Mustafa Khasraw
@mkhasraw.bsky.social
Oncologist @DukeU; interested in cancer research, clinical trials, immunotherapy but many other things - Views are my own
Thekhasrawlab.com
Reposted by Mustafa Khasraw
Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...
November 25, 2025 at 6:18 AM
Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...
The promise of TIL therapy for glioblastoma
www.cell.com/trends/cance...
authors.elsevier.com/a/1m5yH8Z12y...
@dukeneurosurgery.bsky.social
@neurosurgucsf.bsky.social
www.cell.com/trends/cance...
authors.elsevier.com/a/1m5yH8Z12y...
@dukeneurosurgery.bsky.social
@neurosurgucsf.bsky.social
The promise of TIL therapy for glioblastoma
Tumor-infiltrating lymphocyte (TIL) therapy has demonstrated efficacy in refractory
melanoma and durable responses in lung cancer. Glioblastoma presents distinct challenges
for immunotherapy, includin...
www.cell.com
November 14, 2025 at 1:52 AM
The promise of TIL therapy for glioblastoma
www.cell.com/trends/cance...
authors.elsevier.com/a/1m5yH8Z12y...
@dukeneurosurgery.bsky.social
@neurosurgucsf.bsky.social
www.cell.com/trends/cance...
authors.elsevier.com/a/1m5yH8Z12y...
@dukeneurosurgery.bsky.social
@neurosurgucsf.bsky.social
Reposted by Mustafa Khasraw
Yet another great reason to live in Europe!!
Multilingualism protects against accelerated aging 😀
An analysis of aging in >86,000 participants across 27 European countries
Amoruso et al, Nature Aging 🧪⏳
www.nature.com/articles/s43...
Multilingualism protects against accelerated aging 😀
An analysis of aging in >86,000 participants across 27 European countries
Amoruso et al, Nature Aging 🧪⏳
www.nature.com/articles/s43...
November 10, 2025 at 7:51 PM
Yet another great reason to live in Europe!!
Multilingualism protects against accelerated aging 😀
An analysis of aging in >86,000 participants across 27 European countries
Amoruso et al, Nature Aging 🧪⏳
www.nature.com/articles/s43...
Multilingualism protects against accelerated aging 😀
An analysis of aging in >86,000 participants across 27 European countries
Amoruso et al, Nature Aging 🧪⏳
www.nature.com/articles/s43...
Reposted by Mustafa Khasraw
Conrad Hal Waddington was born OTD in 1905.
His “epigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development.
On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape.
🧪 🦫🦋 🌱🐋 #HistSTM #philsci #evobio
His “epigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development.
On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape.
🧪 🦫🦋 🌱🐋 #HistSTM #philsci #evobio
November 8, 2025 at 4:03 PM
Reposted by Mustafa Khasraw
Even chimpanzees think rationally and weigh the evidence when making a choice ;-)
@science.org
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
Chimpanzees rationally revise their beliefs
The selective revision of beliefs in light of new evidence has been considered one of the hallmarks of human-level rationality. However, tests of this ability in other species are lacking. We examined...
www.science.org
October 31, 2025 at 1:52 AM
Even chimpanzees think rationally and weigh the evidence when making a choice ;-)
@science.org
www.science.org/doi/10.1126/...
@science.org
www.science.org/doi/10.1126/...
Reposted by Mustafa Khasraw
Back then, it took almost 40 years for his work to be discovered, and even today science communication remains flawed. We must get better at finding and evaluating science and remember that major discoveries may emerge from non-prestigious institutes and appear in non-glamorous journals.
October 31, 2025 at 5:48 AM
Back then, it took almost 40 years for his work to be discovered, and even today science communication remains flawed. We must get better at finding and evaluating science and remember that major discoveries may emerge from non-prestigious institutes and appear in non-glamorous journals.
Senior Research Tech (Duke) – tumor immunobiology lab. Work with tumor/blood/CSF samples, culture patient-derived cell lines, assist single-cell assays, and support & lead research. Bio degree + research exp required. No visa sponsorship. Title may vary.
Apply → careers.duke.edu/job-invite/2...
Apply → careers.duke.edu/job-invite/2...
RESEARCH TECHNICIAN III
RESEARCH TECHNICIAN III
careers.duke.edu
October 29, 2025 at 9:41 PM
Senior Research Tech (Duke) – tumor immunobiology lab. Work with tumor/blood/CSF samples, culture patient-derived cell lines, assist single-cell assays, and support & lead research. Bio degree + research exp required. No visa sponsorship. Title may vary.
Apply → careers.duke.edu/job-invite/2...
Apply → careers.duke.edu/job-invite/2...
Reposted by Mustafa Khasraw
Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy @science.org
www.science.org/content/arti...
www.science.org/content/arti...
September 12, 2025 at 2:06 AM
Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy @science.org
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by Mustafa Khasraw
We need to do more to find effective treatments for leptomeningeal metastasis from solid tumors but this commentary from our team shows we are making some progress as a field!
@dukemets.bsky.social
@dukecancer.bsky.social
rdcu.be/eySK8
@dukemets.bsky.social
@dukecancer.bsky.social
rdcu.be/eySK8
A HER3-targeting antibody–drug conjugate for leptomeningeal metastasis
Nature Medicine - The phase 2 TUXEDO-3 trial identifies the HER3-targeting antibody–drug conjugate patritumab deruxtecan as a promising new therapeutic option for patients with leptomeningeal...
rdcu.be
August 1, 2025 at 3:00 PM
We need to do more to find effective treatments for leptomeningeal metastasis from solid tumors but this commentary from our team shows we are making some progress as a field!
@dukemets.bsky.social
@dukecancer.bsky.social
rdcu.be/eySK8
@dukemets.bsky.social
@dukecancer.bsky.social
rdcu.be/eySK8
Reposted by Mustafa Khasraw
Are you a top US-based scientist wanting to relocate to Australia? We are now calling for formal applications from both Australian and non-Australian citizens based in the US whose work is internationally recognised as exceptional.
📅 Applications close: Aug 29, 2025
🔗 science.org.au/gtap/?utm_so...
📅 Applications close: Aug 29, 2025
🔗 science.org.au/gtap/?utm_so...
July 11, 2025 at 12:21 AM
Are you a top US-based scientist wanting to relocate to Australia? We are now calling for formal applications from both Australian and non-Australian citizens based in the US whose work is internationally recognised as exceptional.
📅 Applications close: Aug 29, 2025
🔗 science.org.au/gtap/?utm_so...
📅 Applications close: Aug 29, 2025
🔗 science.org.au/gtap/?utm_so...
Reposted by Mustafa Khasraw
'Using a genome-wide in vivo CRISPR screen, we identified phosphodiesterase 5 & its substrate cGMP as key modulators of DC migration. Advanced tumours disrupted cGMP synthesis in DCs to decrease their motility, while PDE5 perturbation preserved the cGMP pool to restore DC migration'
#TumorImmunology
#TumorImmunology
Rescuing dendritic cell interstitial motility sustains antitumour immunity - Nature
Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.
www.nature.com
July 2, 2025 at 12:29 AM
'Using a genome-wide in vivo CRISPR screen, we identified phosphodiesterase 5 & its substrate cGMP as key modulators of DC migration. Advanced tumours disrupted cGMP synthesis in DCs to decrease their motility, while PDE5 perturbation preserved the cGMP pool to restore DC migration'
#TumorImmunology
#TumorImmunology
Reposted by Mustafa Khasraw
A study has found a promising new way to attack high-grade gliomas (HGG), by targeting the cells surrounding a tumour.
The brilliant findings, led by Pofessor Misty Jenkins, Zoe Day
and Dr Ryan Cross are now published in Nature’s npj Precision Oncology.
www.nature.com/articles/s41...
The brilliant findings, led by Pofessor Misty Jenkins, Zoe Day
and Dr Ryan Cross are now published in Nature’s npj Precision Oncology.
www.nature.com/articles/s41...
July 2, 2025 at 1:33 AM
A study has found a promising new way to attack high-grade gliomas (HGG), by targeting the cells surrounding a tumour.
The brilliant findings, led by Pofessor Misty Jenkins, Zoe Day
and Dr Ryan Cross are now published in Nature’s npj Precision Oncology.
www.nature.com/articles/s41...
The brilliant findings, led by Pofessor Misty Jenkins, Zoe Day
and Dr Ryan Cross are now published in Nature’s npj Precision Oncology.
www.nature.com/articles/s41...
Reposted by Mustafa Khasraw
It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below.
prospect.org/politics/202...
prospect.org/politics/202...
Will the Senate Save NIH?
Rescuing biomedical research is every bit as important as saving Medicaid.
prospect.org
June 29, 2025 at 3:17 AM
It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below.
prospect.org/politics/202...
prospect.org/politics/202...
Reposted by Mustafa Khasraw
This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...
June 4, 2025 at 9:00 PM
This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...
Delighted to be back in Melbourne to speak at the BCC symposium, listen to exciting scientific presentations and to be with friends @wehi-research.bsky.social @saskiafreytag.bsky.social
June 5, 2025 at 12:48 AM
Delighted to be back in Melbourne to speak at the BCC symposium, listen to exciting scientific presentations and to be with friends @wehi-research.bsky.social @saskiafreytag.bsky.social
Reposted by Mustafa Khasraw
🧪
I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding.
It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.
unbreaking.org/issues/medic...
It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job.
unbreaking.org/issues/medic...
Medical Research Funding — Unbreaking
How the administration is breaking the government, and what that means for all of us.
unbreaking.org
May 31, 2025 at 1:44 AM
🧪
Reposted by Mustafa Khasraw
1/3
PLEASE READ, LIKE, REPOST this "1/3" post
There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)
PLEASE READ, LIKE, REPOST this "1/3" post
There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)
May 6, 2025 at 11:22 PM
1/3
PLEASE READ, LIKE, REPOST this "1/3" post
There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)
PLEASE READ, LIKE, REPOST this "1/3" post
There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)
Reposted by Mustafa Khasraw
Can an LLM system become conscious? This question has generated significant debate and too much hype. Here's a paper from @cp-trendsneuro.bsky.social on what neuroscience has to say about that shine-lab.org/wp-content/u...
April 30, 2025 at 12:17 AM
Can an LLM system become conscious? This question has generated significant debate and too much hype. Here's a paper from @cp-trendsneuro.bsky.social on what neuroscience has to say about that shine-lab.org/wp-content/u...
JCI - IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models www.jci.org/articles/vie...
JCI -
IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models
www.jci.org
April 18, 2025 at 2:48 AM
JCI - IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models www.jci.org/articles/vie...
A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 2, 2025 at 10:13 PM
A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Integrated Proteogenomic Characterization of Glioblastoma Evolution: Overcoming Barriers to Develop Personalized Treatment Strategies dailynews.ascopubs.org/do/integrate...
March 20, 2025 at 1:34 PM
Integrated Proteogenomic Characterization of Glioblastoma Evolution: Overcoming Barriers to Develop Personalized Treatment Strategies dailynews.ascopubs.org/do/integrate...
Reposted by Mustafa Khasraw
This #science exciting! Collaborate, #clincaltrials, nurses, scientists - my co-lead H Rizos🤩. #immunotherapy 4 #GBM #glioblastoma Handed draft trial design+drugs to @jimwhittle.bsky.social @braincancercentre.bsky.social
@sydneyuni.bsky.social @melanomaau.bsky.social
www.nature.com/articles/s41...
@sydneyuni.bsky.social @melanomaau.bsky.social
www.nature.com/articles/s41...
Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma - Nature Medicine
A patient with newly diagnosed glioblastoma was safely treated with neoadjuvant nivolumab, relatlimab and ipilimumab before maximal resection, with comprehensive immune profiling showing the induction...
www.nature.com
February 28, 2025 at 8:19 AM
This #science exciting! Collaborate, #clincaltrials, nurses, scientists - my co-lead H Rizos🤩. #immunotherapy 4 #GBM #glioblastoma Handed draft trial design+drugs to @jimwhittle.bsky.social @braincancercentre.bsky.social
@sydneyuni.bsky.social @melanomaau.bsky.social
www.nature.com/articles/s41...
@sydneyuni.bsky.social @melanomaau.bsky.social
www.nature.com/articles/s41...
Reposted by Mustafa Khasraw
Reposted by Mustafa Khasraw
Outstanding lecture by Martin van den Bent, receiving the Victor Levin award! #SNO2024
@martinvandenbent.bsky.social
@neuroonc.bsky.social
@eanoassociation.bsky.social
@martinvandenbent.bsky.social
@neuroonc.bsky.social
@eanoassociation.bsky.social
November 23, 2024 at 9:36 PM
Outstanding lecture by Martin van den Bent, receiving the Victor Levin award! #SNO2024
@martinvandenbent.bsky.social
@neuroonc.bsky.social
@eanoassociation.bsky.social
@martinvandenbent.bsky.social
@neuroonc.bsky.social
@eanoassociation.bsky.social
Congratulations to Mitchel Berger for receiving the Lifetime Achievement Award. #SNO2024 #ScientificMeeting
November 23, 2024 at 12:25 AM
Congratulations to Mitchel Berger for receiving the Lifetime Achievement Award. #SNO2024 #ScientificMeeting