Shashank Masaldan
@masaldan.bsky.social
Cell biologist with an interest in metal biology, #ferroptosis, cellular #senescence, #mitochondria and the role they play in #neurodegeneration. Postdoc @dewsonlab.bsky.social
Reposted by Shashank Masaldan
Professor Melanie Bahlo and Dr Fei Wang, from the WEHI Parkinson’s Disease Research Centre are part of an international team working to find a blood-based biomarker for Parkinson’s, funded by $1.77m from the Michael J. Fox Foundation.
www.wehi.edu.au/news/wehi-sc...
www.wehi.edu.au/news/wehi-sc...
November 25, 2025 at 12:13 AM
Professor Melanie Bahlo and Dr Fei Wang, from the WEHI Parkinson’s Disease Research Centre are part of an international team working to find a blood-based biomarker for Parkinson’s, funded by $1.77m from the Michael J. Fox Foundation.
www.wehi.edu.au/news/wehi-sc...
www.wehi.edu.au/news/wehi-sc...
Reposted by Shashank Masaldan
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
November 23, 2025 at 1:51 AM
Scientific journals: we don’t want you using generative AI because it makes shit up.
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote
Same journal: AI cover art which makes no sense? Oooh!
Reposted by Shashank Masaldan
Time to find out what’s the newest insight on the #ubiquitin-proteosome degradation system from our speakers: Shang-Te (Danny) Hsu, Yasushi Saeki, Indrajit Sahu, and Kylie Walters.
While this is our last talk session of Day 2 at #AusUb2025, science goes on at the poster session…
While this is our last talk session of Day 2 at #AusUb2025, science goes on at the poster session…
November 21, 2025 at 9:43 AM
Time to find out what’s the newest insight on the #ubiquitin-proteosome degradation system from our speakers: Shang-Te (Danny) Hsu, Yasushi Saeki, Indrajit Sahu, and Kylie Walters.
While this is our last talk session of Day 2 at #AusUb2025, science goes on at the poster session…
While this is our last talk session of Day 2 at #AusUb2025, science goes on at the poster session…
Reposted by Shashank Masaldan
⏳Three days to go until #AusUb2025! What is Grant Dewson most looking forward to in the upcoming Ubiquitin Summit? 🤔 Perhaps the speakers? Perhaps the free coffee ☕️? Or perhaps the very British prospect of cloudy, sunless days at the beach☁️? Watch the video to find out!
November 17, 2025 at 5:07 AM
⏳Three days to go until #AusUb2025! What is Grant Dewson most looking forward to in the upcoming Ubiquitin Summit? 🤔 Perhaps the speakers? Perhaps the free coffee ☕️? Or perhaps the very British prospect of cloudy, sunless days at the beach☁️? Watch the video to find out!
Reposted by Shashank Masaldan
⏳Four days to go until #AusUb2025! Check out the video below to hear some conference tips and tricks from our committee chair David Komander (and some potentially controversial interest rankings!?!?).
More interviews to come in the next few days so watch this space 😉
More interviews to come in the next few days so watch this space 😉
November 16, 2025 at 12:25 PM
⏳Four days to go until #AusUb2025! Check out the video below to hear some conference tips and tricks from our committee chair David Komander (and some potentially controversial interest rankings!?!?).
More interviews to come in the next few days so watch this space 😉
More interviews to come in the next few days so watch this space 😉
Reposted by Shashank Masaldan
If not registered, do it soon! 👇
www.lorneubiquitin.org
www.lorneubiquitin.org
The Australian Ubiquitin Summit 2025
www.lorneubiquitin.org
October 31, 2025 at 7:10 AM
If not registered, do it soon! 👇
www.lorneubiquitin.org
www.lorneubiquitin.org
Reposted by Shashank Masaldan
📢 All ubiquitin aficionados! 📢
We are gearing up for the first Australian Ubiquitin Summit in three weeks 🤩🗓️
Are you ready for talking ubiquitin by the bay?
🗓️ 20-23 Nov
📍Mantra, Lorne, VIC
Chaired by David Komander (@komanderlab.bsky.social)
#AusUb2025
We are gearing up for the first Australian Ubiquitin Summit in three weeks 🤩🗓️
Are you ready for talking ubiquitin by the bay?
🗓️ 20-23 Nov
📍Mantra, Lorne, VIC
Chaired by David Komander (@komanderlab.bsky.social)
#AusUb2025
October 31, 2025 at 7:10 AM
📢 All ubiquitin aficionados! 📢
We are gearing up for the first Australian Ubiquitin Summit in three weeks 🤩🗓️
Are you ready for talking ubiquitin by the bay?
🗓️ 20-23 Nov
📍Mantra, Lorne, VIC
Chaired by David Komander (@komanderlab.bsky.social)
#AusUb2025
We are gearing up for the first Australian Ubiquitin Summit in three weeks 🤩🗓️
Are you ready for talking ubiquitin by the bay?
🗓️ 20-23 Nov
📍Mantra, Lorne, VIC
Chaired by David Komander (@komanderlab.bsky.social)
#AusUb2025
Reposted by Shashank Masaldan
🔬 Exciting news for the ferroptosis community!
FerrOZtosis 2.0 symposium is happening this 19th September 2025 at The Florey, Melbourne.
📅 Abstract deadline: August 15
📍 Details & registration: lnkd.in/dn7imCzd
FerrOZtosis 2.0 symposium is happening this 19th September 2025 at The Florey, Melbourne.
📅 Abstract deadline: August 15
📍 Details & registration: lnkd.in/dn7imCzd
We are excited to announce FerrOZtosis 2.0! | Scott Ayton
We are excited to announce FerrOZtosis 2.0!
Come join us on the 19th of September at the Florey for a day full of ferroptosis.
Our international guest speaker is the co-discoverer of ferroptosis, Pro...
www.linkedin.com
August 11, 2025 at 6:08 AM
🔬 Exciting news for the ferroptosis community!
FerrOZtosis 2.0 symposium is happening this 19th September 2025 at The Florey, Melbourne.
📅 Abstract deadline: August 15
📍 Details & registration: lnkd.in/dn7imCzd
FerrOZtosis 2.0 symposium is happening this 19th September 2025 at The Florey, Melbourne.
📅 Abstract deadline: August 15
📍 Details & registration: lnkd.in/dn7imCzd
Reposted by Shashank Masaldan
Could a metal ion supplement that cost pennies per day protect from Alzheimer's disease?
erictopol.substack.com/p/lithium-an...
erictopol.substack.com/p/lithium-an...
August 10, 2025 at 3:14 PM
Could a metal ion supplement that cost pennies per day protect from Alzheimer's disease?
erictopol.substack.com/p/lithium-an...
erictopol.substack.com/p/lithium-an...
Reposted by Shashank Masaldan
🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social.
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
PINK1 Parkinson's Disease Research Team – Finalist, 2025 Eureka Prize for Scientific Research
YouTube video by Australian Museum
www.youtube.com
July 31, 2025 at 12:00 AM
🎉 What an honour to be a finalist in the 2025 Australian Museum Eureka Prizes for Scientific Discovery!! With David Komander, @zhongyangan.bsky.social, Alisa Glukhova and @nskirk.bsky.social.
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
Excited for the awards ceremony on Sept 3rd!
@eurekaprizes.bsky.social
@wehi-research.bsky.social
Reposted by Shashank Masaldan
WEHI has formed a partnership with the Parkinson’s Research Foundation with one clear goal: to intensify the search for drug treatments to stop Parkinson’s.
Read more👇 www.wehi.edu.au/news/new-par...
Read more👇 www.wehi.edu.au/news/new-par...
New partnership with Parkinson’s Research Foundation to accelerate Parkinson’s drug discovery
WEHI has formed a partnership with the Parkinson’s Research Foundation with one clear goal: to intensify the search for drug treatments to stop Parkinson’s.
www.wehi.edu.au
July 17, 2025 at 12:52 AM
WEHI has formed a partnership with the Parkinson’s Research Foundation with one clear goal: to intensify the search for drug treatments to stop Parkinson’s.
Read more👇 www.wehi.edu.au/news/new-par...
Read more👇 www.wehi.edu.au/news/new-par...
Reposted by Shashank Masaldan
NYT, Page One:
“Within hours, he had an email from China, offering to move his lab to ‘any city, any university I want,’ he said, with a guarantee of funding for the next 20 years.”
@nytimes.com
“Within hours, he had an email from China, offering to move his lab to ‘any city, any university I want,’ he said, with a guarantee of funding for the next 20 years.”
@nytimes.com
June 4, 2025 at 9:51 AM
NYT, Page One:
“Within hours, he had an email from China, offering to move his lab to ‘any city, any university I want,’ he said, with a guarantee of funding for the next 20 years.”
@nytimes.com
“Within hours, he had an email from China, offering to move his lab to ‘any city, any university I want,’ he said, with a guarantee of funding for the next 20 years.”
@nytimes.com
I am so excited to take part in the 2025 A Walk in the Park for Fight Parkinson's. The event is taking place on Sunday April 27th and I would love your support. Donate today so all those living with Parkinson's get the support they need to live a full life. www.awalkinthepark.org.au/s/2900/5275/t
Join me for A Walk in the Park
I am so excited to take part in the 2025 A Walk in the Park for Fight Parkinson's. The event is taking place on Sunday April 27th and I would love your support. Donate today to help all those living w...
www.awalkinthepark.org.au
April 11, 2025 at 6:38 AM
I am so excited to take part in the 2025 A Walk in the Park for Fight Parkinson's. The event is taking place on Sunday April 27th and I would love your support. Donate today so all those living with Parkinson's get the support they need to live a full life. www.awalkinthepark.org.au/s/2900/5275/t
Really nice step forward towards off-the-shelf DA cell therapies for Parkinson's.
Human brain cells engineered to evade detection by the immune system have successfully restored muscle control in a rat model of Parkinson’s disease
https://go.nature.com/4lqDT3w
https://go.nature.com/4lqDT3w
Brain cells given an ‘invisibility cloak’ fix Parkinson’s symptoms in rats
Neurons engineered to evade the immune system could work as cell-replacement therapy.
go.nature.com
April 11, 2025 at 5:24 AM
Really nice step forward towards off-the-shelf DA cell therapies for Parkinson's.
Reposted by Shashank Masaldan
Human brain cells engineered to evade detection by the immune system have successfully restored muscle control in a rat model of Parkinson’s disease
https://go.nature.com/4lqDT3w
https://go.nature.com/4lqDT3w
Brain cells given an ‘invisibility cloak’ fix Parkinson’s symptoms in rats
Neurons engineered to evade the immune system could work as cell-replacement therapy.
go.nature.com
April 10, 2025 at 8:32 AM
Human brain cells engineered to evade detection by the immune system have successfully restored muscle control in a rat model of Parkinson’s disease
https://go.nature.com/4lqDT3w
https://go.nature.com/4lqDT3w
Absolutely appalling!
NEW: The doctor behind breakthrough Parkinson’s research was among the scientists purged from the National Institutes of Health, the US’s leading medical research agency. www.wired.com/story/doctor...
Doctor Behind Award-Winning Parkinson’s Research Among Scientists Purged From NIH
Leading scientists at the National Institutes of Health, the US’s leading medical research agency, were swept up Tuesday in the Trump administration's latest firing blitz.
www.wired.com
April 2, 2025 at 4:23 AM
Absolutely appalling!
Reposted by Shashank Masaldan
You may have seen that the incoming NIH director and his buddies started a new journal, The Journal of the Academy of Public Health
(One clue: There is no recognized Academy of Public Health)
www.science.org/content/arti...
(One clue: There is no recognized Academy of Public Health)
www.science.org/content/arti...
New journal co-founded by NIH nominee raises eyebrows, misinformation fears
The Journal of the Academy of Public Health claims to open up scientific communication. But its unusual editorial policies have some scientists concerned
www.science.org
March 29, 2025 at 12:36 AM
You may have seen that the incoming NIH director and his buddies started a new journal, The Journal of the Academy of Public Health
(One clue: There is no recognized Academy of Public Health)
www.science.org/content/arti...
(One clue: There is no recognized Academy of Public Health)
www.science.org/content/arti...
Absolute goosebump inducing visual!
In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion.
Learn more in this week's issue: scim.ag/3FA3Ygq
Learn more in this week's issue: scim.ag/3FA3Ygq
March 22, 2025 at 7:53 AM
Absolute goosebump inducing visual!
Reposted by Shashank Masaldan
Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex!
@wehi-research.bsky.social
@wehi-research.bsky.social
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
March 13, 2025 at 7:32 PM
Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex!
@wehi-research.bsky.social
@wehi-research.bsky.social
Reposted by Shashank Masaldan
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
March 13, 2025 at 11:19 PM
More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Shashank Masaldan
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
March 13, 2025 at 7:20 PM
Thrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/...
@wehi-research.bsky.social @komanderlab.bsky.social
@wehi-research.bsky.social @komanderlab.bsky.social
Reposted by Shashank Masaldan
World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons.
www.wehi.edu.au/news/scienti...
www.wehi.edu.au/news/scienti...
Scientists solve decades-long Parkinson’s mystery
WEHI researchers have made a huge leap forward in the fight against Parkinson’s disease, solving a decades-long mystery that paves the way for development of new drugs to treat the condition.
www.wehi.edu.au
March 13, 2025 at 9:58 PM
World-first: researchers have discovered what protein #PINK1 looks like in humans and how it is activated, solving a decades-long mystery in the fight against #Parkinsonsdisease. The team hope to use the knowledge to find a drug to stop #Parkinsons.
www.wehi.edu.au/news/scienti...
www.wehi.edu.au/news/scienti...
Reposted by Shashank Masaldan
February 7, 2025 at 9:54 AM
Reposted by Shashank Masaldan
A new quality control mechanism for mitochondrial import from the Rapé lab! A Cullin E3 ligase binds TOM complexes and senses reductive stress. Really enjoyed writing a spotlight for this!
Spotlight: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Original article: www.cell.com/molecular-ce...
Spotlight: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Original article: www.cell.com/molecular-ce...
kwnsfk27.r.eu-west-1.awstrack.me
January 14, 2025 at 12:08 PM
A new quality control mechanism for mitochondrial import from the Rapé lab! A Cullin E3 ligase binds TOM complexes and senses reductive stress. Really enjoyed writing a spotlight for this!
Spotlight: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Original article: www.cell.com/molecular-ce...
Spotlight: kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Original article: www.cell.com/molecular-ce...
Reposted by Shashank Masaldan
"The current knowledge of ubiquitin signals through a ubiquitin-centric, structural biology lens." Useful resource for ubiuitin-lovers.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
Ubiquitin—A structural perspective
Ubiquitin is a cellular modification that comes in many forms. In this review, Agrata
and Komander analyze the 240 available PDB structures of ubiquitin and polyubiquitin,
alongside ensemble and molec...
www.cell.com
January 17, 2025 at 4:29 AM
"The current knowledge of ubiquitin signals through a ubiquitin-centric, structural biology lens." Useful resource for ubiuitin-lovers.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...