Mathieu Desgroseilliers
@matdesgro.bsky.social
🇨🇦Critical Care pharmacist. PharmD MSc BCCCP Interested in all things #CriticalCare. Aiming to be the best version of myself.
FR/EN(at least trying)
#PharmSky #RxSky #ICUSky #EMSky
🛜 https://linktr.ee/matdesgro
FR/EN(at least trying)
#PharmSky #RxSky #ICUSky #EMSky
🛜 https://linktr.ee/matdesgro
Reposted by Mathieu Desgroseilliers
Fascinating paper suggesting the assumption that there is a sigmoid dose response relationship and threshold effect ( "all-or-nothing") for loop diuretics rests on repeated misinterpretation of original studies from the 70s and 80s. #nephsky #cardiosky #emimcc academic.oup.com/ehjcvp/artic...
What are the pharmacodynamics of loop diuretics?
A recent editorial was entitled ‘Loop diuretics in heart failure: few facts and lots of prejudice’.1 I would argue that we have forgotten or distorted some
academic.oup.com
November 9, 2025 at 6:40 PM
Fascinating paper suggesting the assumption that there is a sigmoid dose response relationship and threshold effect ( "all-or-nothing") for loop diuretics rests on repeated misinterpretation of original studies from the 70s and 80s. #nephsky #cardiosky #emimcc academic.oup.com/ehjcvp/artic...
Reposted by Mathieu Desgroseilliers
"CRT, like a star, is not the destination but a guide for the journey". AS-2 it's not just a trial, it's a manifesto, an act of faith #EMIMCC #Andromeda #AndromedaShock2 #Sepsis
criticalcarereviews.com/blog/current
criticalcarereviews.com/blog/current
Faith, Evidence and the Stars
The most up-to-date critical care website in the world.
criticalcarereviews.com
November 9, 2025 at 9:02 PM
"CRT, like a star, is not the destination but a guide for the journey". AS-2 it's not just a trial, it's a manifesto, an act of faith #EMIMCC #Andromeda #AndromedaShock2 #Sepsis
criticalcarereviews.com/blog/current
criticalcarereviews.com/blog/current
Reposted by Mathieu Desgroseilliers
I'm revising the IBCC septic shock chapter based on ANDROMEDA-SHOCK II
would love any feedback & critique on this
ANDROMEDA algorithm is nice, but it's too complicated for everyday use. We need something simpler.
& maybe it's time to push for IR thermography 😍
emcrit.org/ibcc/sepsis/... #EMIMCC
would love any feedback & critique on this
ANDROMEDA algorithm is nice, but it's too complicated for everyday use. We need something simpler.
& maybe it's time to push for IR thermography 😍
emcrit.org/ibcc/sepsis/... #EMIMCC
November 10, 2025 at 1:16 PM
I'm revising the IBCC septic shock chapter based on ANDROMEDA-SHOCK II
would love any feedback & critique on this
ANDROMEDA algorithm is nice, but it's too complicated for everyday use. We need something simpler.
& maybe it's time to push for IR thermography 😍
emcrit.org/ibcc/sepsis/... #EMIMCC
would love any feedback & critique on this
ANDROMEDA algorithm is nice, but it's too complicated for everyday use. We need something simpler.
& maybe it's time to push for IR thermography 😍
emcrit.org/ibcc/sepsis/... #EMIMCC
Reposted by Mathieu Desgroseilliers
An ICU mentor describes a shift from imitation to shared, reflective learning, using AI alongside clinical judgement, encouraging open debate, and embracing vulnerability to strengthen teams and patient care. zurl.co/zJj7Y
November 10, 2025 at 5:00 PM
An ICU mentor describes a shift from imitation to shared, reflective learning, using AI alongside clinical judgement, encouraging open debate, and embracing vulnerability to strengthen teams and patient care. zurl.co/zJj7Y
Reposted by Mathieu Desgroseilliers
Reposted by Mathieu Desgroseilliers
"The cure for a fallacious argument is a better argument, not the suppression of ideas."
-Carl Sagan
-Carl Sagan
November 10, 2025 at 12:49 AM
"The cure for a fallacious argument is a better argument, not the suppression of ideas."
-Carl Sagan
-Carl Sagan
Reposted by Mathieu Desgroseilliers
Reposted by Mathieu Desgroseilliers
your daily reminder:
☕️ coffee is great
☕️ caffeine-free diets for hospitalized patients are silly & cause misery due to caffeine withdrawal #EMIMCC
☕️ coffee is great
☕️ caffeine-free diets for hospitalized patients are silly & cause misery due to caffeine withdrawal #EMIMCC
From @jama.com: Patients with #AFib who continued their usual caffeinated coffee intake after cardioversion experienced less recurrence of AF or atrial flutter compared to those who abstained from coffee and caffeine.
#AHA25 @ahascience.bsky.social
ja.ma/3XolIkd
#AHA25 @ahascience.bsky.social
ja.ma/3XolIkd
November 9, 2025 at 3:15 PM
your daily reminder:
☕️ coffee is great
☕️ caffeine-free diets for hospitalized patients are silly & cause misery due to caffeine withdrawal #EMIMCC
☕️ coffee is great
☕️ caffeine-free diets for hospitalized patients are silly & cause misery due to caffeine withdrawal #EMIMCC
Reposted by Mathieu Desgroseilliers
this is really excellent.
I was drafting a blog post on ANDROMEDA-SHOCK-2 but this really covers what I was going to say, so I don't have to now.
I am still working on a simplified, pragmatic approach to apply this at the bedside... stay tuned. #EMIMCC
I was drafting a blog post on ANDROMEDA-SHOCK-2 but this really covers what I was going to say, so I don't have to now.
I am still working on a simplified, pragmatic approach to apply this at the bedside... stay tuned. #EMIMCC
Our latest blog is out:
Faith, Evidence and the Stars: The ANDROMEDA‑SHOCK‑2 Trial
https://criticalcarereviews.com/blog/current
Faith, Evidence and the Stars: The ANDROMEDA‑SHOCK‑2 Trial
https://criticalcarereviews.com/blog/current
November 8, 2025 at 4:49 PM
this is really excellent.
I was drafting a blog post on ANDROMEDA-SHOCK-2 but this really covers what I was going to say, so I don't have to now.
I am still working on a simplified, pragmatic approach to apply this at the bedside... stay tuned. #EMIMCC
I was drafting a blog post on ANDROMEDA-SHOCK-2 but this really covers what I was going to say, so I don't have to now.
I am still working on a simplified, pragmatic approach to apply this at the bedside... stay tuned. #EMIMCC
Reposted by Mathieu Desgroseilliers
Our latest blog is out:
Faith, Evidence and the Stars: The ANDROMEDA‑SHOCK‑2 Trial
https://criticalcarereviews.com/blog/current
Faith, Evidence and the Stars: The ANDROMEDA‑SHOCK‑2 Trial
https://criticalcarereviews.com/blog/current
November 7, 2025 at 7:54 PM
Our latest blog is out:
Faith, Evidence and the Stars: The ANDROMEDA‑SHOCK‑2 Trial
https://criticalcarereviews.com/blog/current
Faith, Evidence and the Stars: The ANDROMEDA‑SHOCK‑2 Trial
https://criticalcarereviews.com/blog/current
Reposted by Mathieu Desgroseilliers
As world leaders gather in Brazil for the annual Conference of the Parties #COP30, The BMJ has published our annual climate issue.
This issue focuses on Brazil and the climate emergency, with a focus on the Amazon.
Browse the issue ⬇️
www.bmj.com/content/391/...
@kamranabbasi.bsky.social
This issue focuses on Brazil and the climate emergency, with a focus on the Amazon.
Browse the issue ⬇️
www.bmj.com/content/391/...
@kamranabbasi.bsky.social
November 7, 2025 at 6:01 PM
As world leaders gather in Brazil for the annual Conference of the Parties #COP30, The BMJ has published our annual climate issue.
This issue focuses on Brazil and the climate emergency, with a focus on the Amazon.
Browse the issue ⬇️
www.bmj.com/content/391/...
@kamranabbasi.bsky.social
This issue focuses on Brazil and the climate emergency, with a focus on the Amazon.
Browse the issue ⬇️
www.bmj.com/content/391/...
@kamranabbasi.bsky.social
Reposted by Mathieu Desgroseilliers
I agree with Sara! I reposted a skeetorial on PCN allergies and cross-sensitivities recently which seems relevant to this discussion and adds to what Sara has mentioned already 😊
bsky.app/profile/alau...
bsky.app/profile/alau...
Inspired by @pulmcrit.bsky.social’s recent post on PCN allergies! Thought I’d repost a skeetorial on PCN allergies to add to the great discussion. Link below:
bsky.app/profile/alau...
#medsky #pharmsky #EMsky #RNsky #GPsky #FOAMed #EMIMCC #IDsky
bsky.app/profile/alau...
#medsky #pharmsky #EMsky #RNsky #GPsky #FOAMed #EMIMCC #IDsky
I continue to be shocked by how PCN allergies are misunderstood
This is from UpToDate on neutropenic fever
It's wrong
With PCN allergy, you can absolutely use cefepime, piptazo, or meropenem
The R-chain structure that determines allergy is different
emcrit.org/ibcc/penicil... #EMIMCC #IDsky
This is from UpToDate on neutropenic fever
It's wrong
With PCN allergy, you can absolutely use cefepime, piptazo, or meropenem
The R-chain structure that determines allergy is different
emcrit.org/ibcc/penicil... #EMIMCC #IDsky
November 7, 2025 at 1:34 AM
I agree with Sara! I reposted a skeetorial on PCN allergies and cross-sensitivities recently which seems relevant to this discussion and adds to what Sara has mentioned already 😊
bsky.app/profile/alau...
bsky.app/profile/alau...
Reposted by Mathieu Desgroseilliers
Reminder to discontinue A-lines when they are no longer needed.
Risk of infection is lower than with central lines (since A-lines usually stop working and get pulled relatively soon), but infection risk is real.
Risk of infection is lower than with central lines (since A-lines usually stop working and get pulled relatively soon), but infection risk is real.
Arterial catheter complications:
• 13/100 catheters failed for any reason
• 20/100 catheters failed for reasons not caused by infection
• bloodstream infections - 1/100 catheters
• local infections (around the area where the catheter goes in) - 1/100 cases
#ICUSky #AnSky
doi.org/10.1111/anae...
• 13/100 catheters failed for any reason
• 20/100 catheters failed for reasons not caused by infection
• bloodstream infections - 1/100 catheters
• local infections (around the area where the catheter goes in) - 1/100 cases
#ICUSky #AnSky
doi.org/10.1111/anae...
November 6, 2025 at 3:21 PM
Reminder to discontinue A-lines when they are no longer needed.
Risk of infection is lower than with central lines (since A-lines usually stop working and get pulled relatively soon), but infection risk is real.
Risk of infection is lower than with central lines (since A-lines usually stop working and get pulled relatively soon), but infection risk is real.
Reposted by Mathieu Desgroseilliers
my pressor strategy hepatorenal syndrome in the ICU:
#1) start with NE gtt for immediate BP target acquisition
#2) once pt is improving, use PO midodrine to accelerate weaning off NE
midodrine can be helpful to help liberate patients from ICU
but as initial therapy, midodrine is some weak sauce
#1) start with NE gtt for immediate BP target acquisition
#2) once pt is improving, use PO midodrine to accelerate weaning off NE
midodrine can be helpful to help liberate patients from ICU
but as initial therapy, midodrine is some weak sauce
Midodrine and octreotide should not be first line therapy for HRS-AKI #kidneywk
November 6, 2025 at 5:45 PM
my pressor strategy hepatorenal syndrome in the ICU:
#1) start with NE gtt for immediate BP target acquisition
#2) once pt is improving, use PO midodrine to accelerate weaning off NE
midodrine can be helpful to help liberate patients from ICU
but as initial therapy, midodrine is some weak sauce
#1) start with NE gtt for immediate BP target acquisition
#2) once pt is improving, use PO midodrine to accelerate weaning off NE
midodrine can be helpful to help liberate patients from ICU
but as initial therapy, midodrine is some weak sauce
Reposted by Mathieu Desgroseilliers
In an absolutely shocking turn of events, #PhRMA (Pharmaceutical Research and Manufacturers of America) believes, in their submission to the #USMCA/#CUSMA trade agreement review, that Canada should be paying more for medicines.
🛃💊💰
www.phrma.org/resources/ph...
🛃💊💰
www.phrma.org/resources/ph...
November 6, 2025 at 8:04 PM
In an absolutely shocking turn of events, #PhRMA (Pharmaceutical Research and Manufacturers of America) believes, in their submission to the #USMCA/#CUSMA trade agreement review, that Canada should be paying more for medicines.
🛃💊💰
www.phrma.org/resources/ph...
🛃💊💰
www.phrma.org/resources/ph...
Reposted by Mathieu Desgroseilliers
The misconception that antibiotic allergy assessment is solely the domain of allergists has led to complacency in clinical practice, yet verifying allergy histories should be a core competency for all physicians, particularly infectious diseases. #IDsky #EMIMCC
🆕🔥State-of-the-Art Review with 🌟s @trubianojason.bsky.social : Antibiotic Allergy—A Multidisciplinary Approach to Delabeling #idsky
url: academic.oup.com/cid/article/...
url: academic.oup.com/cid/article/...
November 6, 2025 at 8:58 PM
Reposted by Mathieu Desgroseilliers
In severe ARDS, cardiogenic shock is common. Phenotypes include right-, left- and mixed forms. Extracorporeal options—VV, VA, VVA and VP ECMO—are set out, with cardiorespiratory support used as a potential bridge to recovery. zurl.co/o8ANj
November 6, 2025 at 9:00 AM
In severe ARDS, cardiogenic shock is common. Phenotypes include right-, left- and mixed forms. Extracorporeal options—VV, VA, VVA and VP ECMO—are set out, with cardiorespiratory support used as a potential bridge to recovery. zurl.co/o8ANj
Reposted by Mathieu Desgroseilliers
Today's Paper of the Day is:
Fluid resuscitation in trauma: What you need to know
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
Fluid resuscitation in trauma: What you need to know
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
November 6, 2025 at 9:29 AM
Today's Paper of the Day is:
Fluid resuscitation in trauma: What you need to know
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
Fluid resuscitation in trauma: What you need to know
https://criticalcarereviews.com/latest-evidence/paper-of-the-day
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
Reposted by Mathieu Desgroseilliers
VUMC 🏥 is recruiting for a PGY2 ID Pharmacy resident 🧫🦠 next year! If you or someone you know is interested, come check out one of our virtual open house sessions.
We have an amazing team of 4 inpatient, 2 OPAT, 1 peds, and 1 HIV pharmacists (and more) to work with!
We have an amazing team of 4 inpatient, 2 OPAT, 1 peds, and 1 HIV pharmacists (and more) to work with!
November 5, 2025 at 9:49 PM
VUMC 🏥 is recruiting for a PGY2 ID Pharmacy resident 🧫🦠 next year! If you or someone you know is interested, come check out one of our virtual open house sessions.
We have an amazing team of 4 inpatient, 2 OPAT, 1 peds, and 1 HIV pharmacists (and more) to work with!
We have an amazing team of 4 inpatient, 2 OPAT, 1 peds, and 1 HIV pharmacists (and more) to work with!
Reposted by Mathieu Desgroseilliers
🤯🤯🤯
Je suis sans mot.
50 ans d’expertise chez Transplant-qc.
Mais ils pensent sauver combien de $ en éliminant cet organisme?
lp.ca/xrpmiL?shari...
Je suis sans mot.
50 ans d’expertise chez Transplant-qc.
Mais ils pensent sauver combien de $ en éliminant cet organisme?
lp.ca/xrpmiL?shari...
Disparition de Transplant Québec | « Des vies sont en jeu »
La direction et les employés de Transplant Québec ont appris avec stupeur mercredi que l’organisme responsable des dons d’organe au Québec perdrait son financement en avril prochain. La décision de co...
lp.ca
November 5, 2025 at 11:35 PM
🤯🤯🤯
Je suis sans mot.
50 ans d’expertise chez Transplant-qc.
Mais ils pensent sauver combien de $ en éliminant cet organisme?
lp.ca/xrpmiL?shari...
Je suis sans mot.
50 ans d’expertise chez Transplant-qc.
Mais ils pensent sauver combien de $ en éliminant cet organisme?
lp.ca/xrpmiL?shari...
Reposted by Mathieu Desgroseilliers
Reposted by Mathieu Desgroseilliers
Today's Paper of the Day is:
Liver Cirrhosis: Evolving Definitions, and Recent Advances in Diagnosis, Prevention and Management
criticalcarereviews.com/latest-evide...
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
Liver Cirrhosis: Evolving Definitions, and Recent Advances in Diagnosis, Prevention and Management
criticalcarereviews.com/latest-evide...
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
November 5, 2025 at 10:21 AM
Today's Paper of the Day is:
Liver Cirrhosis: Evolving Definitions, and Recent Advances in Diagnosis, Prevention and Management
criticalcarereviews.com/latest-evide...
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
Liver Cirrhosis: Evolving Definitions, and Recent Advances in Diagnosis, Prevention and Management
criticalcarereviews.com/latest-evide...
Join us to read 1 paper per day and stay up-to-date as we cover the spectrum of critical care across 2025
Reposted by Mathieu Desgroseilliers
Renal Replacement Therapy in Critically Ill Patients: Navigating the Timing Debate
➡️ The early vs delayed RRT debate continues
➡️ Early start may overtreat; delay risks harm
➡️ Best timing? Guided by triggers & trajectory
CCR Journal Watch
criticalcarereviews.com/latest-evide...
➡️ The early vs delayed RRT debate continues
➡️ Early start may overtreat; delay risks harm
➡️ Best timing? Guided by triggers & trajectory
CCR Journal Watch
criticalcarereviews.com/latest-evide...
November 5, 2025 at 12:44 PM
Renal Replacement Therapy in Critically Ill Patients: Navigating the Timing Debate
➡️ The early vs delayed RRT debate continues
➡️ Early start may overtreat; delay risks harm
➡️ Best timing? Guided by triggers & trajectory
CCR Journal Watch
criticalcarereviews.com/latest-evide...
➡️ The early vs delayed RRT debate continues
➡️ Early start may overtreat; delay risks harm
➡️ Best timing? Guided by triggers & trajectory
CCR Journal Watch
criticalcarereviews.com/latest-evide...
Reposted by Mathieu Desgroseilliers
EMCrit Wee - @AndromedaShock 2 Explosion - An amazing discussion with the Lead Investigators. This conversation was educational and so enjoyable. Find out the intricacies of the study
[#FOAMed for now]
emcrit.org/as2-investi...
#edu_kattan
[#FOAMed for now]
emcrit.org/as2-investi...
#edu_kattan
November 4, 2025 at 6:01 PM
EMCrit Wee - @AndromedaShock 2 Explosion - An amazing discussion with the Lead Investigators. This conversation was educational and so enjoyable. Find out the intricacies of the study
[#FOAMed for now]
emcrit.org/as2-investi...
#edu_kattan
[#FOAMed for now]
emcrit.org/as2-investi...
#edu_kattan