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mia

@miarosenfeld.bsky.social

2.9K followers 380 following 37 posts

machine learning drug discovery scientist @ iambic tx | neuralplexer developer computational biophysicist, glycoscientist, feminist, jewish, lover of sufjan stevens. she/they 🏳️‍🌈 ✡︎ 📍 sf/nyc

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mia @miarosenfeld.bsky.social · Nov 15

hi #chemsky! i'm mia! i love mucins, physics-infused ML, proteins, & biophysics!

currently a biophysicist-turned-ML-scientist @ iambic tx, developing & utilizing structure prediction algorithms in drug disco

prev: phd w/ @rommieamaro.bsky.social, postdoc w/ bernie brooks & @jchodera.bsky.social 🤓

mia smiling widely with an NIH coffee mug that says "big place, lots of smart people"

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mia @miarosenfeld.bsky.social · Jul 22

pls RT for reach! can’t wait to see y’all there 😁

@acs.org #CompChem

acscomp.bsky.social @acscomp.bsky.social · Jul 22

Mark your calendars for the ACS COMP *SUNDAY* Social on August 17, 2025! Free German 🥨&🍻 for COMP members, sponsored by OpenEye + Cadence 💻

RSVP link dropping soon in all ACS COMP members' email inboxes :)

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Gabriel Bosslet @gbosslet.bsky.social · Apr 23

Well the NIH has cancelled the Women's Health Initiative, the largest study of women in history

It has been running continuously since 1991 and has provided massive key knowledge about diseases in women

Unreal

www.science.org/content/arti...

NIH cancels its first and largest study centered on women

The Women’s Health Initiative has produced numerous influential findings

www.science.org

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RCSB Protein Data Bank @rcsbpdb.bsky.social · Apr 4

Register Now for Crash Course: Python For Cheminformatics-Driven Molecular Docking
This free virtual course will demonstrate the power and flexibility of python on May 1, 2025
pdb101.rcsb.org/news...

PDB101: Register Now for Crash Course: Python For Cheminformatics-Driven Molecular Docking

PDB-101: Training, Outreach, and Education portal of RCSB PDB

pdb101.rcsb.org

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mia @miarosenfeld.bsky.social · Apr 4

it's so close to being awesome 😭 but skimming code... ligand = any heteroatom (rip waters, ions, buffers). assumes atoms in prediction are perfectly ordered/labeled - not true for chai, boltz, etc. binding site = assumes identical residue IDs.
shameless promo, we hit most of these in np & np-bench ❤️

mia @miarosenfeld.bsky.social · Apr 3

@fionachembot.bsky.social opened up linkedin to this, and honestly, i can't help but immediately see a mucin rendering next to this depressing news headline... 😂

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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Apr 1

People/organizations with means and a vision for the future of biomedical science - we need an “Arc Institute” equivalent in the DMV area to sponge up all the incredible talent, opportunity of a lifetime for a visionary entrepreneur, I will help! @mcuban.bsky.social

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Emma Chory, Ph.D. @chorye.bsky.social · Apr 1

Read: OpenAI raised $40B—i.e., the entire NIH budget.

TechCrunch @techcrunch.com · Apr 1

OpenAI announced that it closed one of the largest private funding rounds in history.

According to a blog post on the company’s website, OpenAI raised $40 billion in a round that values the company at $300 billion post-money.

Read more here: tcrn.ch/4lbbzCf

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Bethany Halford @bethanyhalford.bsky.social · Mar 28

If you love drug candidates but weren't able to attend the #FirstTimeDisclosures symposium at #ACSSpring2025, check out my story about the session for @cenmag.bsky.social - with lots of cool-looking molecules.
cen.acs.org/acs-news/acs...

12 drug candidates debut in San Diego

Structures unveiled during first-time disclosures symposium

cen.acs.org

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acscomp.bsky.social @acscomp.bsky.social · Mar 23

🚨 PLEASE RT 🚨

Are you a comp chem trainee attending Spring ACS in San Diego? Would you like to expand your network with mentors in industry & academia at the COMP Mentor Lunch?

Fill out this form if you are interested in attending!

forms.gle/Sq79TJihHnFW...

forms.gle

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Mark Cuban @mcuban.bsky.social · Mar 22

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

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Kevin K. Yang 楊凱筌 @kevinkaichuang.bsky.social · Mar 20

Unassigned nitrogens in nmr data often indicate biologically relevant motion in proteins, and this can be used train deep learning models of protein dynamics!

Hannah Wayment-Steele
@ginaelnesr.bsky.social @sokrypton.org

www.biorxiv.org/content/10.1...

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Dr. Fiona @fionachembot.bsky.social · Mar 13

This was a massive team effort and I'm forever grateful for the full list of authors helping me to drive this one into the endzone! Thank you to Anthony Bogetti, Carla Calvó-Tussell, @mackevinbraza.bsky.social, @lcasalino88.bsky.social, Amanda Gramm, Sean Braet, @miarosenfeld.bsky.social,... (1/2)

Dr. Fiona @fionachembot.bsky.social · Mar 13

Nevertheless, we persisted ❤️

📣 NEW BIORXIV ALERT!! 🚨

Using WE MD, linguistic pathway clustering, dynamical network analyses, and HDXMS we reveal a hidden allosteric network within the SARS2 spike S1 domain and predict how the D614G mutation impacts this network!

www.biorxiv.org/content/10.1...

D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes

The SARS-CoV-2 spike glycoprotein binds human epithelial cells and enables infection through a key conformational transition that exposes its receptor binding domain (RBD). Experimental evidence indic...

www.biorxiv.org

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mia @miarosenfeld.bsky.social · Mar 13

thrilled I got to plan this year's ACS COMP social in my science home town 🌊♥️💻🧪

hope to see y'all there!!!

acscomp.bsky.social @acscomp.bsky.social · Mar 13

Mark your calendars for the ACS COMP Saturday Social on March 22, 2025! Free 🌮 & 🍻 for COMP members!

If you didn’t get the RSVP link in your email inbox, DM us with a screenshot of your COMP membership and we’ll shoot you the RSVP link 😁

#ACSSpring2025 #chemsky

Reposted by mia

Derek Lowe @dereklowe.bsky.social · Mar 12

This stupid SOB is practically rooting for the measles virus. He will apparently do almost anything to avoid vaccination:

RFK Jr.: It Would Be Better if ‘Everybody Got Measles’

“The measles gave you lifetime protection against measles infection,” Robert F. Kennedy Jr. told Sean Hannity on Fox News.

www.thedailybeast.com

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mia @miarosenfeld.bsky.social · Mar 12

reality of ML+bio research: real methodological innovation is rare, expert application is common. & that's okay! most progress comes from skillfully using existing tools. lets be honest abt contributions & stop repackaging established methods with domain expertise as "novel computational frameworks"

Reposted by mia

Alex Dickson @dicksonlab.bsky.social · Feb 18

What's easier to learn: cryo-EM or MD simulations? Ben Orlando and I couldn't decide, so we are accepting post-doc applications from both fields! Come work with us to explore the intersection between cryo-EM and MD at Michigan State! careers.msu.edu/jobs/researc...

Research Associate-Fixed Term - East Lansing, Michigan, United States

Position Summary A Postdoctoral Research Fellow position is available in the Department of Biochemistry and Molecular Biology (BMB) at Michigan State University. The fellow will work at the interface ...

careers.msu.edu

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Liz Decolvenaere @tallakahath.bsky.social · Feb 18

Mentioned in the below article, Science is running a "Trump tracker" that's attempting to keep up with the ongoing firings at scientific agencies within the US: www.science.org/content/arti...

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darcy-davidson.bsky.social @darcy-davidson.bsky.social · Feb 18

@biophysicalsoc.bsky.social you need to be sharing at the conference this week like our lives depend on it. Because they do.

Speak up. Stand up. Get out there and protect out democracy

Stand Up for Science! @standupforscience.bsky.social · Feb 12

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

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Mark Peifer (He, him) @peiferlabunc.bsky.social · Feb 5

If anyone has the resources to resist, its HHMI. Ending this program with no notice and literally scrubbing evidence it ever existed from the website is shocking and dosappointing

Viji @vijisathy.bsky.social · Feb 5

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mia @miarosenfeld.bsky.social · Jan 8

i’m hiring! come work with our amazing neuralplexer development team at iambic therapeutics to help increase the conformational accuracy of our protein structure predictions!

pls share with folks you think may be interested, & feel free to reach out with questions

jobs.ashbyhq.com/iambic-thera...

Graduate Research Intern - Machine Learning for Protein Structure Prediction

JOB SUMMARY We are seeking a graduate student for a research internship at Iambic Therapeutics to contribute to the development of NeuralPLexer, our protein structure prediction platform. This intern...

jobs.ashbyhq.com

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mia @miarosenfeld.bsky.social · Dec 25

this is so incredibly sweet!!! happy hanukkah ♥️ making my latkes later today and i’ll be sure to grate the onion first ;)

Reposted by mia

Prachee Avasthi @pracheeac.bsky.social · Dec 22

An example of how the limited and biased availability of data narrows the range of functional biology PLMs tap into for prediction and design

research.arcadiascience.com/pub/result-p...

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mia @miarosenfeld.bsky.social · Dec 17

it rigorously and consistently evaluates traditional structure prediction metrics like pocket-aligned ligand rmsd and dockq score. we hope this helps create more consistency in how we evaluate progress in the field of structure prediction & ultimately aids in pushing the field forward as a whole :)

mia @miarosenfeld.bsky.social · Dec 17

also, ConfBench is just one of many aspects of the NP3 technical report - we are also excited to announce we're open-sourcing NPBench: our turnkey dataset distillation and code library for standardized structure prediction benchmarking!

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mia @miarosenfeld.bsky.social · Dec 17

unimaginably large thank you to the amazing team and leadership that made this work possible, especially Zhuoran Qiao and Matt Welborn for believing in my vision of conformational enablement of structure prediction!

& to @rommieamaro.bsky.social, who sparked my love for dynamic proteins ♡

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