Oscar Marín Lab
@marinlab.bsky.social
Brain development and childhood disorders laboratory at King's College London
She is! Thanks for the fantastic comic -- it will go on the wall to make company for the one of your paper (and Clems' paper)
July 16, 2025 at 9:52 AM
She is! Thanks for the fantastic comic -- it will go on the wall to make company for the one of your paper (and Clems' paper)
10/10 Here’s the paper @cellcellpress.bsky.social if you want to dig in www.cell.com/cell/fulltex... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @wellcometrust.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the
late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α
partners with ERRγ and Mef2c to ...
www.cell.com
July 16, 2025 at 7:59 AM
10/10 Here’s the paper @cellcellpress.bsky.social if you want to dig in www.cell.com/cell/fulltex... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @wellcometrust.bsky.social
9/10 In sum, our findings reveal a postnatal molecular switch that drives the activity-dependent maturation of parvalbumin interneurons, a critical population for cortical function. Funded by the @wellcometrust.bsky.social
July 16, 2025 at 7:59 AM
9/10 In sum, our findings reveal a postnatal molecular switch that drives the activity-dependent maturation of parvalbumin interneurons, a critical population for cortical function. Funded by the @wellcometrust.bsky.social
8/10 Importantly, this mechanism also allows PV interneurons to regulate their mitochondrial content and function, which may also contribute to their maturation
July 16, 2025 at 7:59 AM
8/10 Importantly, this mechanism also allows PV interneurons to regulate their mitochondrial content and function, which may also contribute to their maturation
7/10 PGC-1alpha cooperates with ERR-gamma to directly regulate the transcription of many PV-enriched genes. Incidentally, it also seems involved in repressing genes that are typically enriched in other cells, like SST interneurons
July 16, 2025 at 7:59 AM
7/10 PGC-1alpha cooperates with ERR-gamma to directly regulate the transcription of many PV-enriched genes. Incidentally, it also seems involved in repressing genes that are typically enriched in other cells, like SST interneurons
6/10 How is this achieved? We discovered that PGC-1alpha regulates the expression of most genes that are typically enriched in mature PV interneurons
July 16, 2025 at 7:59 AM
6/10 How is this achieved? We discovered that PGC-1alpha regulates the expression of most genes that are typically enriched in mature PV interneurons
5/10 What are the mechanisms regulating the protracted maturation of cortical interneurons? We found that this process requires neuronal activity and is mediated by the transcriptional modulator PGC-1alpha
July 16, 2025 at 7:59 AM
5/10 What are the mechanisms regulating the protracted maturation of cortical interneurons? We found that this process requires neuronal activity and is mediated by the transcriptional modulator PGC-1alpha
4/10 Interestingly, while PV interneurons are generated in the embryo, they are late bloomers: in humans, for example, it takes more than two years for PV interneurons to acquire their mature properties
July 16, 2025 at 7:59 AM
4/10 Interestingly, while PV interneurons are generated in the embryo, they are late bloomers: in humans, for example, it takes more than two years for PV interneurons to acquire their mature properties
3/10 Several unique properties distinguish PV interneurons: They exert a very tight control over the output of pyramidal cells; are fast-spiking, meaning they can fire action potentials at very high frequencies; are covered by perineuronal nets, and have many mitochondria
July 16, 2025 at 7:59 AM
3/10 Several unique properties distinguish PV interneurons: They exert a very tight control over the output of pyramidal cells; are fast-spiking, meaning they can fire action potentials at very high frequencies; are covered by perineuronal nets, and have many mitochondria
2/10 PV interneurons are a type of inhibitory neuron in the cortex, characterized by their expression of the calcium-binding protein parvalbumin. These neurons play a crucial role in regulating neuronal activity and are involved in #memory, sensory processing, and motor control
July 16, 2025 at 7:59 AM
2/10 PV interneurons are a type of inhibitory neuron in the cortex, characterized by their expression of the calcium-binding protein parvalbumin. These neurons play a crucial role in regulating neuronal activity and are involved in #memory, sensory processing, and motor control
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the
late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α
partners with ERRγ and Mef2c to ...
www.cell.com
July 16, 2025 at 7:59 AM
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
Reposted by Oscar Marín Lab
🚨 New Paper Alert! 🚨
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the
late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α
partners with ERRγ and Mef2c to ...
www.cell.com
July 15, 2025 at 3:18 PM
🚨 New Paper Alert! 🚨
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.
Link below 👇
www.cell.com/cell/fulltex...
@cellpress.bsky.social @marinlab.bsky.social
Reposted by Oscar Marín Lab
We're #hiring for a new role as Senior #ExecutiveAssistant to our fantastic Director and Managing Director! Deadline 23 June
@marinlab.bsky.social
www.kcl.ac.uk/jobs/116505-...
@marinlab.bsky.social
www.kcl.ac.uk/jobs/116505-...
Senior Executive Assistant
www.kcl.ac.uk
June 4, 2025 at 12:38 PM
We're #hiring for a new role as Senior #ExecutiveAssistant to our fantastic Director and Managing Director! Deadline 23 June
@marinlab.bsky.social
www.kcl.ac.uk/jobs/116505-...
@marinlab.bsky.social
www.kcl.ac.uk/jobs/116505-...
Reposted by Oscar Marín Lab
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Conservation of regulatory elements with highly diverged sequences across large evolutionary distances
Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...
rdcu.be
May 27, 2025 at 12:19 PM
How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Check out our paper - fresh off the press!!!
We find widespread functional conservation of enhancers in absence of sequence homology
Including: a bioinformatic tool to map sequence-diverged enhancers!
rdcu.be/enVDN
github.com/tobiaszehnde...
Reposted by Oscar Marín Lab
Still openings, check it out!
🧠Job Opening!🧠
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
May 28, 2025 at 5:02 AM
Still openings, check it out!
Reposted by Oscar Marín Lab
On the value of investing in curiosity driven research - which in this case contributed to the personalised gene therapy for a rare disease
on.ft.com/45rXI50 @anjahuja.bsky.social
on.ft.com/45rXI50 @anjahuja.bsky.social
May 28, 2025 at 6:24 AM
On the value of investing in curiosity driven research - which in this case contributed to the personalised gene therapy for a rare disease
on.ft.com/45rXI50 @anjahuja.bsky.social
on.ft.com/45rXI50 @anjahuja.bsky.social
Reposted by Oscar Marín Lab
🎙️[49] ENTENDER EL CEREBRO PARA REGULARLO
👨🔬 con #OscarMarínParra
@MarinLab
Alteraciones durante el desarrollo de nuestro🧠 pueden ser la causa de desordenes psiquiátricos como #autismo, #epilepsia, #bipolaridad o #esquizofrenia
#Neurociencias
(1/3)
👨🔬 con #OscarMarínParra
@MarinLab
Alteraciones durante el desarrollo de nuestro🧠 pueden ser la causa de desordenes psiquiátricos como #autismo, #epilepsia, #bipolaridad o #esquizofrenia
#Neurociencias
(1/3)
May 11, 2025 at 11:33 AM
🎙️[49] ENTENDER EL CEREBRO PARA REGULARLO
👨🔬 con #OscarMarínParra
@MarinLab
Alteraciones durante el desarrollo de nuestro🧠 pueden ser la causa de desordenes psiquiátricos como #autismo, #epilepsia, #bipolaridad o #esquizofrenia
#Neurociencias
(1/3)
👨🔬 con #OscarMarínParra
@MarinLab
Alteraciones durante el desarrollo de nuestro🧠 pueden ser la causa de desordenes psiquiátricos como #autismo, #epilepsia, #bipolaridad o #esquizofrenia
#Neurociencias
(1/3)
Yeah, don’t forget the inferior colliculus
May 20, 2025 at 7:11 PM
Yeah, don’t forget the inferior colliculus
Reposted by Oscar Marín Lab
Great @nature.com paper on the early stages of human cortical development, led by @qianxuyu.bsky.social from C. Walsh’s lab, in collaboration with @drmingyaoli.bsky.social
A wonderful new resource to probe area & layer specification 🧪🧠🧬
A wonderful new resource to probe area & layer specification 🧪🧠🧬
May 15, 2025 at 5:51 AM
Great @nature.com paper on the early stages of human cortical development, led by @qianxuyu.bsky.social from C. Walsh’s lab, in collaboration with @drmingyaoli.bsky.social
A wonderful new resource to probe area & layer specification 🧪🧠🧬
A wonderful new resource to probe area & layer specification 🧪🧠🧬
Reposted by Oscar Marín Lab
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 14, 2025 at 4:09 PM
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
Reposted by Oscar Marín Lab
1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
April 30, 2025 at 3:12 PM
1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
Reposted by Oscar Marín Lab
Meet the 2025 @dev-journal.bsky.social Pathway to Independence (PI) fellows
Eight developmental and stem cell biologists transitioning from postdoc to principal investigator
journals.biologists.com/dev/pages/pi...
Eight developmental and stem cell biologists transitioning from postdoc to principal investigator
journals.biologists.com/dev/pages/pi...
PI Fellows 2025 | Development | The Company of Biologists
PI Fellows 2025 | Development | The Company of Biologists
.align{
margin-right: 10px;
margin-left: 0px;
}
.left {
float: left;
width: 15%;
}
.right {...
journals.biologists.com
May 7, 2025 at 5:38 AM
Meet the 2025 @dev-journal.bsky.social Pathway to Independence (PI) fellows
Eight developmental and stem cell biologists transitioning from postdoc to principal investigator
journals.biologists.com/dev/pages/pi...
Eight developmental and stem cell biologists transitioning from postdoc to principal investigator
journals.biologists.com/dev/pages/pi...
That’s brilliant — congrats!
May 7, 2025 at 7:42 AM
That’s brilliant — congrats!
10/10 Here’s the paper @nature.com if you want to dig in www.nature.com/articles/s41... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @erc.europa.eu
www.nature.com
April 30, 2025 at 3:12 PM
10/10 Here’s the paper @nature.com if you want to dig in www.nature.com/articles/s41... That’s it. Thanks for sharing! @devneuro.bsky.social @mrc-cndd.bsky.social @kingsioppn.bsky.social @kingscollegelondon.bsky.social @erc.europa.eu
9/10 In sum, our findings identify a previously unknown form of interneuron plasticity and strengthen the idea that neuropeptide signalling plays crucial roles in maintaining neural circuit stability. Funded by the magnificents @erc.europa.eu and Rosetrees Trust
April 30, 2025 at 3:12 PM
9/10 In sum, our findings identify a previously unknown form of interneuron plasticity and strengthen the idea that neuropeptide signalling plays crucial roles in maintaining neural circuit stability. Funded by the magnificents @erc.europa.eu and Rosetrees Trust