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Reposted by Michael Ferraro

Jack Wilkinson @jdwilko.bsky.social · Sep 5

www.medrxiv.org/content/10.1...

INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.

INSPECT-SR: a tool for assessing trustworthiness of randomised controlled trials

The integrity of evidence synthesis is threatened by problematic randomised controlled trials (RCTs). These are RCTs where there are serious concerns about the trustworthiness of the data or findings....

www.medrxiv.org

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Reposted by Michael Ferraro

Neil O’Connell @neiloconnell.bsky.social · Sep 3

To do no harm, we must first “know harms”
Our new perspective piece on the
challenge of measuring and reporting adverse
events in interventions for pain is now available in @painthejournal.bsky.social dx.doi.org/10.1097/j.pa...
@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social

To do no harm, we must first “know harms”. The challenge of ... : PAIN

An abstract is unavailable.

dx.doi.org

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Reposted by Michael Ferraro

James McAuley @james-mcauley.bsky.social · Aug 21

Is medical practice ahead of the evidence?

Michael Ferraro @mcferraro.bsky.social · Aug 18

Out today 🚨 Our Cochrane review of 67 RCTs finds no clear evidence of benefit for ketamine or other NMDA antagonists for chronic pain. IV ketamine associated with risk of psychotomimetic effects, nausea, and vomiting. doi.org/10.1002/1465...

Ketamine and other NMDA receptor antagonists for chronic pain - Ferraro, MC - 2025 | Cochrane Library

Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.

doi.org

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Reposted by Michael Ferraro

Neil O’Connell @neiloconnell.bsky.social · Aug 18

@efic.bsky.social @britishpainsoc.bsky.social @auspainsoc.bsky.social

Michael Ferraro @mcferraro.bsky.social · Aug 18

Out today 🚨 Our Cochrane review of 67 RCTs finds no clear evidence of benefit for ketamine or other NMDA antagonists for chronic pain. IV ketamine associated with risk of psychotomimetic effects, nausea, and vomiting. doi.org/10.1002/1465...

Ketamine and other NMDA receptor antagonists for chronic pain - Ferraro, MC - 2025 | Cochrane Library

Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.

doi.org

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Michael Ferraro @mcferraro.bsky.social · Aug 18

@james-mcauley.bsky.social @neiloconnell.bsky.social @iasp.bsky.social @anzca-fpm.bsky.social

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Michael Ferraro @mcferraro.bsky.social · Aug 18

Out today 🚨 Our Cochrane review of 67 RCTs finds no clear evidence of benefit for ketamine or other NMDA antagonists for chronic pain. IV ketamine associated with risk of psychotomimetic effects, nausea, and vomiting. doi.org/10.1002/1465...

Ketamine and other NMDA receptor antagonists for chronic pain - Ferraro, MC - 2025 | Cochrane Library

Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.

doi.org

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Reposted by Michael Ferraro

The Medical Journal of Australia @mja.com.au · Jul 24

Despite a large body of new evidence, our best treatments for neuropathic pain continue to provide only modest benefits, write Michael Ferraro and Dr Nadia Soliman

buff.ly/F5irUsl

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Michael Ferraro @mcferraro.bsky.social · Jul 24

One-Page Patient Fact Sheets for Low Back Pain in Primary Care url:https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2836549?utm_source=bluesky&utm_campaign=content-shareicons&utm_content=article_engagement&utm_medium=social&utm_term=072425

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Reposted by Michael Ferraro

The Medical Journal of Australia @mja.com.au · Jul 21

Despite a large body of new evidence, our best treatments for neuropathic pain continue to provide only modest benefits, write Michael Ferraro and Dr Nadia Soliman

buff.ly/F5irUsl

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Reposted by Michael Ferraro

Florian Naudet @floriannaudet.bsky.social · Jul 18

🥁 This week, we submitted to BMC medicine our stage 2 registered report "Efficacy and safety of esketamine for ‘treatment-resistant depression’: registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-controlled trials". 🧵

Efficacy and safety of esketamine for treatment resistant depression: registered report for a Systematic Review with an Individual Patient Data Meta-analysis of Randomized, Double-Blind, Placebo-Contr...

Background In 2019, the FDA and EMA approved intranasal esketamine for treatment resistant depression (TRD). The current study re–evaluated its efficacy and safety. Methods This registered report pres...

www.medrxiv.org

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Reposted by Michael Ferraro

JAMA Network Open @jamanetworkopen.com · Jul 17

RCT: Among patients with low back pain, a nondirective information sheet listing treatment options improved patient-reported preparedness for decision-making more than a directive advice sheet. https://ja.ma/4nUr96z

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Reposted by Michael Ferraro

hjhansford.bsky.social @hjhansford.bsky.social · Jul 17

One-Page Patient Fact Sheets for Low Back Pain in Primary Care

Fact sheets do better than regular advice to support shared decision making!

jamanetwork.com/journals/jam...

One-Page Patient Fact Sheets for Low Back Pain in Primary Care

This randomized clinical trial compares the effects of 1-page fact sheets that adopt either an information-listing approach or a direct advice approach on management of low back pain to prepare patien...

jamanetwork.com

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Reposted by Michael Ferraro

Neil O’Connell @neiloconnell.bsky.social · Jul 16

Delighted that the editors of 15 Pain and Anaesthesiology have chosen to endorse and amplify the ENTRUST-PE framework. More info here: www.linkedin.com/pulse/entrus...

@iasp.bsky.social @efic.bsky.social @britishpainsoc.bsky.social @ukrio.bsky.social @coarassessment.bsky.social

ENTRUST-PE: endorsement by senior editors of 15 Pain and Anaesthesiology Journals

We are beyond delighted that the ENTRUST-PE framework has been endorsed by the Editors in Chief of 15 International Pain and Anaesthesiology journals. Those editors are copublishing, across the journa...

www.linkedin.com

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Reposted by Michael Ferraro

PAIN @painthejournal.bsky.social · Jul 14

#PAIN joins with other editors of pain-related journals to affirm our editorial commitment to trust and integrity in science. Read our joint statement at bit.ly/4lj3b3b

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Reposted by Michael Ferraro

The Journal of Pain @thejournalofpain.bsky.social · Jul 14

Editorial: The editors-in-chief from @thejournalofpain.bsky.social & other pain/anesthesia journals come together to align and strengthen initiatives to enhance research integrity, trust, and impact across our field.

Full: doi.org/10.1016/j.jp...

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doi.org

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Reposted by Michael Ferraro

Karen Davis @karenddavis.bsky.social · Jul 8

Editorial commitment to trust and integrity in science: implications for pain and anesthesiology research journals.lww.com/pain/fulltex...

Editorial commitment to trust and integrity in science:... : PAIN

An abstract is unavailable.

journals.lww.com

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Reposted by Michael Ferraro

Journal of Clinical Epidemiology @jclinepi.bsky.social · May 17

Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project - Journal of Clinical Epidemiology www.jclinepi.com/article/S089...

Assessing the feasibility and impact of clinical trial trustworthiness checks via an application to Cochrane Reviews: Stage 2 of the INSPECT-SR project

The aim of the INSPECT-SR project is to develop a tool to identify problematic RCTs in systematic reviews. In Stage 1 of the project, a list of potential trustworthiness checks was created. The checks...

www.jclinepi.com

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Reposted by Michael Ferraro

Jennifer Byrne @jabyrnesci.bsky.social · May 15

International #ResearchIntegrity conference taking place in beautiful Sydney Australia on 16-18 November 2025 🐨 🌏
Great speakers including @elisabethbik.bsky.social @jdwilko.bsky.social @jasonchin.bsky.social
For more info contact
@simongandevia.bsky.social 🧪

Simon Gandevia @simongandevia.bsky.social · May 14

International Research Integrity Conference. I am arranging this in Sydney in November 16-18th 2025. researchintegrityconf.com Note the excellent speaker list. Contact me!

International Research Integrity Conference | 17-18 November 2025, Sydney, Australia

researchintegrityconf.com

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Reposted by Michael Ferraro

Simon Gandevia @simongandevia.bsky.social · May 14

International Research Integrity Conference. I am arranging this in Sydney in November 16-18th 2025. researchintegrityconf.com Note the excellent speaker list. Contact me!

International Research Integrity Conference | 17-18 November 2025, Sydney, Australia

researchintegrityconf.com

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Reposted by Michael Ferraro

Jack Wilkinson @jdwilko.bsky.social · Apr 24

www.bmj.com/content/389/...

"Evidence from 68 systematic reviews with conclusions distorted by retracted trials was used in 157 guideline documents."

Investigating the impact of trial retractions on the healthcare evidence ecosystem (VITALITY Study I): retrospective cohort study

Objective To investigate the impact of retracted trials on the production and use of healthcare evidence in the evidence ecosystem. Design Retrospective cohort study based on forward citation searchi...

www.bmj.com

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Michael Ferraro @mcferraro.bsky.social · Apr 22

Updated @iasp.bsky.social NeuPSIG systematic review & guideline for treatment of neuropathic pain now published in @thelancetneuro.bsky.social. A privilege to contribute to this project, brilliantly led by @nadiasoliman.bsky.social

doi.org/10.1016/S147...

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Michael Ferraro @mcferraro.bsky.social · Mar 31

Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions

jamanetwork.com/journals/jam...

Inclusion of Retracted Studies in Systematic Reviews and Meta-Analyses of Interventions

This systematic review and meta-analysis identifies reports of systematic reviews that included retracted studies in their meta-analyses, and assesses the impact of these retracted studies on the resu...

jamanetwork.com

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Reposted by Michael Ferraro

Neil O’Connell @neiloconnell.bsky.social · Mar 24

File under “Never take the company’s word for it” www.thelancet.com/journals/lan...

Misleading marketing claims fuel tapentadol prescriptions

German drugmaker Grünenthal pushed its latest opioid as a safer option. People around the world got hooked. Madlen Davies, Hristio Boytchev, and Rafael Cabrera report.

www.thelancet.com

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Reposted by Michael Ferraro

Neil O’Connell @neiloconnell.bsky.social · Mar 11

@iasp.bsky.social @efic.bsky.social

Michael Ferraro @mcferraro.bsky.social · Mar 11

What are the benefits and harms of antidepressants for low back pain and spine‐related leg pain?

Find out in our Cochrane review, published today: doi.org/10.1002/1465...

Antidepressants for low back pain and spine‐related leg pain - Ferraro, MC - 2025 | Cochrane Library

Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.

doi.org

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Michael Ferraro @mcferraro.bsky.social · Mar 11

What are the benefits and harms of antidepressants for low back pain and spine‐related leg pain?

Find out in our Cochrane review, published today: doi.org/10.1002/1465...

Antidepressants for low back pain and spine‐related leg pain - Ferraro, MC - 2025 | Cochrane Library

Select your preferred language for Cochrane reviews and other content. Sections without translation will be in English.

doi.org

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