This one is quite the tour de force!

Cedric Boeckx @cedricboeckx.bsky.social · May 2

Delighted to share our new preprint, the outcome of many years of collaborative work with Giuseppe Testa’s group, both at the bench & in front of the computer, probing human brain evolution using organoids. We tried something cool, and learned a lot 🧪🧫🧠🧬
[follow 🧵]
www.biorxiv.org/content/10.1...

Regulatory logic of human cortex evolution by combinatorial perturbations

Comparative genomic studies between contemporary and extinct hominins revealed key evolutionary modifications, but their number has hampered a system level investigation of their combined roles in sca...

www.biorxiv.org

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Madeline Lancaster @lancasterlab.bsky.social · Mar 14

Exciting work from the Albert lab on unique signatures of human basal radial glia. And look at those beautiful organoids with their basal progenitors! 🤩

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Madeline Lancaster @lancasterlab.bsky.social · Mar 4

Interesting new work from the McDole lab on the extreme stress primordial germ cells have to endure on their journey to the gonads during embryonic development. It’s wild that a new generation is even possible after all that!

www.biorxiv.org/content/10.1...

www.biorxiv.org

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Madeline Lancaster @lancasterlab.bsky.social · Mar 3

In case you missed it, check out our recent preprint on developmental timing and how slower means bigger, axons that is!

Led by the extraordinary @felinewlindhout.bsky.social

www.biorxiv.org/content/10.1...

Calcium dynamics tune developmental tempo to generate evolutionarily divergent axon tract lengths

The considerably slow pace of human brain development correlates with an evolutionary increase in brain size, cell numbers, and expansion of neuronal structures, with axon tracts undergoing an even gr...

www.biorxiv.org

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Reposted by Madeline Lancaster

James Briscoe @jamesbriscoe.bsky.social · Jan 17

A couple of weeks left to apply to join Development's *Pathway to Independence* programme

Support & mentoring for post-docs on the academic job market

Deadline: January 31

journals.biologists.com/dev/pages/pi...

Development PI Programme | Development | The Company of Biologists

Development PI Programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our second call for our Pathway to I...

journals.biologists.com

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Madeline Lancaster @lancasterlab.bsky.social · Dec 30

It’s been an exciting holiday season for the Lancaster Lab, with not 1, not 2, but 3 new preprints to share!

Check ‘em out:

doi.org/10.1101/2024...

doi.org/10.1101/2024...

doi.org/10.1101/2024...

Happy holidays and best wishes for 2025 from our lab to yours! 🎄🎉

Mouse brain organoids model in vivo neurodevelopment and function and capture differences to human

In the last decade since their emergence, brain organoids have offered an increasingly popular and powerful model for the study of early development and disease in humans. These 3D stem cell-derived m...

www.biorxiv.org

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Reposted by Madeline Lancaster

Sergiu P. Pasca @sergiuppasca.bsky.social · Nov 23

Last preparations for what will be an amazing CSHL conference on human #brain development and modeling with #organoids #assembloids and #transplantation

Keynotes: Carla Shatz & Chris Walsh

@djabaudon.bsky.social @debbysilver.bsky.social @vanderhaeghenp2.bsky.social @graycamplab.bsky.social

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